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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
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Articles 22 Documents
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Search results for , issue "Vol 5, No 1 (2023): Volume 5 Edisi 1 2023" : 22 Documents clear
Formulasi dan Uji Kestabilan Fisik Lilin Aromaterapi Minyak Atsiri Bunga Melati (Jasminum sambac L) Besse Yuliana; Andi Makkulawu; Annisa Ramadhani Amal
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18874

Abstract

Aromatherapy candles are alternative medicine (inhalation) namely inhalation, aroma vapor produced form a few drops esensial oils. Jasmine flower (Jasminum sambac L.) is used widely as Aromatherapy for the manufacture of essential oils, generally brownish yellow in  color with the characteristic odor. Contains chemical compounds of jasmine oil, namely lynalol 10. 13%, nerolidol 19.95%, and indole 4. 05%. Jasmine Flower essential oil Aromatherapy candle (Jasminum sambac L.) This type oh the research was experimental, including physical burning point tests, melting point tests and hedonic tests. The results showed that the preparations had made white and yellow colors, different aromas according to the concentration of the essential oil, the melting point 52-59℃ according to the requirements according to SNI, namely 42-60℃, the fastest burning time was the old formula K(-), formula 2and 3 the fastest burning time, and in the hedonic test, formulation 3 was the most favored by the panelists and the K(-) formulation was less favored by the panelists. The conclusion oh this research is that jasmine essential oil (Jasminum sambac L.) can be formulated aromatherapy candles preparations, jasmine flower essential oil (Jasminum sambac L.) in aromatherapy candles is physical stable and jasmine essential oil aromatherapy candles  (Jasminum sambac L.) has high level of liking by the panelists.
Bioactivity of Purple Sweet Potato (Ipomea batatas) as Anti Inflammatory Agent: Review Shella Carlina Tasya; Paula Mariana Kustiawan
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.14240

Abstract

This Inflammation is a defensive response to tissue damage that occurs locally. NSAID (Non Steroid Anti-Inflammatory Drugs) and AIS (Antiinflammatory Steroids) have been used in Indonesia to treat inflammation but have side effects on the body. Purple sweet potato leaf (Ipomoea batatas) is one of the herbal medicines used by the community to treat inflammation. This research is a literature review by collecting information from Google Scholar, PubMed, Scopus, and Garuda. The results showed that the active anti-inflammatory compounds in purple sweet potato leaves were flavonoids. Flavonoids can work as anti-inflammatory compounds by passing through several pathways such as inhibition of cyclooxygenase (COX) and lipoxygenase enzyme activities, inhibition of neutrophil degranulation, inhibition of histamine increase, and inhibition of leukocyte accumulation. Purple sweet potato (Ipomoea batatas) leaves are scientifically proven to have anti-inflammatory activity as evidenced by the presence of compounds that have anti-inflammatory effects and can be developed into products for inflammation.
Gambaran Penggunaan Antidepresan Pada Pasien Lanjut Usia Danang Sigit Widianto; Nurmainah Nurmainah; Mohamad Andrie
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.15940

Abstract

Depression is a common mental disorder characterized by a loss of interest or pleasure. The types of drugs used in the use of antidepressants include selective serotonin reuptake inhibitors (SSRIs), selective serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclics. The purpose of this study was to describe the patient's description, the level of depression, and the types of antidepressant drugs used in elderly patients hospitalized at Sei Bangkong Hospital, Pontianak. Methods This research is a descriptive observational study with a cross sectional design. Data collection was carried out by using medical record data during the 2021 period using antidepressants. The results showed that the age of patients 61-65 years old who used antidepressants were 20 people (51.28%), while for 65 years who used antidepressants were 19 people (48.71%). The level of minor depression was 20 people (51.28%), while for major depression it was 19 people (48.71%). The types of drug classes used are SSRI group, SNRI group, and tricyclic group. The conclusion of this study is that there are more patients aged 61-65 years than patients 65 years who are depressed, female and male with minor and major depression levels. The types of drug classes used are SSRI group, SNRI group, and tricyclic group.
Uji Aktivitas Antioksidan Ekstrak Etanol Umbi Keladi Tikus (Typhonium Flagelliforme (L.) Blume) Elvira Santi; Andi Juaella Yustisi; Nurfitria Junita
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18573

Abstract

Rodent tuber (Typhonium flagelliforme (L.) Blume) is a medicinal plant used by the community as a drug. This plant is nutritious because one of chemical contents is triterpenoid which is having a role as the free radical scavenger that can lead to degenerative diseases. The aim of the research is to determine the extract antioxidant activities of rodent tuber (Typhonium flagelliforme (L.) Blume) based on the binding of free radicals of 1,1-diphenyl-2-picrylhydrazyl. Extract of rodent tuber (Typhonium flagelliforme (L.) Blume) was obtained by maceration method, the sample was macerated by using ethanol of 96%. This research used DPPH method. The antioxidant activity against free radical were measured by mean of UV-Vis spectrophotometry at a wavelength of 516 nm and calculated the value of IC50. The results showed that each rodent tuber extract (Typhonium flagelliforme (L.) Blume) has IC50 for the ethanol extract was 74.359 µ/mL and the comparison of quercetin with the value IC50 was 10.298 µg/mL respectively
Hubungan Kepatuhan Konsumsi Kalsium Karbonat terhadap Kadar Fosfat Pasien Gagal Ginjal dengan Hemodialisis Fika Nuzul Ramadhani
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19121

Abstract

Non-adherence to renal failure treatment increases the risk of disease complications, such as metabolic disorders of calcium and phosphate. Education is one of way to increase medication adherence. Education is one way to increase patient compliance in therapy. One way of conducting education is by giving leaflets. This study aims to determine the correlation between compliance with consumption of calcium carbonate and phosphate levels in patients with kidney failure on hemodialysis. This research were experimental and prospective study at PKU Muhammadiyah General Hospital, Yogyakarta City for 4 weeks using the one-group pretest posttest design to test patients' phosphate levels pre and post administation of leaflets increase adherence. Sample consisted of 70 kidney disease patients with hemodialysis were divided into 2 groups, each consisting of 35 patients. The intervention group were given education leaflets and checking phosphate levels, while the control group were not given leaflets. Data were obtained from medical records, questionnaire instruments and phosphate laboratory data. The level of patient adherence in taking calcium carbonate medication assessed by MMAS questionnaire and phosphate levels of patients. Data were analysis using the Wilcoxon test and Spearman test.The results of the analysis between adherence and phosphate levels showed no relationship between adherence and phosphate levels p=0.591 (p0.05). Overall, it can be concluded that there is no correlation between adherence to calcium carbonate consumption and phosphate levels
Pengaruh Edukasi Kesehatan Tentang Protokol Kesehatan Covid-19 Terhadap Pengetahuan Dan Sikap Ayu Nurintan; Faisal Kholid Fahdi; Muhammad Ali Maulana
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19063

Abstract

Covid-19 is an infectious disease that affects and infects the respiratory system. From minor respiratory issues like the flu to major ones like pneumonia, lung failure, and even death, Covid-19 can cause a variety of respiratory issues. Close contact and the splash of saliva from an infected individual's talking, coughing, or sneezing can spread Covid-19 from one person to another. Nearly every region of Indonesia has been affected by the Covid-19 illness. To reduce the rate of transmission, the government has set a health protocol policy for daily activities. This can be accomplished by offering health education. Covid-19 and the 5M health regimen, which include utilizing masks, keeping hands, keeping distance, avoiding, and decreasing movement, are two examples of the types of education that can be provided. The purpose of this study was to find out how health education influences changes in students' knowledge and attitudes towards the Covid-19 health protocol. Method: This study is quantitative and uses a pretest-posttest design without a control group as a quasi-experimental approach. With 62 respondents, sequential sampling was the sample technique employed. The Wilcoxon test is the statistical procedure employed. With a significant value of 0.000 (p 0.05) between the pre-test and post-test-1 knowledge variables and a significant value for the pretest attitude variable toward post-test, the results of the various tests using the Wilcoxon test demonstrated that there was a difference in knowledge before and after receiving health education about the Covid-19 protocol. Test-1 is 0.000 (p0.05), indicating that the Covid-19 protocol-related health education had an impact on the attitude variable as well. Conclusion: Students' knowledge and attitudes towards the Covid19 health regimen are influenced by health education.
Studi Fenomenologi : Pengalaman Keyakinan Diri Terhadap Penyembuhan Covid-19 Arizki Rahman Hakim; Ichsan Budiharto; Muhammad Ali Maulana
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.19122

Abstract

The Covid-19 pandemic requires every exposed community to selfisolate, including nursing students. When required to self-isolate, nursing students have many stressors that affect their self-confidence (Self Efficacy). Objective to explore the self-efficacy experience of nursing students at X University during the self-isolation process. Using a qualitative design with a phenomenological approach as many as six participants with the snowball sampling method. Collecting data using a semi-structured interview method for 10-20 minutes using thematic analysis. There were four themes identified from the thematic analysis, namely (1) exposure to Corona Virus Disease (Covid-19) which explained how participants were exposed to Covid-19, when participants were Covid-19, and the signs and symptoms that participants felt; (2) self efficacy enhancement strategies in the form of fulfilling basic needs, fulfilling information needs, and coping mechanisms; (3) self efficacy factors, namely the support of the surrounding environment, expectations, motivation, and level of knowledge; and (4) Barriers to increasing self efficacy in the form of changes in physical condition, stress load, and interaction and communication. The description of the experience of nursing students' beliefs when doing independent isolation is influenced by several aspects including exposure to Covid-19, improvement strategies, self efficacy, self efficacy factors, and barriers to increasing self efficacy.
Analisis Kandungan Flavanoid Daun Sambang Darah (Excoecaria cochinchinensis L) Ariani H. Hutuba; A. Mu'thi Andy Suryadi; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.7157

Abstract

Flavonoids are chemical compounds derived from plants which are a group of secondary metabolites. Flavonoids Flavonoid compounds are polyphenolic compounds that have 15 carbon atoms arranged in a C 6 -C 3 -C 6 configuration, namely two aromatic rings connected by 3 carbon atoms that can or cannot form a third ring. Flavonoids are widely distributed in angiosperms, gymnosperms, and pteridopites. These flavonoids provide physiological and pharmacological effects on living things. The purpose of this study was to identify the flavonoid compounds present in the leaf extract of the blood sambang plant (Excoecaria cochinchinensis L). In this study, a multilevel maceration extraction was used using n-hexane, ethyl acetate and methanol solvents and then the filtrate was evaporated using an evaporator. Positive phytochemical screening results indicated the presence of flavonoids in methanol extract and negative in n-hexane and ethyl acetate extracts. From the methanol extract, TLC was carried out with an eluent ratio of methanol ethyl acetate (8: 2), it was obtained the separation of two stains where one of the stains had the same Rf value as the Rf value of flavonoids, then performed a UV-Vis spectrophotometric analysis resulting in three absorption wavelengths, namely band I (350 nm) and band II (255 nm and 267 nm). the spectrum obtained is a class of flavone compounds.
Potensi Ekstrak Biji Pala (Myristica fragrans L) Terhadap Penyembuhan Luka Bakar pada Mencit (Mus musculus) Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Zulkarnain Marhaba
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18996

Abstract

The Nutmeg Plant (Myristica Fragrans L) is one of the spices plants empirically used as a therapeutic option for injury healing. Burn injury is damage to the skin's integrity caused by contact with a source with a high-temperature difference. This research aimed to determine the effectiveness of Nutmeg (Myristica Fragrans L) Seed extract on burn injury healing in Male Mice (Mus Musculus). Extraction was carried out through Maceration with Methanol solvent. Eighteen mice were divided into 6 groups: negative control (Na-CMC), positive control (Bioplacenton), and treatment groups with concentrations of 3%, 5%, 7%, and 10%. Burn injury was created using a 2 cm x 2 cm iron plate on the mice's back, and the healing of the burn injury diameter was observed from day 1 to day 20, with observation intervals at day 5, 10, 15, and 20. The data were analyzed using one-way ANOVA followed by an LSD test to determine the differences between test groups. The resalts indicate that the ethanol extract of Nutmeg (Myristica Fragrans L) see haseng effect on burn injury, with the most effective concentration being the extraet onoration of 10%, with a burn injury healing rate of up to 89,15%.
Kepatuhan Penggunaan Obat Asma Terhadap Kualitas Hidup Pasien Asma Rawat Jalan Rumah Sakit X Gorontalo Teti Sutriyati Tuloli; Nur Rasdianah; Sitti Nurul Wildan Basrudin
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.7278

Abstract

Asthma, a chronic disease, is characterized by the inflammation in the respiratory tract, followed by coughing, wheezing, and difficulty breathing. This cross-sectional research was intended to explore the effect of medical compliance on the quality of life of outpatients with asthma. It employed a non-experimental analysis. All 30 respondents were outpatients visiting Gorontalo x hospital they were selected purposively. The compliance level was examined using a relevant questionnaire, while the quality of life was examined using Mini-AQLQ questionnaire. The result of the chi-square test, revealing that 95% of confidence interval; ? = 0.05, where p 0.405 (p ?) OR 2.216, suggesting that the medical compliance did not affect the quality of life. One can argue that this notion, thereby, signifies the necessity to view the quality of life of patients with asthma as a complex issue from multiple perspectives

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