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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Effect of Vachadi Ointment in the Management of Scabies - A Case Report Rakesh Khatana1 , Renu Rathi2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13418

Abstract

Introduction: Skin disease has a high prevalence throughout the world. Scabies is contagious and canspread quickly through close physical contact so it is an acute communicable disease. It is highly prevalentin young children. The present study is aimed to show the effect of Vachadi ointment on scabies in children.Scabies is characterized by nocturnal itching, vesicular or pustule eruptions, with small red bumps andblisters. According to Ayurveda Scabies can be correlated to Pama. Pama is one of the eighteen types ofKushtha (Skin Disease) according to the Charak Samhita (Chikitsa-Sthana) which is caused by vitiation ofKapha and Pitta Dosha. Case Description: A 10 years old male patient brought with complaints of itchingin between the fingers of both the hands, wrists and forearms since 10-12 days. On local examination,vesiculopustular lesions were present along with dry scaly patches over both the hands, wrists and forearms.Effect of the treatment was assessed on the basis of clearance of lesion and relief from itching. Conclusion:After intervention of the Vachadi ointment for 14th day, there was a marked improvement in symptomslike itching, scaling, and discharge. So, it can be said that Ayurveda has a better remedy for skin relatedcomplaints.
Effectiveness of Vachadi Ointment in the management of Pama Kushta (Scabies): A Novel Research Protocol Using Science of Ayurveda Rakesh Khatana1 , Renu Rathi2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13419

Abstract

Background: Scabies is a common cause of itching is produced by infestation with the mite Sarcoptesscabiei var hominis. Poor hygienic condition and overcrowding, permitting close body contact favour thetransmission of the disease. Scabies is more prevalent in overcrowded communities with low socioeconomicconditions. The point prevalence in the general population of rural India is about 13%,In Maharashtra81% of inmates of an orphanage in rural area,[6] 72% of cases are seen in the age group of School goingchildren’s. Pama Kushtha characterized by many small Pitikas, Srava, Kandu, Toda and Daha that may beconsidered as scabies in contemporary science. Aim: The present study is aimed at evaluating the effect ofVachadi Ointment in the management of Pama Kushta. Material & Methods: The present study is designedas a Non-randomized controlled clinical study, in which minimum of 30 patients will be enrolled. VachadiOintment will be administered external application 2-3 times in a day. Assessment will be recorded on 3rd,5th, 7th and 14th days. Results: Changes will be observed in subjective parameters such as Kandu (Itching),Toda (Pain), Daha (Burning) and objective parameters such as Pitika (Eruption) and Srava (Discharge).Conclusion: Suitable conclusion will be drawn post completion of the trial.
Palmar Dermatoglyphics and Idiopathic Epilepsy – A Systematic Review Rashmi C Goshi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13420

Abstract

Dermatoglyphics is the science which deals with the study of dermal ridge configuration on the digits, palmsand soles. Etymologically this term is harmonious blend of two words Derma – skin; Glyphe – carve. It givesthe impression that something has been carved out of the skin. The entire human body is clothed with theskin which happens to be the largest and most important organ of the body. However, the skin on the ventralsides of the hands and the plantar sides of feet is exclusively designed and is corrugated with the ridgesand configurations which are functionally useful as they help in the grasping without which the objectswould easily slip away from the hands. Dermatoglyphic traits are genetically determined. Dermatoglyphicabnormalities are due to genetic or other factors that express their effect before the end of 5th month of foetaldevelopment. The permanency of finger patterns, the extreme variability from one individual to the otherand easy analysis are some of the reasons for its wide application in a variety of conditions. Abnormality inthe genetic configurations of parents is inherited by children and is reflected in the dermatoglyphic pattern.Hence dermatoglyphic study proves to be a very useful, easily applicable, inexpensive, indispensable toolas an indicator in the diagnosis of hereditary diseases in patients. The etiology of the epilepsies allows aclassification of syndrome features into two groups – idiopathic or cryptogenic epilepsy, which has isolatedprimary symptoms without apparent cause and is probably hereditary and finger print configurations areinherited with an embryonic origin common to nervous system. Their attractions indicate pleiotropic effectsof the genotype responsible for enaphalographic irregularity and convulsive seizures.
Comparison of the Serum Concentrations of Micronutrients Zinc and Iron in Epileptic Children before and after Administration of Valproic ACID Ratih Dwi Andini1 , Darto Saharso2 , Roedi Irawan2 , Prastiya Indra Gunawan2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13421

Abstract

Introduction: The mortality rate of epileptic patients has increased despite advances in the treatment ofepilepsy. Several studies have indicated that changes of micronutrient homeostasis led to seizures. Theanticonvulsant valproic acid affects the intracellular concentration of micronutrients.Objective: To compare the serum concentrations of micronutrients zinc and iron in paediatric patients withepilepsy before and after administration of valproic acid.Method: A prospective cohort design study was conducted in children with epilepsy from July to December2019 in the outpatient department of paediatric neurology, Dr. Soetomo Regional Public Hospital, Surabaya,Indonesia. Serum concentrations of micronutrients zinc and iron were measured using the colorimetricmethod. Statistical analysis used paired t-test with p<0.05 being considered significant.Results: The study sample comprised 20 children with epilepsy. There were 13 (65%) males. Eight (40%)children were in the 1-5 year age group. Seizure type was generalised in 18 (90%) patients. The mean serumiron concentrations before and after valproic acid treatment were 23.9±16.8 µmol/L and 25.8±16.4 µmol/Lrespectively (p=0.700). The mean serum zinc concentrations before and after valproic acid treatment were13±16.8 µmol/L and 26.8±15.4 µmol/L respectively (p=0.004).Conclusions: There was a statistically significant increase in the mean serum zinc concentration aftervalproic acid treatment in children with epilepsy. There was however no statistically significant increase inthe mean serum iron concentration after valproic acid treatment in children with epilepsy.
Palaskhshar ointment in the management of Abhyantar Gudarsh – An Ayurvedic Management Protocol Ravikumar S Suryawanshi1 , Kiran Khandare2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13422

Abstract

Background: Hemorrhoids or piles are a common ailment among adults. More than half of men and womenaged 50 years and older will develop hemorrhoid symptoms during their lifetime. This disease Gudarshacomes under the heading of Mahagada, as it is Dirghakalanubandhi, Dushchikitsya in nature, Tridoshaj andinvolves the Marma and it is well known for the chronicity and difficult to treat. Aim & Objectives:- Toevaluate the effect of local application of Palash Kshar Ointment in Management of Abhyantar Gudrsha.Methodology:- The study is prospective randomized controlled clinical trial. Total 60 patients will beselected for this study, which will be further divided randomly into two groups. Each group consists ofabout 30 patients. In which group A, will be trial groups and group B will be control groups. Every patientwill be observed at regular follow up. On 7th, 14th, 21th, 28th Day.. Results– Results will be drawn from theobservations of objective parameters. Conclusion – Conclusion of the study will be drawn on the basis ofstatistical data calculated from the collected data.
Response Evaluation on Single Common and Uncommon EGFR Mutation on First-Generation EGFR-TKI Therapy in NSCLC Patients Rena Arusita Maranatha1 , Laksmi Wulandari2 , Gatot Soegiarto3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13423

Abstract

Objective: To compare the response of first-generation EGFR-TKI (epidermal growth factor receptortyrosine kinase inhibitors) in non-small cell lung cancer (NSCLC) patients with single common anduncommon EGFR mutation.Methods: Patients were divided into two groups, the uncommon (exon 21 L861Q, exon 18 G719X, exon18 delE709) and common EGFR mutation group (exon 19 deletion, exon 21 L858R). Health-related qualityof life (HRQOL) using EuroQol EQ-5D® questionnaire, body weight, performance status (PS), ResponseEvaluation Criteria in Solid Tumors (RECIST) on chest CT, progression-free survival (PFS) and overallsurvival (OS) was recorded during TKI therapy.Results: The value of HRQOL was stable and PS was constant in both groups, body weight was constantin uncommon group (42.1%) and increased in common group (44.1%; p=0.165). The uncommon groupshowed mostly progressive disease in RECIST (47.4%) while the common group showed mostly partialresponse (42.2%; p=0.007). PFS in the uncommon group was 4 (2.0-6.0) months and 7.0 (2.0-21.0) monthsin the common group (p=0.001). OS in the uncommon and common group were 4.00±1.71 months and10.00±6.94 months (p<0.001), respectively.Conclusion: NSCLC patients with common EGFR mutations showed a better response and survival ratecompared to uncommon EGFR mutations on first-generation TKI therapy.
Histopathological Assessment of Autopsied Salivary Gland Tissue to Estimate the Post Mortem Interval – A Cross Sectional Observational Study S.Rajkumari1 , R.Mensudar2 , N. Naveen3 , B.Thayumanavan4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13424

Abstract

Background: In biological system, cells are considered as dynamic and complex structures likewise cellulardisintegration is also a complex process which occurs in a sequence. Therefore, these autolytic cellularchanges have been investigated by forensic pathologist in an attempt to find markers that may assist indetermining the time of death. In this study we attempt to analyse the efficacy of oral soft tissues specificallysalivary gland in concluding the time since death.Methodology: After obtaining approval from the human ethical committee, informed consent from therelative of the corpse and the investigating police officer, demographic information, as well as post mortemnumber was recorded. Submandibular Salivary Gland was collected for histopathological analysis duringroutine autopsy procedure. The specimens were fixed immediately in 10% formalin, processed, sectionedand stained with haematoxylin and eosin. The stained sections were evaluated under light microscope forhistopathological changes.Conclusion. The histopathological changes in the autopsied salivary gland tissue can be used as an adjuvantto estimate the post-mortem interval.
Influence of Melatonin in the Treatment of Experimental Enterobius Vermicularis Infection Shaimaa A. Shlash1 , Noor M. Hasnawi2 , Hussein A. Kadhum3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13425

Abstract

This study aims to realization the conceivable therapeutic of melatonin effects experimental againstEnterobius vermicularis in rats. Implement this experiment during the period from August 2019 to January2020. E.vermicularis infected with male wistar rats orally with dose 15mg/kg melatonin former of bodyweight for 30 day showed significantly reduction in the number of eggs and worms compared with ratsorally with dose 15mg/kg melatonin accompanying and untreated rats for 30 day (P < 0.05).Histologically inintestine examined show increase numbers of leucocytes produce, necrosis significant scatter and reductionthis parasite of tissue in rats treated with melatonin. This results show influence of melatonin in the controlon Enterobiosis and suggestion that this drug usefulness in Enterobius vermicularis infection therapy
Comparative Study of Palashgudavarti and Diclofenac Sodium Suppository in the Management of Acute Fissure in Ano (Parikartika)-An Ayurvedic Management Protocol Shubham Golokkumar Biswas1 , Devyani Dasar2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13427

Abstract

Background - Anal Fissure is one of the major causes for pain at anal region. The two primary signs ofthis disease are pain and bleeding, and pain is often unbearable. In males anal fissure typically occursin the midline posterior- 90 %, and 10 % midline anterior. Subsequently, female fissures on the midlineanteriorly are significantly more frequent than posteriorly (60:40). In contemporary sciences Parikartikacan be correlated with Fissure in Ano. Objective- The objective of the prospective study is to find theefficacy of Palashgudavarti & Diclofenac Sodium Suppository in the management of Acute Fissure inano(Parikartika).Material & Method: The present study is designed as a Randomized single blind parallelin which 60 patients will be enrolled. Varti will be applied for local application once a day. Assessment willbe done 0th, 7th day, 14thday, and 28th day. Results: The changes are expected to be observed in subjectiveparameters such as pain bleeding per rectum with itching as well as with objective parameters such asParikartika Healing. Conclusion: The study is expecting the nonsurgical management of fissure in ano withrespect to the impact of Palashgudavarti & Diclofenac Sodium Suppository. The research is expecting to bebaseline and benchmark of the prospective studies in Acute Fissure in ano (Parikartika).
The Observational Study of Reduction in Inflammatory Markers and Simultaneous Reduction in Joint Inflammation in Patients of Rheumatoid Arthritis Treated by Leech Therapy Sheetal Asutkar1 , Kiran Khandare2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13428

Abstract

The sense of pain in arthritis carries the highest stigma among the sufferers as well as the treating physicians.It makes the life miserable for the patients along with the disability the disease rheumatoid arthritis causes,which can be correlated to Aamvata in Ayurveda.There are the conventional treatment options whichare available in the form of shodhana and shanmana. Besides NSAID.s and corticosteroids in modernmedicine rendering many side effects Ayurveda offers drugless healing art in the form of jaloukavacharanalso known as leech therapy which is known for the anti-inflammatory and analgesic, anesthetic actionsof leech salivary gland secretions. Hence, a protocol was designed for the doctoral research on “Study ofinflammatory markers in patients of Rheumatoid Arthritis treated by leech therapy”, for the assessment ofsubjective parameters of pain, swelling, redness, tenderness, loss of function of joints assessed by standardcriterion, and objective parameters like CRP and ESR before and after leech therapy for 10 sittings onalternate days. Observations were taken on day 0 and day 21, and follow up taken on day 30 and day 45.Statistical tests were applied which revealed significant results of anti-inflammatory effect of leech therapyon CRP(relative change 23.54%),with p value =0.0001,than ESR(relative change 10.30). Leech therapy wasfound to be having highly significant effect on pain score (relative change 57.62%), followed by tendernessscore(relative change 72%) and followed by significant increase in walking effect (relative change 56.67%).There was statistically significant improvement in other subjective parameters of assessment like swellingon ankle(relative change by 11.73).,knee joint(relative change 10.29),redness(relative change25%),walkingeffect(relative change 72%),rise in local temperature(relative change 61.90%) withp value,0.0001.with corelatable clinical improvement.

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