cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Mohammad Saifur Rohman
Contact Email
hsj@ub.ac.id
Phone
+628973247705
Journal Mail Official
hsj@ub.ac.id
Editorial Address
Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar General Hospital, 3rd Floor CVCU Jl. Jaksa Agung Suprapto No. 2, Malang, Indonesia
Location
Kota malang,
Jawa timur
INDONESIA
Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 325 Documents
 29   30   31   32   33 
The impact of combined decaffeinated green coffee and green tea, metformin, and empagliflozin on SAMD11 mRNA expression in vascular calcification associated with metabolic syndrome in Sprague Dawley rats Taufiq, Fikri; Saifur Rohman, Mohammad; Fuji Rahimah, Anna
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.9

Abstract

Background: Vascular calcification, a common complication of metabolic syndrome, increases cardiovascular risk, and SAMD11 may be implicated in its development. Improving blood glucose with metformin, empagliflozin or a combination of decaffeinated green tea and green coffee may improve metabolic syndrome which may ultimately lead to SAMD11 expression. However, the precise mechanisms by which SAMD11 play a role on vascular calcification in metabolic syndrome remain unknown. Objective: This study investigated the effect of combined decaffeinated green coffee and green tea, metformin and empagliflozin on SAMD11 mRNA expression in metabolic syndrome-induced vascular calcification. Methods: Twenty-five 12-week-old male Sprague Dawley (SD) rats were randomly assigned to five groups: control, metabolic syndrome (MetS), combine decaffeinated green tea 300 mg/kgBW and green coffee 200 mg/KgBW treatment, metformin 500 mg/kgBW treatment, and empagliflozin 30 mg/KgBW treatment. MetS was induced using established procedures. Vascular calcification and aortic SAMD11 mRNA expression were assessed via HE staining and RT-PCR, respectively. Result: Induction of metabolic syndrome in SD rats successfully led to vascular calcification. Metabolic syndrome induction significantly increased SAMD11 mRNA expression (p=0.018), an effect that was reversed by treatment with metformin (p=0.002) and empagliflozin (p=0.005). While a combination of decaffeinated green tea and green coffee showed a reduction in SAMD11 mRNA expression, but this reduction was not statistically significant (p=0.066). Conclusion: Metabolic syndrome may promote vascular calcification by enhancing SAMD11 mRNA expression. Controlling hyperglycaemia, a characteristic of metabolic syndrome, with metformin and empagliflozin, reduced SAMD11 mRNA expression. Potential hyperglycaemic control by decaffeinated green tea and green coffee did not changes SAMD11 mRNA expression.
Right ventricular function preservation in conduction system pacing (CSP): Impact of lead-to tricuspid annulus distance left bundle branch area pacing (LBBAP) vs. his-bundle pacing (HBP) Mirza, Try Ahmad; Pranata, Raymond; Kamarullah, William; Iqbal, Mohammad; Hidayat, Syarief; Achmad, Chaerul; Karwiky, Giky
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.15

Abstract

Background: Pacemaker remains the most effective therapy for the management of conduction disorders; however, traditional methods of right ventricular (RV) pacing have given way to more advanced conduction system pacing (CSP) techniques, such as His Bundle Pacing (HBP) and Left Bundle Branch Area Pacing (LBBAP). Objective: The impact of these two techniques on RV function is the objective of this study. Methods: This longitudinal prospective cohort study investigates differences in RV function among patients who have undergone HBP and those who have received LBBAP, using the echocardiographic parameters: fractional area change (FAC), RV global longitudinal strain (RVGLS), tricuspid annular plane systolic excursion (TAPSE), and the progression of tricuspid regurgitation (TR), with a focus on lead placement distance to the tricuspid annulus (TA) within LBBAP subgroup. Result: Among the 64 patients (33 in the HBP group and 31 in the LBBAP group), LBBAP patients with a lead-to-TA distance > 21.5 mm showed significantly better preservation of RV function across all metrics compared to HBP, specifically noted in TAPSE (1.83±5.34 vs. -1.06±3.77 in HBP, p=0.048), FAC (7.83±9.98 vs. 2.42±10.63 in HBP, p=0.011), and also RVGLS improvement (p=0.020). Conclusion: LBBAP with lead placement > 21.5 mm from the TA better preserves RV function compared to HBP mainly by minimizing mechanical interference with the tricuspid valve and reducing TR risk.
Comparison of decaffeinated green tea and green coffee with metformin and empagliflozin on the GALNT2 and GALNT3 mRNA expression in metabolic syndrome rats Bahar, Mokhamad Aswin; Rohman, Mohammad Saifur; Kurnianingsih, Novi
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.7

Abstract

Background: Aberrant protein glycosylation mediated by the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase (GALNT) family has been implicated in the pathogenesis of metabolic syndrome (MetS), yet the roles of GALNT2 and GALNT3 remain poorly characterized. Objective: This study aimed to evaluate the modulatory effects of decaffeinated green tea and green coffee on GALNT2 and GALNT3 mRNA expression in MetS rats, compared with standard therapies, metformin and empagliflozin. Methods: Twenty-five male Sprague Dawley (SD) rats were divided into five groups randomly: (1) MetS rats (METS), (2) MetS rats treated with 300 mg/kgBW decaffeinated green tea and 200 mg/kgBW decaffeinated green coffee (TKD), (3) MetS rats treated with 500 mg/kgBW metformin (MFN), (4) MetS rats treated with 30 mg/kgBW empagliflozin (EMPA), and (5) negative control (NC). The MetS model was induced using a high-fat, high-sucrose (HFHS) diet followed by streptozotocin injection (30 mg/kgBW). After 10 weeks, the treatment groups received interventions for 9 weeks. GALNT2 and GALNT3 mRNA expression was investigated using reverse transcription polymerase chain reaction (RT-PCR).. Result: TKD and MFN tended to decrease GALNT2 and increase GALNT3 mRNA expression, although the differences were not significant statistically compared to the METS group (p>0.05). EMPA decreased GALNT2 and increased GALNT3 mRNA expression significantly compared to the METS group (p<0.05). Conclusion: The significant effect of EMPA on GALNT2 and GALNT3 mRNA expression suggests its therapeutic potential in targeting glycosylation pathways in MetS. Although TKD and MFN exhibited similar trends with EMPA, the lack of statistical significance suggests the need for further study.
Integrating acute coronary syndrome services through the PSC 119 platform: The LASKAR model for emergency cardiac care in Indonesia Supriyanto; Nasronudin; Stefanus Supriyanto
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.18

Abstract

Background: The management of acute coronary syndrome (ACS) has been challenged by high rates of morbidity and mortality, prolonged reperfusion times, and a significant number of cases arriving at the hospital already deceased, particularly in Tulungagung, Indonesia. In response to this issue, Rumah Sakir Umum Daerah (RSUD) Dr. Iskak, in collaboration with the local government, established the Layanan Sindroma Koronaria Akut Terintegrasi (LASKAR) in 2016. Objective: This study aimed to evaluate the implementation and outcomes of LASKAR for emergency cardiac management and its impact on the ACS burden in low-resource settings. Methods: A comparative before-and-after design was utilized in this study. Data were collected from hospital reports, 119 logs from the Public Safety Center (PSC), and ACS registries between 2016 and 2019. The data were analyzed using a Chi-square test in JASP to assess the relationship between changes in ACS-related outcomes and the implementation of LASKAR. Result: The results demonstrated significant improvements in the management of ACS. Clinical outcomes improved concurrently, with the rate of Primary Percutaneous Coronary Intervention (PCI) more than doubling, increasing from 14.9% to 37.8% (p<0.001), while in-hospital mortality significantly decreased from 11.8% to 6.1% (p=0.007). Conclusion: Incorporating a locally developed LASKAR model into a national emergency medical platform transforms emergency cardiac care into a sustainable and effective management solution. This innovative approach not only strengthens health system responsiveness to ACS but also serves as a powerful, replicable blueprint for other low- and middle-income countries striving to elevate their healthcare capabilities.
Clinical and molecular perspective of coronary artery calcification Rohman, Mohammad Saifur; Firdaus, Dylan Hanny
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.1

Abstract

Coronary artery calcification (CAC) has been known related to worse procedural outcome, repeated revascularization and increase major cardiovascular events. CAC is caused by chronic progressive inflammation result in deposition of calcium crystallization and phosphate in the form of hydroxyapatite which leads also to an ectopic mineralization formation. Current guidelines on treating CAC emphasized on multimodal approach using not only intravascular imaging but also debulking or lithotripsy device. Future studies are exploring the potential of molecular and genetic therapeutic targets to prevent disease progression.

Page 33 of 33 | Total Record : 325

 29   30   31   32   33 

Filter by Year

2020 2026


Reset
Filter By Issues
All Issue Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua Vol. 6 No. 2 (2025): The Complexity in the Management of Heart Rhythm Disorder Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure Vol. 6 No. Suppl_July (2025): Supplement Issue : Indonesian Acute Coronary Syndrome Summit in Conjun Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease Vol. 5 No. 3 (2024): The Science and Art of Revascularization in Acute Coronary Syndrome Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases Vol. 5 No. 1 (2024): Inflammation and Cardiovascular Disease Vol. 4 No. 4 (2023): The Science and Art of Caring for Critically III Patients in Intensive Cardiac Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul Vol 4, No 2 (2023): Dealing with the Complexity of the Wide Spectrum of Cardiovascular Disease Vol 4, No 1 (2023): Optimizing Outcome in Acute Cardiac Care Vol. 4 No. 1 (2023): Optimizing Outcome in Acute Cardiac Care Vol. 3 No. 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improv Vol 3, No 4 (2022): Prevention, Screening dan Rehabilitation : The Back Bone of Quality Care Improve Vol. 3 No. 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen? Vol 3, No 3 (2022): Cardiovascular Disease in Young Adulthood: Who, When, and How to Screen? Vol 3, No 2 (2022): Improving ST-Elevation Myocardial Infraction Patients Prognosis Vol 3, No 1 (2022): Assesment and Outcome of Coronary Artery Disease in the Reperfusion Era Vol 2, No 4 (2021): Management of Thrombosis in Covid-19 Patient with Cardiovascular Disease Vol 2, No 3 (2021): The Science and Art of Myocardial Revascularization Vol 2, No 2 (2021): Dealing with Vascular Disease Vol 2, No 1 (2021): How to Diagnose Heart Failure and Deal with The Treatment Complexity Vol 1, No 4 (2020): Acute Coronary Syndrome in Daily Practice : Diagnosis, Complication, and Managem Vol 1, No 3 (2020): Management of Coronary Artery Disease: From Risk Factors to The Better Long-Term Vol 1, No 2 (2020): The Assessment of Diagnostic and Treatment Modality in Heart Failure Vol 1, No 1 (2020): The Importance of Adherence to The Guidelines More Issue