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Al-Iqra Medical Journal
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Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran
Published by Universitas Muhammadiyah Makassar
ISSN : -     EISSN : 2549225X     DOI : 10.26618
Core Subject : Health,
Medicine & Pharmacology Public Health
Journal of Medicine and Health Indonesia is a peer-reviewed journal of medicine and health. This journal is designed as a forum for disseminating information and knowledge which is published twice a year. It publishes original articles, review articles, and case reports. It comprises biomedical science, clinical medicine, public health science, and medical science education. This journal has been established since 2018 (Print ISSN 2085-4145, ISSN Online 2527-2950) which is managed by the Faculty of Medicine, University of Muhammadiyah Makassar.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 94 Documents
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TEKNIK EVAKUASI CEDERA KEPALA PASCA BENCANA KETEPATAN TEKNIK EVAKUASI PADA KORBAN CEDERA KEPALA DALAM MENGURANGI KEJADIAN CEDERA SEKUNDER Noer Safita; Anindya Atiqah Ristanti; Eka Pramudian Rismayanti; Hitaputra Agung Wardhana
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 2 (2019): Emergency Medicine
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i2.2818

Abstract

Evacuation is an effort to redeploy the victims from the affected area to a safer region to acquire the rescue. Nowadays the lack of a adequate transfer to evacuate disaster victims are the phenomenom which occur in social case spesifically the health workers who get high potency to increase the occurence of secondary injuries to victims. ratio of the results of health research at 2007 and 2013, point out the enhancement of prevalence of head injury from 7,5% being 8,2% and one of  the hospital in Indonesia has held a data which made into a vocal point assert that head injury cases from year to year have increased. The aim of this literature review is to mitigate morbidity and mortality of head injury which go up every year and underpin the health workers to simplify in carry out evacuation to prevent secondary injuries. This literature review was conducted by seeking the electronic databases journal with engage corresponding keywords. The result of the study postulate the victim of injuries particularly post disaster need rapid and appropriate evacuation, assesment and management techniques to rescue suffers live. The treatment carried out when get a head injury is preserve the patients airway, oversee bleeding and preventing shock, immobilizing patient, avert complication and secondary injuries each circumstances which engage in abnormal and dangerous must be given resuscitation. The handling is done alluding to the necessity of ABCDE method by using the START method and mantain stabilization of the cervical technique using the log roll technique.
POTENSI RIPASUDIL SEBAGAI TERAPI TERBARUKAN UNTUK MENGATASI UVEITIS GLAUCOMA MELALUI INHIBISI RHO KINASE PATHWAY (ROCK) Ilham Dhiya; Iskandar Purba G; Khartika Mahardini
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 2 (2018): Ophthalmology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i2.2755

Abstract

Uveitis is an inflammatory disease that accounts for 300 thousand new cases of blindness each year in America, and is responsible for 5-10% of vision changes worldwide. First-line therapy for uveitis is topical corticosteroids. Unfortunately, corticosteroid use is a risk factor for glaucoma. About 20-40% of patients experience an increase in pathological intra-ocular pressure that requires secondary glaucoma therapy. To reduce this pressure, the first therapy is beta-blockers and adrenergic agonists. But in inflammatory conditions, therapeutic side effects decrease. Over the years, a new glaucoma therapy agent, Ripasudil, has emerged. Research shows that Ripasudil can not only reduce intraocular pressure in glaucoma, but also has the anti-inflammatory effect needed to treat uveitis.  The study of the potential of Ripasudil using literature obtained from the database publications of the journal Pubmed, Clinical Trials and Science Direct. Supporting articles are sought based on specific keywords by the inclusion criteria of articles won in the UK, publications of the past 10 years (except basic science), EBM articles level 1-3 and support the discussion of literature review.  Ripasudil can release inflammatory cell infiltration and exudation proteins in aqueous humor. In addition, MCPI-1 protein levels and IL-1, IL-6, TNF-dan, and MCP-1 mRNA levels in the iris-ciliary body decreased after Ripasudil administration. Clinical trials also show that Ripasudil can be used as a glaucoma therapy agent. Ripasudil can be an updated therapy to treat glaucoma uveitis through inhibition of the ROCK pathway and treatment of proinflammatory mediators.
POTENSI KOMBINASI INDUCED PLURIPOTENT STEM CELL-DERIVED NEURAL PROGENITOR CELL (IPSC-NPC) DENGAN HIDROGEL CHONDROITIN SULFATE SCAFFOLDS YANG MEMEDIASI BASIC FIBROBLAST GROWTH FACTOR (BFGF) SEBAGAI INOVASI TERAPI TERBARU STROKE ISKEMIK Sisca Sisca; Nurul Azizah; M. Salas Al Aldi
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 2 (2020): ALZHEIMER DAN STROKE ISKEMIK
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i2.4161

Abstract

Stroke iskemik adalah jenis stroke yang paling umum terjadi dan merupakan penyakit dengan angka kematian dan kecacatan tertinggi di dunia. Terapi yang ada saat ini dalam menangani stroke masih menyisakan tantangan bagi para peneliti karena belum ditemukannya perawatan yang dapat meregenerasi jaringan otak yang hilang akibat infark. Penggunaan Neural Progenitor Cell (NPC) turunan induced Pluripotent Stem Cell (iPSC) merupakan studi yang berada paling depan dalam tahapan uji praklinis karena diketahui dapat menjadi dan menggantikan neuron serta mempromosikan mekanisme pemulihan endogen seperti angiogenesis. Namun, terdapat hambatan dari penggunaan NPC utamanya pada patofisiologi stroke yang menyebabkan adanya resistensi terhadap terapi seluler. Oleh karena itu, diperlukan kombinasi NPC dengan Scaffold menggunakan Chondroitin sulfate-A (CS-A) berbasis hidrogel yang dapat meningkatkan aliran darah ke inti stroke serta meningkatkan afinitas neurotropik. Kombinasi ini menghasilkan sinergitas terapi yang sangat baik dengan efek utamanya dimediasi oleh basic Fibroblast Growth Factor (bFGF) yang akan memperbaiki kerusakan jaringan di daerah infark. Untuk mengetahui potensi kombinasi NPC dengan Hidrogel CS-A dalam pengobatan stroke iskemik. Literature Review ini disusun menggunakan metode studi pustaka dengan mengumpulkan jurnal yang valid berdasarkan kriteria inklusi dan eksklusi khusus. Kombinasi NPC dengan Hidrogel CS-A secara signifikan meningkatkan perbaikan vaskular, aliran darah kortikal dan hasil perilaku sensorimotor setelah stroke. Peningkatan yang terjadi dimediasi melalui stimulasi pengeluaran bFGF yang mendorong perbaikan jaringan. Efektivitas pemberian NPC secara signifikan dapat ditingkatkan dengan kombinasi Hidrogel CS-A dan telah terbukti dalam berbagai pengujian sehingga diharapkan dapat menjadi upaya terbaru dalam terapi stroke iskemik. 
ANALISIS FAKTOR YANG BERPENGARUH TERHADAP KONVERSI SPUTUM BASIL TAHAN ASAM PADA PENDERITA TUBERKULOSIS Clevia Revi Maretha Mahendrani; Mohammad Subkhan; Annisa Nurida; Kartika Prahasanti; Yelvi Levani
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 1 (2020): INOVASI DAN MANIFESTASI KLINIS
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.4037

Abstract

Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) that most often affect the lungs. The incidence of tuberculosis in Indonesia is high because the success rate of tuberculosis treatment has decreased which causes the chain of transmission continues to occur. The main government programs to decrese the incidence and increasing the success treatment with the Directly Observed Treatment (DOTS) program. One important indicator of the DOTS program to assessing the success of tuberculosis treatment is the conversion of positive AFB sputum to negative at the end of the intensive phase of treatment. AFB sputum conversion to negative at the end of the intensive phase of treatment is influenced by several internal factors such as level of education and income, gender, adherence, patient's nutritional status, and comorbidities. Then external factors can also influence the AFB sputum conversion in anti-tuberculosis treatment such as environmental conditions, smear positivity, drug taking supervisors (PMO), and availability of drugs in health facilities.
PENGARUH TINGGINYA KADAR GULA DARAH TERHADAP KEJADIAN KATARAK PADA PASIEN DIABETES MELLITUS DI BALAI KESEHATAN MATA MASYARAKAT SULAWESI SELATAN TAHUN 2014 Nur Hikma M.Jihad; Rahasia Taufik; Nurmila Nurmila
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 1 (2018): Kedokteran Komunitas
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i1.2765

Abstract

In order to detect the occurrence of shock in dengue patients is difficult. Decrease in platelet levels and increased levels of hematocrit is often used as an indicator of dengue especially in the event of shock. Leukocyte levels to see whether there is leukopenia or leukocytosis. By checking levels that may help in early treatment of shock. To determine the relationship between blood platelets, hematocrit and leukocytes in patients with dengue hemorrhagic fever (DHF) and shock. The study observational analytic cross-sectional retrospective design. Samples were DHF patients who received inpatient services at the hospital. RS. Faisal, Baji Labuang RS and RS. Haji in 2011-2012 taken by using total sampling. Data were obtained from medical records and analyzed by Chi Square test. The number of samples involved in this study were 100 cases. Most samples were children aged 5-15 years 54 people (54.0%), male sex by the number of 52 people (52.0%). The degree of the highest degree DHF III 40 people (40.0%). As well as the many levels of platelets were thrombocytopenia (100,000 / p l) by 55 people (55.0%), most were rising hematocrit levels than normal (36%), as well as the highest levels of leukocyte levels are still normal 55 people (55,0%). In this study the results obtained Chi Square statistical test platelet levels there is a significant relationship between shock DHF and shock (p =0.003), whereas the hematocrit levels showed different results there is no significant relationship between shock DHF and shock (p =0.067) and leukocyte levels show different results there is no significant relationship between shock DHF and shock (p =0.841).
POTENSI 6-AZA-INDAZOLE SEBAGAI TERAPI YANG DAPAT DIPERBAIKI UNTUK PERAWATAN RETINOPATI DIABETIK MELALUI INHIBISI FAKTOR D PENYELESAIAN Dhitta Shabrina; Ihya Fakrurizal; Afid Brilliana P
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 1 (2019): Ophthamology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.2747

Abstract

Diabetes mellitus is a chronic disease that has a high prevalence in Indonesia. One of diabetes’ complications is Diabetic Retinopathy (DR). DR is one of the highest cause of preventable blindness in the world. The treatment for DR up till then uses intravitreal anti-VEGF injection, intravitreal steroid antiinflammation injection. Intravitreal administration can cause some side effects such as increased intraocular pressure and endophthalmitis. Furthermore, patient’s convenience is also disturbed, for always having to see a medical personnel frequently. One pathogenesis of DR is the activation of the complement system which causes lysis of endothelial cells and results in ischemic damage to the retina. This ischemic effect will stimulate VEGF secretion that manifests in the phase of Proliferative Diabetic Retinopathy (PDR). Inhibitor of D factor, 6-aza indazole is a small size protein, less than 300 Da which has the potential to inhibit progress of DR by interfering with the activation of alternative pathway (AP) of the complement system. This is supported by the in-vivo test result, where there is a significant inhibition of intraocular AP activation continuously for 8 hours after an oral administration of this agent at a dose of 30 mg/kg. But this study is still in a pre-clinical phase that uses mice as the subject. Therefore, there must be a further study and clinical trial to find out the dosage and safety of this agent to be applied to humans. Keywords: 6-aza indazole, alternative pathway, complement factor D inhibitor, diabetic retinopathy
POTENSI SOVATELTIDE (IRL-1620) SEBAGAI OBAT NEUROPROTEKTIF MUTAKHIR STROKE ISKEMIK Jonathan Ricardo Hamonangan; Michael Nobel Simanjuntak; Leonardus Yodi Giovanni
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 2 (2020): ALZHEIMER DAN STROKE ISKEMIK
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i2.4157

Abstract

Stroke adalah penyebab kematian tertinggi kedua di dunia. Stroke iskemik terjadi pada 88% kasus stroke, sedangkan stroke pendarahan terjadi pada 12% kasus. Baik pada dewasa maupun anak-anak, stroke dapat menyebabkan kecacatan sehingga memengaruhi produktivitas penderita. Namun, pengobatan stroke iskemik secara farmakologis merupakan tantangan bagi dunia kedokteran karena patologi stroke iskemik yang kompleks. Sebagai intervensi mutakhir, Sovateltide (IRL-1620/PMZ-1620) hadir sebagai agonis endothelin B receptors (ETBR) selektif yang prospektif dengan memberikan efek neuroprotektif dan angiogenesis pada stroke iskemik. Meskipun masih dalam uji coba klinis, belum ada studi pustaka yang membahas mengenai potensi Sovateltide sebagai neuroprotektif stroke iskemik. Sebagai solusinya, studi pustaka ini bertujuan untuk mengetahui potensi Sovateltide sebagai obat neuroprotektif mutakhir stroke iskemik. Studi pustaka secara sistematis ini merupakan hasil analisis dan sintesis dari berbagai referensi yang relevan dengan topik di Pubmed dan Google Scholar, dicari menggunakan berbagai kata kunci, dan jangka waktu tidak lebih dari 10 tahun. Sovateltide merupakan agonis ETBR yang paling selektif sehingga mampu memberikan efek neuroprotektif dengan meningkatkan proliferasi, survival rate, diferensiasi, neurogenesis, fusion mitokondria, dan perkembangan sel saraf. Selain itu, Sovateltide juga mampu meningkatkan Vascular Endothelial Growth Factor (VEGF) sehingga menyebabkan angiogenesis pada pembuluh darah otak yang mengalami oklusi. Berdasarkan penelitian, pemberian Sovateltide pada sampel tikus dewasa dan anak- anak dengan middle cerebral arteries occlusion (MCAO) berpotensi menjadi obat neuroprotektif stroke iskemik fase akut dan subakut. Sovateltide memiliki potensi yang baik sebagai obat neuroprotektif mutakhir stroke iskemik. 
MANAJEMEN PENYELAMATAN IBU HAMIL PASCA BENCANA Ika Nuria Syafira Iswarani; Ismatu Aghni Fatwa Izzati; Rusnaindah Ifta Firdausi; Dodik Nursanto
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 2, No 2 (2019): Emergency Medicine
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v2i2.3953

Abstract

Republic Indonesia is a disaster prone area, usually the victims are women, children, and elderly. The victim which need spesial treatment is pregnant women. The purpose of this literature review is to provide knowledge to readers in helping the post-disaster pregnant women. The method that we use in is reviewing articles through Google Scholar, Pubmed, and Mendeley. Before the evacuation, triage actions need to be carried out as an effort to sort out the patient's priorities based on the urgency of the management and consideration of the resources available for the management. Pregnant women are included in the first priority group (red) which means that they need immediate and appropriate help. The most appropriate evacuation for pregnant women is a sloping position with knees folded. If there is a back injury, make an effort so that the inferior vena cava is not crushed by the uterus. Injuries that need to be watched out for are bleeding, shock, DIC, and eclampsia. Nutritional and psychological recovery of pregnant women is also very important to prevent things that are not desirable for both mother and fetus.
POTENSIAL MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES (MSC-EVS) SEBAGAI TERAPI TERBARU DALAM OBAT ISKEMIK RETINAL Sisca Sisca; Nurul Azizah; M.Salas Al Aldi
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 1, No 2 (2018): Ophthalmology
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v1i2.2756

Abstract

Retinal ischemia (IR) is still the biggest cause of blindness in the world. Several factors contribute to the pathogenesis of Retinal Ischemia. However, oxidative stress and inflammatory processes are the main factors. Various forms of therapy have been applied in clinical care of Retinal ischemia, but none have been optimal for repairing the cells damage and able to avoid immunological and oncogenic reactions. MSC-EVs have opened a new perspective for the treatment of Retinal Ischemia. MSC is a multipotent cell with paracrine characteristic and mediated by extracellular vesicles (EVs) which is derivative of MSC that can be used as a biomimetic agent to help nerve protection and tissue regeneration. In addition, MSC-EVs have a lower tendency to trigger immune responses and the inability to directly form tumors. Therefore, MSC EVs can prove to be an ideal source for the latest therapies in dealing with the problem of retinal ischemia. This Literature Riview is compiled by using a literature study with collecting valid journals, particular inclusion and exclusion criteria. On testing its effectiveness, three indicators were used, that is the protective effect of MSC-EVs on retinal cells, the effects of post-ischemic in vivo administration of MSC-EVs, and the distribution of MSC-EVs in humour vitreous and long-term protective effects estimates. Significantly shows a protective effect, decreases inflammatory factors and apoptosis of retinal cells. Based on the results of testing in vitro and in vivo MSC-EVs are endocytosis by retinal cells that provide neuroprotective effects before and after treatment, and this effect can be developed into long-term therapy. Therefore, using MSC-EVs can be a promising therapy in the treatment of retinal ischemia.
DEMAM TIFOID: MANIFESTASI KLINIS, PILIHAN TERAPI DAN PANDANGAN DALAM ISLAM Yelvi Levani; Aldo Dwi Prastya
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 3, No 1 (2020): INOVASI DAN MANIFESTASI KLINIS
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v3i1.4038

Abstract

Typhoid fever is an acute infectious disease of the digestive system caused by the bacteria Salmonella typhi or Salmonella paratyphi. Typhoid fever is a global infectious disease in which an estimated 26.9 million cases of typhoid fever are found worldwide. Typhoid fever is especially common in developing countries because it is associated with poor sanitation. Clinical manifestations of typhoid fever that arise can vary from mild to severe symptoms. Symptoms of typhoid fever that are often found are fever, malaise, abdominal pain and constipation. Culture examination is a gold standard examination in establishing the diagnosis of typhoid fever. But this examination is rarely done. The first-line treatment option for typhoid fever is chloramphenicol. However, as the bacterial resistance to chloramphenicol increases, the main therapeutic choice for typhoid fever is the fluoroquinolone antibiotic.

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