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Al-Iqra Medical Journal
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Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran
Published by Universitas Muhammadiyah Makassar
ISSN : -     EISSN : 2549225X     DOI : 10.26618
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health Indonesia is a peer-reviewed journal of medicine and health. This journal is designed as a forum for disseminating information and knowledge which is published twice a year. It publishes original articles, review articles, and case reports. It comprises biomedical science, clinical medicine, public health science, and medical science education. This journal has been established since 2018 (Print ISSN 2085-4145, ISSN Online 2527-2950) which is managed by the Faculty of Medicine, University of Muhammadiyah Makassar.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 94 Documents
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HUBUNGAN HIPERTENSI DENGAN FUNGSI KOGNITIF MENGGUNAKAN MINI MENTAL STATE PEMERIKSAAN (MMSE) PADA PASIEN RAWAT JALAN POLA INTERNA DI RSUD KOTA MAKASSAR Andi Riska Gunawati; Andi Weri Sompa
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 1 (2018): Kedokteran Komunitas
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i1.2767

Abstract

For knowing the relation of hypertension with cognitive function in outpatients interna poly in RSU D of Makassar City. Methods : This research type is analytic observational study with a cross sectional approach. The subjects in this study amounted to 60 respondents. The study was conducted in RSUD of Makassar City on 12th December 2014 until 27th January 2015. Samples were taken by purposive sampling. Data were obtained through direct interviews by using Mini Mental State Examination (MMSE) and physical examinations of blood pressure measurement. Data analysis was carried out in stages include univariate analysis, bivariate analysis by using Chi-square test on SPSS program. Results : The results of statistical tests by using chi-square indicate that there is relation of hypertension with cognitive function (p = 0,024; OR = 9,923 dan 95% CI =0,950 - 103,701). Beside it, there is also the relation of long history of hypertension with cognitive function (p = 0,000; OR = 39,000 dan 95% CI = 3,262 – 466,253). Conclusion : There is the relation of hypertension with cognitive function by using Mini Mental State Examination (MMSE). There is also the relation of long history of hypertension with cognitive function.
PENGARUH TRANSPLANTASI SEL PUNCA MESENKIMAL TERHADAP PERJALANAN PENYAKIT ALZHEIMER BERBASIS PENELITIAN PADA TIKUS: SEBUAH TINJAUAN SISTEMATIS Naufal Nandita Firsty; Devi Nadilah; Ilman Arif Aritonang
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i1.2748

Abstract

Penyakit Alzheimer atau Alzheimer’ s disease (AD) merupakan salah satu penyakit neurodegeneratif yang paling umum didiagnosis pada populasi dunia, terkhusus pada wanita. Beberapa manifestasi patologi yang dapat diobservasi adalah deposisi beta-amyloid (Aβ), hiperfosforilasi protein tau, dan inflamasi yang ketiganya berperan sebagai core-pathology dari AD. Permasalahan terberat dari terapi AD saat ini adalah ketidakmampuan berbagai agen farmakologis saat ini untuk menghentikan progresivitas AD. Oleh karena itu, salah satu ikon terapi medis modern yaitu terapi sel punca atau stem cell (SC), khususnya menggunakan sel punca mesenkimal atau mesenchymal SC (MSCs) pada beberapa tahun terakhir telah dijadikan sebagai salah satu fokus studi terapi kuratif penyakit degeneratif yang selama ini hampir selalu tidak mungkin tercapai. Manuskrip tinjauan sistematis ini bertujuan untuk menjabarkan pengaruh transplantasi MSCs secara xenogenik maupun alogenik pada berbagai spesies tikus yang telah diinduksi dengan Aβ untuk mengalami kondisi AD buatan yang dilaporkan oleh berbagai penelitian orisinal pada beberapa tahun terakhir. Sebanyak 32 penelitian dijadikan sebagai referensi utama yang keseluruhannya menunjukkan perbaikan perihal manifestasi patologis seperti reduksi dari deposisi Aβ, penurunan kondisi inflamasi melalui berbagai biomarka, peningkatan aktivitas neurogenesis pada beberapa regio otak seperti hipokampus, dan efek neuroproteksi yang cukup signifikan. Pengaruh tersebut juga dapat diobservasi pada kondisi tingkah laku (behavior) tikus percobaan seperti perbaikan fungsi kognitif dan memori yang diukur berdasarkan metode observasi tertentu. Oleh karena itu, MSCs diduga memiliki potensi untuk menjadi sebuah terapi kuratif bagi AD yang selama ini tidak mampu menghentikan progresivitasnya.
POTENSI PENGGUNAANCAIRANSEREBROSPINAL-AMYLOID42 UNTUK DIAGNOSIS DINI PENYAKIT ALZHEIMER: Puspa Gracella Tambunan; Nia Maylani Hutagaol; Sekar Ayu Wirawan
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 2 (2020): ALZHEIMER DAN STROKE ISKEMIK
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i2.4158

Abstract

Penyakit Alzheimer merupakan salah satu penyakit neurod egeneratif yang kompleks secara klinis dan patologis. Hingga saat ini belum ada gold standard dalam penegakan diagnosa penyakit Alzheimer dan kurang efektifnya pengobatan menjad i sebuah celah kesempat an perkembangan ilmu penget ahuan d alam biomolekuler. Pencarian literatur dilakukan dengan beberapa database elektronik. Hasil didapatkan bahwa dalam kelompok diagnostic, kadar plasma Ab42 lebih rendah pada pasien penyakit Alzheimer dibandingkan dengan kelompok control, SCD, dan MCI dengan meninjau AUC tiap studi inklusi. Kesimpulan studi ini adalah didapatkan bahwa ekspresi Amyloid Beta 42 secara signifikan ditemukan di CSF dan memiliki akurasi diagnostik yang sangat baik dalam membedakan pasien dengan Penyakit Alzheimer dan orang sehat. 
PENANGGULANGAN TRAUMA PADA ANAK-ANAK KORBAN GEMPA BUMI Safitri Sri Handayani; Lupma Miftah Ul Izza Aziz; Zahra Hafizha Fitria Anam
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 2 (2019): Emergency Medicine
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i2.3954

Abstract

The earthquake is one of the natural disasters that should be watched out for. The impact of the disaster was not only a material loss but also a loss of life. The most vulnerable earthquake victims are infants, toddlers, and children. This is because of their weak and bad protection abilities. What is caused by the main earthquake is physical trauma and psychological trauma to the victim. Trauma has a more fatal effect on child victims. The need for special actions to handle it.
POTENSI GO-FUN (GOLD AND FUCOIDAN (SARGASSUM SP.) NANOPARTICLE) DALAM DIAGNOSTIK DAN TERAPI RETINOBLASTOMA Sri Rezki Wahdania J; Indrasari Indrasari
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 2 (2018): Ophthalmology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i2.2757

Abstract

Retinoblastoma is one of the malignant diseases of the eye originating from embryonal tissue. This disease most often occurs in children aged less than 5 years. The prevalence of retionoblastoma ranges from 2-4% of all pediatric malignancies with an incidence of 1 from 15,000-20,000 birth rates. This disease can occur unilaterally or bilaterally. The most common initial symptom is leukoria. The diagnosis of retinoblastoma are biopsy, X photos, ultrasound, Ct-Scan and MRI. However, this detection methods has side effects in children, so a diagnostic method is needed that has minimal side effects. As for the treatment of retinoblastoma are chemotherapy, surgery, focal therapy (cryotherapy, laser thermotherapy), external radiation and enucleation. However, this methods of therapy has side effects in the form of orbital bone growth disorders and mortality due to secondary malignancy. The use of chemotherapy not only attacks cancer cells but also can attack healthy cells so that patients can experience disorders such as diarrhea, anemia, etc. So from tha , the right and effective method of detection and therapy is needed. The writing of this review is to examine the most effective and efficient detection and therapy methods for treating retinoblastoma. In this review, there were Pubmed and Google Scholar-based data searches and no factor index restrictions using the keywords Gold Nanoparticle, fucoidan, nanoparticle, retinoblastoma and Surgassum sp. A review showed that Gold Nanoparticle (GNP) effectively used in the detection of retinoblastoma and Fucoidan nanoparticle is effective for the treatment of retinoblastoma. Gold Nanoparticle (GNP) and Fucoidan nanoparticle are potentially diagnostic and therapy on retinoblastoma . 
POTENSI CIRCULATING MICRORNA SEBAGAI NOVEL BIOMARKER NON-INVASIF UNTUK DIAGNOSIS DAN PROGNOSIS PENDERITA MILD TRAUMATIC BRAIN INJURY: A SYSTEMATIC REVIEW Liani Elisabeth Enggy; Revina Raissa Gunawan; Moh. Anfasa Giffari M.
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 1 (2020): INOVASI DAN MANIFESTASI KLINIS
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.4153

Abstract

Traumatic Brain Injury (TBI) masih menjadi salah satu masalah kesehatan masyarakat global akibat tingginya angka morbiditas dan mortalitas yang disebabkannya. Saat ini, Glasgow Coma Scale (GCS), CT-scan digunakan sebagai acuan utama dalam mendeteksi TBI, tetapi alat diagnostik ini kurang akurat dan belum mampu untuk mendeteksi tingkatan TBI ringan atau mild-TBI (mTBI). Diketahui 80% kejadian TBI merupakan kasus mTBI yang dapat menyebabkan disabilitas jangka panjang apabila tidak ditangani secara cepat dan tepat, sehingga diperlukan suatu biomarker baru yang dapat mengidentifikasi mTBI untuk membedakannya dengan orang sehat. Circulating miRNA merupakan salah satu jenis small non-coding RNA yang tersekresi dari jaringan menuju ruang ekstraseluler yang bersirkulasi dalam tubuh. Trauma pada pasien TBI dapat merubah ekspresi dan regulasi beberapa circulating miRNA spesifik, sehinga miRNA memiliki potensi untuk menjadi indikator diagnosis dan prognosis non-invasif dari mTBI. Menilai kemampuan diagnostik maupun prognostik circulating miRNA dalam mengidentifikasi mTBI dengan menilai sensitivitas, spesifisitas, dan AUC. Kajian sistematis ini mengumpulkan literatur dari PubMed, Science Direct, Directiory of Open Acces Journal (DOAJ), NLM, dan Epistemonikos dengan menggunakan metode berstandarkan cochrane guideline for systematic review (PRISMA) dengan pencarian kata kunci “Traumatic Brain Injury” dan “MicroRNAs”. Dari 307 studi yang didapatkan, ditemukan 6 final studi yang sesuai dengan seluruh kriteria inklusi. Studi yang dikaji berkorelasi dengan tujuan kajian sistematis ini. Circulating miRNA dari spesimen cairan berpotensi menjadi biomarker non-invasif baru untuk mTBI. Secara khusus, miRNA-425 dan miRNA-502 berpotensi tinggi untuk mendiagnosis awal mTBI terhadap orang sehat, serta miRNA-219 sebagai indikator menilai prognosis dari pederita TBI. 
HUBUNGAN KADAR TROMBOSIT, HEMATOKRIT, DAN LEUKOSIT PADA PASIEN DBD DENGAN SYOK DI MAKASSAR PADA TAHUN 2011-2012 Dara Ugi; Nuraini Damayanti
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 1 (2018): Kedokteran Komunitas
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i1.2768

Abstract

In order to detect the occurrence of shock in dengue patients is difficult. Decrease in platelet levels and increased levels of hematocrit is often used as an indicator of dengue especially in the event of shock. Leukocyte levels to see whether there is leukopenia or leukocytosis. By checking levels that may help in early treatment of shock. To determine the relationship between blood platelets, hematocrit and leukocytes in patients with dengue hemorrhagic fever (DHF) and shock. The study observational analytic cross-sectional retrospective design. Samples were DHF patients who received inpatient services at the hospital. RS. Faisal, Baji Labuang RS and RS. Haji in 2011-2012 taken by using total sampling. Data were obtained from medical records and analyzed by Chi Square test. The number of samples involved in this study were 100 cases. Most samples were children aged 5-15 years 54 people (54.0%), male sex by the number of 52 people (52.0%). The degree of the highest degree DHF III 40 people (40.0%). As well as the many levels of platelets were thrombocytopenia (100,000 / p l) by 55 people (55.0%), most were rising hematocrit levels than normal (36%), as well as the highest levels of leukocyte levels are still normal 55 people (55,0%). In this study the results obtained Chi Square statistical test platelet levels there is a significant relationship between shock DHF and shock (p =0.003), whereas the hematocrit levels showed different results there is no significant relationship between shock DHF and shock (p =0.067) and leukocyte levels show different results there is no significant relationship between shock DHF and shock (p =0.841).
KARAKTERISASI MICRORNA TRIPLE HELIX MELALUI METODE HYDROGEL SCAFFOLD SPESIFIK TERHADAP MICRORNA-26A DAN HSA-MICRORNA-15A: MODALITAS KURATIF MUTAKHIR PADA PENYAKIT KATARAK Nisrina Hanifa Afnan; Endah Sari R.Kumala; Mochammad Afifuddin
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2749

Abstract

Cataract is an eye disease that is marked by it decrease in lens transparency. Cataract is a major cause of blindness. Data The World Health Organization (WHO) in 2010 showed that there were 285 million people have visual impairments worldwide, 39 million of them blindness where 33% of them are caused by cataracts. Governance cataracts are currently limited to surgical efforts and administration of eye drops as antioxidant. But both have flaws because of the risk of complications limited ocular and lens penetrating ability. Therefore, the author reviewed the potential for triple helix microRNA characterization through specific Hydrogel Scaffold methods against microRNA-26a and hsa-microRNA-15a as the latest curative modalities on cataract disease. microRNA is a non coding RNA molecule consisting of 22 nucleotide. microRNA is known to have a specific target gene so it will increase the effectiveness of therapy in cataracts. The method used in this writing is a study of literature. The author reviews various sources, the majority come from a global journal. The author enters several keywords such as cataract, microRNA, triplex nanoparticle, and Hydrogel Scaffold. The website is used including nature, sciencedirect, pubmed, and ebsco. After extraction based on the inclusion and exclusion criteria that have been determined, the journal is then analyzed and synthesized whose results are written in this review literature. based on literature obtained, microRNA-26a has decreased expression in cataract cases. So that when microRNA-26a is transfected, there will be an increase in regulation which can increase the positive effect on inhibiting the process of fibrosis oncataract pathomechanism mediated by Notch / Jagged-1. Meanwhile, microRNA- 15a overexpresses, so that when transfected antagomir microRNA-15a, then this microRNA will decrease and give negative feedback so the expression of bcl-2 and mcl-1 as antiapoptotic and antioxidant proteins will be increased. To increase its stability, both microRNA-26a and antagomir microRNA-15a will be formed into a triple helix RNA structure through addition dendrimer with the Hydogel Scaffold method. This allows the microRNA become more stable in circulation and can be released in specific genes. By therefore, through the triple helix RNA characterization specific to microRNA-15a and microRNA-26a, cataract therapy is expected to be more effective and efficient. Keywords : cataracts, triple helix microRNA, microRNA-15a, microRNA-2
POTENSI KOMBINASI MEMANTIN DAN FITOMELATONIN DARI EKSTRAK BIJI BUNCIS (PHASEOLUS VULGARIS L) TERENKAPSULASI NANO-CHELATOR SEBAGAI INHIBITOR AGREGASI β-AMILOID DAN ANTIOKSIDAN : MODALITAS KURATIF MUTAKHIR PADA PENDERITA ALZHEIMER Raafi Haidar Arrasyid; Endah Sari Ratna Kumala; Nisrina Hanifah Afnan
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 2 (2020): ALZHEIMER DAN STROKE ISKEMIK
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i2.4159

Abstract

Alzheimer merupakan penyakit yang menyerang sistem saraf pusat manusia dengan tanda adanya atrofi dan kematian saraf pada beberapa regio di otak. Data dari World Health Orginazation (WHO) pada tahun 2017 menunjukkan angka penderita Alzheimer mencapai 50 juta orang dan di Indonesia mencapai 1,2 juta orang. Tatalaksana yang ada saat ini belum dapat mengobati Alzheimer secara menyeluruh dan tingginya ketidakpatuhan pasien dalam menjalani pengobatannya membuat angka penderita Alzheimer tetap tinggi. Mengetahui kombinasi memantin dan fitomelatonin yang terenkapsulasi nano-chelator sebagai terapi kuratif Alzheimer. Metode yang digunakan adalah studi literatur. Penulis menganalisis sumber-sumber terkait yang mayoritas berasal dari jurnal yang diambil dari PubMed, Science Direct, dan Spinger. Memantin merupakan obat yang telah dipakai dalam pengobatan Alzheimer dengan memblok reseptor NMDA sehingga melindungi sel saraf dari reaksi inflamasi dan menghambat pembentukan agregasi β-Amilod. Namun, penggunaan satu bahan tersebut tidak dapat menunjukkan hasil yang maksimal. Oleh karena itu, penulis mengkombinasikan memantine dengan fitomelatonin yang didapatkan dari buncis (Phaseolus vulgaris L) dengan peran sebagai antioksidan dan mengurangi agregasi β- Amilod melalui jalur yang berbeda dari memantin. Untuk meningkatkan bioavabilitas, ketepatan terapi, dan kemampuan menembus Blood-Brain Barrier (BBB) dari kedua bahan tersebut maka digunakanlah nano-chelator. Melalui efek penghambatan pembentukan agregasi β- Amilod dan antioksidan dari kombinasi memantin dan melatonin dengan enkapsulasi nano- chelator diharapkan terapi Alzheimer dapat lebih efektif dan efisien. 
MINDFULNESS DENGAN PERILAKU PERAN SAKIT PADA PASIEN PASCA STROKE Andi Dian Diarfah; Andi Weri Sompa
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 2 (2019): Emergency Medicine
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i2.3957

Abstract

Stroke is a common cause of disability and has a large impact on an individual's life. Stroke recovery is very individual and requires a long process. Family support is not enough to give effect to the recovery of post-stroke sufferers, the mindfulness of post-stroke sufferers themselves to recover is also needed. The purpose was determined the relationship between mindfulness with sick role behavior in post-stroke patients with. The subjects were 110 people with characteristics aged 30-65 years. The instruments of this study were the Applied Mindfulness Process Scale (AMPS) and Barcylas Sick Role Process Inventory (BSRPI). The technique of Mediated Multiple Regression was the data analysis. The results showed there was a correlation between mindfulness and sick role behavior  (β = 0.51, p 0.05).

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