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Rachmat Hidayat
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dr.rachmat.hidayat@gmail.com
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INDONESIA
Bioscientia Medicina : Journal of Biomedicine and Translational Research
Published by Universitas Sriwijaya
ISSN : -     EISSN : 25980580     DOI : -
Core Subject : Health, Science,
BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.
Arjuna Subject : Kedokteran - Anatomi
Articles 1,209 Documents
Improving the Quality of Life for the Elderly with Degenerative Diseases through to the Charitas Group Virtual Health Education Program during the Pandemic of the COVID-19 Wilma Hannie Daniel; Chairil Anwar; Nur Alam Fajar; Rico Januar Sitorus; Ahmad Ghiffari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.389

Abstract

Background: In the era of the COVID-19 pandemic, various problems were experienced by the elderly, especially those with degenerative diseases, as the population most at risk of being exposed to COVID-19. The elderly are vulnerable to decreased physical, mental and social health; therefore, a new and effective strategy is needed to improve healthy living behavior in this population. This study aimed to analyze the effect of the Charitas Group virtual health education program on improving the quality of life of the elderly with degenerative diseases in the era of the COVID-19 pandemic. Methods: The One Group Pretest-Posttest Pre-Experimental study was with a sample of 33 patients selected by purposive sampling in May - July 2021. The data collection was taken using the World Health Organization Quality of Life – Bref (WHOQOL-Bref) form, translated and validated into Bahasa Indonesia. The data was then compared before and after the intervention and analyzed using the Paired Samples T-Test. Results: The T-Test showed a significant difference between the pre-test and post-test results (p-value 0.041 < 0.05). At the same time, the other T-Test results showed a significant influence on the quality of life of the elderly in the specific domains, namely: Psychological (p-value 0.025), Social Relationship (p-value 0.033) and Environmental (p-value 0.034). Conclusions: The Charitas Group virtual health education program significantly influences the quality of life of elderly people with degenerative diseases in the COVID-19 pandemic era.
Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia Abarham Martadiansyah; Peby Maulina; Putri Mirani; Tia Kaprianti; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.390

Abstract

Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.
COVID-19 Health Protocol and Religious Activities: Knowledge, Attitude, and Compliance among Generation Z Indri Ramayanti; Wieke Anggraini; Fatinah Fairuz Qonitah; Ahmad Ghiffari; Thia Prameswarie
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.391

Abstract

Background: COVID-19 (coronavirus disease 2019) is a contagious infection currently affecting people worldwide, including in Indonesia. The spread of this virus is extremely rapid, and the number of deaths continues to rise. Compliance with the health protocol is one method of preventing the spread of COVID-19. The purpose of this study is to determine the relationship between generation-Z (gen-Z) knowledge and attitudes toward the use of masks, keeping distance, and washing hands as a means of preventing COVID-19 in religious activities at houses of worship in Palembang. Method: The observational analytic cross-sectional research design with the study's population consists of generation Z members who participate in religious activities in places of worship. The cluster random sampling method yielded 147 respondents. The data collected are primary data obtained directly from the research subjects via a questionnaire and secondary data obtained from the Palembang City Ministry of Religion. They were using the Pearson chi-square test to analyze descriptive data. Results: According to the findings, 79 people (53.7%) out of 147 respondents have good knowledge, while 75 people have a good attitude (51% ). The results obtained a statistically significant p-value of 0.05, indicating a relationship between gene Z knowledge and attitude and adherence to the use of masks, keeping distance, and washing hands. Conclusion: There is a significant relationship between knowledge and attitudes toward COVID-19 infection prevention in Generation Z who participate in religious activities in Palembang City.
Cardiac Septal Defects in Children: Hemodynamics, Clinical Manifestations and Detection Ria Nova; Sukman Tulus Putra; Siti Nurmaini; Radiyati Umi Partan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.393

Abstract

Cardiac septal defect in children is one of the congenital heart defects characterized by atrial septal defects (ASD), ventricular septal defects (VSD) and defects in both atrial and ventricular septum (AVSD). The hemodynamic changes that occur are caused by a left to the right shunt. Differences in location, size of the defect and pulmonary vascular resistance make hemodynamic differences and clinical manifestations between the three types of cardiac septal defects. Detection of cardiac septal defects can be done by clinical examination by listening to the characteristic heart sounds and murmurs for each defect. However, clinical examination alone is often still difficult to determine the type of cardiac septal defect so that several supporting examinations such as photothorax, ECG, echocardiogram and cardiac catheterization need to be done to help establish the diagnosis.
Contamination of Soil Transmitted Helminths (STH) Eggs in Raw Vegetables at Street Food Stalls and Restaurant in Lorok Pakjo Village, Palembang Leo Medianto Faziqin; Dalilah; Dwi Handayani; Chairil Anwar; Susilawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 6 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i6.397

Abstract

Background: Infection Soil Transmitted Helminths (STH) is a disease that is a problem in the world, especially in areas with a tropical climate like Indonesia. This infection can be transmitted through consumption of raw vegetables contaminated with STH. This study aims to determine whether there is contamination of STH eggs in raw vegetables at street food stalls and restaurants in Lorok Pakjo Village, Palembang. Methods: This research is a descriptive observational study. Samples in the form of fresh vegetables were collected from 18 street stalls and 14 restaurants in Lorok Pakjo Village, Palembang. Samples were examined using the sedimentation method and observed using a microscope. Results: The results obtained 80 samples consisting of 30 cabbage, 18 basil, 30 cucumber, 1 lettuce, and 1 eggplant. Of the 80 samples, there were 20 (25%) positive samples contaminated with STH eggs consisting of 8 (10%) cabbage samples, 8 (10%) basil samples, 4 (5%) cucumber samples, and no STH contamination was found in lettuce. and eggplant. Of the 20 positive samples of STH contamination, 12 samples came from street vendors consisting of 5 (10.6%) cabbage samples, 6 (12.8%) basil samples, and 1 (2.1%) cucumber samples. While the other 8 samples came from restaurants consisting of 3 (9.1%) cabbage samples, 2 (6%) basil samples, and 3 (9.1%) cucumber samples. Found only eggs of Ascaris lumbricoides infertile decorticate in all samples consisting of 9 eggs on cabbage, 16 eggs on basil, and five eggs on cucumber. Conclusion: There is contamination of eggs Soil Transmitted Helminths in raw vegetables in street food stalls and restaurants in Lorok Pakjo Village, Palembang.
Staphylococcal Scalded Skin Syndrome in Healthy Infant Anggia Perdana Harmen; Eny Yantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.398

Abstract

Staphylococcal scalded skin syndrome (SSSS) describes a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus that originates from a focus of infection that may be a purulent conjunctivitis, otitis media, or occult nasopharyngeal infection. It usually begins with fever, irritability, and a generalized, paint, orange-red, macular erythema with cutaneous tenderness, and the rash progress from scarlatiniform to a blistering eruption in 24 to 48 hours. A diagnosis must distinguish SSSS from other skin diseases, such as toxic epidermal necrolysis, epidermolysis bullosa, bullous erythema multiforme, Streptococcal impetigo or listeriosis and thermal or chemical burns, all of which can manifest with similar symptoms. The prognosis of SSSS in children who are appropriately treated is good, with a mortality of less than 5%. A case was a three moths old boy hospitalized in Pediatric ward M. Djamil hospital with chief complain redness and peeling of the skin since 2 days before hospitalized. Culture of the skin, eyes and nose was Staphylococcus aureus, and patients was given ampicillin and gentamycin for seven days.
Jugular Vein Aneurysm, When We Have to Do Surgery? Rizki Amalia; Johanes Nugroho; Ivana Purnama Dewi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 8 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i8.401

Abstract

Introduction: The most common lesions of jugular vein dilatation are aneurysms and ectasia. A jugular vein aneurysm is less common compare to an arterial aneurysm in adults. Because of the rare incidence, treatment guidelines primarily associated with the timing of surgery are not clearly established. Proper treatment can reduce patient complaints without excessive intervention. Case report: A 54 years old woman complained of swelling in the right neck that started three years ago and cephalgia for two years. From CT angiography, we obtained a jugular vein dilatation of 2.3 cm. During periodic evaluation from ultrasonography doppler, there is no increase in the size of the jugular vein. Conclusion: Jugular vein aneurysm presenting in adults is an infrequent phenomenon. It is a benign condition, and conservative observation is advised. It should be operated only if symptomatic or progressive enlarging. A periodic examination must be done to evaluate the size of the jugular vein before a surgical decision
Surgical Site Infection Post Caesarean Section: A Case Report Hartati; Febi Stevi Aryani; M Satria Erlangga Sinum; Emasrissa Murwani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.404

Abstract

Background. Surgical site infection (SSI) is a major complication of surgery which can increase morbidity, mortality and cost of hospitality. Incidence of SSI at a healthcare provider/facility reflected a service quality of that institution. Case presentation. A 28-years-old woman, a housewife, P2A1, post-caesarean section 12 days ago. Pasien datang dengan keluhan utama badan lemas dan terdapat nanah pada luka bekas operasi. Ia mengeluh perutnya terasa semakin panas, dan keluar cairan bening sebelum muncul nanah pada luka operasi. Pasien juga mengeluh demam, mual dan lemas akhir-akhir ini Laboratory investigations showed Hb 11,9 g/dL, Leukosit 11.100 m/L, trombosit 601.000. MCV 70,7 fL MCH 24 pg MCHC 32 g/dL TIBC 392 mg/dL serum Iron 54 mg/dL Ferritin 19,8 ng/mL, CRP reactive. Patient was wound dressing and given levofloxacin 500mg three times a day intravascular for three days and continue with ciprofloxacin three time a day oral. Patient was suggest to repeat laboratory test after therapy to evaluate therapy response. Conclusion: The result showed that time of prophylactic antibiotics can used to minimize the occurrence of SSI in post-caesarean section patients.
Primary Squamous Cell Carcinoma Thyroid with Regional Recurrence Nugroho Akhbar; Benny Issakh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.405

Abstract

Background. Primary squamous cell carcinoma (PSCC) of the thyroid is a very aggressive malignancy with a poor prognosis. There is no consensus for the management of primary squamous cell carcinoma (PSCC) of the thyroid, and this is based on rare cases in which the frequency of occurrence is less than 1% of thyroid malignancies. How squamous cell carcinoma originates in the thyroid gland is an interesting topic to discuss, because the thyroid gland does not have a squamous cell epithelium. Case Presentation. A 43-year-old man was admitted to the DR Kariadi Hospital with complaints of a lump on the right neck. In June 2020, the patient complained of a lump in the right neck area with a diameter of about 1x1x1 cm, no pain. Ultrasound of the colli at the regional hospital showed the impression of multiple lymphadenopathy of the right colli level 2-5, and there were cystic nodules with solid parts in the right and left lobes of the thyroid suspected of being benign. An adenectomy operation was performed at a regional hospital and the impression of metastatic squamous undifferentiated carcinoma was obtained. Conclusion. The management of thyroid PSCC is a multimodality therapy, namely surgery, chemotherapy and radiation.
Recurrence Prediction Score of the Localy Advance Breast Cancer in West Sumatera Province, Indonesia Shinta Qorina; Wirsma Arif Harahap; Ricvan Dana Nindrea
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.406

Abstract

Introduction: Breast cancer is the most common malignancy that occurs in women in the world, which is about 18% of cancer cases that occur in women. Every year there are 1 million new cases of breast cancer worldwide and nearly 60,000 patients die from this disease. Therefore, the authors want to find out more about the prognosis factors that play a role in influencing the survival of patients with locally advanced breast cancer in Padang city, West Sumatera Province Indonesia. Methods: This study is a retrospective case-control study of locally advanced breast cancer for patients in Padang city. The study was conducted at the Surgical Oncology Division of Dr. M Djamil Padang Hospital, Ropana Suri Hospital, Ibnu Sina Hospital and Siti Rahmah Padang Hospital from September 2018 to December 2018. The total number of samples for the two groups was 242 people. The sampling technique used was convenience sampling. Results: In this study 4 prognostic factors were found that had a significant effect on predicting breast cancer recurrence, namely histopathological type, stage, regional lymph and lymphovascular invasion with p <0.05. Conclusion: Prognosis factors that influence breast cancer recurrence are histopathological type, stage, regional lymph node status and lymphovascular invasion. A scoring system is obtained that is good enough to predict the possibility of breast cancer recurrence.

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