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ISM (Intisari Sains Medis) : Jurnal Kedokteran

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Published by Universitas Udayana

ISSN : 25033638 EISSN : - DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.

Arjuna Subject : -

Articles 1,063 Documents

101 102 103 104 105

The outcome of early rehabilitation therapy for the patient after percutaneous coronary intervention: a systematic review and meta-analysis Pande Made Dwi Budiarta; Adhyasta Nata Prawira S; Citra Wulandari Sofyan; Putu Topan Bagaskara
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Acute myocardial infarction (AMI) is one of the leading causes of mortality, morbidity and physical disability worldwide. The chief treatment for AMI is primary percutaneous coronary intervention (PCI). However, the effectiveness of early rehabilitation therapy after PCI patients still lacks documentation. Therefore, a meta-analysis has assessed the patient's outcome of early rehabilitation therapy after PCI. Methods: The searching protocol was carried out using several databases, such as PubMed, ScienceDirect, and Google Scholar, to identify relevant topics in June 2022. This study used the Preferred Reporting Items for Systematic Review and Meta-Analysis 2020 (PRISMA) guidelines. Result: There were nine studies included in this systematic review and meta-analysis. All of the reviewed studies were written in English. Most of the included studies were carried out in China. Most of the included studies were carried out in China. The mean age of the patient were all above 18 years. The total participants were 858 patients with PCI. There was a significant difference in 6-minute walk distance (MD = 85.64; 95% CI = 78.68–92.60; p < 0.01); left ventricle ejection fraction (LVEF) (MD = 5.97; 95% CI = 5.30–6.63; p < 0.01) and body mass index (BMI) score score (MD = 1.43; 95% CI = 0.86–2.00; p < 0.01) between groups in overall analysis. Conclusion: Early rehabilitation in patients with PCI has better outcomes (6-minutes walk distances, LVEF, and BMI score) than in the control group.

Lumbar spinal stenosis: pendekatan tatalaksana bedah Kevin Giovani Mandua; Alvarez Zefanya Moningka
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Lumbar spinal stenosis (LSS) is the most common subtype of spinal stenosis. This pathologic disorder is the most common cause of low back pain in elderly. LSS can be either congenital or acquired, which the disorder is mainly caused by the degenerative process. Diagnosis of LSS is made by combination of clinical manifestations and radiological findings. Management of LSS may include conservative measures in form of physical therapy, steroid injection on facet joints or epidural space, and also surgical decompression procedure. LSS often reduces invididuals’ quality of life and productivity; hence, it is the most common indication for lumbar spinal canal decompression procedure. Case report: A 41 years old woman complained of low back pain that was referred to the left buttock and leg area. The complaints were also accompanied by numbing sensation on the antero-lateral side of the left leg. Complaints have been felt continuously since 5 months ago. From physical examination, the Visual Analogue Scale (VAS) was 5-6 with positive laseque test on left leg accompanied with hypoesthesia in L4, L5, and S1 dermatome. MRI findings suggested the diagnosis of canalis stenosis of L4-L5 and L5-S1. We perfomed laminectomy and Posterior Lumbar Interbody Fusion (PLIF) on this patient. Conclusion: Surgical approaches are based on the anatomic location, number of segment affected, involvement of thoracolumbar junction, transitional anatomy, instability, and deformity. Factors that affect patients’ clinical outcome after the surgical procedure should be considered before starting the procedure. Latar belakang: Lumbar spinal stenosis (LSS) merupakan jenis stenosis spinal yang paling sering dijumpai, dimana kelainan ini merupakan salah satu penyebab patologis tersering dari nyeri punggung bawah pada populasi lansia. LSS dapat berupa kelainan kongenital ataupun kelainan yang didapat, dimana kebanyakan LSS diakibatkan oleh proses degeneratif. Diagnosis LSS melibatkan kombinasi dari temuan klinis dan radiologis. Tatalaksana pasien LSS dapat meliputi upaya konservatif berupa terapi fisik, injeksi steroid pada persendian facet ataupun ruang epidural, hingga tindakan operasi dekompresi. LSS seringkali menurunkan kualitas hidup serta produktivitas seseorang, sehingga LSS sering dijadikan sebagai indikasi untuk dilakukan prosedur operasi medula spinalis lumbal. Laporan kasus: Wanita, 41 tahun mengeluh nyeri punggung bawah serta nyeri yang menjalar ke bokong dan tungkai kiri, yang disertai sensasi kebas pada tungkai kiri sisi antero-lateral. Keluhan dirasakan terus menerus sejak 5 bulan lalu. Pemeriksaan fisik di dapatkan Visual Analogue Scale (VAS): 5-6, tes laseque positif tungkai kiri serta hipoestesia pada dermatom L4, L5 dan S1. Temuan MRI lumbal mengarah kepada diagnosis stenosis kanalis L4-L5 dan L5-S1. Dilakukan laminektomi dan Posterior Lumbar Interbody Fusion (PLIF). Kesimpulan: Pemilihan modalitas bedah didasarkan pada lokasi anatomis, jumlah segmen, keterlibatan thoracolumbar junction, adanya anatomi transisional, instabilitas, ataupun deformitas. Beberapa faktor yang mempengaruhi luaran klinis pasien pasca prosedur operasi perlu menjadi pertimbangan sebelum memulai tindakan bedah.

Kemampuan Tutor dalam Menstimulasi Self Directed Learning Mahasiswa Kedokteran I Gusti Ayu Harry Sundariyati; Putu Gede Sudira; Ida Bagus Amertha Putra Manuaba; I Gusti Ayu Sri Darmayani
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Self-directed learning (SDL) is a skill that must be possessed by medical students as a form of adult learning. To train these skills, students need tutors to stimulate students' SDL abilities. Methodology: This study was conducted quantitatively using a Dolman and Ginns questionnaire on third-year medical students. Results: Tutors in the Medical Emergency block were able to provide a good explanation of the issues in the case and stimulate students to look for other learning resources. Conclusion: Tutors with academic backgrounds that match the discussion material can be considered as one of the factors that can stimulate students' SDL. Latar Belakang: Self-directed learning (SDL) merupakan keterampilan yang harus dimiliki oleh mahasiswa kedokteran sebagai bentuk pembelajaran dewasa. Untuk melatih keterampilan ini mahasiswa memerlukan tutor dalam menstimulasi kemampuan SDL mahasiswa. Metodologi: penelitian ini dilakukan secara kuantitatif dengan menggunakan kuisioner Dolman dan Ginns pada mahasiswa kedokteran tahun ke-tiga. Hasil: tutor pada blok Medical Emergency mampu memberikan penjelasan yang baik mengenai issue yang ada pada kasus serta menstimulasi mahasiswa untuk mencari sumber pembelajaran yang lainnya. Simpulan: tutor dengan latar belakang akademik yang sesuai dengan materi diskusi dapat dipertimbangan sebagai salah satu factor yang dapat menstimulasi SDL mahasiswa.

Validasi skor Coagulopathy of Severe Trauma (COAST) dalam memprediksi Acute Trauma Coagulopathy (ATC) di Rumah Sakit Umum Pusat Sanglah Denpasar Putu Chandra Wibawa; I Gede Suwedagatha; I Wayan Niryana
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: The Coagulopathy of Severe Trauma (COAST) score is a scoring system that predicts the clinical condition of ATC. The COAST score has a high specificity of 96% and a sensitivity of 80% at a cut-oﬀ 3, which can accurately predict coagulopathy and has a significant outcome. This study tested the validity of the Coagulopathy of Severe Trauma (COAST) scoring in predicting Acute Traumatic Coagulopathy (ATC) at the Sanglah Central General Hospital (RSUP) Denpasar. Method: Observational study with diagnostic test and cross-sectional design carried out from December 1, 2020 to February 28, 2021. Patients suspected of ATC are patients who present with a history of trauma with an increase of two out of three, namely, Prothrombin Time (PT) >18 seconds, Activated Partial Thromboplastin Time (aPTT) >36 seconds, and International Normalized Ratio (INR) >1.6. Samples were excluded if they refused to participate in the study, had severe head injury, concomitant severe systemic disease, had blood clotting disorders or were taking blood thinning drugs, burn patients, and pregnant patients. The COAST score was assessed based on the components of the trapped assessment, blood pressure, temperature, chest decompression, and abdominal/pelvic injury. COAST scores were analyzed using ROC curves and diagnostic tests, as well as logistic regression tests. The value of p <0.05 indicates a significant result. Results: This study involved 60 patients with 10 ATC positive patients and the remaining 50 ATC negative. Significant differences (p<0.05) on the incidence of ATC were found in the variables of age, ISS score, trapped, chest decompression, abdominal/pelvic injury, systolic blood pressure, PT, aPTT, INR, and COAST score. ROC curve analysis showed a COAST score with a cut-off value of 2.5 (60% sensitivity; 88% specificity; p=0.01; 95% CI 0.555-0.965). The results of the diagnostic test cut-off score of 2.5 COAST scores with an OR of 11.00 (p=0.003; 95% CI 2.392-50.589). Multivariate analysis of COAST scores with the incidence of ATC showed a significant relationship (p=0.002). Conclusion: The COAST score is a valid scoring system to predict ATC at Sanglah Hospital Denpasar with a good level of sensitivity and specificity, with a cut off of 2.5. Pendahuluan: Skor Coagulopathy of Severe Trauma (COAST) merupakan sistem skor yang memprediksi kondisi klinis ATC. Skor COAST memiliki spesifisitas tinggi 96% dan sensitifitas 80% pada cut-oﬀ ≥3, yang dapat secara tepat memprediksi koagulopati dan memiliki hasil yang secara signifikan. Penelitian ini menguji validitas skoring Coagulopathy of Severe Trauma (COAST) dalam memprediksi Acute Traumatic Coagulopathy (ATC) di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Metode: Studi observasional dengan uji diagnostik dan desain cross-sectional yang dilaksanakan mulai 1 Desember 2020 sampai 28 Februari 2021. Pasien terduga ATC adalah pasien yang datang dengan riwayat trauma dengan peningkatan dua dari tiga yaitu, Prothrombin Time (PT) >18 detik, Activated Partial Thromboplastin Time (aPTT) >36 detik, dan International Normalized Ratio (INR) >1,6. Sampel dieksklusi apabila menolak keikutsertaan dalam penelitian, mengalami cedera kepala berat, penyakit sistemik berat bersamaan, menderita gangguan pembekuan darah atau mengonsumsi obat pengencer darah, pasien luka bakar, dan pasien hamil. Skor COAST dinilai berdasarkan komponen penilaian terjebak, tekanan darah, suhu, dekompresi dada, dan abdomen/pelvis injuri. Skor COAST dianalisis dengan kurva ROC dan uji diagnostik, serta uji regresi logistik. Nilai p<0,05 menunjukan hasil bermakna. Hasil: Penelitian ini melibatkan 60 pasien dengan 10 pasien ATC positif dan 50 sisanya ATC negatif. Perbedaan signifikan (p<0,05) terhadap kejadian ATC didapatkan pada variabel usia, skor ISS, terjebak, dekompresi dada, abdomen/pelvis injuri, tekanan darah sistolik, PT, aPTT, INR, dan skor COAST. Analisis kurva ROC menunjukan skor COAST dengan nilai cut-off 2,5 (sensitivitas 60%; spesifisitas 88%; p=0,01; CI95% 0,555-0,965). Hasil uji diagnostik nilai cut-off 2,5 skor COAST dengan OR 11,00 (p=0,003; CI95% 2,392-50,589). Analisis multivariat skor COAST dengan kejadian ATC menunjukan hubungan signifikan (p=0.002). Kesimpulan: Skor COAST merupakan sistem skoring yang valid untuk memprediksi ATC di RSUP Sanglah Denpasar dengan tingkat sensitivitas dan spesifisitas yang baik, dengan cut off ≥2,5.

Acute and severe ocular manifestations of a patient with Stevens-Johnson Syndrome in RSUD Wangaya: a case report Jelly Vianti Fransisca Oeiyano; Jessica Yolanda Hadisusanto; Lisa Berliani Tanaya; Ida Ayu Putri Kartiningsih
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Background: Stevens-Johnson syndrome is a severe mucocutaneous disorder with high mortality rates and potentially life-threatening. Ocular manifestations in SJS occurred up to 81%, with manifestation ranging from conjunctiva hyperemia, cicatrizing conjunctivitis with symblepharon, corneal ulceration, corneal blisters and perforation, which can potentially lead to permanent vision loss. Case Description: A 34-year-old male patient was being consulted to ophthalmologist department with the diagnosis Stevens-Johnson syndrome, he was complaint bilateral upper and lower eyelid palpebral conjunctiva adhesion to bulbar conjunctiva. The ophthalmological examination cannot be examined due to the adhesion then the patient was performed bilateral symblepharon separation of the eyelid using blunt-tip of surgical scissors under local anesthesia. After the procedure, the visual acuity was around 3/60 for both eyes. The anterior segment examination in both eyes showed that the palpebral was edema, peeling of the skin. The conjunctiva appears to be chemosis, conjunctival injection, with mucopurulent secret in both eyes. The patient was treated with antibiotic combined with steroid eye ointment and eye drop. Conclusion: Ocular manifestations of SJS are mostly mild-moderate. However, several cases possess grave complication and may progress to vision loss. Treatment for the ocular sequelae can reduce the risk of long-term visual morbidity. Knowing the etiology along with the progression of the disease is necessary for early diagnosis and prompt treatment.

Personal hygiene genitalia wanita Made Hermina Laksmi; Ni Made Dwi Puspawati; Aurelia Stephanie; Putu Gde Hariwangsa
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Since the beginning, genital hygiene has become a concern for women susceptible to infections of the urinary tract and reproductive system where the vagina is an unsterile organ related to external exposure and close to the anus. Several problems related to the personal hygiene of female genitalia arise due to a lack of understanding and literature discussing this matter. This literature review will discuss the normal flora of the female genitalia and procedures for daily vaginal care, which aims to increase understanding of female genital personal hygiene. Sejak dahulu hygiene genetalia sudah menjadi perhatian kaum wanita, karena wanita sangat rentan terkena infeksi traktus urinarius dan sistem reproduksi dimana vagina merupakan organ yang tidak steril yang berhubungan dengan dunia luar serta berdekatan dengan anus. Beberapa masalah terkait personal hygiene genitalia wanita timbul akibat kurang pemahaman dan sedikitnya literatur yang membahas tentang hal ini. Tinjauan pustaka ini akan membahas mengenai flora normal genitalia wanita dan tata cara perawatan vagina sehari-hari yang bertujuan untuk meningkatkan pemahaman terhadap personal hygiene genitalia wanita.

Kadar Urine Urea Nitrogen (UUN) sebagai prediktor mortalitas pada pasien luka bakar >20% di RSUP Prof. Dr. I. G. N. G. Ngoerah Denpasar Grace Inriani Rongre; I Gusti Putu Hendra Sanjaya; Agustinus I Wayan Harimawan; Sianny Herawati
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Background: Urine urea nitrogen (UUN) is an examination of nitrogen balance with the concept of calculating the amount of urea excreted through urine. The amount of urea that comes out of the urine is in line with the amount of protein breakdown in the body and the amount of protein that enters the body. This study aimed to evaluate UUN levels on days 1, 3 and 7 as a predictor of mortality in burn patients >20%. Methods: This study was an observational analytic retrospective study. Data were collected from January 2020 to December 2021. This study used secondary data from medical records of patients with IIAB-III degree burns with burn area > 20% TBSA treated at Prof. Dr. I. G. N. G. Ngoerah General Hospital for 2020-2021. Data were analyzed using SPSS version 21 for Windows. Results: The majority of burn patients were male, about 73.9%. The average age of burn patients is 48.26±15.95 years. On the first examination day, the UUN value was still low (29.4 mg/24 hours). Then on the 3rd day, there was an increase in the average UUN level, namely the maximum value of 61,987 mg/24 hours. Examination on the 7th day showed an increase in line with the previous day, namely the maximum value of 57,489 mg/24 hours. On day 1, the mean UUN value was higher in patients who died, while on days 3 and 7 the mean UUN level in patients with living outcomes was higher than in patients who died, but not significantly (p>0.05). Conclusion: Urine urea nitrogen levels on days 1, 3 and 7 in burn patients >20% at Prof. Dr. I. G. N. G. Ngoerah General Hospital showed an increasing trend. Urine urea nitrogen levels cannot be used to predict mortality in burn patients because the results were insignificant. Latar Belakang: Urin urea nitrogen (UUN) merupakan pemeriksaan keseimbangan nitrogen yang berkonsep pada perhitungan jumlah urea yang dieksresikan lewat urin. Jumlah urea yang keluar bersama urine sejalan dengan jumlah pemecahan protein dalam tubuh serta jumlah protein yang masuk dalam tubuh. Penelitian ini bertujuan untuk mengevaluasi kadar UUN hari ke-1,3, dan 7 sebagai prediktor mortalitas pasien luka bakar >20%. Metode: Studi ini merupakan studi retrospektif analitik observasional. Data dikumpulkan dari Januari 2020 hingga Desember 2021. Studi ini menggunakan data sekunder dari catatan rekam medis pasien luka bakar derajat IIAB-III dengan luas luka bakar > 20% TBSA yang dirawat di RSUP Prof. Dr. I. G. N. G. Ngoerah periode 2020-2021. Data dianalisis dengan SPSS versi 21 untuk Windows. Hasil: Mayoritas pasien luka bakar berjenis kelamin laki-laki yaitu sebesar 73,9%. Usia rata-rata pasien luka bakar yaitu 48,26±15,95 tahun. Pada pemeriksaan hari pertama didapatkan nilai UUN masih rendah (29,4 mg/24 jam). Kemudian pada hari ke-3 didapatkan peningkatan rata-rata kadar UUN yakni nilai maksimum 61.987 mg/24 jam. Pemeriksaan pada hari ke-7 menunjukkan peningkatan yang sejalan dengan hari sebelumnya yakni nilai maksimum 57.489 mg/24 jam. Pada hari ke-1, nilai rerata UUN lebih tinggi pada pasien meninggal, sedangkan pada hari ke 3 dan 7 kadar rerata UUN pasien dengan luaran hidup lebih tinggi dibandingkan pasien yang meninggal, namun tidak bermakna secara signifikan (p>0,05). Simpulan: Kadar UUN pada hari ke-1, 3 dan 7 pada pasien luka bakar >20% di RSUP Prof. Dr. I. G. N. G. Ngoerah menunjukkan adanya trend peningkatan. Kadar UUN tidak dapat dipakai sebagai prediktor mortalitas pada pasien luka bakar karena hasil tidak signifikan.

Karsinoma sel basal tipe campuran yang diterapi dengan eksisi dan island pedicle flap: laporan kasus I Dewa Made Rendy Sanjaya; I Gusti Nyoman Darmaputra; Ketut Kwartantaya Winaya; I Gusti Ayu Agung Elis Indira; Herman Saputra
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Basal cell carcinoma (BCC) is a malignant neoplasm originating from non-keratinized cells. The incidence increases worldwide and one of the triggering factors is excessive exposure to ultraviolet (UV) rays. The therapy aims to eradicate the tumor and maintain optimal organ function and cosmetic results after the procedure, one of which is the excision technique accompanied by an island pedicle flap. Case Description: A man, 67 years old, came with a complaint of a black lump on the left cheek accompanied by a wound that did not heal. Based on the history, physical examination, and investigations, the patient was diagnosed with mixed type BCC. Excision and wound closure were performed with the island pedicle flap technique. Conclusion: The treatment chosen in this case is surgical excision and island pedicle flap. Although the wound healing is classified as good, the prognosis of the patient is dubius. Considering the location of the lesion and the histopathological results showing an aggressive tumor with a tendency to metastasize, the patient is advised to take precautions. Pendahuluan: Karsinoma sel basal (KSB) adalah neoplasma ganas yang berasal dari sel non keratin. Terjadi peningkatan insiden KSB di seluruh dunia dan salah satu faktor pencetusnya adalah paparan sinar ultraviolet (UV) berlebih. Terapi yang dilakukan bertujuan untuk mengeradikasi tumor serta tetap mempertahankan fungsi organ dan hasil kosmetik yang optimal paska tindakan, salah satunya dalah dengan teknik eksisi yang disertai island pedicle flap. Deskripsi kasus: Seorang laki-laki, usia 67 tahun, datang dengan keluhan benjolan kehitaman pada pipi kiri yang disertai luka yang tidak kunjung sembuh di atas benjolan. Berdasarkan anamnesis, pemeriksaan fisik dan penunjang, pasien terdiagnosis KSB tipe campuran. Dilakukan tindakan eksisi dan penutupan luka dengan teknik island pedicle flap. Simpulan: Tatalaksana yang dipilih pada kasus ini adalah pembedahan eksisi serta island pedicle flap. Meskipun penyembuhan luka tergolong baik, namun prognosis pasien dubius. Mengingat lokasi lesi dan hasil histopatologi yang menunjukkan tumor agresif yang memiliki kecenderungan metastase, pasien disarankan untuk melakukan pencegahan.

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita Aurelia Stephanie; Luh Made Mas Rusyati; Ni Luh Putu Ratih Vibriyanti Karna; Ketut Kwartantaya Winaya; Nyoman Suryawati; I Gusti Ayu Agung Dwi Karmila
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Melasma is an acquired pigmentation disorder characterized by symmetrical hyperpigmented patches, most commonly seen on the face. Melasma and iron deficiency are most common in women of reproductive age. Iron deficiency causes a decrease in ferritin levels, which are iron stores in the body. The mechanism of iron deficiency causing melasma is thought to be due to cell hypoxia in the tissue involving mediators that increase melanogenesis. This study aims to prove that the mean ferritin level is lower in melasma than without melasma and that low ferritin levels are a risk factor for melasma in women. Methods: A case-control research included 28 participants with melasma and 28 without melasma who visited the dermatovenereology department of Prof. Dr. I.G.N.G Ngoerah Hospital, medical cosmetic division, in May-July 2022. The two groups will compare ferritin mean and ferritin risk factor analysis on the incidence of melasma. Data were tabulated and analyzed using SPSS 26. Results: The mean age in the melasma group was 40.64±3.39 years old, and the group without melasma was 37.64±3.50 years old (p=0.75). Of the 28 melasma subjects, there were more subjects with low ferritin levels (60.7%) than the group without melasma (32.1%). From the results of the Mann-Whitney test, the mean ferritin level in the melasma group (36.32±31.05) was significantly lower than in the non-melasma group (58.26±5.39); p=0.006. From the results of the Chi-Square test, it was found that low ferritin levels had a risk of 3.2 times the occurrence of melasma [OR (95% CI) = 3.2 (1.098-9.776), p=0.032]. Conclusion: The mean ferritin level in women with melasma is lower than in women without melasma, and low ferritin levels are a risk factor for melasma. Latar Belakang: Melasma merupakan kelainan pigmentasi didapat yang ditandai dengan adanya bercak hiperpigmentasi simetris, paling sering terlihat pada wajah. Melasma dan defisiensi besi paling sering dijumpai pada wanita usia reproduktif. Defisiensi besi menyebabkan turunnya kadar feritin yang merupakan cadangan besi dalam tubuh. Mekanisme defisiensi zat besi menyebabkan melasma diduga akibat hipoksia sel di dalam jaringan melibatkan mediator yang meningkatkan melanogenesis. Studi ini bertujuan untuk membuktikan rerata kadar feritin lebih rendah pada melasma dibandingkan tanpa melasma serta membuktikan kadar feritin yang rendah merupakan faktor risiko melasma pada wanita. Metode: Studi case-control yang melibatkan 28 subjek dengan melasma dan 28 subjek tanpa melasma yang berobat ke poliklinik kulit dan kelamin RSUP Prof. Dr. I.G.N.G Ngoerah divisi kosmetik medik periode Mei-Juli 2022. Kedua kelompok akan dibandingkan rerata feritin dan analisis faktor risiko feritin terhadap kejadian melasma. Data ditabulasi dan dianalisis dengan menggunakan SPSS 26. Hasil: Rerata usia pada kelompok melasma 40.64±3,39 tahun dan kelompok tanpa melasma 37,64±3,50 tahun (p=0,75). Dari 28 subjek melasma, didapatkan lebih banyak subjek dengan kadar feritin rendah (60,7%) dibandingkan kelompok tanpa melasma (32,1%). Dari hasil uji Mann-Whitney didapatkan rerata kadar feritin pada kelompok melasma (36,32±31,05) lebih rendah secara signifikan dibandingkan pada kelompok bukan melasma (58,26±5,39); p=0,006. Dari hasil uji Chi-Square didapatkan kadar feritin yang rendah memiliki risiko sebesar 3,2 kali terjadinya melasma [OR (IK 95%) =3,2 (1,098-9,776), p=0,032]. Simpulan: rerata kadar feritin pada wanita dengan melasma lebih rendah dibandingkan wanita tanpa melasma dan kadar feritin yang rendah merupakan faktor risiko melasma.

A neglected case of blunt eye injury leading to pediatric cataract: a lifetime consequence case report Jelly Vianti Fransisca Oeiyano; Raymond Oliver Mantu; Samuel Samatara
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Background: A pediatric traumatic cataract is one of the children's main causes of unilateral visual impairment. It is defined as a permanent opacification of the lens caused by penetrating or blunt trauma to the eye, which might damage the vision. A traumatic pediatric cataract is preventable and treatable. This case study aims to evaluate a neglected case of blunt eye injury leading to pediatric cataracts. Case Description: A 15-year-old boy came with chief complaints of decreased visual acuity in his left eye for the last 2 years. He has a history of blunt eye injury around 3 years prior in the left eye but left untreated. The patient's visual acuity was 1 per light perception in the left eye. An ophthalmologic examination of the left eye showed an opacity in the lens. The posterior segment cannot be examined. The patient was assessed with a traumatic cataract and was planned to be operated on, but the parents refused. Conclusion: Prompt first aid and timely surgical intervention are necessary for optimal results. Parents play a critical role in the patient's prognosis by observing closely after eye trauma and bringing their children to the right medical facility.

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-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA

Abstract

Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota denpasar, Bali INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota denpasar,

Bali

INDONESIA