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INDONESIA
IJAAM (Indonesian Journal of Anti-Aging Medicine)
Published by Universitas Udayana
ISSN : 26147882     EISSN : 26155079     DOI : https://doi.org/10.36675/ijaam
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Anti-Aging Medicine is published by Faculty of Medicine Universitas Udayana in collaboration with Indonesian Center for Anti-Aging Medicine (INCAAM). Indonesian Journal of Anti-Aging Medicine is an open access, peer reviewed journal aiming to communicate high quality research articles, reviews and general articles in the field of anti aging. Indonesian Journal of Anti-Aging Medicine encompass all aspects of basic research/clinical studies related to the field of anti aging and allied science fileds. The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship, and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 73 Documents
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Pomegranate extract (Punica granatum) not as effective as simvastatin in improving profile lipid in dyslipidemic male wistar rats (Rattus norvegicus) Ken Andrina Anindita; I Gusti Made Aman; Gde Ngurah Indraguna Pinatih
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.89

Abstract

Introduction: Dyslipidemia is one of the factors of the occurrence of heart disease and atherosclerosis. Simvastatin and Pomegranate (Punica granatum) work by improving the lipid profile. The aim of this study was to prove that red pomegranate extract (Punica granatum) improve lipid profile of male white rats that are dyslipidemic. Method: This research is a experimental study with randomized pre test and post test control group design, using 20 adult male white rats as sample. After 30 days, rats were divided into 2 study groups with 10 rats per group. The group was classified into two (P1 and P2). Prior to the treatment, the rats were examined the first diluted T-cholesterol, triglyceride, LDL and HDL levels as pretest data. Treatment was performed for 15 days. Results: The mean pretest HDL level in the simvastatin group was 23.84 ± 2.54 mg / dL and the red pomegranate extract group was 25.41 ± 2.34 mg / dL and p = 0.167. After treatment for 15 days, the mean posttest the red pomegranate extract group was 126.55 ± 3.09 mg / dL and p = 0,001. The mean posttest HDL level in the simvastatin group was 58.72 ± 5.21 mg / dL and the red pomegranate extract group was 40.56 ± 2.87 mg / dL and p = 0,001. Conclusion: The administration of red Punica granatum is not as effective as simvastatin in improving lipid profile in dyslipidemic rats. Although not as effective as simvastatin, red pomegranate extract can significantly improve lipid profile.
Nutrilite green trim® reduced body weight, waist circumference, and body fat percentage in obese men with moderate physical exercise and low-calorie diet Romy Kamaluddin; Wimpie Pangkahila; Alex Pangkahila
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.75

Abstract

Introduction: Management of obesity are including consumption of supplements. Nutrilite GreenTrim® Supplement contains green tea extract and EGCG and squalene. This study aimed to prove the effects of Nutrilite GreenTrim® on body weight, waist circumference, and body fats percentage in obese men. Methods: This clinical trial used pretest-posttest control group design in 22 obese men, aged 25-40 years with a BMI 25-35 kg/m2. Subjects were divided into the control group (K) and the treatment group (P). Subjects were given moderate physical exercise and a low-calorie diet. Results: The results showed K group lost weight (from 85.1±8.99 to 82.3±9.21 kg; p<0.001), while the P group lost weight (from 84.1±10.7 to 80.1±10.9 kg; p <0.001) and the difference showed that the P group lost weight greater than the K group (p = 0.007). K group experienced a decrease in waist circumference (from 96.9±7.69 to 93.8±8.84 cm; p <0.001), while the P group (from 96.5±7.78 to 92.2±7.59 cm; p <0.001) the difference showed that the decrease in waist circumference in the P group was better than the K group (p = 0.041). In the K group, body fat percentage decreased (from 27.5±3.31 to 25.8±3.77%; p <0.001), the P group also decreased (from 26.5±3.78 to 23.3±3.67%; p<0.001) the analysis showed that the decrease in body fat percentage in the P group was better than the K group (p <0.001). Conclusion: Supplementation of Nutrilite Green Trim® reduced body weight, waist circumference, and body fats percentage in obese men with moderate physical exercise and low-calorie diet.
Oral administration of arabica green coffee extract increased fasting insulin, decreased fasting blood glucose, but did not decrease insulin resistance on wistar male rat (Rattus norvegicus) obese with diabetes mellitus Maria Marissa Maharani; Anak Agung Gede Budhiarta; I Wayan Weta
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.60

Abstract

Background: Type 2 DM is characterized by defective insulin secretion and increased insulin resistance, with the main management is the control of behavior, such as diet. Green Coffee Arabica is one of the nutraceutical contains polyphenols which have anti-diabetic activity. This study aimed to prove that Arabica green coffee extract increases fasting insulin, decreases fasting blood glucose levels, and insulin resistance in male rat (Rattus Norvegicus) obese with diabetes. Methods: Experimental pretest-posttest groups study using 18 obese diabetic male albino rats. The control group was treated with placebo and the treatment group was treated with green coffee extract 300 mg/kgBW for 14 days. Fasting blood glucose and fasting insulin were measured before and after treatment. Results: There were a significant decrease of insulin levels in control group [from 6.59 to 3.67 mIU/L; p=0.011]. The change of insulin concentration between control group and treatment group were significant different statistically [-2.91 vs +1.57 mIU/L; p=0.024]. Significant decrease in fasting blood glucose in treatment group [from 162 to 120 mg/dL; p = 0.011]. The change fasting blood glucose between control group and treatment group were highly significant different statistically (+8 vs -44 mg/dL; p<0.001). Posttest HOMA-IR in treatment group and control group were not significant different statistically [2.49vs3.26; p=0.310] and the change HOMA-IR between control group and treatment group were not significant different statistically [-1.83 vs -0.497; p=0.145]. Conclusion: Oral administration of arabica green coffee extract increased insulin, decreased fasting blood glucose, but did not reduce insulin resistance on diabetic wistar rats.
Gel of sandfish (Holothuria scabra) extract prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin Dwindi Saptania; Wimpie Pangkahila; Anak Agung Gde Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 4 No 2 (2020): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v4i2.95

Abstract

Introduction: Hyperpigmentation is a condition of increasing melanin production in the skin due to UV light exposure. Sandfish (Holothuria scabra) contains phenol, quercetin, saponins, tannins, flavonoids and antioxidants such as vitamin C and others that have the potential anti-melanogenesis effects. The purpose of this study was to prove that topical administration of 40% sandfish (Holothuria scabra) extract gel prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin. Methods: This study used a randomized post-test only group design by using of 36 guinea pigs. Guinea pigs were then divided into two groups. The control group were 18 guinea pigs exposed to UVB rays and treated with placebo gel base (P0). The treatment group were 18 guinea pigs exposed to UVB rays and treated with 40% sandfish extract gel. The back skin exposed to UVB rays, was cleaned from fur and swabbed with 70% alcohol. After that a punch-biopsy was carried out in the area and histopathological preparations were made. The amount of melanin was examined using Masson-Fontana staining. Results: The results showed that the average amount of melanin in the control group was 18.11± 1.11%, while the average amount of melanin in the treatment group was 1.82 ± 0.72%. Comparative analysis using independent T- test showed that the value of p was <0.001 means that there were significant differences between the control group and the treatment group. Conclusion: The administration of 40% sandfish (Holothuria scabra) extract gel prevented melanin elevation in UVB-exposed guinea pig (Cavia porcellus) skin.
Cream jengkol seed extract 8% (Archidendron pauciflorum) inhibited the increase melanin amount in the skin of guinea pigs (Cavia porcellus) exposed to ultraviolet-B rays Rafiah Sirikit Saenong; Wimpie Pangkahila; AAGP Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.85

Abstract

Introduction: The exposure to UV rays on the skin causes hyperpigmentation and premature aging. Hyperpigmentation is caused by an increase of melanin count in the epidermal skin layer. The abundant natural resources that come from Indonesia and have the potential to be good antioxidants are jengkol seeds. The aim of this research was to prove that 8% jengkol seeds (Archidendron pauciflorum) extract cream could inhibit the increase of melanin count in the skin of guinea pig (Cavia porcellus) exposed to ultraviolet B rays. Method: This design of this research is an experimental research with the post-test only control group design. This research used 36 male guinea pigs (Cavia porcellus), local strains, aged 3 months with a body weight of 300-350mg, divided into 2 groups, each of which was 18. The research was conducted for 2 weeks, then a tissue biopsy was carried out as a histological preparation and then the Masson-Fontana staining was carried out. Results: The results showed that the mean value of melanin count for the base cream group was 20.851 ± 1.777%, whereas in the treatment group which applied with 8% jengkol seeds extract cream showed the mean value of 1.289 ± 0.391% (p <0,001). This indicated that the base cream group has a bigger melanin count than the jengkol seeds extract group. Conclusion: The 8% jengkol seeds (Archidendron pauciflorum) extract cream inhibited the increase of melanin
Administration of metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin Vitia Tandy; Wimpie Pangkahila; A.A.G.P. Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.71

Abstract

Introduction: Ultraviolet exposure has been known to be the most significant factor influencing skin pigmentation, includes in increasing melanin amount. It is caused by the effect of ultraviolet B radiation in increasing melanin synthesis. Topical administration of metformin can inhibit the melanogenesis process by decreasing the level of cAMP and inhibiting PKC-β activation. This research aimed to prove that administration of 0.5% metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin. Methods: This study was a true experimental research using posttest only control group design. Thirty six male guinea pigs were divided into control and treatment group. Base cream was administered to the control group and 0.5% metformin cream was administered to the treatment group once daily. All of the guinea pigs were exposed to ultraviolet B radiation at 390 mJ/cm2 three times a week. Punch biopsy was conducted two weeks after treatment to obtain skin samples for histologic preparations. Thereafter, those samples were stained with Masson-Fontana to examine the melanin amount. Finally, the average melanin amount in both groups was compared. Results: All samples in both groups successfully made to the end of the research without drop out. This research found that the average amount of melanin in treatment group, which was 2.04 ± 0.62%, was significantly lower than control group, which was 18.57 ± 1.68% (p < 0.001). Conclusion: Administration of 0.5% metformin cream prevented the increase of melanin amount in ultraviolet B exposed guinea pigs (Cavia porcellus) skin.
The Administration of Cinnamon (Cinnamomum burmannii) Extract Reduced Weight and Abdominal Visceral Fat in Obese Male Wistar Strain Rats (Rattus Norvegicus) With Moderate Intensity Physical Exercise Dian Andrieany Husodo; Alex Pangkahila; IGM. Aman
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.55

Abstract

Introduction: Obesity increases the risk of many degenerative disease. Abdominal fat is a sign that someone has great risk for metabolic syndrome. Moderate physical exercise is suggested to reduce weight and body fat percentage. Cinnamon (Cinnamomum burmannii) extract can reduce weight by the lipolysis activity in visceral adipose tissue and supress the appetite. This research aimed to prove that administration of cinnamon extract reduced weight and abdominal visceral fat in obese male wistar strain ratswith moderate intensity physical exercise. Methods: This research was a true experimental with post-test only control group design. The subjects were 36 male albino rats (Rattus norvegicus), Wistar strain, healthy, 4-5 months age, and obese (body weight of > 250 g), which divided into two groups (n= 18). The positive control group (P1) was treated with placebo (2 ml aquadest), standard food, and moderate physical exercise. The experimental group (P2) was treated with 1000 mg/kg BW/day cinnamon extract standard food, and moderate physical exercise. After 2 weeks of treatment, body weight and abdominal visceral fat mass were measured. Results: The average body weight of the P2 group was significantly lower than the P1 group (271.9±5.48 and 284.7±5.05 g respectively, p<0.001). The median abdominal visceral fat mass in the P1 group was 9.0 g, whereas the P2 group was 7.9 g (p<0.001). The median remaining food in the P1 group was 3.43 g, whereas the P2 group was 10.07 g (p<0.001). Conclusion: This study indicated that administration of cinnamon extract reduced weight and abdominal visceral fat in obese male wistar strain ratswith moderate intensity physical exercise.
The moderate physical exercise in reducing post-prandial blood glucose and increasing glut-4 protein serum on diabetic male wistar rat (Rattus norvegicus) Dian Damayanti; Alex Pangkahila; I Wayan Weta
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.80

Abstract

Introduction: A moderate-intensity diet and exercise regimen is highly recommended as a non-pharmacological therapy, which can be used in type 2 diabetes mellitus. It can increase the GLUT-4 protein serum activity in the receptor of the muscle cell membrane. This research aimed to prove that moderate physical exercise was able to reduce post-prandial blood glucose and increase GLUT-4 protein serum on diabetic male Wistar rat (Rattus norvegicus). Methods: This research employed an experimental pre-test post-test control group design by using 26 diabetic male Wistar rats that were randomly selected. The first group without moderate exercise, the second group with moderate exercise. The measurement of post-prandial blood glucose and GLUT-4 protein serum was performed after 14 days of treatment. Results: The median of post-prandial blood glucose levels for the control group (P0) in pre-test was 177.00 mg/dl and in post-test was 168.00 mg/dl, moreover for the treatment group (P1) in pre-test was 158.00 mg/dl and in post-test was 157.00 mg/dl. Moreover, the median of GLUT-4 for the control group (P0) in pre-test was 8.97 ng/dl and in post-test was 9.34 ng/dl, and for the treatment group (P1) in pre-test was 8.44 ng/dl and in post-test was 9.38 ng/dl. The results of the analysis in both groups showed that there was no significant difference between the control group and the treatment group. Conclusion: It can be concluded that moderate physical training did not significantly reduce post-prandial blood glucose, and did not significantly increase GLUT-4 serum on diabetic male Wistar rat.
Administration of Moringa oleifera seeds ethanol extracts cream increased neovascularization and fibroblasts cell, but did not increase epithelialization in wound healing process of wistar rats (Rattus norvegicus) Golda Bernadet Lemewu; I Gusti Made Aman; Anak Agung Gede Putra Wiraguna
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 2 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i2.76

Abstract

Introduction: The aging process causes a decrease in organ function like wound healing. Moringa seed extract contains various compounds that can accelerate wound healing. The purpose of this study was to prove that administration of Moringa oleifera can accelerate wound healing process. Methods: This study used a randomized post-test control group design. Subject were 28 rats (Rattus norvegicus), Wistar strain, which were divided into 4 groups (n = 7). The P0(4) and P0(8) group was given placebo for 4 and 8 days, the P1(4) and P1(8) group was given Moringa seed extract cream for 4 and 8 days. All group were given oral amoxicillin 3x10mg/day. Skin samples were biopsied at the wound site. Results: The results showed that the average neovascularization in P0(4) group was 3.57±1.13, P1(4) = 7.71±2.06, P0(8) = 4.14±1.22, and P1(8) = 8.00±1.41 (p < 0.001). The number of fibroblast cells in the P0(4) = 39.4±6.19, P1(4) = 64.3±6.08, P0(8) = 47.0±16.2, and P1(8) = 75.7±17.1 (p < 0.001). The epithelium thickness of the P0(4) = 39.1±15.9 μm, P1(4) = 33.8±3.50 μm, P0(8) = 28.9±11.5 μm, and P1(8) = 38.9±21.5 μm (p> 0.05). The epithelium gap of the P0(4) = 1239±1079 μm, P1(4) = 380±441 μm, P0(8) = 838±1072 μm, and P1(8) = 1153±594 μm (p> 0.05). Conclusion: It can be concluded that administration of Moringa oleifera seeds ethanol extracts cream increased neovascularization and fibroblast cell, but did not increase epithelialization in wound healing process of wistar rats.
Excessive physical activity increased leucocyte and decreased Endorphin levels in male wistar rats (Rattus norvegicus) Periskila Abigail; Wimpie Pangkahila; Alex Pangkahila
IJAAM (Indonesian Journal of Anti-Aging Medicine) Vol 5 No 1 (2021): Indonesian Journal of Anti-Aging Medicine
Publisher : Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/ijaam.v5i1.61

Abstract

Background: Excessive physical activity triggers hormonal imbalances, one of which is beta endorphin and lead to increasing leukocytes as a response to the inflammation. The purpose of this study was to prove that excessive physical activity increased leucocyte and decreased endorphin levels in male Wistar rats (Rattus norvegicus). Methods: This study was an experimental study with randomized pretest-posttest group design. The research subjects were male rats (Rattus norvegicus), Wistar strain, aged 8-10 weeks with a body weight of 150-200 grams and healthy. A total of 14 rats were randomly divided into two groups. The first group was treated with balanced physical activity (P1), the second group was treated with excessive physical activity (P2). On day 8 and day 28, leukocytes were examined using whole blood method and beta endorphin were examined using ELISA. Results: The results showed that in the group P1, both leukocyte levels (from 14.0±2.73x103/µL to 17.1±5.07x103/µL, p= 0.170) and beta endorphin levels (from 176±30.2 to 161±11.1 ng/mL, p= 0.110) remained stable. Whereas, the P2 group experienced leukocyte reduction (from 12.3±2.19x103/µL to 23.7±2.92x103/µL, p <0.001) and decreased beta endorphin levels (from 212±46.0 ng/mL to 55.3±8.05 ng/mL, p <0.001). Conclusion: This study suggesting that excessive physical activity increased leucocyte and decreased endorphin levels in male Wistar rats (Rattus norvegicus).

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