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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 7 Documents
 1 
Search results for , issue "Vol 5 No 1 (2007): JIFI" : 7 Documents clear
Analisis Glikoprotein dalam Daging Mytilus viridis, Anadara granosa, dan Anadara maculosa Zuhelmi Aziz; Thamrin Wikanta; Tirta Subagio
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Mussels is known to have ability living in clean or polluted waters environment due to it has a specific immunity system. The immunity mechanism is carried out by a glycoprotein that play role as an immunomodulator with high activity. Extraction of glycoprotein from fresh green mussel (Mytilus viridis), blood mussel (Anadara granosa) and bulu mussel (Anadara maculosa) have been carried out, by boiling the mussels for 30 minutes and 60 minutes, precipitation of glycoprotein with ethanol, then purification of glycoprotein through the Sephadex G-100 column. The amino acids composition of the glycoprotein was analyzed by high performance liquid chromatography (HPLC) with normal phase pico tag column, using 1 ml/min isocratic elution with sodium acetate buffer-acetonitril mixture, and detection with UV detector. Result showed that the yield of glycoprotein from 60 minutes boiling was higher than from 30 minutes boiling. The glycoprotein content of green mussel, blood mussel and bulu mussel were 11,97%, 8,36%, and 18,93% from 60 minutes boiling, and 10,32%, 7,93%, and 9,07 from 30 minutes boiling, respectively. It can be concluded that the amino acids composition in the glycoprotein from both treatment were not proportional , but the 60 minutes boiling was given higher result.
Karakterisasi Rekristalit Antalgin-Fenilbutason dengan Pelarut Aseton sebagai Suatu Sistem Interaksi Fisika Ilma Nugrahani; Slamet Ibrahim; Sundani Nurono Soewandhi; Sukmadjaja Asyarie
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Recrystallization with acetone of antalgyne, phenylbutazone, and the mixture of binary system has been characterized. The aim of this research was looking for thermodynamic and x-ray diffraction characteristic of re-crystallite to compare with raw material characteristics. The result used to confirm validity of cool contact methods to identify physical interaction of antalgine-phenylbutazone that has been developed in the preliminary research. Recrystallites characterized by DSC and powder-XRD shows the polymorphism cases, but the co-recrystallite of binary system show the peritecticum physical interaction, similar with the physical interaction of the raw material binary system before recrystallization. Principally, the results of this investigation prove that cool contact methods by acetone could be used for identify physical interaction of antalgine-phenylbutazone.
Produksi dan Penetapan Kadar B-glukan dari Tiga Galur Saccharomyces cerevisiae dalam Media Mengandung Molase Kusmiati Kusmiati; Swasono R. Tamat; S. Nuswantara; Nita Isnaini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Beta-glucan extracted from the cell membrane of Saccharomyces cerevisiae has been used as food and medical ingredients. Molase as a waste-product of the cane sugar industry, containing 4-9% of glucose and other nutrients, has been investigated to substitute glucose in the YPG fermentation media of Saccharomyces cerevisiae, and to improve the yield of B-glucan by three strains of Saccharomyces cerevisiae (RTA, RN4, and SC). Beta-glucan and protein concentration were determined by spectrophotometric method at a 490 nm and 750 nm respectively. The results showed that molase can be used as glucose-substitute in the YPG media for the production of B-glucan by three strains of Saccharomyces cerevisiae. The best yield for each strain was as follows: RTA strain in a media containing molase (8% v/v glucose equivalent) produced 61,79% w/w of B-glucan; RN4 strain in a media containing molase (1% v/v glucose equivalent) produced 98,42% w/w of B-glucan; SC strain in a media containing molase (2% v/v glucose equivalent) produced 56,48% w/w of B-glucan. One-way Anova followed by the Tukey-Bonferroni test indicated that molase can be used as substitute of glucose source in the YPG fermentation media, and significantly increased the B-glucan yield by all the three strains of Saccharomyces cerevisiae, as well as reducing the protein contents. The highest ß-glucan yield (98,42% w/w) was attained by the RN4 strain in a media containing molase (1% v/v glucose equivalent) with a protein impurity of only 10,53% w/w, while the RN4 and RTA strains produced a higher B-glucan yield than that of the SC strain.
Beberapa Kelainan Genetik yang Bersifat Protektif terhadap Infeksi Malaria Syamsudin Syamsudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Resistance to malarial infection is dependent on the development of an immune response by the host and to a varying extend, a certain innate characteristics possessing protective value against infection. Innate resistance is not always absolute and genetically determined factors, but instead can act to reduce the severity of infection and improve survive. Mechanism of action resistance to malarial infection will be discussed in this article.
Uji Sitotoksik Hasil Fermentasi Kapang Endofit Buah Mahkota Dewa (Phaleria macrocarpa) terhadap Sel MCF-7 Syarmalina Syarmalina; Wan Lely; Nazliah Laupa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

In the development of traditional medicine, there are great demands of medicinal plant. Meanwhile, those demands exceed the capacity of natural resource to provide the raw material. The solution for that problem that has been developed is by utilizing organism that live on plant tissue, which known as endophytic microbe. The preliminary Brine Shrimp Lethality Test based research on the polarity degree of supernatant extracts has proved that it has high toxic activity on Artemia salina Leach. Subsequent to that study, a research to examine in vitro cytotoxic effect of supernatant extract fermented from Mahkota Dewa fruit endophytic mould KVM/a and KIVM/b isolate on breast cancer cell has been conducted. Thin layer chromatographic test was performed to identify the patch pattern from each fraction of KVM/a and KIVM/b isolate. Furthermore, preparative thin layer chromatographic test was tested on MCF-7 cell by using neutral red method. The cytotoxic effect was determined based on ICs, value. The results confirm the cytotoxic test effect of semi polar fraction of both isolates on MCF-7 cell with the ICs, value of 36.26 ppm for KVM/a and 30.48 ppm for KIVM/b.
Aktivitas Antioksidan dan Toksisitas Senyawa Bioaktif dari Ekstrak Rumput Laut Hijau Ulva reticulata Forsskal Swasono R. Tamat; Thamrin Wikanta; Lina S. Maulina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Research on the antioxidative activity and toxicity of the bioactive substance of the green seaweed Ulva reticulata Forsskal extract had been carried out. The bioactive substance of the green seaweed Ulva reticulata Forsskal was extracted using methanol. The phytochemistry test on the methanol extract showed that the extract contained triterpenoid compound. The methanol extract was then partitioned using n-hexane-water (1:1) and chloroform-water (1:1). Each of the extract was then dried using freeze dryer. The antioxidative activity test of each fraction against free radical 1,1-diphenyl-2-picrilhydrazil (DPPH) showed that the water extract has the highest activity with IC 30 of 365,95 ug/ml. The toxicity test of each fraction against brine shrimp Artemia salina (Brine Shrimp Lethality Test, BSLT) showed that the chloroform extract showed the highest activity with LCs of 250,67 ug/ml. The water extract was then fractionated through silica column chromatography. The activity test of each fraction against DPPH and BSLT showed that fraction 1 has the highest activity with LCs of 100 ug/ml and ICs of 270,31ug/ ml. Identification using gas chromatography – mass spectrometric method showed that the antioxidative substance presence in the active fraction was probably nonyl phenol (C, H2,0).
Analisis Pendahuluan Metabolit Sekunder dari Kalus Mahkota Dewa (Phaleria macrocarpa [Scheff.] Boerl.) Erlindha Gangga; Henita Asriani; Linda Novita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Callus is a cell mass which is formed by cell tissues and formed in explants surface or explants slice which divide them continuously in a controlled condition. With tissue culture method, the aim in using callus is for reproduce new plants to get the secondary metabolite which match with the secondary metabolite from the origin plants. Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.), from Thymelaceae family is a very useful plant which can be used for medicine. Its leaves and seed's skin are the most important parts that usually used. In this experiment, Mahkota’s seed is planted in germination media to get a sterile plant, and then from the plant, we take the leaves for callus initiation. We do a phytochemical filtering, TLC, and HPLC tests with this callus that we produced then we compared the result with Mahkota Dewa's leaves. From the phytochemical filtering result we found that both of them have alkaloid secondary metabolite, flavonoid saponin, tannin, steroid/triterpenoid. We also found some chromatograms which are similar in TLC and HPLC.

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