IJOEP : International Journal of Ecophysiology
International Journal of Ecophysiology (IJOEP) is a peer-reviewed biannual journal (February and July) published by TALENTA Publisher and organized by Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara (USU) as an open-access journal. It welcomes full research articles in the field of Biological Sciences from the following subject area: Anatomy, Comparative anatomy, Histology, Astrobiology, Biochemistry, Biological engineering, Biogeography, Bioinformatics, Biolinguistics, Biomechanics, Biomedical research, Biophysics, Biotechnology, Synthetic biology, Botany, Phycology, Plant physiology, Cell biology, Chronobiology, Cognitive biology, Conservation biology, Cryobiology, Developmental biology, Embryology, Gerontology, Ecology, Evolutionary biology, Genetics, Genomics, Epigenetics, Immunology, Marine biology, Microbiology, Bacteriology, Mycology, Parasitology, Virology, Molecular biology, Nanobiology, Neuroscience, Paleontology, Pathobiology, Pharmacology, Physiology, Phytopathology, Psychobiology, Quantum biology, Systems biology, Structural biology, Theoretical biology, Zoology, Ethology, Entomology, Herpetology, Ichthyology, Mammalogy, and Ornithology. Each publication will contain 10 (ten) manuscripts.
Articles
114 Documents
<![CDATA[Antibiotic Use in Acne vulgaris: Pharmacological Perspectives and Emerging Resistance - A Brief Review ]]>
<![CDATA[Pane, Yunita Sari]]>;
<![CDATA[Hasanah, Nur]]>
<![CDATA[ International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology ]]>
Publisher : <![CDATA[Talenta Publisher ]]>
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DOI: 10.32734/ijoep.v7i2.21003
<![CDATA[Background: Acne vulgaris (AV) is a chronic inflammatory skin condition that frequently affects adolescents and young adults. It is characterized by comedones, papules, pustules, and nodules. The primary etiological factors include hyperkeratinization, excessive sebum production, colonization of Cutibacterium acnes (C. acnes), and an inflammatory immune response. Objective: This review discusses the pharmacological aspects and challenges associated with the use of antibiotics in AV treatment, particularly in the context of rising antibiotics resistance. Methods: This mini-review was conducted using data collected from online academic databases, including Google Scholar, ScienceDirect, and PubMed. From an initial pool of 60 articles related to AV treatment,antibiotic mechanism, and resistance patterns, 31 publications (1999 – 2024) were selected based on relevance and quality. Results: The pathophysiology of AV is multifactorial, involving sebaceous hyperactivity, follicular hyperkeratinization, microbial colonization, and immune-mediated inflammation. Topical drugs (e.q., tetracyclines) remain central in AV management. However, increased antibiotic resistance, especially by C. acnes has compromised their efficacy. Combining antibiotics with agents like benzoyl peroxide (BPO) or topical retinoids may help mitigate resistance. Alternative treatments, including isotretinoin, hormonal therapies, and physical modalities, provide additional therapeutic options. Conclusion: Antibiotic use in AV treatment requires careful pharmacological consideration, balancing efficacy, safety, cost, and resistance risk. To preserve long-term effectiveness, antibiotics should be combined with non-antibiotic agents and used for limited durations. Tailoring treatment based on disease severity, location, and patient preference is essential for optimal outcomes.]]>
<![CDATA[Modulation of Dilp2 and Dilp5 Gene Expression by Pirdot Leaf Extract (Saurauia vulcani Korth.) in Drosophila melanogaster Hyperglycemia Model: A Literature Review ]]>
<![CDATA[Simamora, Rizka Amini]]>;
<![CDATA[Widjaja, Sry Suryani]]>;
<![CDATA[Rusdiana]]>
<![CDATA[ International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology ]]>
Publisher : <![CDATA[Talenta Publisher ]]>
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DOI: 10.32734/ijoep.v7i2.22255
<![CDATA[Hyperglycemia is a pathological condition caused by impaired glucose metabolism that contributes significantly to the development of diabetes mellitus. The use of medicinal plants such as pirdot leaves (Saurauia vulcani Korth.) as an alternative therapy has become a focus due to their bioactive compounds with antihyperglycemic properties. This article presents a literature review on the potential of pirdot leaf ethanol extract in modulating the expression of Dilp2 and Dilp5 genes in the Drosophila melanogaster hyperglycemia model. Drosophila melanogaster was chosen as a model organism because it has insulin signaling pathways homologous to humans and produces insulin-like peptides (DILPs), including Dilp2 and Dilp5, which play a crucial role in glucose regulation and energy metabolism. A high-sugar diet in this organism has been shown to disrupt glucose homeostasis and affect the expression of Dilp2 and Dilp5 genes. Pirdot leaf extract has been shown in vivo in mouse models to lower blood glucose levels and exhibit regenerative activity toward pancreatic cells. Although no direct studies have been conducted on the effects of pirdot extract on gene expression in Drosophila, previous studies indicate that plant compounds can influence metabolic pathways at the molecular level. Therefore, further research using Drosophila melanogaster is important to evaluate the potential of pirdot extract in gene expression-based hyperglycemia therapy.]]>
<![CDATA[Potential of Pirdot Leaf (Saurauia vulcani Korth.) as Immunomodulator: JAK-STAT Pathway and Turandot A Gene Expression in Drosophila melanogaster Hyperglycemia Model ]]>
<![CDATA[Manik, Enisantaria Br]]>
<![CDATA[ International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology ]]>
Publisher : <![CDATA[Talenta Publisher ]]>
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DOI: 10.32734/ijoep.v7i2.22256
<![CDATA[Type 2 diabetes mellitus (T2DM) is a global health issue characterized by chronic hyperglycemia, insulin resistance, immune system dysregulation, and increased mortality rates. Therapeutic approaches based on natural immunomodulators represent a potential strategy for managing this disease. Saurauia vulcani Korth. (pirdot), an endemic plant of Indonesia, is known to contain bioactive compounds such as flavonoids, saponins, and triterpenoids, which exhibit antioxidant, antidiabetic, and immunomodulatory activities. Drosophila melanogaster, which has a high level of genetic homology with humans, is used as a model for insulin resistance through the induction of a high-sugar diet. One of the key genes in the immune response of this organism is Turandot A (TotA), which is expressed in response to stress and regulated by the JAK-STAT signaling pathway.]]>
<![CDATA[Effects of Combined Lemongrass Extract (Cymbopogon citratus) and Physical Exercise on Lipid Profile in Male Wistar Rats (Rattus norvegicus) with Hyperlipidemia Model: A Literatur Review ]]>
<![CDATA[Pratiwi, Lisa Nabila]]>
<![CDATA[ International Journal of Ecophysiology Vol. 7 No. 2 (2025): International Journal of Ecophysiology ]]>
Publisher : <![CDATA[Talenta Publisher ]]>
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DOI: 10.32734/ijoep.v7i2.22808
<![CDATA[Hyperlipidemia remains a significant global health concern as a major risk factor for cardiovascular diseases. This review examines the potential synergistic effects of combining lemongrass (Cymbopogon citratus) leaf extract and physical exercise on improving lipid profiles in hyperlipidemia male Wistar rats. Current evidence suggests that lemongrass extract contains bioactive compounds with antihyperlipidemia properties that can regulate lipid metabolism and exhibit antioxidant effects. Similarly, regular physical exercise improves lipid profiles through various physiological mechanisms. When combined, preliminary studies indicate that lemongrass extract and physical exercise may produce enhanced therapeutic effects in managing hyperlipidemia compared to either intervention alone. The synergistic mechanisms appear to involve improved antioxidant defense systems, enhanced lipid metabolism, reduced lipid peroxidation, and improved insulin sensitivity. This review synthesizes current research findings on this promising combinatorial approach and identifies areas requiring further investigation]]>
