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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 1,063 Documents
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Efektivitas vaksin influenza terhadap kejadian rawat inap pada anak dengan influenza: sebuah tinjauan sistematik dan meta analisis Dewa Ayu Ketut Oka Sadnyani; I Gusti Agung Ayu Novi Wiraningrat; Romy Windiyanto
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (965.847 KB) | DOI: 10.15562/ism.v13i3.1483

Abstract

Background: Influenza is a respiratory infection that is often experienced by children. Influenza particularly happens in developing countries with a high number of cases. Global influence on influenza vaccine research has now been carried out to reduce the incidence of inpatient and severe influenza complications.Objective: To examine the effectiveness of the influenza vaccine (EVI) on inpatient events related to influenza disease in children.Methods: Search for published scientific articles using the prism method (preferred reporting, items for systematic reviews and meta-analysis). The search was carried out on a PubMed database, Cochrane Library and Medline published in the last 10 years until 1st May 2022, about influenza vaccines on inpatient events related to influenza in children. All types of studies are included if the result is inpatient, respondents under the age of 18 and influenza infections are confirmed for the laboratory results. All analyses in our research were conducted using STATA V13.1 (Stata Corporation, College Station, TX)Results: A randomized meta-analysis of 34 studies that use seasonal cohort and cross-sectional designs assesses the effectiveness of influenza vaccine (EVI) on inpatient events in children by 52.6% (95% CI: 50.9 -54,2) for all influenza. It was found that EVI was higher in influenza A/H1N1PDM09 at 70.0% (95%CI: 66.3-73.6) compared to Influenza A/H3n2 (38.9%; 95%CI: 31.8-46.1) and influenza B (46.7%; 95%CI: 41.9-51.4). According to the type of vaccine, EVI is obtained in the higher QIV type, which is 60.4% (95% CI: 55.3-65.5) compared to other types of vaccines.Conclusion: Based on the results of this meta-analysis reinforces evidence that shows that influenza vaccination is generally an effective action to prevent inpatient events related to influenza in children.   Latar belakang: Penyakit influenza merupakan salah satu penyakit infeksi pernapasan yang sering dialami anak-anak. Influenza khususnya terjadi negara berkembang dengan kondisi jumlah kasus yang masih tinggi. Untuk menurunkan kejadian rawat inap dan komplikasi penyakit infuenza yang berat, saat ini telah dilakukan penelitian vaksin influenza secara global.Tujuan: Untuk menelaah efektivitas vaksin influenza (EVI) terhadap kejadian rawat inap terkait penyakit influenza pada anak-anak.Metode: Penelusuran artikel-artikel ilmiah terpublikasi menggunakan metode PRISMA (Preferred Reporting, Items for Systematic Reviews and Meta Analysis). Pencarian dilakukan dengan basis data PubMed, Cochrane library dan Medline yang diterbitkan pada 10 tahun terakhir hingga bulan Mei 2022, tentang vaksin influenza terhadap kejadian rawat inap terkait penyakit influenza pada anak-anak. Semua jenis studi dimasukkan jika hasilnya adalah rawat inap, responden yang berumur di bawah 18 tahun dan infeksi influenza dikonfirmasi atas hasil laboratorium. Semua analisis dalam penelitian kami dilakukan dengan menggunakan Stata v13.1 (Stata Corporation, College Station, TX)Hasil: Sebuah meta-analisis efek acak dari 34 studi yang menggunakan desain cohort dan cross-sectional musiman yang dikumpulkan menilai efektivitas vaksin influenza (EVI) terhadap kejadian rawat inap pada anak-anak sebesar 52,6% (95%CI: 50,9-54,2) untuk semua influenza. Diperoleh bahwa EVI lebih tinggi terhadap influenza A/H1N1pdm09 sebesar 70,0% (95%CI: 66,3-73,6) dibandingkan influenza A/H3N2 (38,9%; 95%CI: 31,8-46,1) dan influenza B (46,7%; 95%CI: 41,9-51,4). Berdasarkan jenis vaksin, diperoleh EVI pada jenis QIV lebih tinggi yaitu sebesar 60,4% (95%CI: 55,3-65,5) dibandingkan dengan jenis vaksin lainnya.Simpulan: Berdasarkan hasil meta-analisis ini menguatkan bukti yang menunjukkan bahwa vaksinasi influenza umumnya adalah tindakan efektif untuk mencegah kejadian rawat inap terkait penyakit influenza pada anak-anak.
Alopesia universalis pada anak yang berespon baik dengan terapi kombinasi: sebuah laporan kasus I Gusti Ayu Agung Praharsini; I Gusti Ayu Agung Dwi Karmila; Ratih Purnamasari Nukana; Henny Wijaya
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.369 KB) | DOI: 10.15562/ism.v13i3.1484

Abstract

Background: Alopecia universalis is an autoimmune disease of the hair follicles, which results in complete loss of head and body hair. Until now there is no proven effective therapy in dealing with this disease. We report a case of alopecia universalis that responded well to combination therapy. Case: Female, 22 months old, complained by her parents due to hair loss on her head, eyebrows and eyelashes that had not grown back since the age of 8 months. On the fingernails and toenails found pitting nails, trachonycia. On scalp dermoscopy examination, multiple yellow dots were found. Severity of Alopecia Tool Score (SALT) was 100%. The patient was treated with minoxidil 5%, mometasone 0.1%, triamcinolone 12 mg and excimer laser. Administration of minoxidil increases prostaglandin production and maintains the anagen phase. Corticosteroids are immunosuppressive which suppress the immune attack of T cells on hair follicles. UV light on the excimer laser can reduce the proliferation of T lymphocytes, thereby reducing perifollicular inflammation and hair follicle damage. In this case, after 4 months of observation, the growth of terminal hair and vellus hair on the scalp, eyebrows and eyelashes was seen. On the patient's nails, the trachonycia was improved, with pitting nails remaining. SALT decreased to 58%. Conclusion: The combination therapy of minoxidil, corticosteroid and excimer laser gave good results in this case. During treatment, there were no side effects or recurrences.   Latar belakang : Alopesia universalis adalah penyakit autoimun pada folikel rambut, yang mengakibatkan kerontokan seluruh rambut kepala dan tubuh. Hingga saat ini belum ada terapi yang terbukti efektif dalam menangani penyakit ini. Berikut dilaporkan kasus alopesia universalis yang memberikan respon baik dengan terapi kombinasi. Kasus: Pasien perempuan, 22 bulan, dikeluhkan orang tuanya mengalami rambut kepala, alis dan bulu mata yang rontok dan tidak tumbuh kembali sejak usia 8 bulan. Pada kuku tangan dan kaki didapatkan adanya pitting nails, trachonycia. Pada pemeriksaan dermoskopi kulit kepala didapatkan adanya multiple yellow dots. Severity of Alopecia Tool Score (SALT) 100%. Pasien diberikan terapi minoksidil 5%, mometason 0.1%, triamsinolone 12 mg dan laser excimer. Pemberian minoksidil meningkatkan produksi prostaglandin dan mempertahankan fase anagen. Kortikosteroid bersifat imunosupresif yang menekan serangan imunitas sel T pada folikel rambut. Sinar UV pada laser excimer dapat menurunkan proliferasi sel T limfosit sehingga mengurangi peradangan perifolikular dan kerusakan folikel rambut. Pada kasus, setelah pengamatan selama 4 bulan nampak adanya pertumbuhan rambut terminal dan rambut vellus pada kulit kepala, alis dan bulu mata. Pada kuku pasien nampak trachonycia membaik, tersisa pitting nails. SALT menurun menjadi 58%. Simpulan: Terapi kombinasi minoksidil, kortikosteroid dan laser excimer memberikan hasil yang baik pada kasus ini. Selama pengobatan tidak didapatkan adanya efek samping dan rekurensi.
Epidermolisis bulosa tipe distrofik resesif dengan gizi buruk tipe marasmus pada seorang anak laki-laki: sebuah laporan kasus Made Hermina Laksmi; Ni Luh Putu Ratih Vibriyanti Karna; Herman Saputra; Aurelia Stephanie; Putu Gde Hariwangsa
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (796.526 KB) | DOI: 10.15562/ism.v13i2.1490

Abstract

Background: Epidermolysis bullosa (EB) is characteristized of epithelial cell adhesion disorders that cause skin fragility and bullae after minor trauma or friction. EB Classification is based on the skin's morphological appearance and the degree to which The following reports a case of recessive dystrophic bullous epidermolysis with marasmus type malnutrition  Case Report: An 8-year-old man, with complaints of wounds almost all over his body, initially in the form of bubbles filled with fluid which then burst into sores and over time, the bullae spread almost all over the body and oral mucosa. The patient has difficulty eating because of the frequent appearance of sores, so he becomes malnourished with the type of marasmus. The type of ED is inherited in an autosomal recessive manner. Since the age of 4 years, the patient's teeth began to decay, and the patient's fingers and toes were pseudosyndactyly. Histopathological examination results support severe generalized dystrophic recessive type EB (Hallopeau-Siemens). The patient treats with a compress of 0.9% NaCl for 10-15 minutes every 8 hours topically on erosional lesions, giving Petroleum jelly every 12 hours on the whole body, treating the wound using tulle, and then covering it with gauze every 24 hours, providing clinical improvement.  Conclusion: Epidermolysis bullosa (EB) can be inherited in an autosomal recessive manner. Complaints of the fragility of the skin already appear at the age of children. Nutritional disorders are a problem that strengthens the condition of EB patients. Multidisciplinary management is needed to provide a good outcome.   Latar Belakang: Epidermolysis bullosa (EB) memiliki karakteristik gangguan adhesi sel epitel yang menyebabkan kerapuhan pada kulit dan bula setelah terkena trauma atau gesekan ringan. Berikut dilaporkan satu kasus epidermolisis bulosa distrofik resesif dengan gizi buruk tipe marasmus Laporan Kasus: Laki- laki usia 8 tahun, dengan keluhan adanya luka hampir pada seluruh tubuh, berbentuk awal berupa gelembung berisi cairan yang kemudian pecah menjadi luka dan seiring jalannya waktu bula menyebar hampir seluruh tubuh hingga bagian mukosa mulut. Pasien mengalami kesulitan makan karena sering muncul luka sehingga menjadi gizi buruk dengan tipe marasmus. Tipe ED diturunkan secara autosomal resesif. Sejak usia 4 tahun gigi pasien mulai keropos, jari tangan dan jari kaki pasien pseudosyndactyly. Hasil pemeriksaan histopatologi menunjang gambaran epidermolisis bulosa. Pasien mengarah pada EB tipe resesif distrofik generalisata berat (Hallopeau-Siemens). Penatalaksanaan berupa kompres terbuka NaCl 0.9% selama 10-15 menit tiap 8 jam topikal pada lesi erosi, pemberian Petroleum jelly tiap 12 jam pada seluruh tubuh, rawat luka menggunakan tulle kemudian ditutup dengan kasa tiap 24 jam memberikan perbaikan klinis Simpulan: Epidermolysis bullosa dapat diturunkan secara autosomal resesif. Keluhan kerapuhan pada kulit sudah tampak pada usia anak-anak. Gangguan nutrisi menjadi permasalahan yang mempererat keadaan penderita EB. Tatalaksana multidisiplin diperlukan untuk memberikan luaran yang baik
Anosmia dan ageusia sebagai faktor prognosis baik pada pasien COVID-19 rawat inap di RSUP Sanglah Denpasar Senja Decy Ningrum; Ida Bagus Ngurah Rai; I Gede Ketut Sajinadiyasa; Anak Agung Raka Sudewi; Ida Ayu Jasminarti Dwi Kusumawardani; Ni Wayan Candrawati; Ni Luh Putu Eka Arisanti
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.33 KB) | DOI: 10.15562/ism.v13i3.1503

Abstract

Background: Anosmia and ageusia are early symptoms that are widely reported in COVID 19 patients and are associated with low rates of intensive care and mortality, so the hypothesis arises that anosmia and ageusia can be good prognostic factors in COVID-19 patients. This study aims to examine anosmia and ageusia as prognostic factors in COVID-19 patients. Methods: This study is an observational analytic study with a retrospective cohort design conducted at Sanglah General Hospital Denpasar from January to June 2022. Results: obtained a total of 1048 subjects with 344 subjects experiencing anosmia, 210 subjects experiencing ageusia, and 474 subjects experiencing a combination of anosmia and ageusia. Variable symptoms of anosmia and ageusia were statistically significant predictors for the recovery of COVID-19 patients (p<0.05). The cure rate in the group of patients with symptoms of anosmia was 1.8 times (RR = 1.783, 95% CI = 1.667-1.908) and the group of patients with symptoms of ageusia experienced 1.6 times higher recovery (RR = 1.564, 95% CI = 1.478 -1,655). After adjusting for other variables as confounders, the combination of symptoms of anosmia and ageusia in patients was a significant predictor of recovery for COVID-19 patients by 1.5 times compared to patients who did not experience the combination of symptoms of anosmia and ageusia (ARR = 1.523, 95% CI = 1.245- 1.864, p<0.05). Conclusion: Anosmia, ageusia and the combination of both, indicate protective factors against possible mortality and indicate a good prognosis in COVID-19 patients.   Latar belakang: Anosmia dan ageusia merupakan gejala awal yang banyak dilaporkan pada pasien COVID-19 serta dikaitkan dengan tingkat rawat intensif dan mortalitas yang rendah sehingga muncul hipotesis bahwa anosmia dan ageusia dapat menjadi faktor prognosis yang baik pada pasien COVID-19. Penelitian ini bertujuan untuk meneliti anosmia dan ageusia sebagai faktor prognosis pada pasien COVID- 19. Metode: Penelitian ini merupakan studi analitik observasional dengan rancangan kohort retrospektif yang dilakukan di RSUP Sanglah Denpasar pada bulan Januari    hingga Juni 2022. Hasil: Didapatkan total 1048 subjek dengan 344 subjek mengalami anosmia, 210 subjek mengalami ageusia, serta 474 subjek mengalami kombinasi anosmia dan ageusia. Variabel gejala anosmia maupun ageusia secara statistik merupakan prediktor signifikan untuk kesembuhan pasien COVID-19 (p<0,05). Tingkat kesembuhan pada kelompok pasien bergejala anosmia mencapai 1,8 kali (RR = 1,783, IK 95% = 1,667-1,908) lebih tinggi dan kelompok pasien bergejala  ageusia mengalami kesembuhan 1,6 kali lebih tinggi (RR = 1,564, IK 95% = 1,478-1,655). Setelah disesuaikan dengan variabel lain sebagai perancu, kombinasi gejala anosmia dan ageusia pada pasien menjadi prediktor kesembuhan pasien COVID-19 secara signifikan sebesar 1,5 kali lipat dibandingkan pasien yang tidak mengalami kombinasi gejala anosmia dan ageusia (ARR = 1,523, IK95% = 1,245-1,864, p<0,05). Simpulan: Anosmia, ageusia, dan kombinasi keduanya menunjukkan adanya faktor  protektif terhadap kemungkinan mortalitas serta menandakan adanya prognosis yang baik pada pasien COVID-19
Keloid yang diterapi dengan kombinasi bedah eksisi dan injeksi kortikosteroid intralesi: sebuah laporan kasus Ketut Wida Komalasari; Ketut Kwartantaya Winaya; Putu Gde Hari Wangsa; I Dewa Made Rendy Sanjaya
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.486 KB) | DOI: 10.15562/ism.v13i3.1504

Abstract

Background: Keloids are soft solid tumors with a smooth surface that extend beyond the wound margins and invade adjacent normal tissue. Appears at the age of 10-30 years, occurs as a result of an imbalance between increased collagen synthesis and extracellular matrix. There are several types of therapeutic modalities such as intralesional or topical corticosteroids, surgical excision, electrosurgery, frozen surgery, radiotherapy and laser therapy. Combination therapy of surgical excision and intralesional corticosteroids used for this case. Case Description: A woman, 43 years old, complained since 3 years ago, in the lower left abdomen there is a lump, which has been getting bigger over the past 1 year, sometimes feels pain and itching. In the left inferior abdominal region, multiple tumors were found to be erythematous to hyperpigmented, with firm boundaries, oval in shape, 0.2 cm to 0.5 cm in diameter, with a length and width of 0.3 cm and 0.5 cm, respectively. 1 cm and 1.5 cm, the surface feels smooth and shiny. On palpation, the tumor was fixed and firm in consistency. Surgical excision was performed and continued with intralesional injection of triamcinolone acetonide once a week on keloid and post-excision lesions. There was clinical improvement of keloids, on the 21st day of observation. Conclusion: Surgical excision is minimally invasive and can be combined with weekly intrakeloid triamcinolone acetonide injection therapy for keloid lesions and post-excision area to reduce the risk of new keloids appearing. On follow-up observation of keloids in the left inferior abdominal region, the lesion was getting smaller and softened and there was no new keloid growth in the post-excision area.   Latar belakang: Keloid adalah tumor yang padat lunak, dengan permukaan licin berkembang melebihi batas luka dan menginvasi jaringan normal yang berdekatan. Muncul pada usia 10-30 tahun, terjadi akibat dari ketidakseimbangan antara peningkatan sintesis kolagen dan matriks ekstraseluler. Terdapat beberapa macam modalitas terapi seperti kortikosteroid intralesi atau topikal, bedah eksisi, bedah listrik, bedah beku, radioterapi dan terapi laser. Kasus ini membahas terapi kombinasi bedah eksisi dan kortikosteroid intralesi. Kasus: Seorang wanita, berusia 43 tahun, mengeluh sejak 3 tahun yang lalu, pada perut kiri bawah terdapat benjolan, yang semakin lama semakin membesar selama 1 tahun terakhir, rasa nyeri dan gatal terkadang dirasakan. Pada regio abdominalis inferior sinistra ditemukan tumor multipel berwarna eritema sampai hiperpigmentasi, dengan batas yang tegas, berbentul bulat oval, berdiameter 0,2 cm sampai 0,5 cm, dengan panjang dan lebar masing-masing 0,3 cm dan 0,5 cm serta 1 cm dan 1,5 cm, permukaan teraba licin dan mengkilat. Pemeriksaan palpasi ditemukan tumor terfiksir dan konsistensinya keras. Dilakukan tindakan bedah eksisi dan dilanjutkan dengan injeksi triamsinolon asetonid intralesi seminggu sekali pada lesi keloid dan lesi paska eksisi. Terdapat perbaikan klinis keloid, pada pengamatan hari ke-21. Simpulan: Tindakan invasif minimal seperti bedah eksisi dapat dikombinasi dengan injeksi triamsinolon asetonid intrakeloid seminggu sekali pada lesi keloid dan daerah paska eksisi untuk mengurangi risiko munculnya keloid baru. Pada pengamatan lanjutan keloid pada regio abdominalis inferior sinistra, didapatkan lesi semakin mengecil dan melunak dan tidak terdapat pertumbuhan keloid baru pada daerah paska tindakan eksisi.
Gambaran tingkat kecemasan dalam menghadapi UTBK SBMPTN pada calon mahasiswa baru angkatan 2020/2021 di Denpasar Dhanira Mahaliana Bramantya Suanda Putri; Luh Made Indah Sri Handari Adiputra; Ketut Tirtayasa; Indira Vidiari Juhanna
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (758.407 KB) | DOI: 10.15562/ism.v13i3.1506

Abstract

Introduction: Such tight competition is suspected to cause anxiety in prospective new students in facing the computer-based written examination of the joint selection to enter state universities (UTBK SBMPTN). Anxiety is a combination of various responses that include intense networking, feeling worried and disturbing. Preparation for exams can create a high level of anxiety. However, anxiety can also be a positive energy when it is still at a low level. So, it is important when knowing the level of anxiety in prospective students facing the UTBK SBMPTN Methods: This study is a descriptive study with a retrospective approach. Anxiety was measured using the Hamilton Anxiety Rating Scale (HARS) questionnaire which was distributed to prospective students graduating from SMAN 4 Denpasar and SMA PGRI 2 Denpasar in 2021 who registered for the UTBK SBMPTN with a sample of 88 people. Results: The level of anxiety of respondents in this study had a relatively mild level of anxiety, namely 35 people (28%), 25 people (28%) experienced moderate anxiety and only 2 people (2%) experienced severe anxiety. Symptoms experienced by many respondents were difficulty concentrating (55 people), easily distracted (72 people), lethargic (60 people), restless (65 people). Conclusion: The level of anxiety of most of the respondents in this study had a relatively mild level of anxiety, namely as many as 35 people (40%).   Pendahuluan: Persaingan yang begitu ketat diduga menimbulkan rasa cemas pada calon mahasiswa baru dalam menghadapi ujian tulis berbasis komputer seleksi bersama masuk perguruan tinggi negeri (UTBK SBMPTN). Kecemasan merupakan kombinasi dari berbagai respon mencakup ketakutan yang intens, merasa khawatir dan bersifat mengganggu. Persiapan untuk ujian dapat menciptakan tingkat kecemasan yang tinggi. Namun, kecemasan juga bisa menjadi energi positif ketika masih pada tingkatan rendah. Maka, penting mengetahui tingkatan kecemasan pada calon mahasiswa ketika menghadapi UTBK SBMPTN Hasil: Tingkat kecemasan responden dalam penelitian ini memiliki tingkat kecemasan yang tergolong ringan yaitu sebanyak 35 orang (40%), 25 orang (28%) mengalami cemas sedang dan hanya 2 orang (2%) yang mengalami cemas berat. Gejala yang banyak dialami oleh responden adalah sulit konsentrasi (55 orang), mudah terganggu (72 orang), lesu (60 orang), gelisah (65 orang). Simpulan: Tingkat kecemasan sebagian besar responden dalam penelitain ini memiliki tingkat kecemasan yang tergolong ringan yaitu sebanyak 35 orang (40%).
Hubungan kejadian eating disorder dengan status gizi remaja putri di Denpasar, Bali Made Violin Weda Yani; Made Sindy Astri Pratiwi; Made Priska Arya Agustini; Putu Cintya Denny Yuliyatni; I Gede Putu Supadmanaba
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.717

Abstract

Background: Nutrition problems in adolescents both malnutrition and overnutrition in Indonesia are quite high. Nutrition problems are multifactorial, but several previous studies have shown that eating behavior will interfere with eating disorders related to nutritional quality. This study aims to analyze the relationship between eating attitude and eating disorders on nutritional status in adolescent girls. Methods: This research design was cross sectional observation conducted at SMAN 1 Denpasar, Bali. The samples were 119 adolescent girls that were selected by simple random sampling. Assessment of eating behavior used the adolescent food habit checklist, and eating disorders were assessed by EAT-26 questionnaire. Results: The subjects were 119 adolescent girls. Most of them were 15 and 16 years old. There were 53.8% of subjects having unhealthy food behavior and 86.6% did not experience eating disorders. There were 75.6% of students having normal nutritional status, followed by thin, overweight, and obese respectively 3.4%, 15.1%, and 5.9%. There was a significant relationship between eating attitude with nutritional status of adolescent girls (p value = 0.04; PR (95% CI) = 2.15 (1.09-4.21)). There is also a significant relationship between eating disorder with nutritional status of adolescent girls (p value=0.01; PR (95% CI) = 2.45 (1.32-4.56)) Conclusion: This study found that eating behavior was not related to nutritional status. The condition of eating disorders has a significant relationship with adolescent nutritional disorders. Individuals with eating disorders have a greater risk of experiencing nutritional disorders than individuals without eating disorders.   Latar Belakang: Masalah gizi pada remaja baik undernutrition ataupun overnutrition di Indonesia cukuplah tinggi. Masalah gizi pada remaja bersifat multifaktorial, namun beberapa penelitian sebelumnya menunjukkan bahwa faktor perilaku makan yang tidak baik akan memicu eating disorder yang berhubungan dengan kualitas gizi remaja putri. Sejauh ini belum terdapat studi terkait hubungan eating disorder dengan status gizi remaja putri di Bali. penelitian ini bertujuan untuk menganalisis hubungan antara perilaku makan dan eating disorder terhadap status gizi pada remaja putri. Metode: Desain penelitian yaitu observasi cross sectional yang dilakukan di SMAN 1 Denpasar, Bali. Sampel berjumlah 119 orang remaja putri berusia 14-18 tahun yang dipilih dengan simple random sampling. Penilaian perilaku makan menggunakan the adolescent food habbit checklist, dan gangguan makan dinilai menggunakan kuesioner EAT-26. Hasil: Dari 119 subjek penelitian, dominasis siswi putri berusia 16 tahun. Sebanyak 53.8% remaja putri memiliki perilaku makanan yang tidak sehat dan 86.6% tidak mengalami eating disorder. Mayoritas siswi memiliki status gizi yang normal yaitu 75.6%, diikuti dengan status gizi kurus, gemuk, dan obesitas berturut-turut yaitu sebesar 3.4%, 15.1% dan 5.9%. Terdapat hubungan yang signifikan antara perilaku makan buruk dengan gangguan gizi (p value=0.049; PR(95%CI) = 0.52 (0.27-1.01)) dan terdapat pula hubungan yang signifikan antara eating disorder dengan gangguan gizi remaja putri (p value=0.01; PR (95% CI) = 2.45 (1.32-4.56)) Simpulan: Penelitian ini mendapatkan bahwa perilaku makan dan kondisi eating disorder memiliki hubungan signifikan dengan gangguan gizi remaja putri.  Individu dengan eating disorder memiliki risiko lebih besar mengalami gangguan gizi dibandingkan individu tanpa eating disorder.
A review of multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 Carlson Kurniawan
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.866

Abstract

Global pandemic of Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2, a novel virus which first reported in Wuhan in December 2019. It can cause severe respiratory conditions including respiratory failure. Different from adults, children usually have milder symptoms of the disease. A post-infection complication that involves multisystem organ failure in children is reported in numerous countries. It is mentioned as multisystem inflammatory syndrome in children (MIS-C) or Kawa-COVID-19, because it resembles Kawasaki Disease. The pathogenesis remains unclear, but it is presumed that hosts’ innate immune response triggered the condition. Modulating the immune response is the main target of the therapy. High doses of intravenous immunoglobulins, low doses of corticosteroids (methylprednisolone), anti-IL-1 (anakinra), antiplatelet such as aspirin can be used to treat MIS-C. Antiviral therapy is not proven to be effective and other immunomodulatory agents still needed further studies.
Prevalence of dry eye syndrome associated to face mask among Tabanan General Hospital Health workers in 2021 Rania Ayu Permata Putri Kornia; I Putu Rustama Putra; Ni Wayan Sedani; Cynthia Dewi M
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v12i3.1135

Abstract

Background: The continuous development of COVID-19 has made face masks became a mandatory part of our daily routine, but there has been an increase in dry eye syndrome (DES) from the regular used of face masks. Health workers who are obliged to use face masks are the one that has risk factors for experiencing DES, including health workers at Tabanan General Hospital, as one of the COVID-19 referral hospitals in Bali. The purpose of this study was to calculate the prevalence of DES associated to face masks and characteristics of DES among Tabanan General Hospital health workers in 2021. Methods: This research was a descriptive cross sectional study that conducted at Tabanan General Hospital from March to April 202. The sample was 64 health workers at Tabanan General Hospital with consecutive sampling techniques using the Ocular Surface Disease Index (OSDI) questionnaire. Data were collected by using questionnaire. Data were annalyse descriptively by using SPSS 25 and the result were provide in table. Results: The prevalence of DES associated to face masks among Tabanan General Hospital health workers in 2021 was 70.3%, with a prevalence of mild degrees 15.6%, moderate 12.5%, and severe 42.2%. The prevalence of surgical mask users was greater than Filtering Face Piece (FFP) 2 mask users in mild and severe degrees of DES. Characteristics of DES among Tabanan General Hospital health workers in 2021 were found mostly in age 30-39 years old, more in females, without DM history, non-smokers, and without eye surgery history. Conclusion: Most of the health workers at Tabanan General Hospital experiencing DES associated to face masks, and mostly with a severe degree. Among those with DES, there were more surgical mask users than FFP2 mask users. Future studies are needed to analyze the association between DES and face masks.
Faktor risiko yang berhubungan dengan kejadian bayi berat lahir rendah di Rumah Sakit Umum Daerah Negara I Ketut Krisna Indrawan; I Gusti Ketut Winata Adnyana
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.1180

Abstract

Background. Sustainable Development Goals (SDGs) targets the decrease of neonatal mortality rate until 12 per 1.000 live birth. One of the neonatal death’s causes is premature baby which is related to the low birth weight (LBW) infant. The incidences of LBW were 15%-20% and almost 95% of those were born in developing countries. The aim of this study is to know several risk factors that related to the incidences of LBW infant in Regional Public Hospital Negara. Material. This case control study was conducted in September 2021. The subjects were inpatient babies in Perinatology ward and was born in Regional Public Hospital Negara, from 01 January 2020 to 30 December 2020. Consecutive sampling and gender matching were performed for the subjects selection. There are 42 sampels that match to the inclusion and exclusion criteria for each group. The data of risk factors and LBW were collected from the medical record. Statistical analyses included McNemar and logistic regression using SPSS v22 software with p<0,05 . Results. Bivariate statistical analyses results from LBW’s risk factors were p value=0.001 for gestational age, p value=0.031 for parity, p value= 0.049 for anemia during pregnancy, p value=0.267 for maternal age, p value=1.000 history of LBW before, p value=0.344 for miscarriage history, and p value=0.804 for preeclampsia. Meanwhile, multivariate statistical analyses showed that gestational age risk factor, p value=0,001 (OR=44,97; 95%IC: 8,44-239,75) and parity risk factor, p value=0,011 (OR=5,04: 95%IC: 1,44-17,66) were the risk factors that related to the incidences of LBW infant in Regional Public Hospital Negara Conclusion. Gestational age and parity were the risk factors that related to the incidences of LBW infant in Regional Public Hospital Negara   Latar Belakang : Sustainable Development Goals (SDGs) memfokuskan penurunan angka kematian neonatus hingga 12 per 1.000 kelahiran hidup. Salah satu penyebab utama kematian pada neonatus di dunia adalah bayi prematur yang merupakan komponen dalam bayi berat lahir rendah (BBLR). Angka kejadian BBLR sekitar 15%-20% dari seluruh kelahiran dan hampir 95% BBLR terjadi di Negara berkembang. Penelitian ini bertujuan untuk mengetahui beberapa faktor risiko yang berhubungan dengan kejadian BBLR di Rumah Sakit Umum Daerah (RSUD) Negara. Metode : Penelitian ini adalah penelitian kasus kontrol yang dilakukan pada bulan September 2021. Penelitian ini melibatkan bayi lahir hidup di RSUD Negara yang dirawat di ruang Perinatologi RSUD Negara mulai 01 januari 2020 - 30 Desember 2020. Pengambilan sampel menggunakan metode consecutive sampling dan dilakukan matching jenis kelamin. Sampel yang memenuhi kriteria inklusi dan eksklusi adalah 42 sampel kasus dan 42 sampel kontrol. Data faktor risiko dan BBLR di ambil dari catatan rekam medis. Uji statistik menggunakan uji McNemar dan regresi logistik dengan perangkat lunak SPSS versi 22 dengan batas nilai p <0,05. Hasil : Uji statistik bivariat terhadap BBLR menemukan bahwa faktor risiko usia gestasi p=0,001, paritas p=0,031, anemia ibu p=0,049, faktor risiko usia ibu p=0,267, faktor risiko riwayat melahirkan anak BBLR p=1,000, faktor risiko riwayat abortus p=0,344, dan faktor risiko preeklampsia p=0,804. Sementara itu, uji Satistik multivariat menemukan bahwa faktor usia gestasi, nilai p=0,001 (OR=44,97; 95%IK: 8,44-239,75) dan faktor risiko paritas, nilai p=0,011 (OR=5,04: 95%IK: 1,44-17,66) merupakan faktor risiko kejadian BBLR di RSUD Negara.

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