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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 12 Documents
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Search results for , issue "Vol 17, No 2 (2011)" : 12 Documents clear
THE DIAGNOSTIC VALUE OF HEART-TYPE FATTY ACID BINDING PROTEIN (h-FABP) RAPID TEST RELATED TO CARDIAC TROPONIN I IN NON ST ELEVATION MYOCARDIAL INFARCTION (NSTEMI) F.R. Marpaung; Sidarti Soehita SFHS; Yogiarto Yogiarto; Yusri Yusri
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1017

Abstract

Acute coronary syndrome (ACS) is caused by atherosclerotic plaque rupture and microembolization which lead to decreased oxygensupply into the myocardium. Generally, ACS includes an unstable angina (UA), non ST elevation myocardial infarction (NSTEMI) andST elevation myocardial infarction. ACS may lead to ST elevation Myocardial Infarction (STEMI) and finally a sudden death. Cardiactroponin is used routinely for diagnosing acute coronary syndrome (ACS); however, troponin is not elevated in the initial hours ofACS—precluding their usefulness in the early diagnosis. The aim of this study is to determine the diagnostic value of h-FABP Rapid testin relation to Cardiac Troponin I in NSTEMI. Seventy five patients with ACS were enrolled in this study. All patients presented symptomswithin six hours of the onset and suffered typical chest pain. Blood samples were obtained for rapid test h-FABP (cardiodetect) andTroponin I (tropospot). The h-FABP showed a 93.5% sensitivity, 95% CI: 81.1–98.3 and 82.8% specificity, 95% CI: 63.5–93.5, PositivePredictive Value 89.6%, 95% CI: 76.6–96.1, Negative Predictive Value 88.9%, 95% CI: 69.7–97.1, respectively in the first six hours.Troponin I had a 60.9% sensitivity, 95% CI: 45.4–74.5 and 96.6% specificity, 95% CI: 80.4–99.8, Positive Predictive Value 96.6%,95% CI: 80.4–99.8, Negative Predictive Value 60.9%, 95% CI: 45.4–74.5, respectively in the first six hours. Based on this study resulton patients with Non ST Elevation Myocardial Infarction (NSTEMI), it is suggested to determine the h-FABP as well. For this purpose,point-of-care h-FABP test can be utilized, as it has the advantage of highly sensitivity and specificity, beside it can carry on a bedsidetesting and show a rapid test results as well.
HUBUNGAN ANTARA FLAGGING ATYPDEP DI ALAT CELL-DYN 3200 DAN KEBERADAAN PLASMODIUM Spp DI DALAM DARAH PENDERITA DI RSUD DR.SOETOMO SURABAYA Esti Rohani; J Nugraha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1022

Abstract

Malaria is a parasitic disease worldwide with a high morbidity and mortality. A rapid and accurate methods is needed to detectthe presence of malaria parasites in blood. A flagging system atypical depolarization (atypdep) on CBC result from Cell-Dyn 3200instrument has been related with malaria infection. An observational cross sectional approach with a total of 48 samples were obtainedfrom inpatients in the Dr. Soetomo Hospital Surabaya. Samples were screened with Cell-Dyn 3200 analyzer for CBC found atypdepflagging. The positive samples were later confirmed by microscopic to detect malaria parasites. From 48 samples with atypdep flagging,seven samples were positive of malaria in peripheral blood smear (13.1%). Most frequent atypdep flagging was seen in malignant disease(18.7), an approximately 54.6% of the sample is not accompanied by symptoms of fever. Lekositosis and anemia were found in each of20 samples (41.6%) and thrombocytopenia in 33.3% of the samples. The presence of atypdep flagging does not necessarily indicate theexistence of malaria infection or it could be said that atypdep flagging is not always associated with the presence of malaria infection.The usage of an atypdep flagging on Cell-Dyn instrument in non-endemic areas such as Surabaya is just an alert sign to evaluate themalaria infection rather than a screening method to detect malaria.
PATOGENESIS dan PEMERIKSAAN LABORATOPRIUM MIELOFIBROSIS PRIMER Johanis Johanis; Arifoel Hajat
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1025

Abstract

Primary myelofibrosis (PMF) is a neoplastic hematologic disease, characterized by clonal hemapoietic stem cell and collagenaccumulation in bone marrow. PMF is not related with underlying myeloproliferative disorders or other diseases. The features of PMFshow marrow fibrosis, megakaryocytes and granulocytes proliferation, and extramedullary hemapoiesis. PMF is classified as BCR-ABLnegativemyeloproliferative disorders. Diagnosis of PMF is based on clinical symptoms of splenomegaly and myelopthisis; bone marrowbiopsy shows granulocytes/megakaryocytes hyperplasia, megakaryocytes dysmorphic and fibrosis; cytogenic testing for mutation ofJAK2V617F+, MPLW5I5L/K+ and BCR-ABL. The diagnostic criterion according to the 2008 WHO classification considers major andminor crieria. The primary purpose for treatment is to improve the quality of life by paliative tratment. The five year survival of PMFpatients is low.
DIAZO TEST AS A SCREENING TEST OF TYPHOID FEVER A PRACTICAL APPROACH J. Nugraha; Meiti Muljanti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1016

Abstract

Typhoid fever represents an endemic acute infection with a high mortality, in this case a laboratory test is needed to establish theearly diagnosis. For this study the researchers prefer urine diazo test which is a relatively easy, simple and inexpensive test. The aimof this study is to know whether the urine diazo test can be used for screening typhoid fever and whether there is a concordance withthe Widal and TUBEX® TF serological tests. Forty patients aged 2–18 years, attending to the Jeremy Medical Service Clinic, Surabaya,suffering of fever more than 3 days were studied from June up to August 2010. Urine samples were tested by diazo test, while bloodsamples as comparison were tested by Widal and TUBEX® TF tests, and blood culture was carried out as the gold standard. The sensitivityand specificity of those tests were then recorded. From the 40 samples, 12 patients showed positive Salmonella typhi blood cultures,26 diazo positive, 22 Widal positive and 14 TUBEX® TF positive. Of the 12 positive blood cultures, 10 (83%) diazo positive, 7 (58%)Widal positive and 9 (75%) TUBEX® TF positive were found. The sensitivity and specificity of diazo test was 83% and 43%, Widal test58% and 46%, TUBEX® TF test 75% and 82%. It is shown that the Diazo test had a higher sensitivity value, while the TUBEX® TF testshowed a higher level of specificity. In conclusion, so far it can be concluded that the Diazo test is quite reliable in aiding the diagnosisof typhoid fever and can be considered as a screening test for typhoid fever.
PENGARUH (EFEK) KEMOTERAPI TERHADAP KERJA (AKTIVITAS) ENZIM TRANSAMINASE DI PENDERITA KANKER PAYUDARA Helena Leppong; Mutmainnah Mutmainnah; Uleng Bahrun
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1024

Abstract

Breast cancer is one of the malignancies with unknown exact aetiology. The management of breast cancer can be done by severalways including it’s related chemotherapy. This therapy leads to cancer cells damage as well as healthy liver cells. Aspartate transaminase(AST) and Alanine transaminase (ALT) are the sensitive parameters to evaluate hepatocellular damage, the levels will raise rapidly inliver cells injury. The objective of this study was to evaluate the effect of chemotherapy in the activity of liver transaminase enzymes ofbreast cancer patients. A cross-sectional study was conducted by taking data from Medical Records of breast cancer patients who receivedchemotherapy at the Dr. Wahidin Sudirohusodo Hospital Makassar during the period of May 2008–May 2009. The data were analyzedstatistically by t-Test using SPSS software for Windows version 11.5. From 71 evaluated samples, the level of the liver transaminaseenzymes in all grades of cancer did not show a significant change (p>0.05). Chemotherapy of breast cancer patients does not increasethe activity of transaminase enzymes. In this study, the level of AST and ALT in chemotherapy patients can not predict the liver functiondisorder.
PEMBERIAN PROTEIN ADHESIN 38-KILODALTON MYCOBACTERIUM TUBERCULOSIS PERORAL MENINGKATKAN JUMLAH MAKROFAG DAN LIMFOSIT USUS MENCIT BALB/c Rahma Triliana; Ade A Kartosen; Dianika P Puspitasari; Sri Murwani; Sanarto Santoso; Maimun Z Arthamin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1015

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is one of the world health problems. Oral vaccination of M.tb hasa potential to reduce the risk and complication of TB. The 38-kDa adhesin protein as one of oral TB vaccine candidates has not beenproven. This study is aimed to determine M.tb 38-kDa adhesin protein effect on macrophage and lymphocyte numbers in mice intestineafter an oral administration. BALB/c mice (n=20), age 6–8 weeks, and were divided into 4 groups: control (K), adjuvant (A), 38-kDa100μg adhesin protein (P), and combination of 100μg 38-kDa adhesin protein with adjuvant (PA). An oral administration was givenat the beginning with 2 boosters every 4 weeks. After 3 days of the second booster, the mice were killed and the intestine was taken andstained with haematoxylin eosin (HE) to measure its macrophages and lymphocytes number. The mean ±2SD were 18.4 (3.71) and6.09 (0.34), 23.0 (7.78) and 8.86 (1.19), 42.2 (13.63) and 23.49 (3.91), 95.4 (30.11), and 53.57 (13.79) respectively for K, A, Pand PA group. The statistical test showed a significant difference among each group revealing the role of M.tb 38-kDa adhesin proteinas immunogenic inducing cellular immunity in intestine. In this study, so far it was found that the oral administration of M. tb 38-kDaadhesin protein has an ability to increase macrophage and lymphocyte numbers in the mice intestinal BALB/c.
STATUS PENGGUMPALAN (AGREGASI) TROMBOSIT SEBAGAI FAKTOR PROGNOSTIK TEJADINYA KELUARAN KLINIS STROK INFARK MENDADAK (STROK INFARK AKUT) Linda Rosita; Usi Sukorini; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1021

Abstract

The propriate management of acute infarction stroke will be able to reduce the morbidity and mortality of the disease. In diagnosingand managing the diseases, for the detection of the risk or prognostic factors information’s such as the history physical findings,confirmation and other supporting tests are needed. One of the supporting test is the laboratory examination i.e. platelet aggregationtest. Platelet aggregation is suggested having an important role in haemostasis especially to prevent excessive bleeding by forming plateletplug. Finally, further hyperactivity of platelet in terms of platelet hyper aggregation can create a thrombus and moreover lead to obstructthe vessels. The occlusion will give a negative outcome of an acute infarction stroke. The aim of this study is to know whether platelethyper aggregation has a contribution in the outcome of the disease or not by certain testing. A prospective cohort study was carried out,to compare between two groups of exposed and non-exposed group in Sardjito hospital Yogyakarta during the period of March up toearly July 2007. Eighty four subjects who met the inclusion and exclusion criteria were involved in this study. The exposed group was agroup of acute infarction stroke patient who were exposed to platelet hyper aggregation 48 (57%), on the other hand, patients who didnot have platelet hyper aggregation was separated as non-exposed group is 36 (43%). Inception of cohort was applied when the patientwas admitted to the emergency unit during 72 hours of the onset, before receiving antithrombotic drugs and had no previous history ofstroke. The patients were followed after 7 days hospitalization in the stroke unit and neurology unit and the outcome was measured byevaluating the score using Gadjah Mada stroke scale. The characteristics of the subjects were grouped by baseline data X2 test. Unvariedanalysis and multivariate analysis were taken to get the relative risk of having acute infarction stroke. In this case logistic regressionanalysis was used to know the relative risk (RR) measurement. Prognostic factors had influenced the outcome of acute infarction strokein patients who had a history of cardiovascular disease and aggregation status. The outcome of the platelet hyper aggregation grouphad a RR=2.15 (95% CI: 2.01–4.07) and the history of cardiovascular disease had a RR=1.78 (95% CI: 1.18–13.28).
PROKALSITONIN SEBAGAI PENANDA PEMBEDA INFEKSI BAKTERI DAN NON BAKTERI Bastiana Bastiana; Aryati Aryati; Dominicus Husada; M.Y. Probohoesodo
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1019

Abstract

Early diagnosis of an infection and prompt administration of an antibiotic can dramatically reduce morbidity and mortality.Procalcitonin (PCT), a precursor of calcitonin, has been proposed as a marker of bacterial infection. The aim of this study is to assess theefficiency of procalcitonin in children for the diagnosis of bacterial vs. non bacterial infection. This was a prospective, cross-sectional study.The subjects were enrolled consecutively, consisting of feverish children (temperature ³38.5° C) admitted to the Pediatric EmergencyDepartment with ages up to 12 years old. The subjects were divided into two groups according to their final diagnosis, bacterial and nonbacterial infection. Serum PCT concentration was measured by enzyme linked fluorescent assay (ELFA) method. Sensitivity, specificity,positive predictive and negative predictive values, and receiver operating curve (ROC) of PCT were calculated. Out of 54 patients,24 (44.4%) had a final diagnosis of bacterial infection. PCT showed a wide concentration range in the bacterial infection group (median:1.09 ng/mL, lower (L)=0.05 ng/mL, upper (U)=128.7 ng/mL) compared with non bacterial infection group (0.21 ng/mL; L=0.05ng/mL; U=12.15 ng/mL). There was a significant difference in PCT between the 2 groups (p=0.020). ROC analysis demonstrated anarea under curve (AUC) of 0.686 (95% CI, 0.534 to 0.838). Using a cut-off point of 0.5 ng/mL, the sensitivity, and specificity, positivepredictive and negative predictive values of PCT were 66.7%, 76.7%, 69.6%, 74.2%, respectively. In this study, PCT may be useful fordifferentiation of bacterial vs. non bacterial infection in children.
KADAR SERUM KREATININ DAN KALIUM PASIEN DENGAN DAN TANPA DIABETES JENIS (TIPE) II Tonang Dwi Ardyanto; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1018

Abstract

Hyperkalemia is a metabolic disorder caused by either renal insufficiency for potassium excretion (like in renal failure), thedysmechanism of potassium transportation into the intracellular space (regards on the hyperglycemia status) or combinations of thoseetiologies. In nephropathy diabetic patients, hyporeninemic hypoaldosteronism syndrome might also be the etiology resulting from thehigh potassium level. The objective of the present study was to evaluate the correlation between the serum creatinine and potassiumlevel in patient with and without type II diabetes. The data of this study were drawn from patients admitted to the laboratory for themeasurement of serum creatinine and potassium with or without the measurement of blood glucose level at the Clinical PathologyLaboratory of Moewardi Hospital in Surakarta. The subjects were then classified into two groups: A (non-diabetic patients) and B(diabetic patients). The data were analyzed statistically with T-student test and Pearson Correlation test based on the total samples, pereach group (A and B groups) and the diabetic status (only B group) one. In this study so far it was found that the serum creatinine andpotassium level were significantly correlated in the total sample and group A analysis (p<0.05). Surprisingly, the correlation was notfound or very weak in group B (p>0.05). Furthermore, no correlation was found in the analysis based on the diabetic status amongthe B group subjects (p>0.05). It can be suggested that other factors may play a significant influence on the correlation between thehyperglycemia state, renal failure and serum potassium level in diabetic patients. Further detailed analysis should be warranted toelucidate those factors.
KORELASI ANTARA HITUNG TROMBOSIT DENGAN JUMLAH CD4 PASIEN HIV/AIDS M. I. Diah Pramudianti; Tahono Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1023

Abstract

The Acquired Immune Deficiency Syndrome (AIDS) is the presence of symptoms caused by Human Immunodeficiency Virus (HIV)which belongs to human retroviruses (retroviridae). Thrombocytopenia is a common finding in patients with HIV infection. HIV infectionmay induce thrombocytopenia through immune and non-immune mechanisms, autoimmune combination and inhibition of plateletproduction. The aim of this study is to analyze the correlation between thrombocyte and CD4 count in HIV/AIDS patients. This studyuses a cross sectional design with a total of 17 patients. The subject of this study is HIV/AIDS patients who came to and examined atVCT clinic, dr. Moewardi Hospital Surakarta. To analyze this result the researchers used Spearman (r) correlation with p<0.05, andconfidence interval 95%. Patients’ median age was 30 (21–49) years, 11 (64.7%) men and 6 (35.3%) women. The subjects with AIDSwere 11 (64.7%), and HIV were 6 (35.3%) patients. The duration of antiretroviral (ARV) was 7.5 (4–20) months in 10 subjects.The median of thrombocyte count was 203 (143–327)×103/μL, CD4 absolute 207 (5.0–734)/μL, and CD4 (% lymphocytes) 13.0(2.0–29.0)%. The thrombocyte count was not correlated with CD4 absolute (r=0.456; p=0.066) and CD4% (r=0.218; p=0.400). InHIV patients, low platelet counts will be the result of a host of problems and complications that are associated with the progressive HIVinfection or its management.

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