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Wimpie Pangkahila
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INDONESIA
IJAAM (Indonesian Journal of Anti-Aging Medicine)
Published by Universitas Udayana
ISSN : 26147882     EISSN : 26155079     DOI : https://doi.org/10.36675/ijaam
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Anti-Aging Medicine is published by Faculty of Medicine Universitas Udayana in collaboration with Indonesian Center for Anti-Aging Medicine (INCAAM). Indonesian Journal of Anti-Aging Medicine is an open access, peer reviewed journal aiming to communicate high quality research articles, reviews and general articles in the field of anti aging. Indonesian Journal of Anti-Aging Medicine encompass all aspects of basic research/clinical studies related to the field of anti aging and allied science fileds. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship, and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 73 Documents
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Oral Ashitaba Aeaves (Angelica keiskei) Extract Prevented The Increase of Tyrosinase Levels and Total Melanin in The Ultraviolet B­Exposed Guinea Pig (Cavia porcellus) Skin Meiny Linda Setiawan; Wimpie Pangkahila; Anak Agung Gede Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 4 No 2 (2020): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v4i2.100

Abstract

Introduction: UVB rays stimulate the tyrosinase which activates the biosynthesis of melanin and cause skin aging characterized by hyperpigmentation. Ashitaba is a plant rich of chalcone, a flavonoid compound with tyrosinase inhibitor activity. This study aimed to prove that oral Ashitaba (Angelica keiskei) extract prevented the elevation of tyrosinase levels and total melanin in the UVB-exposed guinea pig (Cavia porcellus) skin. Methods: This study used randomized posttest only control group design. The subjects were guinea pigs (Cavia porcellus), male, healthy, local strains, aged 3-4 months, weighing 300-­350 grams, one hybrid, which were divided into 2 groups (n = 18). The first group was the control group (treatment with exposure to ultraviolet B and placebo), the second group was the treatment group (treatment with exposure to ultraviolet B and oral Ashitaba leaves extract of 25 mg/kgBB). After 2 weeks of treatment, tyrosinase level was examined by the ELISA method, while the amount of melanin was examined for Masson­Fontana staining. Results: The mean tyrosinase level in the control group after 2 weeks of treatment was higer (30.64 ± 4.19ng/ml) than on the treatment group (11.47 ± 0.62ng/ml) with (p<0.05). In addition, the average number of melanin in the control group was also higer (19.05 ± 2.53%) than the treatment group (1.85 ± 0.84%) (p <0.05). Conclusion: Based on the results of this study, it can be concluded that oral Ashitaba (Angelica keiskei) extract prevented the increase of tyrosinase levels and total melanin in the UVB-exposed guinea pig (Cavia porcellus) skin.
The application of kenikir (Cosmos caudatus) extract cream to inhibit the increase of melanin counts in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet B Olivia Olivia; I Gusti Made Aman; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.86

Abstract

Introduction: Hyperpigmentation is caused by the increase of melanin in the skin layer, especially the epidermal layer. Kenikir (Cosmos Caudatus) is a plant that can be used as an antioxidant and anti-melanogenic. The aim of this research was to prove the effectiveness of the cream with 4% kenikir (Cosmos Caudatus) extract to inhibit the increase of melanin in the skin of guinea pig (Cavia porcellus) exposed to ultraviolet B. Methods: The kenikir (Cosmos Caudatus) that have been extracted in Food Laboratory of Agriculture Faculty in Universitas Udayana became the main requirement in this research. This research employed an experimental design with post-test only control group method. To conduct this study, 36 male guinea pigs (Cavia porcellus), local strain, aged 3 months with 300-350mg body weight divided into 2 groups, each of which was 18. The duration of irradiation was 3 times a week with a total irradiation dose of 65 mJ/cm2. After 2 weeks of research, then the back skin tissue of guinea pigs biopsied as the histological preparations and then the Masson-Fontana staining was performed. The results were analyzed by using descriptive analysis, the test of normality and homogeneity and also independent t-test. Results: The control group (P0) (20,57±2,90%) had a bigger average melanin count than the treatment group (P1) (1,41±0,437%) significant statistically (p<0.001). Conclusion: this research is the cream with 4% of kenikir (Cosmos Caudatus) extract can inhibit the increase of melanin counts in the skin of a male guinea pig (Cavia porcellus) exposed to Ultraviolet B.
Topical administration of red ginger (Zingiber officinale Rosc) extract gel increased the number of fibroblast, neovascularization, and epitelization of wound healing in old male mice (Mus musculus) Hayyu Kusumaningtyas; I Gusti Made Aman; Ida Sri Iswari
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.72

Abstract

Introduction: Wound healing is slower with advancing age. Red ginger extract is a natural compound that contains flavonoids and polyphenols. This study aims to prove that the topical administration of red ginger (Zingiber officinale Rosc) extract gel increases the number of fibroblasts, neovascularization, and epithelialization of wound healing in old male mice (Mus musculus). Methods: This study was an experimental study using randomized posttest only control group design using 32 male mice, aged 12 months, weighing 20 grams, which was divided randomly into 2 groups. The control and treatment group was further divided into 4-day group and 8-day group. The control group was applied with placebo gel twice a day and given oral amoxicillin for three days (3 times a day) in the wound site, while the treatment group was applied with 30% red ginger extract gel twice a day and given oral amoxicillin. Results: The average number of neovascularization in the fourth day of the control group was 31.37±3.98, while in the treatment group was 68.17±11.56 (p< 0.001). The average number of fibroblasts on the fourth day of the control group was 77.04±5.57, and in the treatment group was 103.99±10.68 (p< 0.001). On the fourth day there was no epithelialization observed, and on the eight day the mean epithelialization in the control group observed was 30.35±6.01 μm, while in the treatment group was 78.25±18.26 μm (p<0,001). Conclusion: Topical administration of red ginger extract gel increased the number of fibroblasts, neovascularization, and epithelialization of wound healing in old male mice.

Page 8 of 8 | Total Record : 73

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