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Viskasari P. Kalanjati
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Departemen Anatomi dan Histologi Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia Jl. Prof Dr Moestopo 47 Surabaya 60132 Indonesia
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Majalah Biomorfologi (Biomorphology Journal)
Published by Universitas Airlangga
ISSN : 02158833     EISSN : 27160920     DOI : 10.20473/mbiom.v30i1.2020.1-7
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health
Majalah Biomorfologi publishes articles in the form of original research report, excel-literature review, communication and special case report. The scope of this journal includes Medicine and Health sciences, focusing in basic and applied Anatomy and Histology (i.e., neuroscience, medical and health education, anthropology, clinical genetics, embryology, medical education, clinical anatomy, histotechnics, and photomicroscopy) although other correlated topics are also welcomed.
Arjuna Subject : Kedokteran - Anatomi
Articles 116 Documents
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ESKAPE Pathogens in Hospitalized Patients: A Comprehensive Profiling of Infections and Characteristics at Universitas Airlangga Hospital, Surabaya, Indonesia Dinda Rachma Harlisa; Tri Pudy Asmarawati; Firman Setiawan; Pepy Dwi Endraswari
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.103-112

Abstract

Highlights This study found that ESKAPE pathogenic infections at Universitas Airlangga Hospital were dominated by Gram-negative bacteria, particularly Klebsiella pneumoniae, with sputum as the most commonly collected specimen providing valuable data for infection control strategies. Most patients exhibited significant clinical manifestations involving neurological disorders, with the respiratory system being the most affected information that may enhance the effectiveness of patient management in the hospital.   ABSTRACT Background: Infections pose a significant threat in Indonesia, particularly in healthcare settings where healthcare-associated infections (HAIs) are prevalent. At a hospital in Jakarta, the prevalence of ESKAPE pathogens was reported to be 69.8%. However, detailed data on the infection profiles of these pathogens remain scarce. This underscores the importance of studying ESKAPE pathogenic bacteria to better understand their characteristics. Objective: This study aimed to determine the infection profile of ESKAPE pathogens in hospitalized patients at Universitas Airlangga Hospital, Surabaya, Indonesia in 2022. Material and Method: This descriptive observational study employed a retrospective design using secondary data from non-ICU inpatients at Universitas Airlangga Hospital infected with ESKAPE pathogens in 2022. Total sampling was applied to eligible medical records. Result: The study included 119 specimens from inpatients infected with ESKAPE pathogens that met the inclusion and exclusion criteria. Of these, 78% were Gram-negative bacterial infections, with Klebsiella pneumoniae being the most prevalent (29%). Sputum was the most commonly collected specimen (49%). Most patients were male (57%), aged 56–65 years (29%), and had no comorbidities (46%). Additionally, 63% of patients had used invasive devices during hospitalization. The majority were admitted to low-care inpatient wards. The primary clinical features were neurological complaints (29%) and respiratory disorders (37%), predominantly associated with Klebsiella pneumoniae. Conclusion: ESKAPE infections were primarily caused by Klebsiella pneumoniae, a Gram-negative bacterium, most frequently identified in sputum samples. The predominant clinical manifestations were decreased consciousness and respiratory disorders. Affected patients were mainly male, aged ≥56 years, hospitalized in low-care wards, with a history of invasive device use and no comorbidities.
Investigating the Prospect of C-Type Lectin-like Receptors-2 for Predicting Prognosis of Ischemic Stroke: Rapid Review of Molecular Mechanisms to Clinical Study Farandy, Rayhan; Rakasiwi, Muhammad Ilham Dhiya; Amaanullah, Muhammad Zaki Bariz; Khatimah, Nurul Gusti
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.157-165

Abstract

Highlights The potential of CLEC-2 as a prognostic biomarker for ischemic stroke is supported by in vivo and clinical studies demonstrating its role in thrombo-inflammatory mechanisms and clinical outcome prediction. Analysis of clinical studies indicates that elevated plasma CLEC-2 levels are associated with an increased risk of recurrent vascular events and mortality in acute ischemic stroke, suggesting its promise as a noninvasive tool for stroke prognosis assessment.   ABSTRACT Background: Every year, over 13.7 million individuals experience strokes, resulting in approximately 5.8 million deaths. C-type lectin-like receptor 2 (CLEC-2) plays a significant role in platelet activation, which is elevated in ischemic stroke and is associated with disease progression and prognosis. Objective: To review the literature on the potential of CLEC-2 as a biomarker for assessing the prognosis and progression of ischemic stroke. Material and Method: This rapid review followed the Cochrane interim guidelines and adhered to PRISMA standards. A comprehensive search was conducted in PubMed, Cochrane Library, and Google Scholar to identify original research articles published in English over the past 10 years. Studies at various stages—including in vitro, in vivo, and clinical trials—were included if they evaluated the association between CLEC-2 and acute ischemic stroke. Risk of bias was assessed using the QUIPS tool for clinical studies and SYRCLE’s tool for animal studies. Study selection and data extraction were performed independently by three reviewers. Result: The search identified five relevant articles: two experimental studies and three clinical prognostic studies examining CLEC-2 in the context of ischemic stroke. CLEC-2, a receptor for podoplanin expressed in various tumors and lymphatic endothelial cells, induces a calcium surge independent of secondary platelet activation. In vivo studies have demonstrated increased levels of CLEC-2 and podoplanin, which are highly expressed on neurons and microglia in ischemic brain regions. The three clinical studies showed that plasma CLEC-2 levels have prognostic value in predicting recurrent vascular events and mortality in patients with acute ischemic stroke. Conclusion: Plasma CLEC-2 shows potential as a biomarker for evaluating the progression and prognosis of acute ischemic stroke.
Immunomodulatory Activity of Ganyong Tuber (Canna edulis K.) Extract on Phagocytosis, Leukocytes, and Antibody of Mice against Bacterial Infections Savira, Nadyatul Ilma Indah; Qulbi, Siti Shofa Assyifa; Marditianingsih, Meilia Putri; laili, Mumtahana; Narulita, Erlia; Pramudya, Manikya; Maulana, Alfan Irsyad
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.113-122

Abstract

Highlights Ganyong tuber exhibits immunomodulatory activity against Staphylococcus aureus infection in mice. Ganyong tuber extract increases phagocytic activity, leukocyte count, and spleen weight in infected mice.   ABSTRACT Background:  Ganyong tubers (Canna edulis K.) are widely consumed by Indonesians as an alternative food source. However, no studies have investigated the pharmacological properties of ganyong tubers, particularly their immunomodulatory activity. Objective: This study aimed to evaluate the immunomodulatory effects of ganyong tubers in mice infected with Staphylococcus aureus. Material and Method: This study used a randomized experimental design involving 30 male BALB/c mice divided into five groups, including a normal control, a negative control (infected with Staphylococcus aureus), and three groups treated with ganyong (Canna edulis K.) extract at doses of 50, 100, and 150 mg/kg BW. The extract was administered orally for seven days, followed by S. aureus injection. Phagocytic activity, leukocyte count, spleen weight, and antibody levels were evaluated using microscopy and ELISA. Data were analyzed using one-way ANOVA and Duncan’s post hoc test. Result: This study evaluated the immunomodulatory effects of ganyong tuber (Canna edulis K.) extract on phagocytosis activity and capacity, leukocyte count, spleen weight, and antibody levels in mice infected with Staphylococcus aureus. Phagocytosis activity and capacity were highest in the group receiving 50 mg/kg body weight (BW) extract, with decreasing effects at higher doses. Leukocyte counts were highest in the infected untreated group, while spleen weight was significantly increased in the 50 mg/kg BW treatment group compared to controls. Although the 100 mg/kg BW group showed the highest antibody levels, these differences were not statistically significant. Conclusion: Ganyong tuber extract demonstrated immunomodulatory activity by enhancing innate immune responses against S. aureus infection.
Antibacterial Activity Test of Green Betel Leaf Extract (Piper betle Linn.) against Methicillin-Sensitive Staphylococcus aureus Manaf, Syifa Az Zahrah; Wiqoyah, Nurul; Setiawati, Yuani
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.131-139

Abstract

Highlights Green betel leaf extract, particularly cultivated in Batu City, can inhibit and kill MSSA. Green betel leaf extract, particularly cultivated in Batu City, can be developed into a new alternative treatment as an effective antibiotic to kill MSSA bacteria.   ABSTRACT Background: Asia is one of the regions with the highest prevalence rates of Staphylococcus aureus (S. aureus) infection. Green betel leaves (Piper betle Linn.) have been shown to possess antibacterial potential due to their active compound content. Objective: To investigate whether betel leaf extract affects methicillin-sensitive Staphylococcus aureus (MSSA). Material and Method: This research was a descriptive experimental study focusing on the antibacterial activity test of green betel leaf extract against MSSA. The MSSA bacteria used were bacterial preparations in the Microbiology Laboratory of the Faculty of Medicine, Universitas Airlangga. The green betel leaf extract was obtained in 2023 in Batu City, East Java, Indonesia. The antibacterial activity test technique used was the dilution test. The tool used in data processing was Microsoft Excel. Results: Germs were found in the dilution test, particularly in tubes with concentrations of 50 mg/mL. The study also highlighted that no growth of germs was found based on the results obtained for the increase of MSSA on agar plates at concentrations of 800 mg/mL, 600 mg/mL, 400 mg/mL, and 200 mg/mL. The study also found that the growth of MSSA germs was at 100 mg/mL and 50 mg/mL. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of green betel leaf extract against MSSA were 100 mg/mL and 200 mg/mL, respectively. Conclusion: The extract of green betel leaves, particularly cultivated in Batu City, East Java, Indonesia has been shown to possess antibacterial activity, which can inhibit and kill MSSA bacteria. Further research is needed on the antibacterial activity of green betel leaf extract against other bacterial species.
Front Matter Vol. 35 No. 2 July 2025 Majalah Biomorfologi
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

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Back Matter Vol. 35 No. 2 July 2025 Majalah Biomorfologi
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

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