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Jurnal Farmasi Higea

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Published by Sekolah Tinggi Ilmu Farmasi Padang

ISSN : - EISSN : 25413554 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Arjuna Subject : -

Articles 10 Documents

Search results for , issue "Vol 8, No 2 (2016)" : 10 Documents clear

Pengaruh Pengulangan Dan Lama Penyimpanan Terhadap Ketengikan Minyak Kelapa Dengan Metode Asam Thiobarbiturat (TBA) Zikra Azizah; Roslinda Rasyid; Desi Kartina
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

The research aims to determine the effect of repeat frying and duration of storage to rancidity coconut oil used thiobarbituric acid (TBA) method. The sample used were coconut oil with three different brands namely coconut oil A, B, dan C. The highest TBA number of samples coconut oil A, B, dan C was after three frying and 2 days of storage, TBA number was 0.879, 0.694, and 1.336 mg malonaldehyde/Kg sample. Based on data, can conclude samples coconut oil A, B dan C has under gone rancidity, but still below the maximum limit set by Badan Standarisasi Nasional (1991) was 3 mg malonaldehyde/Kg sample. The quality coconut oil A, B, dan C still below the maximum limit set by Badan Standarisasi Nasional (2013) such as acid number was 0.6 mg KOH/g, peroxide number was 2 meq/kg, saponification number was 196-206, iod number was 45-46, and free fatty acid was 0.3 %.

Penetapan Kadar Protein Dalam Telur Unggas Melalui Analisis Nitrogen Menggunakan Metode Kjeldahl Dwi Dinni Aulia Bakhtra; Rusdi Rusdi; Aisyah Mardiah
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Eggs consumed by many people because it’s easily to processed, low cost, and have perfect substances, especially proteins. The purpose of this research were to determine levels of the protein in the fowl’s eggs. The sample used in this research are rooster chicken egg, ayam kampung egg, duck egg, and quail egg. The protein content in fowl’s eggs were evaluated using Kjeldahl method by calculating the total nitrogen content and converted (conversion factor is 6.25). Result of the research protein content contained in rooster chicken egg 6.4506 % ± 0.1418, ayam kampung egg 6.9102 % ± 0.0475, duck egg 6.5996 % ± 0.0497, and quail egg 6.5532 % ± 0.0110. The result of the test statistics clarify that the sample eggs are examined to contain the protein with the levels of different significantly (F = 94.461 and sig. 0.000 (<0.05)). Where ayam kampung egg have protein content higher than another eggs sample and the lowest protein content contained in rooster chicken egg.

Pembuatan dan Karakterisasi Dispersi Padat Nifedipin dengan Poloxamer 188 Menggunakan Metode Peleburan Rina Wahyuni; Auzal Halim; Sri Oktavia; Rahmi Purwaningsih
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Nifedipin is a poorly water soluble calcium channel blocking agent. Solid dispersion is one of several pharmaceutical technologies that enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to prepare and characterize nifedipin-poloxamer 188 solid dispersion by fusion method. Combination of nifedipin and poloxamer 188 for F1, F2 and F3 were 1:9, 2:8 and 3:7 respectively. The physical mixture and solid dispersions were characterized for particles size distribution, drug-carrier interaction, drug content and dissolution rate. The physicochemical characterization showed a specific characterized of solid dispersion. As indicated from X Ray Diffractograms, DTA thermograms and SEM photographs, nifedipin was in the amorphous form and entrapped in polymer matrix. FTIR results proved no chemical interaction between nifedipin and poloxamer 188. SEM images showed a new morphology of solid dispersions compare with pure drug and physical mixture. The dissolution rate was increased with increasing polymer concentrations. F1 showed the highest dissolution rate among all formulas. Statistic analysis showed a significant differences (P<0.05) of dissolution efficiency among all formulas.

Pengembangan Dan Validasi Metode Analisis Ranitidin Hidroklorida Tablet Dengan Metode Absorbansi Dan Luas Daerah Di Bawah Kurva Secara Spektrofotometri Ultraviolet Boy Chandra; Harrizul Rivai; Marianis Marianis
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Development and validation of methods of analysis of ranitidine hydrochloride tablets have been done by absorbance method and the method of the area under the curve by ultraviolet spectrophotometry. This study use the principle of calculation of absorbance and the area under the curve obtained from the measurement of the analyte solution by using UV-Vis spectrophotometer and distilled water as the selected solvent. Linearity ranitidine hydrochloride obtained in the concentration range of 6 - 14 ppm with correlation coefficient value by absorbance and the area under curve method respectively 0.99943 and 0.99947. Results of the study showed that the samples of generic ranitidine hydrochloride tablets obtained by absorbance method and the area under curve method was 99.57 ± 0.001 % and 103.30 ± 0.001 %. The average percent recovery obtained by the absorbance and the area under curve method was 98.31 % and 95.39 %. While the research results for the samples of Gasela tablets obtained by the absorbance and the area under curve method was 96.98 ± 0.002 % and 104.33 ± 0.009 %. The average percent recovery obtained by the absorbance method and the area under each curve was 98.89 % and 94.78 %.

Pengaruh Pemberian Campuran Jahe Merah, Bawang Putih, Cuka Anggur Dan Madu Terhadap Kadar Kolesterol Total Dan Histopatologis Pembuluh Darah Aorta Jantung Tikus Putih Jantan Rahimatul Uthia; Surya Dharma; Friska Mulya Dewita
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Study of the effect of red ginger (Zingiber officinale Roscoe), garlic (Allium sativum L.), wine vinegar, and honey have been carried out on total cholesterol levels by using the tool Easy Touch GCHb and histopathological tests on male rats. The assortment of were given orally for 28 days with a dose of red ginger 0.162 g/kg BB, garlic 0,09 g/kg BB, wine vinegar 0.27 g/kg BB, and the honey of 1.8 g/kg BB. The data were analyzed by one-way ANOVA followed by Duncan test. The results showed a decrease in total cholesterol levels and may improve lumen area and lower scores damage to the blood vessels were significant (P <0.05), which means the provision of a assortment of red ginger (Zingiber officinale Roscoe), garlic (Allium sativum L.), wine vinegar and honey can lower total cholesterol and improve lumen area and lower scores damage to the blood vessels.

Pengaruh Pemberian Kombinasi Jahe Merah, Bawang Putih, Apel, Lemon Dan Madu Terhadap Kadar Kolesterol Total Dan Histopatologis Pembuluh Darah Aorta Jantung Tikus Putih Jantan Ifora Ifora; Surya Dharma; Diken Maywidia Darma
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Study of the effect of red ginger (Zingiber officinale Roscoe), garlic (Allium sativum L.), apple (Malus domestica Borkh.), Lemon (Citrus limon (L.) Osbeck and honey have been carried out on total cholesterol levels by using the tool Easy Touch GCHb and histopathologic examination aorta in male rats.The combination dosage were given orally for 28 days with a dose of red ginger 0.162 g / 200 g, garlic 0.09 g / 200 g, apples 1.8 g / 200 g, lemon 50 mL / 200 g, and the honey of 1.8 g/ 200 g. The data were analyzed by one-way ANOVA followed by Duncan test.The results showed a decrease in total cholesterol levels may affect histopathologic aorta is extensive aortic lumen of blood vessels and blood vessel damage scores were significant (P <0.05), which means the provision of a combination of red ginger (Zingiber officinale Roscoe), garlic (Allium sativum L.), apple (Malus domestica Borkh.), lemon (Citrus limon (L.) Osbeck and honey can lower total cholesterol and improve lumen area and lower scores damage to the blood vessels.

Uji Toksisitas Akut Ekstrak Etanol Daun Kirinyuh (Chromolaenodorata (L) R.M.King & H. Rob) Pada Mencit Putih Jantan Aried Eriadi; Helmi Arifin; Nirwanto Nirwanto
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

A research on the acute toxicity of ethanol extracts of leaves kirinyuh (Chromolaena odorata (L) R.M.King & H.Rob). Parameters observed toxicity is LD50 and delayed toxic effects for 14 days of observation including changes in weight, the volume of water consumption, and the relative weight of the organs of the heart, liver, kidneys, stomach and lungs. The extract ethanol leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) orally at a dose of 4 g/kgBB, 8 g/kgBB and 16 g/kgBB, showed that the ethanol extract of leaves kirinyuh (Chromolaena odorata (L) R.M King & H.Rob) categorized practically non-toxic (LD50> 15 g/kgBB). Delayed toxic effects are seen from the significant differences in body weight, the volume of water, relative organ weight of lung and stomach (P<0.05). There were no significant differences in the relative organ weight of the heart, liver and kidneys (P<0.05).

Penetapan Kadar Tanin Pada Teh Celup Yang Beredar Dipasaran Secara Spektrofotometri UV-Vis Anzharni Fajrina; Junuarty Jubahar; Stevani Sabirin
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

The assay was conducted on tannins tea bag on the market Ultraviolet Visible spectrophotometry method. The samples used was tea bags with brand TM, TS, TP, TR, TJ and pure tea as a comparison. Tea powder sample were extracted using 70 % ethanol.to determine the type and content of tannin used catechins. On the quantitative test is obtained maximum wavelength of 222.00 nm catechins. The calibration curve cathecin is y = 0.04943x + 0.06692. with the value count r = 0.9995. The result showed levels of tannins in tea bag brand TM (0.00919 %), TS (0.00882 %), TP (0.00863 %), TR (0.00766 %), TJ (0.01184 %) and pure tea (0.01207 %). The research shows. kruscal wallis test results showed significant difference (P<0,05) between all brands of used tea bag with pure tea and significant difference between each tea bag.

Pengembangan Dan Validasi Metode Analisis Tablet Furosemid Dengan Metode Absorbansi Dan Luas Daerah Di Bawah Kurva Secara Spektrofotometri Ultraviolet Ridho Asra; Harrizul Rivai; Via Lovita Riani
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Development and validation of analysis methods of furosemide tablet have been done by absorbance method and area under the curve methods using ultraviolet spectrophotometry. Linearity of pure furosemide was obtained with range concentration 8 - 18 ppm. Coefficient correlations absorbance and area under curve methods were 0.99999 and 0.99725 respectively. The percentage of stated content were determined, which were compared with Gralixa Furosemide tablets and generic furosemid tablets. The results showed that the percentage of stated content from Gralixa tablet with absorbance and the area under curve methods were 99,33 % ± 0,004 and 98,44 % ± 0,003 and the recovery were 98,75 % and 97,88 % respectively. While the research results showed that the percentage of stated content from generic furosemide tablets with absorbance and area under curve methods were 98,42 % ± 0,005 and 97,78 % ± 0,008 and the recovery were 98,61 % and 95,06 %. Statistical analysis proves that the method is reproducible and selective for the analysis of furosemide.

Pembuatan Kafein Salisilat Secara Semisintetis Dari Bubuk Kopi Olahan Tradisional Kerinci Sestry Misfadhila; Zulharmita Zulharmita; Deni Hardian Siska
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

The caffeine contained in coffee powder processed traditionally taken in Kerinci can be isolated, crystallized and made into a caffeine salicylate. Isolation of caffeine conducted through the coffee powder with water extraction, fractionation with methylene chloride, and crystallized using acetone and petroleum ether. The crystallization process is obtained of caffeine powder which is then reacted with salicylic acid, caffeine salicylate formed by using the solvent toluene and petroleum ether. Identification of caffeine powder and caffeine salicylate include: organoleptic, melting range, color reaction, the ultraviolet spectrum, infrared spectrum and thin layer chromatography. The identification caffeine results meet the requirements listed in the Indonesian Pharmacopoeia V edition of 2014. The results of determining the wavelength of maximum absorption of caffeine powder isolation results was 276 nm, caffeine salicylate 243 & 307 nm. Rf values obtained from thin layer chromatography test for caffeine is 0.30 and caffeine salicylate 0.36.

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