Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Bioscientia Medicina : Journal of Biomedicine and Translational Research

bsm
Website

Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

20 21 22 23 24

Anatomy and Histologic of Intrinsic Aging Skin Putri Laksmi Karim; Inda Astri Aryani; Nopriyati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.417

Aging is an inevitable and dynamic biological process that is characterized by the progressive deterioration of body systems and declines in physiological reserve capacity. Aging skin has distinct two types: intrinsic and extrinsic. Intrinsic changes reduce collagen production, blood flow, amount of skin lipid, and loss of rete ridges. Intrinsic aging or chronological aging is cannot be restored to the skin with characterized by sagging skin and some expression of excess wrinkling lines. Intrinsic aging changes in thickness and characteristics of the epidermis, dermis, and hypodermis. Histologically, epidermis thinner by leveling off the dermo-epidermal junction. In the dermis, collagen fibers become thicker and irregular than younger skin, reducing the elasticity of the skin, while hypodermis reduces lipid volume.

Analysis of the Electronic Implementation of A Malaria Surveillance Information System (E-SISMAL) in the Lahat District Eni Nuraini; Hamzah Hasyim; Haerawati Idris; Ahmad Ghiffari; Chairil Anwar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.419

Background: The requirement for malaria elimination to be recognized is to prove API lower than 1 per 1000 in the population, together with no indigenous case. Lahat Regency is an area of low-endemicity for malaria, where the target for elimination is projected for 2024. Since 2019, Lahat Regency has received socialization about E-SISMAL, which was developed as a web-based basis to speed up the reporting process. However, there are still delays in reporting malaria on E-SISMAL. Methods: Descriptive research with a qualitative approach was designed. The study subjects were the malaria person in charge, the head of seven selected community health centers (Puskesmas) and the Lahat District Health Office. Primary data came from observation, focus group discussion (FGD) and in-depth interviews with eighteen informants selected by the purposive sampling method. Results: The available inputs are inadequate, such as the human resource education was not up to standard, the internet network was not smooth, and there were no guidelines on E-SISMAL in the health centers. Malaria person in charge does not understand how to use E-SISMAL. In the process, there was the involvement of cross-sectoral and networked establishments. The output shows that the report indicators on E-SISMAL are not up to standard with less than 80%. Conclusions: The use of E-SISMAL in the Lahat district has not been maximized. It has an impact on delays in reporting. It is recommended that training and practice of E-SISMAL occur to improve officers' ability through socialization and that the Lahat Health Office establishes partnerships with telecommunications companies to ensure the smooth running of the network. Developing specific guidelines on E-SISMAL and a mobile phone-based malaria surveillance information system to speed up the malaria reporting process in the Lahat district is also advisable.

Preliminary Result in Endoscopic Video Assisted Breast Surgery Randi Dwiyanto; Kristanto Yuli Yarso
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.420

Background : The development of technology has grown rapidly in surgical science, especially the use of endoscopy to develop operations in producing minimal scar tissue. Endoscopic VABS is a surgical technique and began to develop since 1995. The technique has several approaches, namely through the chest wall, mammary and axilla. The descriptive study aims to report our first experience in the management of benign breast tumors with Endoscopic Video Assisted Breast Surgery. Methods : Ten patients with benign breast tumor have performed Endoscopic VABS in the period March 2017 to September 2017 at the Hospital in Surakarta. The largest diameter at the nodule, duration of operation, length of postoperative care, postoperative pain, cosmetic outcomes and complications were observed retrospectively. Result : All patients are women with median age 28 years. The largest diameter that can be taken is 3.5 cm with median 2 cm. One patient performed the conversion into a lumpectomy with conventional techniques due to difficult dissection and uncontrolled bleeding. The median duration of surgery was 60 minute with an average length of treatment for 2 days postoperatively. Average VAS Score was 4. No postoperative complications were found. But cosmetically, all patients are satisfied with the results of surgical wounds. Conclusion : The VABS endoscopic procedure is safe and effective procedure and has excellent cosmetic benefits because it does not show scar tissue in the breast area. This VABS Endoscopic technique has a weakness in terms of longer duration of operation compared to conventional techniques, but this can be overcome with the expertise and experience of the operator.

Regulation and Intervention of Intracranial Pressure Ni Wayan Lisa Suasti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.421

Intracranial pressure is the total amount of pressure exerted by the brain, blood and cerebrocinal fluid in the rigid cranial space. Compliance is an indicator of the brain's tolerance for increased ICP, when compliance is exceeded, there will be a dramatic increase in the pressure/volume curve so that ICP will increase rapidly. In the injured brain, cerebral blood flow (CBF) is regulated to supply sufficient oxygen and substrates to the brain. Certain physiological factors such as hypercarbia, acidosis and hypoxemia cause vasodilation which causes an increase in CBF, seizure activity and fever will increase the level of brain metabolism and CBF. Cerebral edema is the most common cause of non-traumatic brain injury such as central nervous system infections, metabolic and systemic encephalopathy. Vasogenic brain edema occurs due to injury to the blood-brain barrier and increased capillary permeability in the area around the injury, or to inflammation, especially in CNS infections. Medical management of elevated intracranial pressure includes sedation, cerebrospinal fluid drainage, and osmotherapy with either mannitol or hypertonic salts.

Accuracy of Cell-Free DNA (cfDNA) in Colorectal Cancer Diagnosis Anjab Akmal Sya’roni; Suyata; Imam Supriyanto; Vidi Orba Busro; Ayus Astoni; Mediarty Shahrir; Taufik Indrajaya; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.422

Background: Colorectal cancer is the third most common type of cancer following lung and breast cancer with the second most common cause of cancer-related death globally. Delayed diagnosis due to limited source and modality to perform early diagnosis lead to advanced-stage condition which contributes to higher morbidities and mortalities. Recent diagnosis of colorectal cancer depends on biopsy of suspected tissues, either obtained surgically or per colonoscopy. Colorectal cancer detection through cell-free DNA measurement allowing small-size cancer being detected even in early stage. cfDNA originated from derivates of increased and abnormality apoptosis-necrosis pathway from cancer lesion, therefore can be managed as specific tumor marker. Methods: Diagnostic test was performed at the Gastroentero Hepatology Outpatient Unit and Internal Medicine Inpatient Unit of Dr. Mohammad Hoesin General Hospital Palembang from March to June 2021. Data processing and analysis using SPSS version 26.0 for Windows. Results: Among 50 subjects included, 39 subjects (78%) are diagnosed with colorectal cancer, whereas 11 subjects (22%) as control. The median of cfDNA result is 59,71 ng/mL with 92,3% sensitivity, 90,9% specificity, 95,2% positive predictive value, 82,3% negative predictive value, and 92,4% accuracy rate. Combination the measurement of cfDNA, CEA, and CA19-9 appears to have better AUC instead of single measurement. Conclusion: The study reveals that cell-free DNA (cfDNA) demonstrated a very promising accuracy rate in diagnosing colorectal cancer.

The Role of Histone Deacetylase and Histone Deacetylase Inhibitors in Rheumatoid Arthritis Rina Kriswiastiny; Radiyati Umi Partan; Hermansyah; Surya Darma; Muhammad Reagan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.423

Rheumatoid Arthritis or RA disease is a chronic inflammatory and systemic disease associated with broad synovitis resulting in erosion of the articular cartilage and marginal bone causing joint damage. RA is an autoimmune disease with the discovery of an autoantibody, namely rheumatoid factor. The relevant antibody is anti-citrullinated protein (ACPA) antibody. Citullination on the introduction of several proteins such as fibrin, vimentin, fibronectin, collagen type II, which is expressed in the synovial membrane during inflammation by ACPA. In a recent study increased HDAC activity in the synovial tissue of RA patients has increased. Histone deacetylase or abbreviated as HDAC is an enzyme that is important in regulating gene transcription by altering the acetylation of histone proteins which results in an important regulation of repression in the implementation of inflammation. HDAC enzyme inhibitor (HDACi) is an HDAC enzyme inhibitor that can provide benefits for the treatment of various diseases including malignancy and inflammation. In inflammatory disease HDACi overcomes inflammatory cytokines such as TNF-α, IL-6 and IL-1β. One of the HDAC classes is HDAC1 which is highly expressed in the synovial fibroblasts of RA patients. HDACi can burden swollen joints, reduce mononuclear cell infiltration, request pannus orders, inhibit bone and cartilage damage.

Relationship between Preventive Behavioral Factors and Malaria Incidence in Endemic Areas of Lahat Regency in 2021 Debby Andhika Putri; Hamzah Hasyim; Hilda Zulkifli; Ahmad Ghiffari; Chairil Anwar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.424

Background: Malaria is still one of the main infectious diseases of concern in the world. Lahat Regency is a moderate malaria-endemic area in South Sumatra, where there are still several villages with an API value above 1 and indigenous cases, although the average API value in all health facilities is below 1. Methods: Quantitative research with a case-control design was employed. The sampling technique used stratified random sampling with year strata, namely 2018, 2019 and 2020 with 50 case respondents and 100 control respondents. The total number of samples collected was 150. Case respondents were people who suffered from malaria and are recorded in the Malaria Surveillance Information System in the working area of the community health center, which has a village with an API value of 1 and the presence of indigenous cases. Control respondents were the closest neighbours of cases with the same age characteristics as the case. This study aimed to identify and analyse risk factors for preventive behaviour related to malaria incidence in the endemic area of the Lahat Regency. Results: : Bivariate analysis revealed that the habit of using insect repellent was connected with the incidence of malaria in the endemic region of Lahat Regency, with a p-value of 0.042 and an odds ratio of 2.160 in the endemic area. The results of multivariate analysis showed that the most dominant risk factor was the habit of using mosquito repellent. Conclusions: The habit of using mosquito repellent is a risk factor for malaria incidence in endemic areas of the Lahat Regency. It is necessary to increase individual self-prevention behaviour and counselling activities regarding preventive behaviour by local health service facilities.

Effectivity of Large Intestine 4 Point Accupressure on Labour Pain Stage-I Active Phase Noviyanti; Ratna Dewi; Adri Idiana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.425

Background: Law of the Republic of Indonesia No. 36 of 2009 concerning traditional health services (Yankestrad), namely articles 1, 48, 59, 60 and 61. Acupressure is included in Yankestrad skills that are easy, cheap, simple, effective, and without any side effects. harmful. Acupressure at the Large Intestine 4 Point (LI4) based on the literature is able to reduce labor pain in the first stage of the active phase. Methods: This type of research is quasi-experimental with a pre-test and post-test research design. The samples were divided into two groups, the treatment group and the control group. Results: Based on the results of the research that has been carried out, it can be concluded as follows: Active phase I labour pain before being given Acupressure Therapy for primigravida mothers in PMB Aceh Besar District averaged 7.35. Active phase I labour pain after being given Acupressure Therapy to primigravida mothers in PMB Aceh Besar District decreased by an average of 5.47. Conclusions: There are differences in labour pain in the stage-I of active phase in the Acupressure therapy group with the Routine care group for the stage-I of labour for primigravida mothers in PMB Aceh Besar District.

Relation of Normal Childbirth Care Training to Midwives Knowledge and Attitudes at Bebesen Health Center Bebesen District of Central Aceh Regency in 2021 Hasritawati; Barirah Madeni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.426

Background. Mortality and morbidity in pregnant and maternity women is a big problem in developing countries. In poor countries, about 25-50% of deaths of women of childbearing age are caused by pregnancy-related causes. It is estimated that every year 585,000 women die from pregnancy and childbirth. 99% of these deaths occur in developing countries. According to WHO, 60-80% of maternal deaths are caused by bleeding during childbirth, obstructed labor, sepsis, high blood pressure during pregnancy, and complications from unsafe abortion. The purpose of this study was to determine the relationship between normal delivery care (APN) training on the knowledge and attitudes of midwives at the Bebesen Health Center, Bebesen District, Central Aceh Regency in 2020. Methods. The research method uses an analytical survey method with a cross sectional approach, which is a study to study the dynamics of the correlation between risk factors and effects, by approaching, observing or collecting data at once. The population in this study was all 63 midwives. The sampling method uses a total sampling technique that uses all members of the population as a sample. Data collection was carried out from November 14-16, 2020. Results. The results showed that from the analysis obtained a value for the p-value of good knowledge as many as 20 respondents (31.7%) and a positive attitude that is as many as 32 respondents (50.8%). Conclusion. There is a relationship between normal delivery care training (APN) with knowledge with a p value of 0.014 (p < 0.05) and normal delivery care (APN) with changes in the attitude of midwives with a p value of 0.00 (p < 0.05) in Bebesen Public Health Center, Bebesen District, Central Aceh Regency.

Factors Affecting Midwives Knowledge About Early Initiation of Breastfeeding at Lut Tawar District Health Center of Central Aceh Regency in 2020 Barirah Madeni; Hasritawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.427

Background: Data from the World Health Organization (WHO) shows that there are 170 million children worldwide experiencing malnutrition, 3 million of whom leave each year due to malnutrition. Therefore, WHO recommends, all infants need to receive colostrum (first and second day milk) to fight infection and exclusively breastfed for 6 months to ensure adequate nutrition for infants. This study aims to determine the factors that influence the knowledge of midwives about early initiation of breastfeeding in the working area of the Lut Tawar City Health Center, Central Aceh Regency in 2020. Methods: The research method used is an analytical survey method with a cross sectional approach. The population in this study were all midwives in the area. The city health center serves as many as 59 people. The sampling method uses a total sampling technique that uses all members of the population as a sample. Data collection was carried out on November 15-19, 2020. Results: The results showed that respondents aged > 40 years had good knowledge, namely 64.3%, respondents with DIII education had less knowledge, namely 56.8%, respondents who had never attended breastfeeding initiation training 69.6% respondents who did not often do early initiation of breastfeeding have good knowledge that is 63.9%, respondents who do not get information about early initiation of breastfeeding mostly lack of knowledge that is 58.1%. Conclusion: Factors that influence the knowledge of midwives on early initiation of breastfeeding are education and experience participating in training related to early initiation of breastfeeding.

Page 22 of 121 | Total Record : 1209

20 21 22 23 24

Filter by Year

2017 2025

Filter By Issues

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
-

Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
-

Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Rachmat Hidayat

Contact Email dr.rachmat.hidayat@gmail.com

Phone -

Journal Mail Official dr.rachmat.hidayat@gmail.com

Editorial Address -

Location Kab. ogan ilir, Sumatera selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
-

Journal Mail Official
dr.rachmat.hidayat@gmail.com

Editorial Address
-

Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA