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Ni Made Dharma Shantini Suena
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Jurnal Ilmiah Medicamento
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 23564814     DOI : https://doi.org/10.36733/medicamento.v6i1
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Medicamento (JINTO) dengan nomor registrasi e-ISSN 2356-4814 didirikan pada tahun 2014, dan publikasi online dimulai pada tahun 2015. Jurnal diterbitkan dalam bahasa Indonesia. Awalnya JINTO diterbitkan oleh Akademi Farmasi Saraswati Denpasar. Namun sejak awal tahun 2019, penerbit jurnal berubah menjadi Fakultas Farmasi Universitas Mahasaraswati Denpasar karena institusi penerbit sebelumnya yaitu Akademi Farmasi Saraswati Denpasar telah mengalami penyatuan ke dalam institusi Universitas Mahasaraswati Denpasar menjadi Fakultas Farmasi. Jurnal Ilmiah Medicamento diterbitkan setiap enam bulan sekali (Maret dan September) yang berisi penelitian di bidang ilmu farmasi. JINTO menerima artikel yang mencakup berbagai bidang ilmu farmasi seperti: Farmakologi dan Toksikologi; Farmasi Klinik dan Komunitas; Kimia Farmasi; Biologi Farmasi; Teknologi Farmasi; Farmasi Mikrobiologi dan Bioteknologi; Regulatory Affairs and Pharmacy Marketing Research; Pengobatan alternatif.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 314 Documents
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Aktivitas Antidiabetes Kombinasi Ekstrak Daun Jambu Biji dan Daun Rambutan pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus) yang Diinduksi Streptozotocin Pradani, Lintang Oktavian; Widiastuti, Tri Cahyani; Khuluq, Muhammad Husnulq
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.9887

Abstract

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to insulin deficiency or resistance. Long-term use of oral antidiabetic drugs can lead to adverse effects and high costs, making safer alternatives necessary. Herbal medicines derived from natural sources offer a promising option with relatively fewer side effects. Guava (Psidium guajava) and rambutan (Nephelium lappaceum) leaves are known to contain bioactive compounds with potential antihyperglycemic properties. This study aimed to determine the optimal dose combination of guava and rambutan leaf extracts for controlling blood glucose levels in streptozotocin-induced Wistar rats (Rattus norvegicus). The extracts were prepared using maceration, standardized, and analyzed by Thin Layer Chromatography (TLC) to identify active compounds. Thirty-two rats were divided into eight groups: healthy control, negative control (CMC-Na 0.5%), positive control (glimepiride 0.036 mg/kg BW), single extract of guava leaves (50 mg/kg BW), single extract of rambutan leaves (70 mg/kg BW), and three combinations of extracts (50%:50%, 75%:25%, and 25%:75%). Diabetes was induced intraperitoneally using streptozotocin. Blood glucose levels were measured every seven days for 21 days using a glucometer. Data were analyzed using One-Way ANOVA followed by Games-Howell post hoc test. The extracts met standardization requirements and contained flavonoids. The highest glucose reduction (72%) was observed in the 25%:75% combination (guava:rambutan), showing a significant difference compared to the negative control. These findings suggest that the combination of guava and rambutan leaf extracts has strong potential as a natural antidiabetic agent.
Analisis Penggunaan Antibiotik dengan Metode ATC/DDD dan DU90% di Puskesmas Banjarbaru Selatan Tahun 2023-2024 Sari, Okta Muthia; Intannia, Difa; Lingga, Herningtyas Nautika; Sandi, Dita Ayulia Dwi; Setiawan, Deni; Andini, Rizka Syawal; Dania, Sri Rahmah
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11811

Abstract

Antibiotic resistance is an escalating global health concern, with Indonesia increasingly reporting resistance across various bacterial species. This trend contributes to rising morbidity and mortality and influences patterns of antibiotic use, highlighting the need for systematic monitoring. The Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology is a widely accepted standard for evaluating antibiotic consumption and serves as a key indicator of antimicrobial stewardship effectiveness. This study aimed to: (i) identify the most consumed antibiotics based on DDD/1000 outpatient visits, (ii) compare consumption between 2023 and 2024, and (iii) determine the DU90% segment of antibiotic use at Banjarbaru Selatan Health Center. A quantitative, descriptive, cross-sectional design was conducted from January to May 2025, involving adult outpatients prescribed antibiotics during 2023–2024. Data analysis included DDD/1000 outpatient visit calculations and year-to-year comparisons using the Wilcoxon test. Amoxicillin consistently showed the highest consumption, with 272.94 DDD/1000 outpatient visits in 2023 and 274.26 in 2024. Statistical analysis revealed no significant difference in overall antibiotic use between the two years (p = 0.063). DU90% analysis identified Amoxicillin as the dominant antibiotic in 2023, while Amoxicillin and Cefadroxil led in 2024. Antibiotic consumption at Banjarbaru Selatan Health Center remained stable over the two years, with Amoxicillin as the predominant agent. These findings underscore the importance of routine monitoring using ATC/DDD and DU90% methodologies to inform targeted interventions and enhance antimicrobial resistance control strategies.
Tablet Ekstrak Daun Spondias pinnata: Pengaruh Variasi Primojel® dan Maltodekstrin terhadap Karakteristik dan Stabilitas Fisik serta Aktivitas Antioksidan Suena, Ni Made Dharma Shantini; Mayuni, Putri Diah Gita; Dewi, Ni Nyoman Ayu Pramesti; Mendra, Ni Nyoman Yudianti; Rahadi, I Wayan Surya; Wardani, I Gusti Agung Ayu Kusuma
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.12233

Abstract

Cemcem leaves (Spondias pinnata) are rich in phenolic and flavonoid compounds with antioxidant potential. However, their traditional beverage form lacks stability, necessitating tablet formulation to improve stability and dosing convenience. This study evaluated the effect of varying concentrations of maltodextrin (binder) and Primojel® (disintegrant) on the physical quality and antioxidant activity of cemcem leaf extract tablets. Prior to formulation, extraction temperature optimization was performed using ultrasonic-assisted maceration at 30°C and 45°C, each for 3 minutes per cycle over three cycles. Three tablet formulations were prepared using optimized extract with different maltodextrin–Primojel® ratios: F1 (3%-8%), F2 (6.5%-5%), and F3 (10%-2%). Granule evaluation included moisture content, flow rate, angle of repose, and compressibility index. Tablets were assessed on days 1, 14, and 28 under room temperature storage for organoleptic properties, weight and size uniformity, hardness, friability, and disintegration time. Data were analyzed using Repeated Measures ANOVA and the Friedman test at a 95% confidence level. Extraction at 30°C yielded superior antioxidant activity, with lower IC₅₀ values and higher total flavonoid content and was therefore selected for formulation. All granules met physical quality standards; however, among tablet parameters, only disintegration time complied with pharmacopeial requirements. Formula F3, containing the highest maltodextrin concentration (10%) and lowest Primojel® concentration (2%), demonstrated the best physical stability from day 1 to day 28 (p > 0.05) and the strongest antioxidant activity, with the lowest IC₅₀ value (23.88 µg/mL; AAI 1.68). These findings confirm a causal relationship between excipient concentration and tablet performance, supporting F3 as a promising prototype for antioxidant supplement development.
Formulasi dan Identifikasi Senyawa Minyak Atsiri Citrus hystrix DC. dengan GC-MS untuk Aktivitas Repelan terhadap Nyamuk Aedes aegypti Juliadi, Debby; Cahyaningsih, Erna; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11352

Abstract

Plant-based mosquito control offers a promising alternative to reduce the health and environmental risks associated with chemical insecticides. Citrus hystrix DC. (kaffir lime), a member of the Citrus genus, produces essential oils rich in bioactive compounds such as limonene, citronellal, and terpinolene, which are known for antimicrobial and insecticidal properties. This study focused on extracting essential oil from kaffir lime fruit, identifying its chemical constituents using gas chromatography–mass spectrometry (GC-MS), and evaluating the repellent efficacy of its spray formulation against Aedes aegypti. Essential oil was obtained through steam distillation and analyzed by GC-MS to determine its chemical profile. Repellent activity was assessed experimentally using 100 adult mosquitoes divided into five treatment groups, with spray formulations prepared at concentrations of 5%, 10%, and 15%. Data was analyzed using one-way ANOVA followed by post-hoc tests. GC-MS analysis revealed 90 compounds, with five major constituents: D-limonene (14.57%), limonene (13.92%), citronellal (6.66%), terpinolene (6.47%), and α-terpineol (5.74%). Repellent testing demonstrated that the 15% concentration provided the highest protection against mosquito landings. These findings confirm the potential of kaffir lime essential oil as an effective natural mosquito repellent and provide a scientific basis for developing eco-friendly, plant-derived vector control products. This research contributes to reducing dependence on synthetic insecticides and supports sustainable strategies for vector management that prioritize human health and environmental safety.

Page 32 of 32 | Total Record : 314

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