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Dina Keumala Sari
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Jl. Dr. T. Mansur No. 9 Padang Bulan, Kecamatan Medan Baru, Kota medan, Sumatera Utara, Indonesia
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Sumatera Medical Journal
Published by Universitas Sumatera Utara
ISSN : 26229234     EISSN : 26221357     DOI : 10.32734
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology
Sumatera Medical Journal (SUMEJ) provides a forum for publishing the full research articles in the area of Medical Science related to topics from the following subject areas: -Cancer and Related Aspects -Biomoleculer in Basic Sciences -Biomoleculer in Clinical Sciences -Tissue Engineering including Stem Cell -Medical and Health Sciences
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 182 Documents
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Changes in Knowledge About Mothers Stunting Before and After Watching the Video on Mothers of Stunting Toddlers in Puskesmas Anak Air Kota Padang Yaumil Fauziah Milfa; Fitri Khairani; Annisa Namirah Nasution
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.16791

Abstract

Background: Stunting is a developmental disorder in children caused by chronic malnutrition and recurrent infections. One effective way to convey information about nutrition to mothers of stunted toddlers is by watching videos. Objective: This study aimed to determine the changes in knowledge of mothers of stunted toddlers before and after watching intervention videos. Methods: A "One-group pretest and posttest" design was used in this study, conducted at the Anak Air Health Center in Padang City, from October 25, 2023, to January 15, 2024. A sample of 27 participants was selected using the Simple Random Sampling technique through the Random Number Application. Normality tests and bivariate analysis were performed using the Kolmogorov-Smirnov and Paired t-test (p < 0.05). Results: Statistical analysis using the paired t-test showed a significant change in knowledge scores before and after the video intervention, with a p-value of 0.001 (p < 0.05). This indicates that video media has a significant effect on the knowledge of mothers of stunted toddlers. Conclusion: The study concluded that there was an increase in knowledge among mothers of stunted toddlers before and after being exposed to video media intervention.
Anti-Inflammatory Activity Test of Ethanolic Extract of Transdermal Patch Crinum asiaticum L Against Male Wistar Rats Induced by Carrageenan Robiatun Rambe; Armansyah Maulana Harahap; Yurike Elanda; Ali Affan Silalahi; Yetty Machrina
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.17888

Abstract

Background:Crinum asiaticum leaves are recognized for their wound healing properties, particularly in treating abrasive or inflamed wounds. Objective: This study aims to evaluate the efficacy of a transdermal patch prepared from Crinum asiaticum leaf extracts in reducing inflammation. Methods: The preparation involved applying coconut oil to the fruit, roasting it, and then using it on the affected area. Leaf samples and extracts were utilized to formulate transdermal patches at three different concentrations (1%, 3%, and 5%). The patches were assessed organoleptically for thickness, weight uniformity, folding resistance, and pH. Results: The findings demonstrated that the 5% concentration transdermal patches exhibited superior anti-inflammatory effects compared to the 1% and 3% concentrations. This suggests that higher concentrations of Crinum asiaticum extracts enhance the therapeutic potential of transdermal applications. Conclusion: The study concludes that transdermal patches formulated with Crinum asiaticum leaves are effective in reducing inflammation, with 5% concentration offering the highest efficacy. Further research is recommended to explore the clinical applications of these patches in wound management.
Effectivity and Safety Profile of Metformin as an Adjuvant Immunomodulator in Psoriasis: A Literature Review Jessica Tjia; Eugenia Agnes Rombelayuk; Muh. Iqra Romadhan
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.18218

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder associated with an increased risk of comorbidities and reduced quality of life. Metformin, a first-line therapy for type 2 diabetes mellitus (T2DM), has been investigated for its potential as an adjuvant therapy for psoriasis. Objective: This literature review aims to explore the molecular mechanisms by which metformin exerts immunomodulatory effects and assess clinical studies that evaluate its efficacy and safety profile. Methods: A literature search was conducted in PubMed, MDPI, Epistemonikos, ScienceDirect, and Wiley Online Library, with the keywords: metformin AND psoriasis AND immunomodulator AND safety. Results: Qualitative synthesis revealed that metformin exhibits anti-inflammatory, anti-proliferative, and pro-apoptotic effects through induction of G0/G1 cycle arrest and  inhibition of mechanistic target of rapamycin (mTOR), nuclear factor-kappa B (NF-κB), and Raf/MEK/extracellular signal-regulated kinase (Raf/MEK/ERK) pathways. These mechanisms correlate with improvements in psoriasis severity indices, including Psoriasis Area Severity Index (PASI), Erythema, Scaling, and Induration (ESI), and Physician Global Assessment (PGA) scores (p < 0.05. A rare case of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome has been reported. Conclusion: Metformin demonstrates potential as an adjuvant immunomodulatory treatment for psoriasis. However, a rare adverse effect highlights the need for careful patient selection and evaluation.
Borassus flabellifer Effectively Reduces MDA Levels in High Oxidative Stress Population in Jakarta, Indonesia Reza Aditya Digambiro; Himmi Marsiati; Restu Syamsul Hadi; Edy Parwanto
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.18966

Abstract

Background: Malondialdehyde (MDA) is commonly used to assess oxidative stress levels. Objective: This study aimed to investigate the effect of Borassus flabellifer  fruit consumption on MDA levels in individuals with high oxidative stress, providing insights into the fruit’s potential as a natural antioxidant therapy. Methods: A prospective interventional study was conducted in Jakarta, recruiting fifty participants aged 30–60 years with baseline MDA levels >10 nmol/L. Participants consumed 150 grams of Borassus flabellifer fruit daily for 30 days. Blood samples were collected at baseline and post-intervention to assess MDA levels. Results: The average MDA level decreased significantly from 14.35 ± 2.43 nmol/L to 12.00 ± 1.74 nmol/L after 30 days of fruit consumption (p < 0.0001). The Cohen’s d value of 2.92 indicated a large effect size, demonstrating the intervention’s substantial impact. A strong positive correlation (r = 0.91, p < 0.0001) between baseline MDA levels and reduction was observed, suggesting that participants with higher baseline oxidative stress benefited more from the intervention. Conclusion: Borassus flabellifer fruit consumption effectively reduces MDA levels in individuals with high oxidative stress. The results support the inclusion of this fruit in recommendations for managing oxidative stress-related conditions.
A First Branchial Cleft Cyst Masquerading as a Chronic Non-Healing Wound Ng Syiao Wei; Aaron Wong Chun Chian; Aziah Ab Rani; Yoke Chin Mun; Jothi Shanmuganathan
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.19026

Abstract

Background: First branchial cleft anomaly exhibits variable clinical features, ranging from a painless swelling, discharging sinus or pit, to recurrent infection. It could be easily misdiagnosed and mismanaged, resulting in recurrence.  Hence, any swellings or pits in Poncet’s triangle with a history of recurrent infection should raise the suspicion of a first branchial cleft anomaly. Objective: To present a case of chronic non-healing wound caused by an incompletely excised first branchial cleft anomaly. Methods: Case observation of a patient with a history of incomplete excision of a first branchial cyst. Results: Our patient was a case of incompletely excised first branchial cyst which subsequently presented as a chronic non- healing wound. She had undergone several workup for non-healing wound resulting in delay in receiving definitive treatment. Conclusion: Early recognition of first branchial cleft anomalies is important to prevent chronic complications and mismanagement.
Relationship Between Nutritional Status and Hemodialysis Therapy in Patients With Chronic Kidney Disease at Adam Malik Medan Hospital, Indonesia Muhammad Siddik Nasution; Sumi Ramadani; Edy Ardiansyah; Deryne Anggia Paramita
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.19070

Abstract

Background: One of the measures taken to control chronic kidney failure is through the hemodialysis procedure. Hemodialysis therapy can cause various side effects in patients, one of which is the risk of decreased nutritional status which can result in malnutrition. When the nutritional status of kidney failure patients worsens, the quality of life also decreases. Objective: This study aimed to determine the relationship between nutritional status and hemodialysis therapy at Haji Adam Malik General Hospital, Medan. Methods: This research was conducted from February to October 2024. This research is an analytical observational study using a cross sectional study design. The sample taken in this study was 80. Data was obtained from medical records at H. Adam Malik General Hospital, Medan. Results: The correlation test with the Chi-square test showed no relationship between Body Mass Index and several criteria, namely: Gender (p=0.645), age (p=0.410), creatinine (p=0.296), urea (p=0.296), albumin (p=0.315). Conclusion: There is no relationship between BMI and age, gender, albumin levels, creatinine levels and albumin levels in hemodialysis patients at H. Adam Malik General Hospital, Medan. The majority of patients undergoing hemodialysis at H. Adam Malik General Hospital Medan have a normal BMI (66%).
The Relationship Between Body Mass Index (BMI) and the Occurrence of Gastroesophageal Reflux Disease (GERD) Among Students of the Faculty of Medicine, Universitas Sumatera Utara, Batch of 2021 and 2022 Dimas Zainuddin Amir; M. Aron Pase; Melvin Nova Gunawanto Barus; Adriansyah Lubis
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.19071

Abstract

Background: Gastroesophageal Reflux Disease (GERD) is a common digestive disorder, especially among young adults like college students. One factor linked to GERD is Body Mass Index (BMI). Although higher BMI is associated with a greater risk of GERD, limited data exists on this relationship in university populations, particularly at the Faculty of Medicine, Universitas Sumatera Utara. Objective: This study aims to analyze the relationship between BMI and GERD incidence in FK USU students from the 2021 and 2022 batches. Methods: An analytical, cross-sectional study was conducted using simple random sampling. The subjects were Medical Education students from the 2021 and 2022 batches. Data collection was done through direct distribution of the GERD-Q questionnaire. Statistical analysis included univariate and bivariate methods using chi-square tests. Results: Among 100 respondents, 52 (52.0%) had GERD. Among those with GERD, 43 (29.6%) were obese and 9 (22.4%) had normal BMI. Of those without GERD, 34 (20.6%) had normal BMI and 14 (27.4%) were obese. A significant relationship was found between BMI and GERD (p = 0.011). Conclusion: There is a significant relationship between BMI and GERD incidence among FK USU Medical Faculty students from the 2021–2022 batches.
Levels of Squamous Cell Carcinoma Antigen and Interleukin-6 as Biomarkers in NSCLC Patients Lydia Arieta; Noni Novisari Soeroso; Setia Putra Tarigan; Putri Chairani Eyanoer
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.20027

Abstract

Background: Squamous Cell Carcinoma Antigen (SCC-Ag) and Interleukin-6 (IL‐6) has been widely used for monitoring Non-Small Cell Lung Cancer (NSCLC). Objective: This concentration also known to be higher in Non Small Cell Lung Cancer. Methods: This research used descriptive study among NSCLC patients. Blood sampling was used with serum. ELISA platform was used to rate SCC-Ag and IL-6 serum. Results: From 20 samples NSCLC, we found 20 males (100%), active smokers (80%). From histology type, Adenocarcinoma 12 cases (60%). The most of subjects were in stage IVA (70%). The Squamous Cell Carcinoma Antigen levels of NSCLC patients showed that as many as 20 samples (100%) were within normal limits and did not show an increased. Conclusion: Levels of IL-6 increased as many as 15 samples (75%), and IL-6 levels were still within the normal range sample (25%). Tumor marker are not meant to detect marker growth, but only as a marker that found in lung cancer,but IL-6 as the one of the pro-inflammation cytokines that shows an increased in patients NSCLC.
Characteristics of Breast Cancer Patients Undergoing Radiotherapy at the H. Adam Malik Central General Hospital Medan in 2020-2021 Luthfi Aidil Rizal Lubis; Muhammad Fauzi Siregar
Sumatera Medical Journal Vol. 8 No. 3 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i3.10951

Abstract

Background: Breast cancer can affect both women and men, originating in the mammary glands, fatty tissue, or connective tissue of the breast. Radiation therapy is a key treatment option applicable at nearly all disease stages. Objective: To examine the characteristics of breast cancer patients receiving radiotherapy, focusing on body mass index (BMI), histopathological classification, breastfeeding history, previous treatments, clinical stage, and age. Methods: This descriptive observational study involved total sampling and secondary data from medical records. Univariate analysis was performed. Out of 120 reviewed records, 43 met the inclusion criteria. Results: Most patients had normal nutritional status (48.8%) and were diagnosed with Invasive Ductal Carcinoma (74.4%). The majority had a history of breastfeeding (95.3%), underwent chemotherapy beforehand (59.4%), were at clinical stage IIB (41.9%), and belonged to the early elderly age group (39.5%). Conclusion: The primary characteristics of breast cancer patients undergoing radiotherapy at Haji Adam Malik General Hospital, Medan (2020–2021), include normal BMI, Invasive Ductal Carcinoma, breastfeeding history, prior chemotherapy, stage IIB disease, and early elderly age. These findings underscore the importance of early detection, managing modifiable risk factors, and integrated treatment approaches for improved outcomes.
Primary Spinal Syringomyelia with Hemianhidrosis: A Rare Case Report Dwi Fitria Nova; Dian Ayu Hamama Pitra
Sumatera Medical Journal Vol. 8 No. 3 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i3.14462

Abstract

Background: The incidence of syringomyelia is very rare, at 8.4 per 100,000 people, or about 2%. It is characterized by a cyst filled with cerebrospinal fluid (CSF) within the spinal cord tissue or central canal. Symptoms may include sensory and motor disturbances. Objective: We report a case of a 35-year-old woman who presented with pain, weakness, and stiffness in her back, shoulders, arms, and legs. Methods: She experienced weakness on her right side for the past five years and had no sweating on that side for two years. Motor examination showed flaccid hemiparesis and muscle atrophy in her right upper limb. Reflex testing revealed hyperreflexia in her right hand and leg. Sensory testing (touch, temperature, pain, vibration) showed dissociation of sensation on the medial-lateral side of her right arm and leg. Results: After 1.5 years of treatment, including routine Short Wave Diathermy (SWD), Transcutaneous Electrical Nerve Stimulation (TENS), physical therapy, and medication, her condition improved, and her quality of life was enhanced. Conclusion: This case highlights that a multidisciplinary approach, including SWD, TENS, physical therapy, and medication, can effectively reduce symptoms and improve quality of life in syringomyelia patients, even with extensive spinal involvement (C1-T11).

Page 16 of 19 | Total Record : 182

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