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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by Universitas Sriwijaya

ISSN : - EISSN : 25980580 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

BioScientia Medicina is an open access international scholarly journal in the field of biomedicine and translational research aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to medical sciences, Traditional Herb, genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Anatomi

Articles 1,209 Documents

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The Role of High Sensitivity C-Reactive Protein as an Inflammation Predictor in Cardiovascular Diseases Cici Nuriah; Iswanti, Febriana Catur; Ariel Pradipta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1075

Inflammation can be measured by analyzing the levels of inflammatory markers, such as High Sensitivity C-reactive Protein (hs-CRP). This protein plays a crucial role as a strong independent predictor indicating the risk of cardiovascular. The hs-CRP can measure the levels of C-reactive protein with high sensitivity, making it a highly responsive marker to acute-phase inflammation. The presence of hs-CRP serves as an inflammation indicator that can predict the potential occurrence of heart attacks, strokes, peripheral artery diseases, and sudden death due to Acute Coronary Syndrome (ACS). Produced by the liver in response to inflammation, hs-CRP is nonspecific and can elevate various types of inflammation, including infections and chronic inflammatory conditions in cardiovascular. This study is a literature review using secondary data from related research. The hs-CRP has a very high sensitivity and specificity level compared to CRP as an inflammation marker. Therefore, hs-CRP serves not only as a diagnostic tool but also as a strong predictor of inflammation, capable of predicting cardiovascular risk.

Overview of Bacterial Patterns and Antibiotic Sensitivity in Diabetic Foot Ulcers: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Huda, Sri Nurul; Rismawati Yaswir; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1076

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus with a high risk of infection. Patterns of causative bacteria and antibiotic sensitivity can vary between hospitals and time periods. Methods: This descriptive research involved all swabs and pus samples from DFU patients at Dr. M. Djamil General Hospital Padang between January and June 2023. Samples were processed through culture, Gram staining, and identification using VITEK 2. Patient medical record data was analyzed for demographic characteristics. Results: Of the 23 samples, 65% were gram-negative bacteria, dominated by Escherichia coli (30%). Gram-positive bacteria were found in 35%, with Staphylococcus aureus (18%) as the most. E. coli showed resistance to ampicillin and ceftriaxone but was sensitive to meropenem and amikacin. S. aureus is resistant to vancomycin but sensitive to benzylpenicillin. Conclusion: Gram-negative bacteria, especially E. coli, were more dominant in DFU at Dr. M. Djamil General Hospital Padang during the research period. The pattern of antibiotic resistance found emphasizes the importance of selecting appropriate antibiotic therapy based on sensitivity test results.

Long-Term Effects of Tea Consumption Habits on Cardiovascular Performance of Adolescent Population: An Observational Study of Adolescent Community in Jakarta, Indonesia Laura Evangelia; Lontoh, Susy Olivia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1077

Background: Tea is a popular drink that is widely consumed in Indonesia. Some studies show the potential benefits of tea on cardiovascular health, but evidence regarding long-term effects in adolescents is limited. This study aims to evaluate the relationship between tea consumption habits and cardiovascular performance in the adolescent population in Jakarta. Methods: This prospective observational cohort study involved 1,500 adolescents aged 15-18 years in Jakarta. Data on tea consumption habits was collected through a structured questionnaire, while cardiovascular performance was measured through blood pressure tests, body mass index (BMI), and treadmill tests. Logistic regression and Cox proportional hazards analyzes were used to identify the association between habitual tea consumption and cardiovascular events over a 5-year period. Results: The results showed that regular tea consumption (≥3 cups/week) was associated with a reduced risk of hypertension (OR 0.65; 95% CI 0.48-0.88) and an increase in cardiovascular functional capacity as measured by treadmill testing (HR 0 .72; 95% CI 0.55-0.94). Conclusion: The habit of regular tea consumption among adolescents in Jakarta is associated with a reduced risk of hypertension and improved cardiovascular performance. Further research is needed to confirm these findings and explore the mechanisms underlying tea's protective effects.

Efficacy of Topical Niacinamide on Skin Hydration of Adolescents with Acne Vulgaris: An Experimental Study on the Adolescent Community in Jakarta, Indonesia Nabila Jingga Permatasari; Tan, Sukmawati Tansil
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1078

Background: Acne vulgaris (AV) is a chronic inflammatory skin disorder common in adolescents, often accompanied by dry, irritated skin. Topical niacinamide (vitamin B3) has shown potential in increasing skin hydration and reducing AV symptoms. This study aims to evaluate the efficacy of topical niacinamide on skin hydration in adolescents with AV in Jakarta, Indonesia. Methods: This research is a randomized controlled experimental study involving 100 adolescents (14-19 years) with mild to moderate AV in Jakarta. Participants were randomly divided into two groups: the intervention group (receiving topical 4% niacinamide cream) and the control group (receiving placebo cream). The intervention was carried out for 8 weeks, and skin hydration was measured using a corneometer at baseline, week 4, and week 8. Data analysis was carried out using paired t-tests and independent t-tests. Results: There was a significant increase in skin hydration in the intervention group compared to the control group at week 4 (p < 0.001) and week 8 (p < 0.001). No significant side effects were reported. Conclusion: Topical niacinamide was effective in increasing skin hydration in adolescents with AV in Jakarta, Indonesia. This study supports the use of topical niacinamide as an adjunct therapy in the management of AV, especially in adolescents with dry, irritated skin.

Efficacy of Garlic Extract (Allium sativum L.) as a Therapeutic Modality of Condyloma Acuminata: A Meta-Analysis Lestari, Andriani Fuji; Satya Wydya Yenny
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1079

Background: Condyloma acuminata (CA) is a sexually transmitted infection caused by human papillomavirus (HPV). Current standard treatment has limitations, so effective and safe alternative therapies are needed. Garlic (Allium sativum L.) has long been used in traditional medicine and has potential as an antiviral and antitumor agent. This study aims to evaluate the efficacy of garlic extract as a CA therapy modality through meta-analysis. Methods: A literature search was conducted on PubMed, Scopus, and Web of Science databases to identify randomized controlled clinical studies (RCTs) evaluating the efficacy of garlic extract in CA patients. Extracted data included study characteristics, interventions, sample size, clinical outcomes, and side effects. Statistical analysis was performed using Review Manager 5.4 software. Results: A total of 8 RCTs involving 542 CA patients met the inclusion criteria. Meta-analysis showed that garlic extract was significantly more effective in clearing CA lesions compared with placebo (OR 2.87; 95% CI 1.95-4.23; p < 0.00001). Garlic extract also demonstrated comparable effectiveness to standard therapies such as podophyllin and imiquimod. There was no significant difference in the incidence of side effects between the garlic extract group and the control group. Conclusion: Garlic extract is an effective and safe therapeutic modality for CA. Further studies with more robust designs are needed to confirm these findings and explore the mechanism of action of garlic extract on CA.

Analysis of the Role of SARS-CoV-2 Infection on Clinical Superficial Mycosis: An Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Ariani, Tutty; Andriani Fuji Lestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1080

Background: The COVID-19 pandemic, caused by SARS-CoV-2 infection, has had multiple impacts on human health, including its potential influence on the manifestation and severity of skin diseases such as superficial mycoses. This study aims to analyze the relationship between SARS-CoV-2 infection and the clinical characteristics of superficial mycosis in patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This analytical observational study included 150 patients with laboratory-confirmed superficial mycoses. Demographic data, medical history, SARS-CoV-2 infection status (based on RT-PCR results), and clinical characteristics of superficial mycoses were collected and analyzed using SPSS software. Results: Of the 150 patients studied, 75 patients had a history of SARS-CoV-2 infection. No significant differences were found in the distribution of gender, age, and location of superficial mycosis infections between the groups of patients with and without SARS-CoV-2 infection. However, patients with a history of SARS-CoV-2 infection tended to have a higher severity of superficial mycosis (p < 0.05). In addition, there was a significant difference in the type of agent causing superficial mycosis between the two groups (p < 0.01). Conclusion: SARS-CoV-2 infection may influence the clinical manifestations of superficial mycoses, especially in terms of disease severity. These findings support the importance of monitoring and management of superficial mycoses in patients with a history of SARS-CoV-2 infection.

Analysis of Bioterrorism Studies on Lung Health: A Meta-Analysis Nutari, Hasbi; Yessy Susanty Sabri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1083

Background: Bioterrorism, the use of biological agents to cause mass harm, poses a significant threat to lung health. This meta-analysis aims to evaluate the impact of bioterrorism on lung health, identifying the most frequently used agents, clinical manifestations, and policy implications. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases from 2018 to 2024. Studies reporting the impact of bioterrorist attacks on lung health were included. Epidemiological, clinical, and interventional data were extracted and analyzed using random effects models. Results: Twenty studies met the inclusion criteria, covering a total of 15,482 participants. The most common bioterrorism agent was Bacillus anthracis (43.5%), followed by Yersinia pestis (21.7%) and Francisella tularensis (17.4%). The most frequently reported clinical manifestations were pneumonia (78.3%), acute respiratory failure (39.1%), and sepsis (26.1%). Mortality rates vary from 5% to 35%, depending on the agent and intervention administered. Conclusion: Bioterrorism poses a serious threat to lung health, causing significant morbidity and mortality. Pneumonia, acute respiratory failure, and sepsis are the most common clinical manifestations. It is important to improve preparedness, early detection, and clinical management to reduce the impact of bioterrorist attacks.

Analysis of Risk Factors and Predictors of Endoscopic Findings in Patients with Gastrointestinal Disorders: A Single Center Observational Study at Sanjiwani General Hospital, Gianyar, Bali, Indonesia Dwi Putri Anjani, I Gusti Agung; I Wayan Eka Saputra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1084

Background: Gastrointestinal disorders are a common health problem in Indonesia. Endoscopy is an important procedure in diagnosing and managing this disorder. This study aims to analyze risk factors and predictors of endoscopic findings in patients with gastrointestinal disorders at regional hospitals in Bali. Methods: This research is an analytical observational study with a cross-sectional design. The research subjects were patients with gastrointestinal disorders who underwent endoscopy at regional hospitals in Bali during the period January 2022 to December 2023. Data was collected through medical records and interviews. Data analysis was carried out using the Chi-square test and logistic regression. Results: A total of 1074 patients were included in this study. The mean age of patients was 45.3 years (SD 15.2). The most common endoscopic finding was gastritis (35.2%), followed by gastric ulcer (15.8%) and esophagitis (12.4%). Risk factors that were significantly associated with endoscopic findings were age > 45 years (OR 1.78; 95% CI 1.23-2.57), male gender (OR 1.54; 95% CI 1.11- 2.14), history of smoking (OR 2.31; 95% CI 1.65-3.24), and history of use of non-steroidal anti-inflammatory drugs (NSAIDs) (OR 1.98; 95% CI 1.39-2.82). Conclusion: Age > 45 years, male gender, smoking history, and history of NSAID use are risk factors that are significantly associated with endoscopic findings in patients with gastrointestinal disorders at regional hospitals in Bali.

Systemic Metastase in Late Management of Group D Retinoblastoma: A Case Report Suryawijaya, Ernes Erlyana; I Wayan Eka Sutyawan; Ni Made Ayu Surasmiati; I Made Agus Kusumadjaja
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1085

Background: Retinoblastoma (RB) is a common malignancy that affects children and is fatal if left untreated. This case report aims to raise awareness the importance of starting therapy immediately in RB patients. Case presentation: A girl aged 1 year 9 months, came with complaints that her left eye (LE) appeared white for 2 weeks. Anterior segment examination was normal. On funduscopic examination, optic nerve was difficult to evaluate, covered by a mass, multiple mass scars on the retina, a size of > 6 mm at the posterior pole, and vitreous seeding. Ultrasound examination and CT scan showed an intraocular mass with calcification. The patient was diagnosed with group D intraocular LE RB and was planned for enucleation but was postponed due to cost constraints. The patient came back after 1 year and was diagnosed with extraocular LE RB stage IVB. Conclusion: Early diagnosis without adequate therapy leads to tumor spread and reduces patient survival.

Analysis of Risk Factors for Cognitive Frailty: A Meta-Analysis Hendriani, Nani; Roza Mulyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1086

Background: Cognitive frailty (CF) is a syndrome characterized by cognitive and physical decline in older adults, which increases the risk of disability, dependency, and mortality. This study aims to identify and analyze risk factors for CF incidence through a systematic review and meta-analysis. Methods: A literature search was conducted on PubMed, Scopus, and Web of Science databases until June 2024. Observational studies reporting associations between potential risk factors and CF incidence in the elderly population were included. Two independent researchers performed study selection, data extraction, and risk of bias assessment. Meta-analysis was performed using a random effects model, and heterogeneity between studies was evaluated. Results: A total of 25 studies (n=45,678 participants) met inclusion criteria. Meta-analysis showed that advanced age (OR=1.89; 95% CI 1.65-2.16), female gender (OR=1.38; 95% CI 1.19-1.60), history of cardiovascular disease (OR=1.52; 95% CI 1.23-1.87), diabetes mellitus (OR=1.45; 95% CI 1.18-1.78), depression (OR=2.08; 95% CI 1.72-2.51), and low physical activity (OR=1.63; 95% CI 1.35-1.97) are risk factors significant for the incidence of CF. Low educational level (OR=1.71; 95% CI 1.43-2.04), low socioeconomic status (OR=1.58; 95% CI 1.29-1.93), and smoking history (OR=1.31; 95% CI 1.05-1.64) were also associated. with an increased risk of CF. Conclusion: This study identified several modifiable and nonmodifiable risk factors for CF occurrence. Interventions targeting these risk factors may help prevent or delay the development of CF in older adults.

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Rachmat Hidayat

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Location
Kab. ogan ilir,

Sumatera selatan

INDONESIA