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Majalah Biomorfologi (Biomorphology Journal)
Published by Universitas Airlangga
ISSN : 02158833     EISSN : 27160920     DOI : 10.20473/mbiom.v30i1.2020.1-7
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health
Majalah Biomorfologi publishes articles in the form of original research report, excel-literature review, communication and special case report. The scope of this journal includes Medicine and Health sciences, focusing in basic and applied Anatomy and Histology (i.e., neuroscience, medical and health education, anthropology, clinical genetics, embryology, medical education, clinical anatomy, histotechnics, and photomicroscopy) although other correlated topics are also welcomed.
Arjuna Subject : Kedokteran - Anatomi
Articles 123 Documents
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ANALYSIS OF THE CLINICAL CHARACTERISTICS OF ORBITAL INFLAMMATION PATIENTS AT TERTIARY HOSPITAL IN EAST JAVA, INDONESIA Anggia dewi, Karina; Delfitri Lutfi; Kusuma Eko Purwantari; Indri Wahyuni
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

Background: Orbital inflammation is a benign inflammatory condition affecting the eye socket and can involve the orbital soft tissue, ocular muscles, and optic nerve. The diagnosis of orbital inflammation can be tricky due to the lack of standardized clinical criteria and the potential for overlap with other orbital diseases. Method: This retrospective, observational, and analytical study focused on patients diagnosed with orbital inflammation at The Outpatient Ophthalmology Oncology Clinic. Data from 68 samples that met the inclusion and exclusion criteria were classified and analyzed with descriptive statistics, and the Chi-square test and Odds Ratio (OR) was used to measure the likelihood of two clinical characteristics occurring together, indicating the strength of the relationship between paired symptoms that may commonly appear simultaneously in orbital inflammation. Result: Most patients were female (55.9%) and within the 18-75 age group (97.1%). Orbital inflammation predominantly presented unilaterally (89.7%). The study found that the most frequent clinical characteristics were proptosis, red eyes, decreased vision, and orbital pain. Among all assessed clinical characteristics, proptosis and red eye showed the most significant association, followed by proptosis and dry eye, red eye and eyelid edema, and proptosis and ptosis. Conclusion: Orbital inflammation presents with a wide range of clinical characteristics, reflecting the diverse inflammatory processes that may occur in the orbit. The study identified key clinical characteristics of orbital inflammation, including proptosis, red eyes, decreased vision, and orbital pain. Particularly between proptosis and red eye, followed by proptosis and dry eye, red eye and eyelid edema, and proptosis and ptosis. These clinical features, when found together, support clinicians in recognizing and establishing a diagnosis of orbital inflammation.
Protective Effect of Ethanol Extract of Tamarillo (Solanum Betaceum) on Renal Interleukin 1 Expression in Lead Acetate-Exposed Mice Trimitasari, Kurnia; Yuliawati, Tri Hartini; I'tishom, Reny; Fatimah, Nurmawati
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

Background: The rise in environmental pollution due to industrial and transportation activities has led to widespread lead (Pb) contamination , which enters the body through inhalation or ingestion and accumulates in the kidneys, triggering excessive Reactive Oxygen Species (ROS) production, which in turn causes oxidative stress and inflammatory responses marked by increased IL-1 expression. Tamarillo, a fruit rich in flavonoids, anthocyanins, and phenolic compounds, exhibits antioxidant and anti-inflammatory properties that may protect renal tissue against lead-induced oxidative stress and inflammation. Objective: To analyze the impact of ethanol extract from tamarillo (Solanum betaceum) on interleukin-1 (IL-1) expression in the kidneys of lead acetate-exposed mice (Mus musculus). Material and Method: This true laboratory experimental study used preserved biological material (BBT) from 30 male mice (Mus musculus), categorized into five distinct groups. The negative control group, labeled K0, received only distilled water; the positive control group, K1, was administered lead acetate at 0.075 g/kgBW; while group P1, P2, and P3 were treated with lead acetate alongside Solanum betaceum extract for 35 days at 100, 200, and 400 mg/kgBW, respectively. IL-1 expression was analyzed via immunohistochemistry (IHC) using the Immunoreactive Score (IRS) method focusing on glomerular and tubular epithelial cells. Result: Significant difference in IL-1 expression among groups (p<0.05). The treatment group that received 100 mg/kgBW tamarillo extract had the lowest levels of IL-1 expression in glomerular cells (mean 4.0) and tubular epithelial cells (mean 5.0) compared to the positive control, indicating dose-dependent. Conclusion: Tamarillo (Solanum betaceum) ethanol extract effectively reduces IL-1 expression in glomerular and tubular regions of lead-exposed mice, with the optimal dose at 100 mg/kg BW, demonstrating its potential as a natural anti-inflammatory agent for combating lead-induced renal inflammation.
The Potential of Ethanol Extract of Dutch Eggplant (Solanum betaceum) against caspase-3 Expression in the Kidneys of Mice (Mus musculus) Exposed to Lead Acetate Rifatus Solicha; Rahaju, Anny Setijo; Qorib, Mohammad Fathul; I’tishom, Reny; Arfian, Nur
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

Background: Lead (Pb) exposure remains an environmental health concern due to its toxicity, particularly to the kidneys, where it can cause nephrotoxicity. The accumulation of lead acetate induces oxidative stress through elevated reactive oxygen species (ROS) levels, which subsequently activate the apoptosis pathway characterized by increased caspase-3 expression. Caspase-3 serves as the primary executor enzyme in apoptosis and functions as a key indicator of kidney cell injury. Natural antioxidants, such as the ethanol extract of Dutch eggplant (Solanum betaceum), are rich in flavonoids and can protect kidney tissue by neutralizing free radicals and inhibiting apoptosis. Given these properties, Solanum betaceum has emerged as a candidate for protecting the kidneys against damage caused by heavy metals. Objective: This study investigated whether ethanol-extracted Dutch eggplant could protect the kidneys of mice (Mus musculus) exposed to lead acetate by looking at its effect on caspase-3 expression. The research also examined whether the extract’s protective effect depended on the dose given. Materials and Methods: This experimental research employed a post-test control group design. The authors classified the mice into five groups (K0, K1, P1, P2, and P3). The treatment groups received Dutch eggplant extract at varying doses administered concurrently with lead acetate exposure. Caspase-3 expression was evaluated using immunohistochemistry (IHC) and assessed using an H-score, followed by statistical analysis with SPSS. Results: Lead acetate increased caspase-3 expression compared to the negative control group (K1: 122.00 vs. K0: 71.00). Administration of Dutch eggplant extract reduced caspase-3 expression in a dose-dependent manner. Conclusion: The ethanol extract of Dutch eggplant has demonstrated potential nephroprotective effects against lead acetate-induced kidney damage by reducing caspase-3 expression.

Page 13 of 13 | Total Record : 123

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