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Hirowati Ali
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Majalah Kedokteran Andalas
Published by Universitas Andalas
ISSN : 01262092     EISSN : 24425230     DOI : https://doi.org/10.25077
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Majalah Kedokteran Andalas (MKA) (p-ISSN: 0126-2092, e-ISSN: 2442-5230) is a peer-reviewed, open-access national journal published by Faculty of Medicine, Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of medicine and health, and other related disciplines
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol 46, No 11 (2024): July 2024" : 13 Documents clear
Derajat Ekspresi Fibroblast Activation Protein Pada Cancer-Associated Fibroblast Karsinoma Kolorektal Vonny Amalia
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1839-1850.2024

Abstract

Objective: to determine the degree of expression of Fibroblast Activation Protein in Cancer Associated Fibroblasts of colorectal carcinoma. Methods: descriptive study with a cross sectional research design. Using 36 paraffin blocks of CRC cases that met the inclusion criteria. FAP expression was assessed through immunohistochemical staining with anti-FAP and histopathological data were recorded in the form of depth invasion, degree of differentiation, lymphovascular invasion and lymph node metastatic status. Results: FAP in CAFs showed a high expression in most cases (52.8%). High-grade expression of FAP more common at T3-T4 depth of invasion, low-grade differentiation, CRC without lymphovascular invasion and CRC without lymph node metastases. Conclusion: there are variations in the expression of FAP as a marker of CAFs in colorectal carcinoma histopathology features.
The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital Yuliany Christy Coloay; Idral Purnakarya; Indrawaty Lipoeto
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1757-1765.2024

Abstract

Breast cancer is a non-communicable disease, the development of cancer cells affects a series of organ functions. Treatment for breast cancer is generally divided into three, namely mastectomy, chemotherapy and radiotherapy. Objective: To determine the relationship between frequency of therapy, food intake and nutritional status with the quality of life of cancer patients. Results: Cancer cell activity in the body is characterized by pain, especially in the cancer area. The frequency of therapy >3 months has an effect on decreasing nutritional status, the therapy undertaken has side effects, both chemotherapy and radiotherapy, resulting in side effects such as nausea and loss of appetite. Conclusion: Patients who undergo therapy for 3 months tend to be underweight, if the food intake they receive according to their needs will reduce the risk and disruption of a series of body system functions. Regulating the types of food with a regular eating pattern increases the body's physical defenses. Maintaining normal nutritional status while undergoing therapy can maintain physical quality that is related to quality of life.The Relationship Of Therapy Frequency, Food Intake, And Nutritional Status With Quality Of Life In Breast Cancer Patients At The Andalas University Educational Hospital
Organoleptic and Nutrient Tests of Bareh Randang Formula with the Addition of Curd to Reduce Hypercholesterolemia Lastrie Asrya
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1801-1816.2024

Abstract

Objective: This study aims to determine the organoleptic test and nutritional content of the Bareh Randang formula with the addition of curd to reduce hypercholesterolemia. Method: This type of research is experimental by conducting direct experiments using a Completely Randomized Design (CRD) with four levels of curd addition, namely 0 gr, 15 gr, 25 gr and 35 gr per dough formula which is carried out in two repetitions. Organoleptic tests were carried out by 25 panelists. Data were analyzed using the Kruskal Wallis test and Mann Whitney advanced test. Laboratory tests carried out proximate nutrient content tests and BAL tests. Results: Based on organoleptic tests, the best formula was obtained with the addition of 25 grams of curd. The results of the Kruskal Wallis test showed that there was a significant difference of P<0.05 in color, taste and texture, while in aroma there was no significant difference of P>0.05. From testing the LAB content, it was found that the bareh randang product contained LAB 108 CFU/g which is useful as a probiotic food. Conclusion: When making bareh randang products, it is best to add 25 grams of curd.
Harnessing the Potential of Synbiotic Therapy for Childhood Malnutrition: A Narrative Review of Onion Inulin Extracts and Probiotic-Rich Dadih Refa Rahmaddiansyah; Wahida Rahmi; Dessy Arisanty; Rauza Sukma Rita; Sukarsi Rusti
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1875-1886.2024

Abstract

Malnutrition and undernutrition in children are predominantly attributed to insufficient dietary intake and diseases, posing substantial risks without timely intervention. The emerging field of synbiotics, a symbiotic combination of probiotics and prebiotics, presents a promising avenue in nutritional therapy. It effectively modulates the composition and metabolic activities of the intestinal microbiota. This approach aligns seamlessly with the Sustainable Development Goals for 2030, offering a cost-effective strategy for both prophylaxis and immunomodulation. This study delves into a narrative literature review, examining the potential application of an extract derived from onion (Allium cepa Linn.) inulin, coupled with the beneficial attributes of the probiotic-rich traditional Sumatran dadih, as a supportive therapy. The emphasis lies in manipulating the intestinal microbiota and modulating the immune system, aiming to alleviate the severity of malnutrition-related complications in children. However, achieving optimal efficacy and safety with synbiotics necessitates further rigorous trials. These trials should specifically target refining dosage regimens and formulating compositions conducive to eliciting the desired, safe responses in clinical settings. In conclusion, the exploration of inulin sourced from onion extracts, integrated with supportive therapy focusing on gut microbiota manipulation and immune modulation alongside probiotic-rich dadih, shows immediate potential for practical application in addressing childhood malnutrition.
Biscuit Formulation With Substitution Of Mackerel Fish Meal (Rastrelliger Sp.) And Black Rice Flour (Oryza Sativa L. Indica) As An Alternative Snack For Diabetes Mellitus Sufferers Rizka Adelia Lubis; Syahrial Syahrial; Deni Elnovriza
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1766-1779.2024

Abstract

Objective: This research aims to develop a biscuit formulation with the substitution of mackerel fish flour and black rice flour as an alternative snack for diabetes mellitus sufferers.Method: This research was an experiment with a Completely Randomized Design (CRD) consisting of four treatments, namely 0% (F0), 25% (F1), 50% (F2), and 75% (F3). Organoleptic tests were carried out on 7 trained panelists. The organoleptic test data was tested for normality using the Shapiro Wilk test. The results of the data distribution are normally distributed, so to determine whether there are real differences in each treatment, the data is processed using the ANOVA test at the 5% level, if it is known that there are significant differences (p value <0.05), followed by the Duncan New Multiple Range Test (DNMRT) at the 5% level to see which treatments are different. Results: The biscuits selected based on organoleptic tests were F1 biscuits with a water content of 3.1%, ash 1.5%, protein 5.2%, fat 3%, magnesium 117 gr, anthocyanin 14.88 mg. Conclusion: Biscuits substituted for mackerel fish flour and black rice flour can be used as an alternative snack for diabetes mellitus sufferers.Keywords: diabetes mellitus, biscuits, mackerel flour, black rice flour 
THE EFFECTIVENESS OF THE HEALTHY KITCHEN PROGRAM TO OVERCOME STUNTING IN IMPROVING THE NUTRITIONAL STATUS OF STUNTING TODDLERS Fadhilla Puja Sridefi
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1817-1824.2024

Abstract

Stunting is a problem of chronic malnutrition which is caused by a lack of nutritional intake for a long time. One of the programs initiated by the BKKBN to reduce stunting rates is the Healthy Kitchen to Overcome Stunting (DASHAT) program. One of the DASHAT programs is providing local supplementary food to stunted toddlers. The aim of this research was to determine the effectiveness of DASHAT on weight gain and nutritional status of stunted toddlers during the program and after 3 months of completion of the program. This research uses a Quasy Experiment approach. The population in this study were all stunted toddlers who received the DASHAT program, while the sample in this study was 34 toddlers taken by random sampling in three areas of the South Padang District Health Center, Padang City. The results of this research show that the DASHAT program is effective in increasing the weight of toddlers with a p-value of 0.000 during the program and 0.048 after the program, but is not effective in changing nutritional status (TB/U) after the DASHAT program ends. Maximum monitoring is needed from various parties regarding stunting toddlers after the DASHAT program is completed.
Medical Rehabilitation Program for Knee Osteoarthritis: A Narrative Review Refa Rahmaddiansyah; Riri Prima Yolanda; Rini Agustin
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1887-1899.2024

Abstract

Osteoarthritis, a prevalent form of arthritis linked to bone degeneration, particularly affects the elderly population. In Indonesia, its prevalence rises with age, impacting various ethnic groups, notably women, and leading to substantial disability in individuals aged 65 and older. Vigilance is essential against potential complications like gastritis, bleeding, or kidney issues resulting from prolonged use of non-steroidal anti-inflammatory drugs (NSAIDs). The condition's pathophysiology involves joint aging, injuries, excessive use, genetic predisposition, obesity, and hormonal changes. Its clinical signs develop gradually but can accelerate due to injuries or joint strain, significantly reducing patient productivity and life quality. Managing osteoarthritis involves non-drug approaches like education, physical and exercise therapy, followed by medication and supportive devices. The treatment selection depends on severity and the number of affected joints, aiming to control pain, improve joint function, ease physical limitations, and hinder disease progression and complications. Prompt intervention with suitable modalities aligned with the patient's condition offers a favorable prognosis. Factors like muscle weakness, obesity, and depressive disorders can exacerbate osteoarthritis outcomes. Comprehensive management addressing these factors can significantly improve the prognosis and enhance the patient's quality of life.
Uncontrolled diabetes and nephropathy diabetic: implication from retrospectively studied at RSUP Dr. M. Djamil Padang Dela Sasqia Amanda
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1780-1789.2024

Abstract

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kontrol glikemik dengan kadar kreatinin serum pada pasien diabetes melitus tipe (DMT2); Metode: Penelitian cross-sectional ini dilakukan pada bulan November 2022 hingga Januari 2024. Sebanyak 1.130 rekam medis pasien DMT2 yang melakukan pemeriksaan kadar HbA1c dan kadar kreatinin serum di Instalasi Laboratorium Patologi Klinik RSUP Dr. M. Djamil Padang pada tahun 2019–2021 diikutsertakan. Uji Mann-Whitney digunakan untuk menganalisis hubungan antara kontrol glikemik dan kadar kreatinin serum; Hasil: Sebanyak 52,7% pasien DMT2 adalah laki-laki dengan rata-rata usia 55,8 tahun. Lebih dari separuh (52,7%) pasien DMT2 memiliki kontrol glikemik yang buruk dan ditemukan bahwa median kadar kreatinin serum pada pasien DMT2 dengan kontrol glikemik buruk adalah 5,3 (1,3-15,3) mg/dL, sedangkan pasien dengan kontrol glikemik baik adalah 4,2 (0,4-8,0)mg/dL. Hasil analisis bivariat menunjukkan terdapat hubungan bermakna antara kontrol glikemik dengan kadar kreatinin serum pada pasien DMT2 (p<0,05); Kesimpulan: Temuan pada penelitian ini menunjukkan adanya hubungan antara kontrol glikemik dengan kadar kreatinin serum pada pasien DMT2.
Relationships Quality of Diet in Pregnant Women With Baby Birth Weight Yosa Oktari Syahda
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1862-1874.2024

Abstract

Objective : Writing this article in the form of a systematic literature review aims to analyze the relationships between food quality in pregnancy women and the baby's birth weight .Method : Systematic literature review method by taking 9 journals , namely 9 international journals according to the specified keywords criteria .Results : From the results of the literature review analysis of 9 journals , all journals found significant results between the quality of diet and the baby's birth weight .Conclusion : From this research it is concluded that there is a relationship between the quality of diet and birth weight . It is hopefully that this systematic literature review can become a reference for future researchers and that further research can be carried out on other birth outcomes
Probiotic and Its Fundamental Role In Gastrointestinal Health: A Literature Review Fatridha Yansen
Majalah Kedokteran Andalas Vol 46, No 11 (2024): July 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i11.p1851-1861.2024

Abstract

The gastrointestinal tracts are hosts to a wide variety of microorganisms known as intestinal microbiota. This gut microbiome may get disrupted that will influence the human health. Probiotics can restore the balance of gut microbiota by changing its composition and promoting its stability. Objective: This review aims to compile the role of probiotics in maintaining gastrointestinal health based on evidence-based through the modulation of the human gut microbiome.  Method: This article is structured based on a literature review method by collecting and reviewing papers published in PubMed, Scopus, ScienceDirect, Springer, and Google Scholar.  Results: The administration of probiotics have successfully shown evidenced beneficial health effects to prevent or treat for several main these several diseases including diarrhea, lactose intolerance and intestinal bowel diseases. Conclusion: Probiotics have been demonstrated to play key functions in the digestive system and to considerably reduce the symptoms of a variety of illnesses.

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