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Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua Jalan Besar Deli Tua No. 77, Kabupaten Deli Serdang, Sumatera- Utara
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Jurnal Penelitian Farmasi dan Herbal
Published by INSTITUT KESEHATAN DELI HUSADA DELI TUA
ISSN : -     EISSN : 26547619     DOI : 10.36656/jpfh
Core Subject : Health,
Medicine & Pharmacology
Aims and Scope The Pharmaceutical & Herb Research Journal is a scientific journal published by Institut Kesehatan Deli Husada which publishes research journals in the field of pharmacy. Indonesia has a lot of natural resources that have the potential to have pharmacological effects. This journal is a place for researchers in the field of pharmacy to be able to publish their researches in 2 main areas, namely Pharmacy and Herbs In the Pharmacy area, accepted research articles include: • Pharmaceutical Biology • Pharmaceutical Chemistry • Pharmacology • Pharmaceutical Technology While the Herb area includes • Herb medicinal formulations from natural ingredients The Pharmaceutical & Herb Research Journal can also be a forum for informations and sources of knowledge related to the field of pharmaceutical science and herb medicine in Indonesia.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 193 Documents
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DETERMINATION OF MINERAL Ca CONTENT IN SEVERAL KINDS OF FRESH FOOD AND PROCESSED PRODUCTS AS SWEETMEAT Ahmad Syukur Hasibuan; Fahma Shufyani; Rinaldo Rinaldo
Jurnal Penelitian Farmasi & Herbal Vol 1 No 2 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v1i2.69

Abstract

The basic thing that differentiate both is how to make it, lasting power, and design products. This study aims to determine the level of calcium in the sample of fresh guava, ginger, and nutmeg, and to investigate the mineral calcium levels in samples of fresh and processed products as wet sweetmeat and dry sweetmeat. Each sample must first be destructed by dry destruction, then the mineral assay performed with quantitative assay atomic absorption spectrophotometry (AAS) using a gas burner nitrous oxide-acetylene at a wavelength of 422.7 nm. The advantage of this method is to have a high sensitivity (limit of detection of less than 1 ppm), and the implementation is relatively simple. Calcium levels in samples of fresh guava, ginger and nutmeg in a row each each sample as follows (7.7105 ± 0.1224) mg / 100 g, (14.5232 ± 0.117) mg / 100 g and (38, 8834 ± 0.6996) mg / 100 g. In the wet sweetmeat guava, ginger and nutmeg for (13.7787 ± 0.4123) mg / 100 g, (22.8345 ± 0.8247) mg / 100 g and (0.2284 ± 0.3759) mg / 100 g. While on dry sweetmeat guava, ginger and nutmeg for (160.9401 ± 0.4223) mg / 100 g, (176.0465 ± 1.0458) mg / 100 g and (120.4426 ± 0.7932) mg / 100 g. Levels of calcium contained in a sample of fresh guava, ginger and nutmeg and sweetmeat processed as wet and dry sweetmeat has different levels
PENGARUH EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana Linn) TERHADAP PERISTALTIK ILEUM TERPISAH MARMOT JANTAN SEBAGAI ANTI DIARE Zaim Anshari; Chrismis Novalinda Ginting; Linda Chiuman; Yuliani Mardiati Lubis
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.73

Abstract

Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice.
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN PERIA LAUT (Colubrina Asiatica L.) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Firdaus Fahdi; Harwitavia Harwitavia; Herviani Sari
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.77

Abstract

The discovery of new antibiotic drugs is getting more and more reactive. The plant of the peria laut leaf is one of the drugs that is often used as a traditional medicine and contains bioactive compounds of polyphenols, flavonoids, and saponins, which can inhibit antibacterial growth. Purpose of this study was to determine the antibacterial activity of ethanol extract of peria laut leaves (Colubrina asiatica L.) against Staphylococcus aureus and Escherichia coli bacteria. Method the experimental, of the sample used was concentrated marine peria laut leaf extract of 25mg/ml, 50mg/ml, 75mg/ml, 100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml, and 500mg/ml, positive control of amoxicillin tablet 500 mg, negative control of dimethylsulfoxide with the method of disc diffusion testing using media Nutrient Agar. Results the showed thet the peria laut leaf extract positively contained bioactive alkaloid compounds, flavonoids, saponins, steroids, and tannins, and had inhibitory effects on Staphylococcus aureus and Escgerichia coli bacteria with various concentrations which had been tested on the average area of the highest inhibition zone of 18,6 mm in Staphylococcus aureus bacteria, and 10,2 mm in Escherichia coli bacteria. Conclusion peria laut leaf extract (Colubrina asiatica L.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria in the most inhibitory zone at a concentration of 500mg/ml with a diameter of 18,6 in Staphylococcus aureus bacteria and 10,2 in Escherichia coli.
UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH Herviani Sari; Vera Estefania Kaban; Friska Raulina Situmorang; Firdaus Fahdi
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.79

Abstract

Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide.
EFEKTIFITAS EPHEDRINE 20 μg/KgBB DIBANDINGKAN DENGAN LIDOKAIN 30 mg TERHADAP NYERI DAN RESPON HEMODINAMIK AKIBAT PENYUNTIKAN PROPOFOL PADA ANESTESIA UMUM DENGAN INTUBASI ENDOTRAKEA Dody Firmanda
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.81

Abstract

Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation.
PENGARUH MEDIA AUDIO DAN VIDEO TERHADAP MAHASISWA PROGRAM STUDI FARMASI DALAM KEMAMPUAN BERBICARA DI INSTITUT KESEHATAN DELI HUSADA DELI TUA Mona Fitri Gurusinga
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.83

Abstract

This study aims to find out: whether the use of video is more effective than using audio inimproving students' pharmacists 'speaking skills. Find out whether the use of video is moreeffective than general media use in improving students' speaking skills. Whether audio usage moreeffective rather than using conventional media in improving students 'speaking skills. Find outwhich media is the most effective among the use of Video, Audio, and conventional media onimproving students' speaking skills. This research is an experimental study using Quasi PretestPost-test Control Group design. The research sample was students pharmacist class 1A, 1B, and1C taken by a simple cluster random sampling technique. This research shows that video usage isthe most effective medium among all of them, and the use of video is more effective than usingaudio in improving students ' speaking skills.
FORMULASI DAN EVALUAI STABILITAS FISIK PATCH TRANSDERMAL ALKALOID NIKOTIN DAUN TEMBAKAU (Nicotiana tobacum Linn) DENGAN VARIASI POLIMER DAN ASAM OLEAT Adi Nurmesa; Nurhabibah Nurhabibah; Aji Najihudin
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.124

Abstract

Research on the tobacco leaves nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law
ANALISIS DESKRIPTIF EFEK SAMPING PENGGUNAAN OBAT ANTI TUBERCULOSIS PADA PASIEN TBC DI RSUD Dr. PIRNGADI MEDAN Eva Sartika Dasopang; Fenni Hasanah; Chairul Nisak
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.180

Abstract

The bacteria Mycobacterium tuberculosis causes tuberculosis. That bacteria is a very strong bacterium, so it should used some antibiotics to kill the bacteria. Tuberculosis (TB) treatment has two stages of intensive and advanced stages. To improve the compliance of TB, patients generally use anti-tuberculosis drugs (OAT) a fixed-dose combination. In the intensive stage, there are at least four antibiotics in the OAT combines fixed-dose. The use of polypharmacy drugs leads to the onset of unwanted side effects and is one of the causes of tuberculosis patients to stop treatment. The purpose of this research is analyzing the side effects that occur during the treatment of anti-tuberculosis. Sampling techniques performed in a prospective observation of tuberculosis patients who consume OAT for two months with analysis using statistics. The results of the study are the most frequent adverse effects on OAT are itching, headache and nausea with a percentage of each 72%, joint pain 45%, abdominal pain 36.4%, less appetite and rash respectively 27,3% and reddish colour in the urine 18.2 %.
UJI EFEKTIVITAS ANTIKOLESTEROL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalina Del.) DENGAN EKSTRAK ETANOL DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS HIPERKOLESTEROL Herviani Sari; Nurmaulia Nurmaulia; Wahyudi Wahyudi; Firdaus Fahdi
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.206

Abstract

African leaves (Gymnanthemum amygdalina Del.) and palm leaves (Elaeis guineensis Jacq.) which is contain flavonoid, saponin, alkaloid, and tannin can be used to decrease cholesterol levels and reduced the risk of cardiovascular disease. This study aims to determine the effect of EEDA dan EEDKS combination on blood cholesterol levels in hypercholesterolemic mice. Sample in this study was African leaves and palm leaves which were taken purposively without comparing samples from other regions, then extracted by maceration using ethanol 96%. The results of data analysis from the three EEDA and EEDKS groups effected cholesterol reduction due to the sig value <0.05. Based on ANOVA one way analysis of the five most effective treatments is simvastatin then dose 400-600mg/kgBB, dose 200-300mg/kgBB, dose 100-150mg/kgBB and CMC Na 1%. The combination of EEDA and EEDKS has an antihypercholesterol effect, the combination of EEDA and EEDKS has an antihypercholesterol effect that is comparable to the positive control, and the finding from this study that the most effective dosage of EEDA and EEDKS as antihypercholesterol is at dosage 400-600 mg/kgBB.
EFEKTIVITAS PENYEMBUHAN LUKA SAYAT MENGGUNAKAN SALEP EKSTRAK ETANOL DAUN SENGGANI (Melastoma malabathricum L.) PADA KELINCI Vera Estefania Kaban; Jessi Octavia Aritonang; Yulia Citra Hasibuan; Dian Ika Perbina Meliala
Jurnal Penelitian Farmasi & Herbal Vol 2 No 2 (2020): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i2.207

Abstract

Senggani plants also have a reddish purple flower, ripe fruit will break the color purple and reddish brown beans. However, the utilization of senggani leaves is still not getting attention, therefore, to increase the economic value and utilization of this plant, senggani leaf can be formulated in the extract ointment of senggani leaf ethanol to healing the cut on the rabbit so it is expected to give healing effect on the rabbit wound.The purpose of this research is to know the concentration of ethanol extract of senggani leaf in the formulation of the ointment which is most effective in healing the rabbit wound in rabbit and to know the ointment ratio of ethanol extract of senggani leaves with betadine ointment .The samples in this study were extract from senggani leaf extracted by maceration using 80% ethanol solvent and formulated in ointment preparation using ingredients of adeps lanae and vaseline album. All data were tested statistically using ANOVA ONE WAY.Preparation of ointment extract of ethanol senggani leaf can accelerate the healing process of the wound and the most effective is the syrup leaf extract of 50% with an average healing for 11 days while betadine ointment does not experience healing until day 14.Indicating differences between treatment groups were more effective in healing of cuts on rabbits and 50% extracts of ethanol extracts of senggani leaf were more effective than with betadine ointment.

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