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Jurnal Farmasi Higea

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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 10 Documents

Search results for , issue "Vol 6, No 2 (2014)" : 10 Documents clear

Pengaruh Pemberian Ekstrak Daun Gaharu (Aquilaria Malaccensis Lam.) Terhadap Aterosklerosis Pada Burung Puyuh Jantan (Coturnix-Coturnix Japonica) Suhatri Suhatri; Dian Zaini Putra; Elisma Elisma
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Study about the influence of agarwood leave’s extract (Aquilaria malaccensis Lam.) on the formation of atherosclerosis in male quail (coturnic-coturnix japonica) induced high fat feeding and prophylthiourasil. Animal experiments were grouped into 5 consisting of Group I as a negative control only given food strander, group II as a positive control and PTU given MLT groups III, IV, V given leaf extract of aloes with a dose of 100 mg / kg BW, 300 mg / kg BW, 900 mg / kg BW and, along with the MLT and PTU the extract was given orally once a day for 60 day. The doses used were 100, 300, 900 mg/kg body weight respectively. Control groups was given food standar. Result showed that the administration of the agarwood leaf extract could prevent formation of atherosclerosis in male quail significantly (P < 0.05). The optimal effect showed doses 100 mg/kg BW.

Pembuatan Dan Karakterisasi Ekstrak Kering Daun Sirih Hijau (Piper Betle L.) Harrizul Rivai; Putri Eka Nanda; Humaira Fadhilah
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

A study about production and characterization of dried Piper betle L. Leaf extracts with the a ddition of lactose as drying agents has been perfomed with various ratio 1:1, 1:1½ and 1:2. Ekstrak mode better various ratio 1:2 with dried extracts characterization result are : powder, fawn color.odor like plant and somewhat bitter taste. The dry extractswas madebycomparison ofextracts: lactose 1:1, 1:1½ and 1:2 and the best ekstract was in ratio 1:2, levels ofwater-soluble compounds extract 1:2 is 23.0699% ± 1.6353, levels ofethanolsolublecompounds 3.8094% ±0.2109%, losses on drying 2.1367% ± 0.0144%, moisture content 2.0196 % ± 0.0019 %,apparentspecific gravity 0.5482 g/mL ± 0.0003 %, specific gravity of incompressible 0.5558 g/mL ± 0.0004 g/mL, The total ash content of 0.5660% ± 0.0613% and acidinsolubleash content of 0.5179% ± 0.0309%.

Pengaruh Ekstrak Wortel (Daucus Carota Linn.) Terhadap Aterosklerosis Pada Burung Puyuh Jantan (Cortunic-Cortunix Japonica) Suhatri Suhatri; Hel Amir; Zet Rizal
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Has done research the effect of extracts of carrot (Daucus carota Linn.) Against atherosclerosis in male quail (Cortunix-cortunix japonica). Atherosclerosis induced by administering Prophylthiouracyl (PTU) and high-fat foods (MLT). Carrot extract dose given on quail is 50 mg / kg BW, 100 mg / kg BW and 200 mg / Kg BW on quail males given orally for 60 Days. The results showed that the administration of carrot extract at a dose of 100 mg / kg BW and 200 mg / kg BW can prevent the formation of atherosclerosis in male quail, marked on the wall thickness of the aorta, the aortic lumen and extensive damage to endothelial cells was not different from the negative control (P < 0.05). Carrot extract dose of 50 mg / kg BW for 60 days can not be pried prevent its established atherosclerosis, characterized in aortic wall thickness, area of the aortic lumen and endothelial cell damage is not different from the positive control (P> 0.05).

Pengaruh Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Volume Urin Dan Hambatan Pembentukan Batu Ginjal Pada Tikus Terinduksi Etilen Glikol Helmi Arifin; Vivi Resviana; Elisma Elisma
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Research on the effect of binahong leaf extract (Anredera Cordifolia (Tenore) Steen) on urine volume and resistance kidney stone formation in rat induced by ethylene glycol has been done. It purposed to look up the ability of the binahong leaf extract to increase the urine volume and kidney stones shed on rats white males. That kidney stone formation induced by 0,75% ethylene glycol and 2% ammonium chloride for 7 days. 25 white male rats were divided into 5 groups, group I were given drinking water (negative control), group II in the induction for 7 days (positive control), group III, IV and V were induced dose groups and given the extract at a dose of 50 mg/kg BB, 150mg/kg BB and 450mg/kg BB. Extracts was given on day 8-28, 24-hour urine volume were collected on days 7, 14, 21 and 28 for calcium level was measured by atomic absorption spectrophotometer and oxalat levels with ultraviolet and visible spectrophotometer. Data were analyzed by two-way ANOVA followed by advenced Duncan test. The urine volume was not significantly influenced by treatment factors and the duration of administration (P>0.05), while the levels of calcium and oxalat significantly influenced by treatment factors and the long time of administration (P<0.05) based on these results it could be concluded that binahong leaf extract could increase the urine volume and kidney stones shed. The effective dose is the dose kidney stone shed 450mg/kgBB. So the higher the dose and the longer the time of administration of calcium and oxalate levels also increased in the urine volume of rat white males.

Pemanfaatan Ekstrak Etanol Daun Murbai (Morus alba L.) Sebagai Bahan Aktif Pasta Gigi Dan Uji Aktivitas Anti Bakteri Terhadap Plak Gigi Akmal Djamaan; Fatimah Saidah; Rina Wahyuni
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

The formulation of leaf´s murbey ethanol extract´s toothpaste and its activities against dental plaque´s bacteries had been done. Pre test showed the leaf´s murbey ethanol extracts at 4% of concentration gave an optimal diameter of inhibition against dental plague. Based that fact, this research would have made 3 formulas at toothpaste from leaf´s murbey extract at 1%, 2%, and 4% of concentration. All of formulas would have wade with the same base of toothpaste. All of formulas would be characterized of pharmaceutic´s properties and antibacteria´s activities, that would be compared with toothpaste “S” and “P” as a standard. The result shawed all formulas gave a good characteristic of pharmaceutic properties. F3 had gave a good diameter of inhibition, that was 21.875 mm, where as the “S” and “P” of toothpaste had gave a diameter of inhibition respectively 23.875 mm and 22.75mm. There was a significant difference of inhibition´s diameter of all formulas at 0.05 level of confidence.

Mikroenkapsulasi Karbamazepin dengan Polimer Hpmc Menggunakan Metoda Emulsifikasi Penguapan Pelarut Rina Wahyuni; Yustina Susi Irawati; Auzal Halim
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Microencapsulation of Carbamazepine using HPMC as a polymer by emulsification solvent evaporation method had been studied. Microcapsules had been made into 3 formulation with 3 ratio variation between Carbamazepine and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were evaluated by SEM, DTA, FT-IR, particle sized distribution, drug content and dissolution profile. The evaluation result showed that HPMC as a polymer of sustained release was influence characteristic microcapsules of Carbamazepine. Microcapsules were white to slightly yellow and almost perfectly spherical. Disolution profiles of microcapsules showed that the formula containing the greatest amount of HPMC gave the slower release of Carbamazepine. Resistance release of biggest drug shown by formula 3 giving disolution during 6 hour counted 24.5296 %. Dissolution kinetics of microcapsules allowed Higuchi equation, where the realese of Carbamazepine from microcapsules were controlled by diffution process.

Pengaruh Lama Pencucian Terhadap Kadar Vitamin B1 Pada Beras Putih Dan Beras Merah Secara Spektrofotometer Visibel Roslinda Rasyid; Anisa Nurul Fitria; Humaira Fadhilah
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

A research about analysis of vitamin B1 on the effeccts of long leaching on levels of vitamin B1 on white rice and red rice using UV-Visible spectrophotometry. Vitamin B1 reacted with bromthymol blue for compose ion-association complex. For improve solubility of Vitamin B1 complex compounds with bromthymol blue be added polivinyl alcohol as a solubilization substance, and added amonia buffer as pH buffer, that measured with wavelength of maximum absorbance was 431,0 nm. Average (%) Vitamin B1 level of white rice after leaching minutes 1 is 0,0166. Average vitamin B1 level of red rice after leaching minutes 1 is 0,0262. The highest level of vitamin B1 from the white rice and red rice was found on minute 1 after leaching. From the statistical analysis one way ANOVA using SPSS 17 program found a significant difference (p<0,05) from each sample.

Analisis Senyawa Fenolat Dan Uji Aktivitas Antioksidan Buah Markisa (Passiflora Edulis Sims) Secara Spektrofotometri Visibel Fithriani Armin; Ermadanis Ermadanis; Roslinda Rasyid
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

Has done research on the analysis of phenolic compounds and antioxidant activity test on passion fruit (Passiflora edulis Sims) by visible spectrophotometry method. To determine the presence of phenolic compounds in the sample to be identified with iron (III) chloride is characterized by the formation of dark blue color on the sample. Samples were macerated with 96% ethanol, performed three repetitions and the filtrate was concentrated using a rotary evaporator at a temperature of 400 C. Extracts were obtained determined the levels of phenolic compounds using Folin-ciocalteau method and test the antioxidant activity using DPPH method. Standard solution used is gallic acid. Equation linearity gallic acid used in the determination of phenolic compounds in the sample is y = 0.004x + 0.1366 with correlation coefficient (r) = 0.9956 measured at λ max 761.5 nm. the levels of phenolic compounds were obtained on average at the sample was 0.0377% w / w. The average percent inhibition of passion fruit sample solution were counted against the maximum wavelength of 512.0 nm DPPH is 19.8763%. The antioxidant activity of the sample solution of 10 mg is equivalent to 618.9760 mg gallic acid and gallic acid solution IC50 of 1.5604 mg / mL of the sample solution while the IC50 14.4751 mg / mL.

Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen -Urea Salman Umar; Monica Selfia; Rieke Azhar
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

A research on the study of physical and chemical stability of ketoprofen-urea solid dispersions. Solid dispersions prepared through dissolution method with ketoprofen-urea ratio is 1:1, 1:3, 1:5. Powder solid dispersion system was evaluated physicochemical properties include analysis Differential Thermal Analysis (DTA), FT-IR spectroscopy, and dissolution profiles. Accelerated stability test for 3 months at a temperature (40±2)°C. The parameters tested include organoleptic test and ketoprofen levels. Ketoprofen levels were measured by UV spectrophotometer at a wavelength of 255.5 nm after being stored for 1, 2, and 3 months at a temperature (40±2)°C. DTA analysis results showed endothermic peak shift ketoprofen meaningful. FT-IR spectra showed no chemical interaction between ketoprofen-urea solid dispersion powder. The results showed that solid dispersions of ketoprofen-urea can improve the physicochemical properties and can enhance the dissolution profile of solid dispersion compared to pure ketoprofen with the highest dissolution results indicated by solid dispersion formula 3 (1:5) is 105.674%. Test chemical and physical stability of solid dispersions of ketoprofen-urea showed a change in the physics and chemistry of solid dispersions. Organoleptic test the change in color the three formulas. While the test by the chemical assay, the three formulas while showed that increasing the concentration of urea in the solid dispersion of a decrease in the levels of ketoprofen. The most stable formula is the formula 1 (1:1) to 24.748 months of age.

Pengaruh Cara Pengeringan Dengan Oven, Kering Angin Dan Cahaya Matahari Langsung Terhadap Mutu Simplisia Herba Sambiloto Rina Wahyuni; Guswandi Guswandi; Harrizul Rivai
Jurnal Farmasi Higea Vol 6, No 2 (2014)
Publisher : STIFARM Padang

The influence of drying method to the quality of sambiloto’s herbal crude had been done. The drying methode that used are oven drying at 45o C, direct sunlight drying and wind drying. The results showed that oven drying gave the best result with drying shrinkage value of 9.1147%, 9.3339% total ash value, acid insoluble ash content of 0.7768%, the levels of water-soluble extract 19.3226% and levels of 17.5160% ethanol-soluble extract.

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