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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,328 Documents
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Author Guideline and Subcribes Form Dian Wahyu Utami
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 1 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Author Guideline and Subcribes Form
PROPORTION OF RHESUS BLOOD TYPE PHENOTYPES OF ROUTINE BLOOD DONORS AT BLOOD DONOR UNIT INDONESIAN RED CROSS IN BANDUNG CITY Ivana Dewi; Nadjwa Zamalek Dalimoenthe; Anna Tjandrawati; Nida Suraya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.807

Abstract

Blood type phenotype incompatibility including Rhesus between donors and patients may result in cross-matching problems, triggering alloimmunization, and causing Hemolytic Transfusion Reaction (HTR). Rhesus blood type incompatibility between mother and fetus may cause Hemolytic Disease of Fetus and Newborn (HDFN). Pretransfusion phenotypic blood groups matching also reduce cost efficiently which means antibody screening is no longer needed. The purpose of the study was to find the proportion of Rhesus blood type phenotypes in routine blood donors at the Blood Donor Unit, Indonesian Red Cross in Bandung city, Indonesia. The study was descriptive and observational with a cross-sectional design. The study was done at the Blood Donor Unit, Indonesian Red Cross in Bandung city from April 2016 to September 2017. The subjects were 142 routine blood donors. Blood sampling was done simultaneously with blood donation. Rhesus antigen examination of ethylenediaminetetraacetic acid (EDTA) blood was done by gel method. Subjects characteristics were males (68%) and females (32%), with the mean age of 39 years. Examination of Rhesus antigen found antigen D(100%), antigen e(98.6%), antigen C(97.9%), antigen c(38.7%) and antigen E(31.7%). Results of Rhesus phenotypes were DCe/DCe(61.3%), DCe/DcE(29.6%), DCe/dce(7%), DcE/DcE(1.4%) and DcE/dce(0.7%). The distribution of Rhesus blood type was affected by factors such as genetics, race, ethnicity, marriage, demography, and migration. Rhesus blood phenotypes proportion in routine blood donors at Blood Donor Unit, Indonesian Red Cross in Bandung city sorted from the most were DCe/DCe, DCe/DcE, DCe/dce, DcE/DcE, and DcE/dce.
LEVELS OF INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA IN PREGNANT PATIENTS WITH PREECLAMPSIA AND PATIENTS WITH NORMAL PREGNANCY Mawardi Sarengat; Ratna Akbari Ganie; Sarma N. Lumbanraja
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1171

Abstract

Preeclampsia is a pathological condition often found during pregnancy with a prevalence of about 5-7%. Abnormal implantation, abnormal trophoblast invasion, and endothelial cell dysfunction will result in increased proinflammatory cytokines. One of preeclampsia's pathogenesis is increasing levels of TNF-alpha and IL-6. Because of this, the researchers wanted to know the level of expression of TNF-alpha and Interleukin-6 in pregnant females with preeclampsia. This was an analytical study with a case-control design, done on 30 preeclampsia patients at the Adam Malik Hospital Medan in August - October 2016, who fulfilled the inclusion criteria of the study. IL-6 and TNF-alpha level were then examined, engage ethnic by ELISA with Human Interleukin-6 QY-E04262 reagent and Human Tumor Necrosis Factor-Alfa QY-E00182 reagent. The results of IL-6 in patients with preeclampsia increased (48.60±10.85) as compared to the control (31.99±2.65). TNF-alpha levels in patients with preeclampsia also increased (79.24±10.43) compared to the control (79.24±10.43). Statistical results showed significant differences in the expression of TNF-alpha and IL-6 levels in patients with preeclampsia compared with controls (p=0.0001). In this research, there were significant differences in the expression of TNF-alpha and IL-6 levels in preeclampsia patients.
D-DIMER AND FIBRINOGEN IN PATIENTS UNDERWENT SURGERY IN MALIGNANT AND BENIGN OVARIAN TUMOR Ismail Aswin; Herman Hariman; Fauzie Sahil
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1288

Abstract

Ovarian tumour ranks second in gynecology tumour cases and ranks second in gynecology tumour death in Indonesia. Tumour cause hypercoagulable that increase risk of thrombosis by procoagulant mechanism. Tumout cells also can cause hyperfibrinogenemmia that can cause bleeding. The aim of study was to know D-dimer and fibrinogen value to investigate primary hyperfibrinolysis on malignant and benign ovarian tumour; and to know whether operation procedure on malignant and benign tumour change D-dimer and fibrinogen value. Prospective analysis study, subject were malignant and benign ovarian tumour patients undergoing surgery in Haji Adam Malik Hospital, Medan. One way Annova test dan Wilcoxon Sum-Rank test were performed. Stastical differentiation is indicate with p<0,05. Study subject was 16 patient where 8 malignant and benign ovarian tumour patient respectively. Malignant ovarian tumour D-dimer values was higher than benign ovarian tumour (p<0,01) that indicate fibrinolysis increase in malignant ovarian tumour. Malignant ovarian tumour fibrinogen values as same as benign ovarian tumour (p>0,05) that indicate the fibrinolysis in ovarian tumour wasn't primary hyperfibrinolysis. Surgery procedure didn't influence D-dimer and fibrinogen values. Primary hyperfibrinolysis wasn't occur in ovarian tumour.Keywords : Ovarian tumour, malignant, benign, D-dimer, fibrinogen.
ANALYSIS OF VITAMIN D IN PATIENTS WITH DIABETES MELLITUS TYPE 2 Arfandhy Sanda; Uleng Bahrun; Ruland DN. Pakasi; Andi Makbul Aman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1360

Abstract

Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 years (mean 56,59+12,15 years). The minimum HbA1c level was 4,8% and the maximum level was 12,9% (mean 6,95+1,81%). The minimum Vitamin D level was 9,07 ng/ml dan  the maximum level was 66,49 ng/ml (mean 26,85+9,30 ng/ml). Kruskal Wallis test showed p value=0,132, Spearman correlation test showed p value>0,05. The clonclusion from this study, there is no significant correlation between vitamin D level and type 2 Diabetes Melllitus consist of Prediabetic group, controlled Type 2 Diabetes Mellitus, and uncontrolled type 2 Diabetes Mellitus.
PREVALENCE AND CHARACTERISTICS OF MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII CASES AT THE DR.WAHIDIN SUDIROHUSODO GENERAL HOSPITAL IN MAKASSAR Dewi Kartika Tungadi; Nurhayana Sennang; Benny Rusli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1363

Abstract

Multidrug-resistant Acinetobacter baumannii (MDRAB) is a strain that is resistant to three or more classes of antibiotics. As the prevalence of MDRAB increases, the antibiotics of choice become limited. Identification of MDRAB is required to manage and control infection. This research was conducted to determine the prevalence and characteristics of MDRAB in the Wahidin Sudirohusodo Hospital Makassar. This research was a retrospective study, conducted from January to December 2016. Bacterial identification and antimicrobial susceptibility testing (AST) were performed using VITEK 2. The patient data were obtained from the medical records. A total of 323 Acinetobacter baumannii isolates was obtained, consisting of 188 isolates in January-June 2016 and 36 of which were MDRAB (19.15%) with the average length-of-stay 33 days; and 135 isolates in July-December 2016 and 31 of which were MDRAB (22.96%) with the average length-of-stay 27 days. Multidrug-resistant Acinetobacter baumannii was mostly discovered from patients using three or more medical devices and on a single antibiotic therapy. Multidrug-resistant Acinetobacter baumannii isolates were mostly obtained from sputum and pus specimens, and the majority of patients had an infection and respiratory diseases. The most comorbid diseases in MDRAB were endocrine-metabolic diseases. The result of AST showed 100% and 96% susceptibility to Polymyxin B; 71.43% and 54.84% to Amikacin; 66.67% and 50% to Trimethoprim/Sulfamethoxazole, respectively. Prevalence of MDRAB in 2016 increased from January-June (19.15%) to July-December (22.96%), suggesting a need to identify patients at risk for MDRAB infection and to promote the rational use of antibiotics. Polymyxin B, Amikacin, and Trimethoprim/Sulfamethoxazole are the antibiotics of choice to treat MDRAB.
USING SIX SIGMA TO EVALUATE ANALYTICAL PERFORMANCE OF HEMATOLOGY ANALYZER Robiul Fuadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1375

Abstract

Many medical decisions in the hospital based on hematology examination results, must be aware of their method performance. Sigma-metric is an excellent way to evaluate analytical performance quality. The performance analysis of laboratory hematology analyzer and Cell Dyne Ruby can use Sigma-metric. This study aimed to evaluate the analytical performance of Abbott Cell Dyne Ruby hematology analyzer, by Six Sigma in Clinical Pathology Laboratory of the Dr. Soetomo Hospital Surabaya, Indonesia. Sigma analysis was calculated by a formula, sigma = (TEa – CV)/ Bias. The CLIA proficiency testing criteria specified Total Error Allowable (TEa). The Coefficient of Variant (CV) and bias data were supplied from analyzer running three levels of control Low (L), Normal (N), and High (H) include following analytes: hemoglobin (Hb), Red Blood Cell count (RBC), Hematocrit (HCT), White Blood Cell count (WBC), and Platelet count (PLT). Sigma-value as follows Hb(L:4.33 N:6.68 H:2.62), RBC(L:3.43 N:3.84 H:3.46), HCT(L:2.52 N:1.73 H:2.27), WBC (L:7.14 N:8.44 H:6.38), and PLT (L:2.46 N:8.75 H:7.84). Average Sigma-value for all parameters was 4.75. Minimum Sigma-value for any business or manufacturing process was three. More than Six Sigma-value was a world-class performance. Hematology analyzer Cell Dyne Ruby provides “Good” performance by Sigma-metric.
RELATIONSHIP BETWEEN SPECIFIC GRAVITY OF CUPRIC SULFATE AND SATURATION OF BLOOD DROPLETS DURING DONORS'HEMOGLOBIN SCREENING Resna Hermawati; Solichul Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1376

Abstract

There are several methods of hemoglobin screening. A technique that is practical, easy, and fast,as well as does not require high costs is needed for blood donor activities. Cupric sulfate method is still used in blood donor activities nowadays. There are several types of the specific gravity of cupric sulfate which will determine saturation speed. On the other hand, one of the requirements for a blood donor, according to the WHO, is that its hemoglobin level must be ≥ 12.5 g/dL. This research aims was to reveal how many blood droplets could be dripped into cupric sulfate solutions at certain specific gravities. This research was an observational analytic study using a cross-sectional design. One mL of venous blood sample was consecutively collected from thirty donors who came to the blood service of the Dr. R. Soedjono Selong Hospital in August 2017. Next, screening for hemoglobin levels was carried out on those blood samples using the cupric sulfate method with a specific gravity of 1.054. Autoanalyzer was also used as a reference method in this research. Results of cupric sulfate examination were categorized into sinking and non-sinking. The results of cupric sulfate examination with sinking category showed significant suitability with hemoglobin levels of >12.5 g/dL from autoanalyzer (p=0.002) with 100% sensitivity and 70.83% specificity. The results of cupric sulfate examination with non-sinking category (with daily replacement) showed a significant match with hemoglobin levels of >12.5 g/dL from autoanalyzer (p=0.003) with 68% sensitivity and 100% specificity. The use of ten samples in this research could reach 100% sensitivity and 100% specificity. Meanwhile, according to the WHO, 30 mL of cupric sulfate solution with a specific gravity of 1.053 can accommodate 25 donor blood droplets.Thus, it can be concluded that unlike the reference from the WHO of 25 droplets, based on hemoglobin screening test cupric sulfate solution with a specific gravity of 1,054 can be saturated with ten droplets.
DIFFERENTIATION T LYMPHOCYTE CELLS EXPRESSING INTERLEUKIN-17 PERCENTAGE ON HEALTHY PERSON AND ADULT ACUTE MYELOID LEUKEMIA PATIENT Elvan Dwi Widyadi; Yetti Hernaningsih; Endang Retnowati; Ugroseno Ugroseno; Ryzky Widi Atmaja
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1383

Abstract

Acute Mieloid Leukemia (AML) is a hematologic cause of cancer deaths of 1.2% including a relatively rare disease but by the end of the decade there is an increase in the number of new cases. The immune system in AML is caused by gene mutations giving immunosuppressive effects so that the immune system will be inhibited in eliminating leukemia cells. The immune response of tumors is important to determine the prognosis, development of new cancer immunotherapy as well. One of the subset of lymphocytes T is  gdT lymphocyte cell with innate nature, but until now no information is required about gdT cell profile in AML patients. gdT cells have properties as antitumors played by Interferon production g (INF g), and the nature of protumor by interleukin 17 (IL-17). The percentage of lymphocyte T (CD3 +) of AML patients and healthy people did not differ (p = 0.528), indicating, not being activated for proliferation. gdT Lymphocyte cells percentage in healthy people by race, genetic and exposure to the surrounding environment such as infection. Percentage of gdT lymphocyte of AML patients and healthy people was not different from (p = 0.694), showed an immune response by gdT cells Unefected to proliferate. The percentage of gdT llimfocytes expressing the interleukin 17 (gdT17 cells)in patients AML and healthy people did not differ significantly (p = 0.436), this indicates inhibited proliferation.
ANALYSIS OF MEAN PLATELET VOLUME, PLATELET DISTRIBUTION WIDTH, AND PLATELET COUNT IN HEMORRHAGIC AND NON-HEMORRHAGIC STROKE Gita Medita Sunusi; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 25 No. 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1392

Abstract

Stroke is a sudden and acute focal or global cerebral functional disorder lasting more than 24 hours due to cerebral blood flow impairment. Platelets play an essential role in the pathophysiology of non-hemorrhagic stroke by causing thrombus formation in blood vessels after erosion or rupture of atherosclerotic plaques. Mean platelet volume, PDW and platelet counts are hematological parameters that can be measured on routine blood tests that can describe platelet function and activity and are standard tests carried out in hospitals. The aim of this study was to analyze the differences in MPV, PDW and platelet count between non-hemorrhagic strokes and hemorrhagic strokes. This was a retrospective cross-sectional study conducted in the Dr. Wahidin Sudirohusodo General Hospital of Makassar. A total of 375 Non-Hemorrhagic Stroke (NHS) and 221 Hemorrhagic Stroke (HS) patients were included in this study. Mean platelet volume, PDW and platelet counts were obtained from complete blood count at the time of admission. There was a significant difference in platelet count between NHS and HS patients (p=0.01). Nevertheless, there were no significant differences between MPV and PDW between NHS and HS patients (p=0.19 and p=0.54, respectively). The results of this study indicated that there were significant differences in platelet counts in HS and NHS with increased platelet counts being a risk factor for NHS and a decrease in platelet counts as a risk factor for HS. However, there were no significant differences in the values of MPV and PDW in NHS and HS patients. It is recommended  to study using a better sample selection method so that it can eliminate the occurrence of bias with other diseases, which can also cause a decrease and increase in MPV values, PDW and platelet counts.       

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