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Andalas obstetrics and gynecology journal
Published by Universitas Andalas
ISSN : 25798324     EISSN : 25798413     DOI : https://doi.org/10.25077/aogj
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health
Andalas Obstetrics And Gynecology Journal (AOJ) (e-ISSN: 2579-8324) is a peer-reviewed, open-access national journal published by Universitas Andalas and is dedicated to publish and disseminate research articles, literature reviews, and case reports, in the field of obstetrics, gynecology, and other related disciplines.
Arjuna Subject : Kedokteran - Obstetrics and Gynaecology
Articles 469 Documents
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Efficacy of EMCO Therapy on Serum β-hCG Levels in Case of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang 2019-2021 Attahhal Fikrian Syadiq Siregar; Syamel Muhammad; Elly Usman
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.754-762.2024

Abstract

Backgrounds: Etoposide, Methotrexate, Cyclophosphamide, and Vincristine (EMCO) Chemotherapy is used as an alternative therapy for patients with a diagnosis of Gestational Trophoblastic Neoplasm (GTN) at Dr. M. Djamil Hospital Padang because Actinomycin D has not been included in the National Formulation (FORNAS). Purpose: To determine the efficacy of EMCO therapy with limited Actinomycin D on serum β-hCG levels in Gestational Trophoblastic Neoplasm (GTN) cases at Dr. M. Djamil Padang Hospital in 2019-2021. Methods: The type of research used is numerical comparative analytics with a cross sectional approach. The number of samples was 17 GTN patients who had done EMCO chemotherapy and checked β-hCG levels before and after chemotherapy. The research was conducted from April to October 2022 at Dr. M. Djamil Hospital Padang. Data processing using total sampling technique and tested using Wilcoxon Test. Results: Most GTN patients were found to be <40 years old (64,7%), history of molar hydatidiform pregnancy (47,1%), last pregnancy interval <4 months (58,8%), β-hCG level before chemotherapy ranged from 104-105 mIU/mL (52,9%), tumor size >5 cm (58,8%), metastasis location in the internal genital tract (35,5%), and patients who did not have metastasis (52,9%). Conclusion: There was a significant decrease in β-hCG levels after chemotherapy using EMCO for three cycles in patients with a diagnosis of GTN.
PLACE OF FIRST TRIMESTER ULTRASOUND AT THE UNIVERSITY TEACHING HOSPITAL OF BOGODOGO (UTH-B) IN BURKINA FASO Adama Ouattara
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.610-619.2024

Abstract

AbstractObjective: To describe the experience of the UTH-Bogodogo obstetrics and gynecology department in ultrasound determination of fetal sex in the first trimester of pregnancy.Patients and methods: This was a prospective descriptive study conducted over a 30-month period from February 1, 2021 to June 30, 2022 in the gynecological and obstetric ultrasound unit of the UTH-Bogodogo in Ouagadougou. The study sample consisted of 311 fetuses. The sample included all pregnant women who came for an obstetrical ultrasound scan in a non-emergency situation, whose gestational age was between the 11th and 14th week of amenorrhea, and who expressed a wish to know the fetal sex. The methods described by Mazza and Efrat were used to determine fetal sex. Patients were followed until delivery, after clinical verification of the sex of their newborns. Data were collected using an individual data collection form. Participation in the study was conditional on patients signing an informed consent form.Results: Fetal sex determination was possible in 280 of 311 fetuses, for a feasibility rate of 89.7%. In the remaining 31 cases, it was not possible to determine the fetal sex, as the position of the fetus did not allow a clear view of the genital bud. In terms of reliability, of the 238 fetuses monitored, fetal sex determination was correct in 204 fetuses, for a success rate of 85.7%. Accuracy was better when sex determination was performed after 12 weeks of amenorrhea. There was no significant difference in measurements between single and multiple fetuses.Conclusion: ultrasound determination of fetal sex at first birth could be an effective, simple, available and inexpensive option in developing countries.
From Molar Pregnancy, Thyrotoxicosis, to Pulmonary Hypertension: A Case Report Rudi Saputra; Dieni Azra; Fidya Mayastri Aswad; Setyawan Nurtanio
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.660-666.2024

Abstract

Background: Molar pregnancy is a benign condition with the dominant symptom being dark brown to bright red bleeding from the vagina. This disease can induce hyperthyroidism and result in pulmonary hypertension. This case report describes a patient who had molar pregnancy with thyrotoxicosis and pulmonary hypertension.Case: A 30-year-old woman presented with complaints of lower abdominal pain for the last month. The patient feels that her stomach has enlarged in the last 3 months. Other complaints include bleeding and observed bubbles from the birth canal, shortness of breath, and chest pain. The serum cobas β-hCG level of 7954.00 mIU/mL. On abdominal ultrasound examination, vesicles formed a honeycomb appearance, measuring 7.4 cm×5.3 cm. Hematologic laboratory tests revealed low TSH levels (<0.01 μIU/mL), T3 levels of 2.35 ng/ml, and FT4 levels of 2.62 ng/dL. The results of the echocardiography examination showed there is a high probability of pulmonary hypertension.Conclusion: Molar pregnancy can exacerbate thyrotoxicosis through hCG activity. Smoking and breastfeeding also have similar effects. Consequently, increased thyroid hormone levels can worsen or cause pulmonary hypertension.
THE ROLE OF MAGNESIUM SUPPLEMENTS ON HYPERTENSION IN PREGNANCY AND PREECLAMPSIA Raissa Nurwany; Shafira Fitri Ramadhina; Pariyana Pariyana
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.517-524.2024

Abstract

Objective:This article aims to discuss the effects of magnesium supplementation on clinicaloutcomes of pregnancy and highlights the benefits of magnesium supplementation in reducing therisk of hypertension in pregnancy and preeclampsia. Method: In this systematic review article, theauthor conducted a literature search using certain keywords and selected articles that were publishedfrom 2013-2023, can be accessed in full-text in pdf format, and are in Indonesian or English. Themethods used were in accordance with the reporting guidelines provided in the Preferred ReportingItems for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Results: After carefullysearching the database and eliminating articles that were not related to the topic, 6 articles wereobtained for review. Hypertension in pregnancy and preeclampsia are serious health problems thatcan harm both mother and baby. Magnesium supplements have been studied as a way to reduce therisk of hypertension in pregnancy and preeclampsia. Conclusion: Magnesium supplements may helpreduce the risk of hypertension in pregnancy and preeclampsia.
LONG-TERM RISKS OF EARLY INITIATION OF BREASTFEEDING TO MOTHERS AND INFANTS IN ASIA: A SYSTEMATIC REVIEW Raisa Nurwany; Syifa Alkaf; Ajay Varmaa Jeyaseelan
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.508-516.2024

Abstract

Objective: This systematic review aims to determine the long-term risks of early initiation of breastfeeding in mothers and babies in Asia. Method: The method used in writing this literature review is systematization using keywords, namely "Early Initiation of Breastfeeding", "Breastfeeding", "ASI", "Asia", "Risk", "Baby and Mother", "Long Term Risk" , and "Benefits".A literature search was conducted using Google Scholar, Pubmed and NCBI databases. Results: From the results of a literature search based on keywords, 25 journals were obtained, of which seven journals met the criteria for long-term risk of IMD for mothers and babies in Asia. One study in this study used a systematic review, five studies used a retrospective cohort study, and one study used a cross-sectional study. The study found many positive risks and benefits of early initiation of breastfeeding for mothers and babies in the long term in Asia. Conclusion: Positive risks for babies include increasing immunity, reducing the risk of death, and preventing obesity. Meanwhile, long-term risks for mothers include accelerating uterine involution, preventing breast cancer, and reducing the risk of diabetes and prediabetes in mothers who have experienced gestational diabetes.
DIFFERENCES OF FIBRONECTIN LEVELS IN FIRST TRIMESTER NORMAL PREGNANCY AND MISCARRIAGE Maisarah Fadhilah; Bobby Indra Utama; Tofrizal Tofrizal
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.647-652.2024

Abstract

Introduction: Miscarriage is a reflection of the low quality of health in pregnant women. The incidence of miscarriage in the world accounts for 23 million (15%) of the 130 million births per year and up to 80% of miscarriages occur in the first trimester of pregnancy. Miscarriage will affect a woman's social, physical, and psychological. The complexity of the negative impact of miscarriage makes it necessary to pay special attention. Biomarker examination is needed to more accurately identify pregnancies at risk of miscarriage before the appearance of clinical symptoms. The use of fetal fibronectin (fFN) levels have been used as a marker of unexpected labor and as evidence of premature rupture of the fetal membranes. Normally fFN can be detected in cervical and vaginal secretions at <20 weeks gestation. The presence of fFN at >22 weeks gestation indicates disruption of the uteroplacental surface. Therefore, if screening for fibronectin levels using the Enzyme-Linked Immunosorbent Assay (ELISA) test can be carried out in the first trimester of pregnancy, there is a high possibility that miscarriage can be prevented.Method: The type of research is analytical observational research with a cross-sectional research design. The stored samples were examined for fibronectin levels using the ELISA test, which included 21 blood serum samples from normal pregnancy patients in the first trimester and 21 miscarriage samples.Results: The results of the ELISA test produced an average first-trimester normal pregnancy fibronectin level of 118.8 ± 18.4 ng/mL while the miscarriage fibronectin level was 208.2 ± 152.0 ng/mL. Data analysis using the Mann-Whitney test obtained a p-value = 0.138, which means there was no significant difference in fibronectin levels between normal pregnancy in the first trimester and miscarriage.Conclusion: This study concludes that fibronectin levels are not specific biomarkers in detecting miscarriage in the first trimester of pregnancy.
Description of Post Anesthetic Shivering (PAS) in Post Spinal Anesthesia Caesarean Section Tuffahati Naura Rafifa; Rinal Effendi; Aladin
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.763-774.2024

Abstract

Background: Post anaesthetic shivering (PAS) is a fasciculation of the face, jaw, or head or the occurrence of muscle hyperactivity so that the body can produce heat after anesthesia. Multiple factors can influence the incidence of PAS including age, sex, ASA physical status, body mass index, type of anesthesia, duration of surgery, room temperature, preoperative body temperature (<36,5⁰C), and type of surgery.  Objective : The purpose of this study was to describe the incidence of PAS in post-spinal anesthesia caesarean section patients at RSIA Siti Hawa Padang Method: This research is a descriptive observational study using accidental sampling technique and obtained a total sample of 52 patients Result: The result showed that 25 of 52 patients (48,1%) experienced PAS. Most PAS events were experienced by moderate grade (25%), the age group >35 years (60%), underweight body mass index (62,5%), ASA II status (52,2%), preoperative temperature in the hypothermia group (51,4%), postoperative temperature in the normothermia group (66,7%), and operation duration >30 minutes (57,1%) Conclusion: Most of the patients did not experience PAS and most of PAS experience was moderate grade.
MANAGEMENT OF HYPERPROLACTINEMIA CAUSED PITUITARY MICROADENOMA Ibnu Muttaqin; Haviz Yuad
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.502-507.2024

Abstract

Hyperprolactinemia is an increase in fasting levels of the hormone prolactin above 20 ng/ml in menand above 25 ng/ml in women. Hyperprolactinemia occurs more often in women of reproductive age,with a percentage of 9 – 17%. The etiology of hyperprolactinemia can occur due to abnormal pituitarysecretions, systemic disease, use of drugs, damage to the hypothalamus-pituitary axis. A 33-year oldfemale patient came to the FER Polyclinic at M. Djamil Hospital with complaints of not menstruatingfor the past 2 months. Irregular menstruation since 15 years ago, menstruation 2-3 times in 6 months,irregular cycle for 7-8 days. The patient also complained of a fluid like breast milk coming out of thebreast for 5 years, initially the fluid came out in a trickle and then gradually reduced and now the fluidcomes out occasionally if the breast is squeezed. From the supporting examinations carried out, it wasfound that the prolactin hormone level in this patient was 134.53, and the results of the MRIexamination showed a mass measuring 1.05x1.12x0.5 mm, which was diagnosed as secondaryamenorrhea, hyperprolactinemia, and suspected pituitary microadenoma. The patient will bemonitored for general condition and vital signs, as well as consultations with colleagues involved, suchas consultations to the Internal Medicine section, Endocrinology, Metabolic and Diabetes Subdivision.
PERITONEAL TUBERCULOSIS IN YOUNG AGE LADY MIMICKING GYNECOLOGY MALIGNANCY : A CASE REPORT Lusi Jelita Sari; Puja Agung Antonius; Syamel Muhammad
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.653-659.2024

Abstract

Background : Peritoneal tuberculosis is one of the most challenging forms of extrapulmonarytuberculosis to diagnose. Extrapulmonary TB is very difficult to diagnose because of its non-specific signs and symptoms, thus it sometimes leads to a diagnosis of gynaecologicalmalignancy such as advanced ovarian carcinoma.Case Report : A teenage girl, 12 years old, with a chief complaint of intermittent abdominalpain since the last 1 month. There was no history of an enlarged abdomen, fever and weightloss. Ultrasound examination revealed an irregular adnexal mass suggesting an ovarianmalignancy with other possibilities of an infectious process. Diagnostic laparoscopy andperitoneal biopsy were performed on the patient. Intraoperatively, multiple friable nodular-mylar peritoneal masses with abdominopelvic attachments and fibrin fibres and white vesicleswere found on the entire surface of the genitalia, peritoneum, and intestines. A mass biopsywas performed with histopathological results showing peritoneal tuberculosis. Currently, thepatient is undergoing anti-tuberculosis drugs (OAT) treatment.Discussion : The diagnosis of this disease is difficult to establish. Symptoms are highlyvariable and non-specific and can lead to the wrong tumour pathology. The clinicalcharacteristics are dominated by changes in general condition, abdominal pain and transitdisorders, as well as masses (20 to 25%). The gold standard for definitive PTB diagnosisremains laparoscopy with peritoneal biopsy and subsequent pathological or microbiologicalconfirmation. Yellow/white nodules in the peritoneum observed on the patient's laparoscopicimages are the hallmark of wet peritoneal TB. Omental thickening and abdominal cocoon withmatted small bowel are other classic laparoscopic findings for peritoneal TB.Conclusion : PTB has similar characteristics to peritoneal carcinoma, which makes diagnosisdifficult for clinicians. Early and correct diagnosis of PTB helps to initiate medical managementquickly and helps reduce morbidity and mortality.
PAPP-A Levels and IGF-1 Levels in Early-Onset Preeclampsia and Late-Onset Preeclampsia Juan Habli Soufal; Yusrawati Yusrawati; Vaulinne Basyir
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.525-530.2024

Abstract

Introduction: The pathophysiology of preeclampsy is not yet fully understood, but failure of tropoblastinvasion and placentation, which is influenced by factors such as pregnancy-associated plasma proteinA (PAPP-A) and insulin-like growth factor 1 (IGF-1), is thought to play a role.Aims: This study aimed to explore the difference in PAPP-A and IGF-1 levels between Early OnsetPreeclampsia (PEAD) and Late Onset Preeclampsia (PEAL) assuming that the role of PAPP-A andIGF-1 is more significant in the pathogenesis of PEAD than PEAL.Methods: This is an analytical observational study with a cross-partition comparative study design.Clinical data were obtained at Dr. M. Djamil Padang Hospital, while PAPP-A and IGF-1 levels weremeasured at the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Samples aretested according to reagent procedures and analyzed by experts.Results: Average PAPP-A levels were 2.45+0.35 pg/mL in the early onset preeclampsy group and2.85+0.50 pg/mL in the late onset preeclampsy group. These two levels differed statisticallysignificantly (p=0.006). That means that low levels of PAPP-A are associated with and play a role inthe pathogenesis of early onset preeclampsy. Average IGF-1 levels were 4.66+0.91 pg/mL in the earlyonset preeclampsy group and 5.39+0.74 pg/mL in the late-onset preeclampsy group. These two levelsdiffered statistically significantly (p=0.010). That means that low levels of IGF-1 are associated withand play a role in the pathogenesis of early onset preeclampsy. PAPP-A levels were significantlypositively correlated with IGF-1 levels (p=0.000).Conclusion: PAPP-A levels are lower in PEAD than PEAL, as are IGF-1 levels. These findings confirmthe role of PAPP-A and IGF-1 in preeclampsia. Both of these hormones have potential as indicatorsand markers for the prediction and management of preeclampsy in early and late onset periods.

Page 19 of 47 | Total Record : 469

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