cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Dr. dr. Farhat, M.Ked(ORL-HNS), Sp.T.H.T.K.L(K)
Contact Email
-
Phone
-
Journal Mail Official
ijnpc@usu.ac.id
Editorial Address
Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara (PUI KNF USU), Hospital of Universitas Sumatera Utara, 4th floor, JL. Dr. Mansyur No. 66 Kampus USU Medan 20154, Sumatera Utara
Location
Kota medan,
Sumatera utara
INDONESIA
International Journal of Nasopharyngeal Carcinoma
Published by Universitas Sumatera Utara
ISSN : 26569027     EISSN : 26569035     DOI : https://doi.org/10.32734/ijnpc
Core Subject : Health,
Health Professions Medicine & Pharmacology
The International Journal of Nasopharyngeal Carcinoma (IJNPC) is an open access journal that publishes research findings from disciplines related to nasopharyngeal carcinoma. This journal was published by the Center of Excellence Nasopharyngeal Carcinoma Universitas Sumatera Utara, collaborated with TALENTA Publisher Universitas Sumatera Utara. The publication of papers is quarter yearly, published in March, June, September, and December within 10 articles per issue. The journal is purposed to provide international sources of information to doctors and other health professionals who are interested in nasopharyngeal carcinoma. This journal is expected to improve communication between researchers so that it has an impact on the development of knowledge regarding nasopharyngeal carcinoma and stimulates further research related to head and neck surgical oncology, diagnosis, and clinical management.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 94 Documents
 2   3   4   5   6 
COMPARISON OF POLYMORPHISM rs2070672 CYP2E1 GENE PROPORTION IN EARLY AND ADVANCED STAGE OF UNDIFFERENTIATED TYPE NASOPHARYNGEAL CARCINOMA IN BALINESE I Ketut Suanda; I Gde Ardika Nuaba; Ni Putu Ayu Wiarni Susanthi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.2652

Abstract

Introduction: Nasopharyngeal carcinoma is the most common malignancy in the ENT field. The cause of nasopharyngeal carcinoma is multifactorial. One of the risk factors for an increase in nasopharyngeal carcinoma is the rs2070672 polymorphism of the CYP2E1gene. Purpose: To determine the rs2070672 CYP2E1gene polymorphism proportion in early and advanced stage undifferentiated type NPC subjects in Balinese. Method: This research is a cross sectional comparative study. The case population were all subjects with undifferentiated type NPC in the ENT outpatient clinic at Sanglah General Hospital Denpasar. This study uses 65 samples. Data collected in the form of subject characteristics and rs2070672 CYP2E1gene polymorphisms which examined by ARMS-PCR technique. Results: The average age of the sample was 48.1 years, the most were male as many as 48 subjects (73.8%), and the highest was advanced stage as many as 56 subjects (86.2%). In the chi square test the proportion of polymorphisms in the advanced stage was 2.357 times higher than the early stages. The results of multivariate analysis using logistic regression proved that the rs2070672 CYP2E1gene polymorphism at advanced stage was 7.469 times higher than early stage. Conclusion: There is a difference in the proportion of rs2070672 CYP2E1gene polymorphism in undifferentiated type NPC of Balinese, where advanced stage is higher than early stage.
PREVALENCE OF NASOPHARYNGEAL CARCINOMA PATIENTS IN DEPARTEMENT OF ORL-HNS HASAN SADIKIN GENERAL HOSPITAL 2010 -2017 Riri Handayani; Yussy Afriani Dewi; Deasy Z Madani
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3191

Abstract

Introduction: Nasopharingeal Carcinoma starting from Rosenmuller fossa and intracranial or local spread as a mass in the head area. Nasopharyngeal carcinoma is also associated with hearing problems, serous otitis media, tinnitus, nasal congestion, anosmia, nose bleeding, difficulty swallowing, and dysphonia. Nasopharyngeal carcinoma is a disease that spreads globally and divides races around the world. The purpose of this study is to determine the prevalence of nasopharyngeal disease in Otorhinolaringology-Head and Neck Department, Dr. Hasan Sadikin General Hospital Bandung in 2010-2017. Methods: Medical record method description of Nasopharyngeal Carcinoma at Departement of Otorhinolaringology- Head and Neck Surgery, Dr. Hasan Sadikin General Hospital Bandung in 2010-2017 that used sampling method. Results: There were 1378 patients nasopharyngeal carcinoma, 976 people that included, 657 were men and 319 were women. Obtain most elementary school education (54.9 %) the majority of male patients (67.3 %) with various job background, whereas female patients were housewives (28.1%), and those aged 41-50 years (34%). Most histopathology are undifferentiated carcinoma (58.3 %). Conclusion: Nasopharyngeal Carcinoma patients at the Otorhinolaringology-Head and Neck Surgery Departement. Dr. Hasan Sadikin General Hospital Bandung are 1378 cases. There was higher instance in middle age, and older men and elementary school educated with major histopathology finding was undifferentiated carcinoma
FACTORS THAT HAVE PROGNOSTIC VALUES IN THE MANAGEMENT OF NASOPHARYNGEAL CARCINOMA PATIENTS Chandra Kangga; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3454

Abstract

Introduction: The survival rate of Nasopharyngeal carcinoma (NPC) patients is influenced by several prognostic factors, Such aspatient factors, tumor factors and therapeutic interventions carried out as well as the quality of care. Tumor factors in the form of spread of local invasion, regional lymphatic involvementand metastasis that is reflected in the TNM stage (Tumor, Nodule and Metastatic) are the most important prognostic factors of NPC. Objective: To determine the Prognostic factors that effectedsurvival rate of nasopharyngeal carcinoma patients. Material and methods: Analytic observational studywith particular design of survival analysis. Data was taken from medical records and then performed survival analysis on the studiedfactors. Sample of this studywas all patients who were first diagnosed NPC From January 2013 until December 2013 and meetinclusion and exclusion criteria is52 patients. Results:From 52 patients in the fifth year, 50% died and 50% survive. Survival was worse in the 30-39 year age group (30.8%), male sex (47.2%), Stage IV (44.4%), T4 size (40%), N1 size (23,1%), Distant metastases (40%), WHO type III (48.5%), chemoradiation (48.9%). In multivariate analysis, it was found that the variables that most influenced the survival of NPC patients based on p <0.05 and based on hazard ratio strength were T-size, N-size categories and Metastasis with 95% CI. Conclusion: Prognostic factors that affect the survival of NPC patients in RSUP. Dr. Mohammad Hoesin Palembang is a category of size T, N, and Metastasis.
CORRELATION OF TNF-Α EXPRESSION TO CLINICAL STADIUM IN NASOPHARYNGEAL CARCINOMA Susilo, Riko; Farhat; Asnir, Rizalina A; Yudhistira, Ashri; Daulay, Elvita Rahmi; Chrestella, Jessy
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA (IJNPC) Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3503

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia with over 13.000 new cases reported yearly, especially in the male. The TNF-? serum is reported as a new biomarker to predict bone invasion, post-therapy distant metastasis, and poor life sustainability in NPC. Objective: To identify the expression of TNF-? in regards to the clinical stage of NPC. Material and methods: This is an analytic study with 126 NPC samples of patients in Haji Adam Malik General Hospital. Results: NPC mostly found in age group 41-60 years (57.1%), male (71.4%),non-keratinizing SCC (79.4%), and stage IV group (54.8%). In immunohistochemistry evaluation, most of TNF-? overexpressed in non-keratinizing SCC(68.0%), T3-T4 (50.8%), N2-N3 (62.7%) and clinical stage III-IV (69.9%). Spearman's test for categorical correlation yield a p-value of &lt;0,001. Conclusion: There is a significant correlation between TNF-? expression and the stage of NPC.
VISUAL IMPAIRMENT IN NASOPHARYNGEAL CARCINOMA Apryanza Akbar; Denny Satria Utama
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3504

Abstract

Introduction: he most common complaint in almost half of nasopharyngeal carcinoma (NPC) patients is a lump in the neck. Neurological symptoms occur less frequently, whereas blindness occurs in only less than one percent of cases. Case report: A 47-year-old male had complained about headache, nasal voice, and blindness in the right eye since a month ago. An examination found a mass in the right nasal cavity, right neck lymph nodes enlargement, damage to the right oculomotor (III), trochlear (IV), and abducens (VI) nerve, and right optic nerve (II). On funduscopy, the right macular reflex decreased. On CT scan there was a right nasopharyngeal mass extending to intracranial and right intraorbital spaces. Conclusion: There was a direct infiltration of NPC into surrounding and intracranial structures. Unilateral blindness might be caused by expansion to middle cerebral fossa and orbita. It could also be caused by optic nerve compression from surrounding tumor tissue.
RADIOTHERAPY EFFECT ON COMPLETE BLOOD COUNT PARAMETER IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA Achmad Chusnu Romdhoni; Firas Farisi Alkaff; Mega Kahdina; Melinda Masturina; Ristra Ramadhani
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3505

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is the most common malignant tumor of the nasopharynx. Radiotherapy is a therapy of choice for NPC that has been recognized for a long time and used in various centers of the world. However, radiotherapy is known to still have an adverse effect. It is common practice to evaluate Complete Blood Count (CBC) before, during, and after radiotherapy. However, there has been no study regarding the effect of radiotherapy on all CBC parameters. This study aims to analyze the effect of radiotherapy on CBC in NPC patients before and after radiotherapy treatment. Material and methods: This study was an observational study using secondary data from medical records at the radiotherapy outpatient clinic at Dr. Soetomo General Hospital Surabaya. The subject of this study was patients with NPC who underwent a full cycle of radiotherapy treatment on radiotherapy outpatient clinic in 2016. Patients with incomplete medical records and did not finish the radiotherapy treatment were excluded. A paired T-test and Wilcoxon signed-rank test were used for statistical analysis. Results: There were 105 patients included in this study. Mean Corpuscular Hemoglobin Concentration (MCHC), total leucocyte, lymphocyte, and thrombocyte was significantly decreased after a full cycle of radiotherapy (all p <0.05). Eosinophil, basophil, neutrophil, monocyte, Neutrophil to Lymphocyte ratio (NLR), and Platelet to Lymphocyte ratio (PLR) was significantly increased after a full cycle of radiotherapy (all p <0.05). Conclusion: Radiotherapy had a significant effect on the CBC parameter in NPC patients.
THE RELATIONSHIP BETWEEN THE STAGE OF NASOPHARYNGEAL CARCINOMA WITH ANEMIA AND NUTRITIONAL STATUS IN WEST NUSA TENGGARA GENERAL HOSPITAL Ni Ketut Susilawati; Hamsu Kadriyan; Wayan Putu Sutirtayasa
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3579

Abstract

Introduction: Nasopharyngeal carcinoma is the most common malignant tumor in the ENT-HNS were the highest of all malignant tumors of the head and neck. Malnutrition and cachexia is a common problem in cancer patients and impact on quality of life and survival. Anemia is a major problem in patients with nasopharyngeal cancer receiving chemotherapy or radiotherapy. Objective: Determine the relationship of nasopharyngeal carcinoma stage with anemia and nutritional status. Material and methods: This study used cross sectional analytic method. Data were obtained from medical records of patients with nasopharyngeal carcinoma who were treated in province hospital West Nusa Tenggara period January 2018 to December 2018. Data collected include the identity, diagnosis, hemoglobin value, weight and height. Having analyzed the data collected are looking for is there a relationship between stage nasopharyngeal carcinoma with anemia and nutritional status. Results: In this study, Shapiro-Wilk normality test. Anova is then performed to analyze the relationship stage nasopharyngeal carcinoma with anemia status obtained 95% CI, p value 0.847, there is no difference between stage nasopharyngeal carcinoma with anemia. Kruskal Wallis test to analyze the relationship with BMI (body mass index) with stage nasopharyngeal carcinoma obtained 95% CI, p value 0.565. There is no difference in BMI with stage nasopharyngeal carcinoma. Conclusion: There is a tendency to lower Hb in patients with nasopharyngeal cancer further stage although there is no significant difference between each stage. The same thing was found in BMI, BMI decreased tendency in patients with advanced nasopharyngeal cancer although there was no statistically significant difference.
RESPONSE OUTCOMES OF CONCURRENT CHEMORADIOTHERAPY (CCRT) FOR STAGE III NASOPHARYNGEAL CARCINOMA Feri Danil
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3596

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a rare malignancy with an incidence of 0.5-2 per 100,000 in Europe and the United States [1]. NPC has high prevalence in certain regions of the world, especially in Southeast Asia with a poor prognosis. In Indonesia, the prevalence of NPC is 6.2/100 000, with 13 000 yearly new cases, [2]. NPC is the forth most cancer found in Indonesia. Case Report: This paper reported a case of 39 years old man with nasopharyngeal carcinoma and subsequently underwent concurrent chemoradiotherapy (CCRT). Conclusion: The purpose of this paper is to explain experience at one of the largest single-centre of weekly cisplatin concurrently with radiotherapy with potential to be an optimal therapeutic regiment in the nonsurgical management of squamous cell carcinoma of head and neck (SCCHN) clinical stage III.
EPIDEMIOLOGY STUDY OF NPC PATIENTS IN BANGLI HOSPITAL AT 2015-2017 Yully Prapyatiningsih
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3632

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a malignancy of the nasopharyngeal epithelium. Nasopharyngeal carcinoma is the five positions among other malignancies. Objective: To determine the distribution of patients with nasopharyngeal cancer (NPC) in department of ENT Bangli hospital, the period during January 2015-December 2017. Material and methods: This descriptive study by collecting data from the medical record of NPC patients who come to the outpatient's clinic ENT Bangli hospital and data from the Department of Pathologic Anatomy at Bangli hospital. Results: The distribution patients with NPC was conducted from January 2015 until December 2017 there were 169 people. This research obtained the highest patients with NPC in 2016 as 67 cases. NPC based on sex in 2015 is males as 27 cases (58.70%), in 2016 is males as 43 cases (64.18%) and 2017 is males as 36 cases (64.29%). NPC based on age group is 41-50 years that in 2015 as 16 cases (34.70%), in 2016 as 27 cases (40.30%) and by age group 51-60 years in 2017 as 23 cases (41.07%). NPC patients based on stage most in stage III in 2015 as 18 cases (39.13%), in 2016 as 24 cases (35.82%) and in 2017 as 16 cases (28.57 %). NPC patients based on sex was found in stage III were males in 2015 as 14 cases, in 2016 as 16 cases and 2017 as 12 cases. NPC patients based on histopathology result at most on the WHO-3 classification, in 2015 as 44 (95.65%), in 2016 as 62 cases (92.54%) and in 2017 as 53 cases (94.64%). Conclusion: Distribution of patients with NPC in Bangli hospital from January 2015 until the highest December 2017 were 169 people. This research obtained the highest population of NPC in 2016 as 67 cases. NPC based on sex in 2016 is male as 64.18%. NPC most found by age group in 41-50 years in 2016 as 40.30%. NPC based on stage most found in stage III, in 2016 as 35.82%. NPC based on sex most found in stage III in 2016 as 16 cases. NPC based on histopathology result is WHO-3 in 2016 as 92.54%.
MISDIAGNOSED OF NASOPHARYNGEAL CARCINOMA Martina Marthatilova; Nani Iriani Djufri
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3667

Abstract

Introduction : Nasopharyngeal carcinoma is the most common head and neck malignancy in Indonesia. Diagnosis errors often occur in nasopharyngeal carcinoma due to non-specific symptoms such as symptoms of an infectious disease that resemble the symptoms of nasopharyngeal carcinoma. Case Report : In this case, it was explained how this diagnostic error occurred. A man, 39 years old with complaints of right and left neck lumps, the patient initially came to an ear nose throat (ENT) specialist and performed fine needle aspiration (FNA) and suggested a biopsy. But the patient did not continue his treatment at an ENT doctor. The patient continued his treatment at pulmonologist and was diagnosed with glandular Tuberculosis (TB) and received TB treatment. In the following 4th month on TB therapy, a lump in the right and left neck was felt getting bigger, then the pulmonary expert refers the patient to the oncology surgeon, the oncology surgeon department then refers to the ENT specialist because of the suspicion towards nasopharyngeal carcinoma. In the ENT department biopsy is performed on the nasopharynx and the result is bilateral nasopharyngeal Non-Keratinizing Cell Carcinoma, undifferentiated (WHO type III). Conclusion: The patient was diagnosed with stage IV B nasopharyngeal carcinoma (T1N3M0). Currently, the patient has undergone chemotherapy with the paclitaxel and cisplatin regimen, and the 3rd cycle chemotherapy has been done.

Page 4 of 10 | Total Record : 94

 2   3   4   5   6 

Filter by Year

2019 2021


Reset
Filter By Issues
All Issue Vol. 3 No. 02 (2021): International Journal of Nasopharyngeal Carcinoma Vol. 3 No. 01 (2021): International Journal of Nasopharyngeal Carcinoma Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma Vol. 2 No. 03 (2020): International Journal of Nasopharyngeal Carcinoma Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma Vol. 1 No. 02 (2019): International Journal of Nasopharyngeal Carcinoma Vol. 1 No. 01 (2019): International Journal of Nasopharyngeal Carcinoma