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Jurnal Ilmiah Medicamento
Published by Universitas Mahasaraswati
ISSN : -     EISSN : 23564814     DOI : https://doi.org/10.36733/medicamento.v6i1
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmiah Medicamento (JINTO) dengan nomor registrasi e-ISSN 2356-4814 didirikan pada tahun 2014, dan publikasi online dimulai pada tahun 2015. Jurnal diterbitkan dalam bahasa Indonesia. Awalnya JINTO diterbitkan oleh Akademi Farmasi Saraswati Denpasar. Namun sejak awal tahun 2019, penerbit jurnal berubah menjadi Fakultas Farmasi Universitas Mahasaraswati Denpasar karena institusi penerbit sebelumnya yaitu Akademi Farmasi Saraswati Denpasar telah mengalami penyatuan ke dalam institusi Universitas Mahasaraswati Denpasar menjadi Fakultas Farmasi. Jurnal Ilmiah Medicamento diterbitkan setiap enam bulan sekali (Maret dan September) yang berisi penelitian di bidang ilmu farmasi. JINTO menerima artikel yang mencakup berbagai bidang ilmu farmasi seperti: Farmakologi dan Toksikologi; Farmasi Klinik dan Komunitas; Kimia Farmasi; Biologi Farmasi; Teknologi Farmasi; Farmasi Mikrobiologi dan Bioteknologi; Regulatory Affairs and Pharmacy Marketing Research; Pengobatan alternatif.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 322 Documents
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Pengaruh Pemberian Ekstrak Kunyit Putih (Curcuma zedoaria Rosc.) terhadap Kadar Malondialdehid (MDA) Tikus Putih (Rattus norvegicus) yang Terpapar Asap Rokok Putra, I Made Agus Sunadi; Suwantara, I Putu Tangkas; Sasadara, Maria Malida Vernandes; Udayani, Ni Nyoman Wahyu
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10793

Abstract

Cigarette smoke generates free radicals that induce oxidative stress and damage various biomolecules in the body. An increase in malondialdehyde (MDA) levels is a key marker of oxidative stress. The body’s antioxidant mechanisms rely on compounds capable of neutralizing free radicals. White turmeric (Curcuma zedoaria Rosc.) contains antioxidant compounds predicted to prevent oxidative damage, though its in vivo potential remains to be proven. This study aimed to evaluate the effect of white turmeric ethanol extract on MDA levels in male Wistar rats (Rattus novergicus) exposed to cigarette smoke. A post-test only control group design was employed. The rats were divided into five groups: healthy control (P1), smoke-exposed control (P2), extract-treated groups receiving 100 mg/kgBW (P3) and 200 mg/kgBW (P4), and a positive control group receiving vitamin C (P5). Cigarette smoke exposure was administered for 14 days, and blood samples were collected from the orbital vein on day 15. MDA levels were measured using the ELISA method. The mean MDA levels (mmol/ml) for P1 to P5 were 0.118, 0.121, 0.094, 0.059, and 0.089, respectively. ANOVA and post hoc LSD tests (α = 0.05) showed a significant difference between P2 and P4 (p < 0.05), while no significant differences were found between P3, P4, and P5. In conclusion, white turmeric extract at 200 mg/kgBW significantly reduced MDA levels and demonstrated antioxidant activity comparable to that of vitamin C.
Hubungan Faktor Sosiodemografi dengan Perilaku Swamedikasi Obat Analgesik pada Masyarakat Kota Malang Yusuf, Muhammad Faishal; Sugihantoro, Hajar; Hakim, Abdul; Maulina, Novia; Ummah, Syifaul Khoiro
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.10708

Abstract

The prevalence of self-medication among the population of Malang City reached 64.35% in 2022. This figure indicates a considerable potential risk, particularly related to inappropriate medication practices. Analgesics are among the most used drugs for pain relief through self-medication. Improper use of analgesics may lead to adverse effects, including gastrointestinal disturbances, hypersensitivity reactions, and damage to the kidneys and liver. This study aims to examine self-medication behavior involving analgesics and to analyze the relationship between respondents’ sociodemographic factors and such behavior. The research employed quantitative analytic observational design with a cross-sectional approach and survey method. Sampling was conducted using a non-probability sampling technique, involving 100 respondents who met the inclusion and exclusion criteria. Data analysis was performed using non-parametric statistical tests, namely the Chi-Square test for gender, occupation, and residence variables, and the Spearman Rank test for age, income, and education level. The results showed that the self-medication behavior with analgesics among the people of Malang City was categorized as “moderate,” with a prevalence of 72%. Statistical analysis revealed significant associations between age, income, education level, and residential area with analgesic self-medication practices. Conversely, gender and occupation did not show statistically significant relationships. These findings provide a foundation for developing targeted educational strategies and public health policies to promote safer and more rational self-medication practices.
Penggunaan Antibiotik dan Resistensi Escherichia coli and Klebsiella pneumoniae: Studi Ekologikal Lima Tahun di Sebuah Rumah Sakit Umum Daerah Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Mahaputra, Yudistira; Kamalia, Made Gek Adisti
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11156

Abstract

Antibiotic resistance is a growing global health threat, partly driven by high antibiotic consumption. The World Health Organization (WHO) has identified critical-priority bacteria, including Escherichia coli and Klebsiella pneumoniae, due to their increasing resistance to multiple antibiotics. This study aimed to evaluate the correlation between antibiotic consumption and resistance rates in Escherichia coli and Klebsiella pneumoniae. This ecological study was conducted at a Regional Hospital in Indonesia based on retrospective inpatient data from January 2019 to December 2023. The population in this study is all data on systemic antibiotic consumption based on the J01 category of the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) classification system and antibiogram from inpatient databases. Pearson and Spearman’s rank correlation analyses were performed to examine the associations between systemic antibiotic consumption levels and the percentage of Escherichia coli and Klebsiella pneumoniae resistance to other antibiotics. The most frequently used antibiotics were cefixime (305.664 DDD/100 bed-days), levofloxacin (139.552 DDD/100 bed-days), and ceftriaxone (109.805 DDD/100 bed-days). A strong and statistically significant correlation was observed between doxycycline consumption and Escherichia coli resistance to meropenem (r=0.894; p=0.041). Moreover, consumption levels of cefazolin, ceftazidime, cefepime, and ciprofloxacin were correlated with Escherichia coli resistance to ceftriaxone (p<0.05), while cefoperazone use demonstrated a very strong and statistically significant correlation with Escherichia coli resistance to ampicillin-sulbactam (r=0.952; p=0.012). Conversely, no significant correlation was found between antibiotic consumption and resistance in Klebsiella pneumoniae, suggesting that alternative factors such as intrinsic resistance mechanisms, mobile genetic elements, and environmental reservoirs may influence resistance development.
Analisis Bibliometrik Formulasi Poliherbal sebagai Afrodisiak: Tinjauan Tren Penelitian Terkini Kartika, I Gusti Agung Ayu; Nugraha, Iwan Saka; Mahardika, Ida Bagus Putra; Suryani, Suryani
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11418

Abstract

In recent years, the therapeutic potential of polyherbal formulations as aphrodisiacs, particularly as natural alternatives to synthetic treatments for sexual health disorders, has garnered significant attention. Polyherbal formulations are believed to enhance efficacy through synergistic effects, making them a preferred option in both traditional and modern therapeutic practices. This review aims to provide a comprehensive analysis of research trends relating to the use of polyherbal formulations for aphrodisiac purposes. A bibliometric analysis was conducted using the Scopus database, extracting relevant articles with the keywords 'Aphrodisiac AND Polyherbal OR Combination.' From an initial pool of 88 articles, 16 were selected for in-depth analysis. VOSviewer software was used to visualize collaboration networks, co-authorship patterns, and keyword trends, highlighting the increasing research interest in polyherbal formulations for sexual health enhancement. The narrative review supplements these findings by exploring study methodologies, sources of herbal ingredients, formulation compositions, and commonly used herbs. Results indicate that while polyherbal aphrodisiac formulations show promising therapeutic potential, research in this field remains fragmented, with limited clinical trials evaluating safety and efficacy. The most frequently studied herbs include Tribulus terrestris, Mucuna pruriens, and Withania somnifera, known for their effects on testosterone levels, vascular function, and libido enhancement. Future studies should focus on clinical validation, standardization, and pharmacokinetic assessments to facilitate their integration into modern medical practice. These findings provide valuable insights for researchers and industries developing polyherbal-based nutraceutical and pharmaceutical products.
Uji Aktivitas Antiinflamasi Ekstrak Daun Benalu Jeruk (Dendrophthoe glabrescens (Blakely) Barlow) terhadap Mencit (Mus musculus) yang Diinduksi Karagenan Udayani, Ni Nyoman Wahyu; Mahendra, I Putu Aldy; Widiasriani, Ida Ayu Putu; Mahardika, I Made Agus; Wardani, I Gusti Agung Ayu Kusuma
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11434

Abstract

Inflammation is a natural defense mechanism of the body against injury or disease; however, excessive inflammation can lead to various chronic conditions. Prolonged use of synthetic anti-inflammatory drugs is associated with adverse effects, creating a need for safer natural alternatives. One such candidate is the citrus benalu leaf (Dendrophthoe glabrescens (Blakely) Barlow), a parasitic plant rich in flavonoids, saponins, and tannins. This study aimed to evaluate the anti-inflammatory activity of ethanol extract from citrus benalu leaves in carrageenan-induced mice. A laboratory experimental design using a Randomized Pre- and Post-Test Control Group approach was employed with 25 mice divided into five groups: negative control (CMC-Na 0.5%), positive control (sodium diclofenac), and three treatment groups receiving citrus benalu leaf extract at doses of 100, 200, and 400 mg/kgBW, respectively. The extract was administered orally 30 minutes after carrageenan induction, and paw edema was measured every 30 minutes for 180 minutes. One-way ANOVA revealed significant differences among groups, and LSD post hoc analysis indicated that all treatment groups differed significantly from the negative control (p < 0.05) but not from the positive control (p > 0.05). The 400 mg/kgBW dose demonstrated the greatest efficacy, reducing paw edema to 3.08%. These findings suggest that citrus benalu leaf extract has promising potential as a natural anti-inflammatory agent, offering an alternative to synthetic drugs with fewer side effects.
Proliferasi Nano Kitosan dan Platelet Rich Plasma dari Sel Pre-Osteoblast dengan Ki67 sebagai Pengganti Marker In Vitro Wedagama, Dewa Made
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11435

Abstract

This study investigated the effect of nano-chitosan mix with platelet rich plasma (PRP) to proliferation rate of pre-osteoblast cell with incubation time used in vitro culture system. The culture media of pre-osteoblast cell MC3T3-E1 used alpha-MEM, 2mm L-glutamine, 1mm sodium pyruvate, 10% FBS and 10% pen strep in 25cm2 flask bottle and incubated in an incubator with 5% CO2 at a temperature of 37oC until the cell was confluent 70-80% and planting in well-24 to give treatments. Treatment was divided into two groups, nano-chitosan+PRP and hydroxyapatite+PRP. The proliferation of pre-osteoblast cells saw with immunocytochemical staining and proliferation of cells were counted and investigated with confocal laser scanning microscope (CLSM). The normality of sample data was analyzed with Shapiro-Wilk. Comparison test used independent sample t-test and one-way ANOVA (F-test). All data were analyzed with SPSS software. The experiment results showed that nano-chitosan+PRP can accelerate proliferation than hydroxyapatite+PRP of 0% and 10% concentrations. The independent sample t-test showed there were a significant difference (p=0.010<) from proliferation rate mean (0%) between treatment group nano-chitosan+PRP (1076.3±176.4au) and treatment group hydroxyapatite+PRP (659.5±272.7au) on five days incubation time, and proliferation mean (10%) between treatment group of nano-chitosan+PRP (710.3±109.7au) and hydroxyapatite+PRP (581.8±76.4au) on seven days incubation time. Based on proliferation mean (0%) and (10%), the treatment group of nano-chitosan+PRP with five- and seven-days incubation have higher mean than 0% and 10% on treatment group nano-chitosan and PRP and can accelerate bone healing with incubation time of five and seven days compared to treatment group of hydroxyapatite+PRP.
Uji Aktivitas Tabir Surya dari Formula Emulgel yang Mengandung Nanokapsul Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas (L.)) Varietas Antin-3 Dipahayu, Damaranie; Adenka, Daffa Sachio; Srianto, Jefri Ilyasa; Astutik, Novita Dwi
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11725

Abstract

Flavonoids in purple sweet potato leaf extract (Ipomoea batatas (L.)) variety Antin-3 (Antin-3 extract) have properties as sunscreen. Flavonoids have a large molecular weight and easily decomposed by light, high temperature and external environmental. Modification of Antin-3 extract, namely nanoencapsulation with chitosan: NaTPP, is needed to reducing size and protect flavonoids so that they can remain in the skin layers longer to provide sunscreen protection. This study aims to formulate Antin-3 extract nanoencapsulation into emulgel sunscreen preparations and measure sunscreen activity through SPF, erythema and pigmentation values. The samples tested were base: Antin-3 nanoencapsulation of 0.3%: 0.6% and 0.9% = Base: F1: F2: F3. The results of the physical characteristics test of pH were respectively 6.39 ± 0.04: 5.98 ± 0.28: 5.62 ± 0.25: 5.3 ± 0.42 (sig 0.027 < 0.05) and the spreadability test were respectively 5.91 ± 0.17: 5.89 ± 0.15: 6.08 ± 0.31: 6.28 ± 0.16 (sig 0.266 > 0.05). For the SPF value respectively were 7.48 ± 0.01: 21.03 ± 0.03: 38.02 ± 0.10: 38.29 ± 0.07 (sig 0.00 < 0.05). Based samples has a weak protection, Antin-3 extract emulgel of 0.3% has a medium protection and Antin-3 extract emulgel of 0.6% and 0.9% have a high protection category. All of emulgel sunscreen has the ability to protect the skin from redness and pigmentation due to UV exposure.
In-Use Stability Sediaan Injeksi Hidrokortison di Rumah Sakit Rujukan Daerah Jawa Tengah Genatrika, Erza; Sundhani, Elza; Fitri, Adriana Eka
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11538

Abstract

Hydrocortisone Sodium Succinate 50mg injection is widely used in perinatology wards. These wards cater to newborns (0-28 days), low birth weight (<2.5 kg), or premature babies (<37 weeks), requiring special handling. The use of this injection requires a very small dose, so one vial of hydrocortisone injection can be used for more than one patient. Therefore, the remainder of this hydrocortisone injection is often stored for 24 hours in the refrigerator which will later be reused on other patients. This study aims to determine the in-use stability of hydrocortisone injection stored for 24 hours at 4oC and 25oC. This is certainly to improve patient safety. The data collection technique uses an observational method on hydrocortisone injection samples with 3 replications. In-use stability is assessed from the results of organoleptic tests, pH tests, viscosity tests, determination of drug levels using UV-VIS spectrophotometry and sterility tests. Testing was conducted on days 0, 1, 2, 3, 7, 14 and 30. The results of the study showed that hydrocortisone injection preparations stored for 1 day at 4°C or 25°C in the perinatology ward were no longer physicochemically stable (concentration). Chemical degradation began on day 1, then microbial contamination occurred immediately after completion of compounding in the ward (day 0). This is because reconstitution was not carried out in a clean room in accordance with USP <797>. It can be concluded that hydrocortisone injection preparations prepared in this hospital are not recommended for administration to patients after 1 day of storage and must be compounded in a clean room.
Perkembangan Tren Terapi Pulpa Vital melalui Aplikasi berbagai Biomaterial: Penelitian Bibliometrik Widyastuti, Wiena; Anggraini, Wita; Fibryanto, Eko; Roeslan, Moehamad Orliando; Gunardi, Indrayadi; Rizal, Muhammad Ihsan; Khazin, Sobrina Mohamed; Wedagama, Dewa Made
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11749

Abstract

Vital pulp therapy (VPT) is a crucial dental intervention designed to maintain the vitality of the dental pulp, particularly in carious lesions or trauma. The evolution of biomaterials in VPT has significantly affected dental practices by providing less invasive alternatives that safeguard tooth vitality and functionality. Continued exploration of the properties and effects of these materials is crucial for enhancing treatment strategies and optimizing dental care outcomes. Bibliometric analysis allowed the assessment of trends in the biomaterials used for VPT. Data mining was performed using the Scopus database and Boolean expressions. Data extraction and analysis were conducted using VOSviewer version 1.6.20., VOSviewer thesaurus, and Microsoft Excel. A total of 856 documents were identified, and the United States had the largest number of documents and citations (110 documents, 6,938 citations). The top three sources were the Journal of Endodontics, International Journal of Endodontics, and Dental Materials Journal. Mineral trioxide aggregate (MTA) is still the dominant biomaterial used in VPT to this day. MTA can accelerate dentinogenesis in VPT. The prominence of “MTA” and “VPT” as keywords highlights research on prevalence, causes, prevention, and evaluation, emphasizing the need to investigate biomaterial-driven healing, regeneration, stem cell activity, and gene expression.
Skincare Antijerawat: Formulasi Masker Gel Peel-Off Etil P-Metoksisinamat dari Kaempferia galanga L dengan Polivinill Alkohol sebagai Gelling Agent Kusuma, Ika Maruya; Indrawati, Teti; Zulfah, Zulfah
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11465

Abstract

Herbal medicines are increasingly used as antibacterial therapy due to their accessibility and affordability. Kaempferia galanga L. (kencur) rhizome contains ethyl p-methoxycinnamate (EPMS), an active compound with anti-acne properties. EPMS at 1.2% in cream formulations has shown antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. However, creams are unsuitable for oily skin as they may worsen acne. Peel-off gels offer a better alternative because it is non-greasy, supports exfoliation, stimulates cell regeneration, minimizes pores, and helps cleanse and moisturize the skin. This study aimed to formulate a physically stable anti-acne peel-off gel containing EPMS using polyvinyl alcohol (PVA) at 10% and 12%. EPMS was isolated from kencur rhizome and incorporated into gel bases. Evaluations included organoleptic properties, viscosity, homogeneity, pH, drying time, spreadability, and accelerated stability at 27 ± 2 °C and 40 ± 2 °C for 21 days. Results showed that EPMS can be successfully formulated into peel-off gels with PVA 10% and 12%. The gels exhibited yellowish-white color, honey-like odor, homogeneity, pH 5.21–5.35, drying time 17–30 minutes, spreadability 55–68 mm, and viscosity 4,900–16,000 cPs. All formulations maintained physical stability under test conditions. This study provides a scientific basis for the development of natural-based cosmetic products that are safe, particularly for oily skin, and do not worsen acne conditions.

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