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Maulana Yusuf Alkandahri
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pharmaxplore@ubpkarawang.ac.id
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+6282167757738
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pharmaxplore@ubpkarawang.ac.id
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Jl. H.S. Ronggowaluyo Telukjambe Timur, Karawang 41361, Jawa Barat
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INDONESIA
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Published by Universitas Buana Perjuangan Karawang
ISSN : 25275801     EISSN : 25809601     DOI : https://doi.org/10.36805/farmasi
Core Subject : Health,
Medicine & Pharmacology
Biologi Farmasi, Farmakoekonomi, Farmakologi dan Toksikologi, Farmasetika dan Teknologi Farmasi. Farmasi Klinik, Farmasi Sosial, Kimia Farmasi
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 8 Documents
 1 
Search results for , issue "Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi" : 8 Documents clear
PERBEDAAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN ALPUKAT (Perseae Americanae Mill.) BERDASARKAN PERBEDAAN KETINGGIAN TEMPAT TUMBUH Dyah Anggun; Neni Sri Gunarti; Lia Fikayuniar
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2892

Abstract

Avocado leaves are a source of flavonoid active compounds, quercetin, and polyphenols that function as antioxidants. Flavonoids are secondary metabolites consisting of a group of polyphenolic compounds that have a pyron structure. Antioxidants are needed as an antidote to free radicals, antioxidants are needed by the body to neutralize free radicals and also to prevent damage caused by free radicals. This research was conducted using a pre-experimental method with a one-shot case study design using avocado leaf sampels growing in Blitar village and Tulungagung village. Determination of antioxidant activity testing was carried out using the DPPH method which was measured using a Uv-Vis spectrophotometer. The results of the extracts and the results of antioxidant activity obtained by the ethanol extract of avocado leaves in Blitar village with IC₅₀ value of 114.0851 ppm and Tulungagung village with IC₅₀ value of 99.2852 ppm. Blitar avocado leaf ethanol extract has an IC value of 114.0851 ppm and Tulungagung avocado leaf ethanol extract has an IC value of 99.2852 ppm. And it can be concluded that the ethanol extract of avocado leaves (Tulungagung) in the highlands has a stronger antioxidant activity than the ethanolic extract of avocado leaves (Blitar) in the lowlands.
ANALISIS KADAR RHODAMIN B PADA LIPTINT YANG BEREDAR DI PASAR SEGIRI KOTA SAMARINDA DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Hiasinta Meliana Hangin; Susana Linden; Nurillahi Febria Leswana
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2903

Abstract

Liptint is one type of cosmetic lip color that is often used by women. The use of rhodamine B as a cosmetic coloring agent is prohibited by BPOM because Rhodamine B can be carcinogenic and spur the growth of cancer cells if used continuously. The purpose of this study was to determine the presence or absence of harmful substances Rhodamine B in Liptint circulating in the market Segiri Samarinda. Liptint samples were studied as many as 10 samples. Qualitative test of rhodamine B by thin layer chromatography observed under UV lamp light 254 nm. Based on the qualitative test results, samples that tested positive for Rhodamine B were samples A, B, C, E, G, H, I, and J. sample A, B have Rf value (0,907), sample G, I and J (0,802), sample C (0,789), sample H (0,828) and sample E (0,921) and raw Rf Rhodamin B (0,921) with pink spots when viewed vusual and orange spots stain when placed under UV light 254 nm. Quantitative test results from 10 samples, 9 samples tested positive for rhodamine B, namely samples A , B, C, E, F, G, H, I and J with an average content of 0,02%-0,5% w/w.
EVALUASI TINGKAT KEPUASAN PASIEN DIABETES MELITUS TERHADAP PELAYANAN INFORMASI OBAT DI PUSKESMAS KARAWANG Maya Arfania; Seputri Nonifili Daeli; Yuliana Latifah
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2918

Abstract

Drug information service is one part of pharmaceutical services. Providing accurate and complete drug information can support the provision of good health services to the community because it can increase the efficacy and safety of drug use. The purpose of this study was to determine the level of patient satisfaction with drug information services at the Karawang District Health Center. This study is a descriptive study with a cross sectional design, to describe the level of patient satisfaction with DM drug information services at the Karawang Health Center. The number of samples was 176 patients. The results of this study, most of the patients were very satisfied with the drug information services provided by pharmacy officers at the Puskesmas.
STUDI IN SILICO SENYAWA TUMBUHAN FAMILI ASTERACEAE SEBAGAI PENGHAMBAT ENZIM XANTIN OXIDASE Oky Hermansyah; Fadila Jeni Salsabila; Reza Pertiwi; Riana Versita; Ikhsan Ikhsan
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2942

Abstract

Asteraceae family plants contain flavonoid and phenolic compounds which have many benefits including inhibiting the xanthine oxidase enzyme, this enzyme plays a role in the conversion of purines into uric acid. Excessive production of uric acid in the body can cause deposition in the joints which causes pain and stiffness and swelling of the joints. Inhibition of this enzyme can normalize the amount of uric acid in the body and reduce its effects. This study aims to determine the potential of Asteraceae family plants with the best inhibition of the xanthine oxidase enzyme using the in silico method with molecular docking. The potential of the compound was assessed based on the parameters of bond energy values, inhibition constants, hydrogen bonds and amino acid residues. The size of the molecular docking center in this study x= 95,226; y= 47,251; z = 112,78 with volume x, y, and z = 40. The simulation results show that the test compound that has the best bond energy value (ΔG) is myrisetin of -10.58 kCal/mol. In general, from the research results, myrisetin compounds contained in the asteraceae family of chrysanthemum plants are compounds that have the potential to be further tested in vitro or in vivo as inhibitors of the xanthine oxidase enzyme.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SALEP EKSTRAK ETIL ASETAT BATANG KECOMBRANG (Etlingera elatior (Jack) R.M.Sm.) TERHADAP BAKTERI Pseudomonas aeruginosa Linda Nur Azizah; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2946

Abstract

Kecombrang stems contain flavonoid compounds, alkaloids, saponins and tannins that have the potential to inhibit bacterial growth. This study aims to determine the physical properties, stability and antibacterial activity of the ethyl acetate extract of kecombrang stem ointment.This type of research is an experimental laboratory. Extraction using maceration method with ethyl acetate solvent. The concentrations of the extracts used were F1 (10%), F2 (15%) and F3 (20%). Testing of physical properties seen from organoleptic, homogeneity, pH, adhesion and spreadability. The results were analyzed by One Way Anova and there were significant differences in the pH value, adhesion and dispersion. Formulas 1, 2 and 3 can inhibit Pseudomonas aeruginosa bacteria with an average inhibition zone of (F1) 8.02 mm, (F2) 9.34 mm and (F3) 11.00 mm. Based on this research, it can be concluded that F3 is the best formula with a strong inhibition zone, while F1 and F2 have moderate inhibition.
FORMULASI SEDIAAN SALEP ANTIJERAWAT EKSTRAK ETANOL DAUN TEH HIJAU (Camellia sinensis (L.) (Kuntze) DENGAN KOMBINASI BASIS PEG 400 DAN PEG 4000 TERHADAP BAKTERI Propionibacterium acnes Dewi Rahmawati; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2947

Abstract

Ointment is semisolid preparations used by topical. Leaf tea green contain beneficial flavonoid compounds, tannins and catechins as antibacterial. On research this extract leaf tea green made preparation ointment using a watersoluble base i.e combination of PEG 4000 and PEG 400 with comparison (2:3) on formula 1, (1:1) on formula 2 and (3:2) on formula 3. Research this aim for see nature physique preparation ointment as well as power resistor to bacteria Propionibacterium acnes. Test results nature physique from the three formulas include color, odor, shape, homogeneity, pH have good result during the storage period, while power spread and power sticky have less result good. The results of the One Way ANOVA analysis show that existence significant difference in the value of power spread and power sticky. The results of the paired test t test analysis show existence influence During storage to pH and power spread ointment. Test antibacterial conducted use method well. Antibacterial test results show the three formulas have zones of inhibition categorized strong.
FORMULASI SEDIAAN SALEP DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA ARAB (Ziziphus spina-christi (L.) Desf) TERHADAP BAKTERI Staphylococcus Epidermidis alviony trista hapsari; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2952

Abstract

Ointment is a semi-solid preparation that is used topically. Arabic bidara leaves contain secondary metabolites in the form of saponins, tannins, alkaloids, polyphenols and flavonoids which can inhibit the antibacterial growth of Staphylococcus epidermidis so that it can be made in ointment preparations. The purpose of thi study was to determine the physical properties and zone of inhibition of the formulation of the ethanol extract of bidara arabic leaf ointment. Extraction using remaceration method with 70% ethanol solvent was formulated using a water-soluble ointment base in the from of PEG 400 and PEG 4000. Made in 3 variations of extract concentration 40%, 50%, 60%. Furthermore, the evaluation of the preparation include: organoleptic test, homogeneity, pH, disperbility, adhesion. The results of the One Way ANOVA analysis showed that there werw differences in the pH test, dispersion and adhesion with a p-value of <0,05 the homogeneity test showed differences during storage for 6 cycles, while the organoleptic test was in a stable state during storage. The results obtained showed that the preparation of bidara arabic leaf extract ointment was able to inhibit the growth of Staphylococcus Epidermidis bacteria, namely the FI of 9.16±0.76 mm, FII of 8.56±1.01 mm and FIII of 10.08±0.10 mm is included in the medium category.
PENGARUH KOMBINASI BASIS PEG 400 DAN PEG 4000 PADA PEMBUATAN SEDIAAN SALEP EKSTRAK ETANOL BIJI MAHONI (Swietenia mahagoni (L). Jacq SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acne Umi Hanifatun Nikmah; Galih Samodra
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 7 No 2 (2022): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v7i2.2955

Abstract

Ointment preparations are semisolid preparations intended for topical use. Mahogany seeds (Swietenia mahagoni (L) Jacq) contain saponin compounds that have antibacterial activity, so they can be made into ointment formulations. This study aims to determine the stability of the physical properties as well as the antibacterial inhibition zone produced from the ointment preparation with the active ingredient of mahogany seed extract (Swietenia mahagoni (L)). Jacq) based on PEG 400 and PEG 4000. Physical properties were tested for 6 cycles of storage at a temperature of 5 C and at a temperature of 45 C, seen from the organoleptic, homogeneity, pH, spreadability, adhesion and viscosity. The results were analyzed using One ­Way ANOVA and paired t -test. The results of the One_ Way ANOVA test showed a significant difference <0.05 in the adhesion, spreadability and viscosity tests. The results of the paired t_test analysis showed that there was an effect of storage on the pH test with a value of <0.05, while the organoleptic test, homogeneity, viscosity, spreadability and adhesiveness had no effect during storage. Antibacterial tests on different formulas showed antibacterial activity on Propionibacterium acne. Before stability had an average inhibition zone at F1 (60%:40%) 12.76 mm, F2 (50%:50%) 10.58 mm and F3 (40%:60%) 8.74 mm, while after stability at F1 (60%:40%) 14.20 mm F2 (50%:50%) 12.44 mm, and F3 (40%:60%) 8.90 mm.

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