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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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The Interleukin-6 (rs1800797) Variant in Healthy Individuals at Medan City, North Sumatera Province Mutiara Indah Sari1*, Siti Syarifah2 , Milahayati Daulay3 , Zaimah Z Tala4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13603

Abstract

The Interleukin-6/IL6 (rs1800797) variant play a role in several diseases pathogenesis. The frequencygenotype of IL6 (rs1800797) varied based on different race, ethnicity, and underlying character inpopulation. This study aimed to assess the frequency of genotype and allele of IL6 (rs1800797) in healthyindividuals at Medan city, North Sumatera Province Province and this study can be used as a reference indetermining of several diseases for further studies. Genotyping of IL6 (rs1800797) in the promoter regionusing polymerase chain reaction and restriction fragment length polymorphism method, analysis using FokIrestriction enzyme. This study showed that the genotype frequency of GG, GA, and AA were 95.8 %, 4.2%, and 0 %, respectively. The allele frequency of G and A were 97.9 % and 2.1 %, respectively. The resultsindicated that the homozygous wild-type (GG) of IL6 (rs1800797) was higher than the heterozygous mutant(GA) and there was absent of homozygous mutant (AA) in this population. The frequency of G allele alsohigher than A mutant allele.
Effect of Malus sylvestris Extract on Histopathological Features of Hypercholesterolemic Wistar Rat (Rattus norvegicus) Fatty Liver Nadhifa Tanesha Aufazhafarin1 , Alphania Rahniayu2 , Ema Qurnianingsih3 , Arifa Mustika4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13604

Abstract

Objective: To evaluate the effect of Malus sylvestris extract on improving the degree of steatosis and portalinflammation histopathological features of hypercholesterolemic Rattus norvegicus strain wistar. Method:Forty-two male rats were divided into 6 groups randomly. Hypercholesterolemic fatty liver induced bygiving high-fat diet (HFD) for 46 days on groups 1 to 5, while group 6 given standard diet with the sameamount of time. Simvastatin was administered in group 2 at a dose of 0.36 mg/day. Groups 3, 4, and 5 weregiven Malus sylvestris extract (MSE) as a treatment at doses of 90 mg/day, 180 mg/day, and 360 mg/day insequential order. Simvastatin and MSE were administered for 14 days, from day 33 to 46. On day 47, all ratswere sacrificed and the liver was removed for histopathological slides preparation with hematoxylin-eosin(HE) staining. Histopathological results were analyzed using Kruskal Wallis test followed by Mann Whitneytest. Result: Histopathological analysis showed that Malus sylvestris extract improved steatosis and portalinflammation features compared to HFD-fed rats in group 1 (p<0,05). Conclusion: Malus sylvestris extractimproved the degree of steatosis and portal inflammation histopathological features of hypercholesterolemicrat fatty liver.
Hyperglicemia in Childhood Acute Lymphoblastic Leukemia During Induction Chemotherapy Nengcy Erlina Tasik Rerung1, Andi Cahyadi2 , Nur Rochmah3 , Maria Christina Shanty Larasati4, Mia Ra
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13605

Abstract

Background: Hyperglycemia is a recognized side effect of the corticosteroids and asparaginase givenduring induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). The ALL is the malignanttumor with the highest incidence in the childhood. The aim of this study is to investigate the impact ofhyperglycemia during induction chemoteraphy in childhood ALL.Methods: This prospective study was done in Dr. Soetomo hospital from January to April 2018. The subjectwas newly diagnosed as ALL under the age of 18 years, treated with Indonesian childhood ALL 2013protocol (Standard Risk (SR) group and High Risk (HR) group). Hyperglycemia was defined as at leasttwo separate random plasma glucose levels > 200 mg/dL, which was evaluated before and during inductionchemotherapy. Statistical analysis using Paired T-test for parametric and Wilcoxon Test for nonparametric.Results: Thirty-three children were enrolled, 18/33 boys with mean age 5.8 (SD 3.78) years, compromisedas ALL-L1 30/33. They were treated with ALL-HR 19/33 and ALL-SR 14/33. In overall groups, the meanrandom blood glucose level significantly increased from 108 (SD 21.3) mg/dL to 147 (SD 48.1) mg/dL,(mean difference 38.67 mg/dL; 95% CI 18.08 to 59.26 mg/dL, P=0.008). In SR group, there was a significantincreased of mean random blood glucose level from 102 (SD 13.5) mg/dL to 133 (SD 37.3) mg/dL, (meandifference 31.8 mg/dL; 95% CI 8.78 to 54.8 mg/dL; P=0.01). In HR group, the mean random blood glucoselevel increased from 113 (SD 51.9) mg/dL to 165 (SD 25.4) mg/dL, (mean difference 51.9 mg/dL; 95% CI18.6 to 85.2 mg/dL, P=0.004).Conclusion: Blood glucose level is significantly increase during induction chemotherapy in both SR and HR Indonesian childhood ALL 2013 protocol.
Correlation of Hot Work Climate with Dehydration on Bricks Workers Nesya Shera Putri Iksani1 , Endang Dwiyanti2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13606

Abstract

Each workplace must have its own source of danger which can cause health problems or occupationaldiseases due to the exception of informal sector workers such as brick workers. Health problems that canbe experienced are dehydration caused by exposure to hot working climate. Incidence of dehydration cancause workers to get tired quickly and decrease productivity. The purpose of this study was to analyze thecorrelation between hot working climate with dehydration on bricks workers in one of Mojosulur’s brickhome industries. Methodes of his research is an analytic observational study, with cross sectional design.The subjects of this study were all brick workers in one of the brick home industries in Mojosulur by 30respondents. The results of the study showed that most brick workers were dehydrated, varying in level,both moderate and severe dehydration. The results of statistical analysis show that the correlation coefficient(r = 0.638) which can be interpreted as a work climate factor has a strong correlation with the incidenceof dehydration Conclusion of this research on work climate and dehydration of brick workers in one ofMojosulur’s brick home industries have a very strong correlation.
Equality of Suffrage for People with Mental Disorders in Malang City Nofi Sri Utami1 , Nanik Prasetyoningsih2, Kuswanto Kuswanto3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13607

Abstract

Constitutional Court of Indonesia in 2015 established Constitutional Court’s Decision Number 135 / PUUXIII / 2015 that revoked the provisions of Article 57 paragraph 3 letter a of Indonesian Law Number 8 of2015 concerning Amendment of Law Number 1 concerning the Stipulation of Government Regulation inLieu of Law Number 1 of 2014 which the substance prohibited person with disabilities for voting in election.Then, Law Number 7 of 2017 concerning General Elections, which exclusively gave political rights forpeople with disabilities to implement their political rights.Qualifications for people with mental disabilities in elections of The Constitutional Court decides that thephrase “mental disorders/ memory impairment” must be interpreted as “experiencing mental illness and/ orpermanent memory impairment which according to mental health professionals, has abolished one’s abilityto vote in elections”. It means that sufferers with mental disorders and/ or impermanent memory impairmentmust still be registered as voters and they have the opportunity to use their voting rights in elections.Equality of political rights for people with mental disorders (Orang Dengan Gangguan Jiwa (ODGJ)) inelections is very important because general election gives opportunity to increase participation and changepublic perception for the ability of people with disabilities. As the result, people with disabilities can havestronger political voice and they are recognized more as equal citizens. Moreover, this research was incategory of normative research with normative juridical approach. In conclusion, the equality of politicalrights for people with mental disorders (orang dengan gangguan jiwa (ODGJ)) in elections is very importantbecause general election gives opportunity to increase participation and change public perception for theability of people with disabilities. As the result, people with disabilities can have stronger political voice andthey are recognized more as equal citizens.
Determining the Exposure of Benzene, Toluene, Xylene (in Condensate ) in a Chemical Laboratory of Natural Gas Company by Chemical Health Risk Assessment (CHRA) Nora Putri Sabilla1 , Noeroel Widajati2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13608

Abstract

Introduction: Chemical risk assessment is needed to find out how high the hazard level of chemicals in thelaboratory. This chemical health risk assessment will assess how often the chemical is exposed to workers,how much exposure it is so that the level of risk can be understood. The purpose of enabling decisions to bemade on appropriate control measure, training of employees, monitoring and surveillance activities as maybe required to protect the health of employees who may exposed by hazardous chemicals to health at work.Methods: This research is research with a qualitative approach. Based on the data collected, this study isobservational. This study uses the Chemical Health Risk Assessment (CHRA) method. This method is carriedout by identifying chemicals, determining Hazard Rating, evaluating exposure, assessing the adequacy ofthe control measures that have been carried out, concluding the CHRA results, and identifying the effortsthat need to be made.Result: In this study, there are three work units, namely a wet laboratory, oil laboratory, and gas laboratory.The chemicals analyzed are benzene, toluene, and xylene in the condensate. The hazardous chemical havesignificant risk now and already adequately controlled could increase in future (C2) which mean that theemployees are at risk due to hazardous chemicals and it adequately controlled but the risk can increase inthe future.Conclusion : Therefore, several steps can be taken to control the risk of health hazards from benzene,toluene, and xylene in the condensate, for example: determine precaution to maintain controls and minimizechances of higher exposure occurring; determine additional measures for regaining control if a high-riskevent occurs despite precaution; identify measures, procedures, and equipment to prevent or control anyaccidental emission of chemical hazardous to health, determine if monitoring or health surveillance isrequired to check on the effectiveness of controls; and review assessment every five years or when is achange in circumstances
A questionnaire-based Study of Knowledge and Attitude in Healthcare Professionals about Child Sexual Abuse related to POCSO (Protection of Children from Sexual Offences) Act: A Cross-sectional Study Nowsheen Goni1 , Mukesh Kumar Goyal2 , Chahat Shikarwar3 , Chahat Jangir4
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13609

Abstract

Introduction: The Government of India has passed special law, The Protection of Children from SexualOffences (POCSO) Act, 2012 which provides strong shield for protection of children from heinous crimesof sexual assault, sexual harassment and pornography, there by safe guarding the interest of children at everystage of judicial proceeding.Methodology: A questionnaire based study was carried among 100 healthcare professionals working at thetertiary care Hospital, randomly selected. The questionnaire had 15 Multiple Choice Questions about ChildSexual Abuse related to POCSO Act. Collected data was analysed statistically.Objective: The study is aimed to assess knowledge and attitude about Child Sexual Abuse related to POCSOAct among healthcare professionals.Result: Greater percentage of healthcare professionals have knowledge about major aspects of POCSOAct, as related to its full form (75%), enactment (62%), definition of child (62%), different types of sexualoffence (86%), its mandatory reporting (81%), and trial in child friendly special courts (64%). But in fewareas, knowledge related is scarce as only 40% participants knew punishment scales of POCSO Act and 46%knew failure to report is punishable offence. 84% participants suggest multidisciplinary approach is the needof hour to tackle cases of child sexual abuse.Conclusion: To curb this menace educating health care professionals along with children, spreadingknowledge and awareness at community level with strict law enforcement will play a key role.
Level of Knowledge and Family Support toward Medication Adherence among Patient with Diabetes Mellitus in Malang, Indonesia Nur Lailatul Masruroh1*, Alifia Fatehana Pangastuti2 , Nur Melizza1 , Anggraini Dwi Kurnia1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13610

Abstract

Patient compliance with long-term therapy for chronic diseases in developing countries is still low. Efforts tocontrol blood sugar levels remain normal with medication adherence depending on family support and patientknowledge of the disease. This study aimed to determine the relationship between the level of knowledgeand family support with medication adherence in patients with diabetes mellitus in Malang, Indonesia. Thestudy design was cross-sectional. The sample of this study was 48 people with diabetes mellitus recordedin Ciptomulyo Health Center. This study uses a simple random sampling technique. The questionnaire usedconsisted of demographic data, knowledge, family support, and medication adherence. The results of thestudy were that there is no relationship between the variable level of knowledge and medication adherencein patients with diabetes mellitus with a significance value of p = 0.561. There was a relationship betweenfamily support and medication adherence in patients with diabetes mellitus with a significance value of p =0,000 and a Correlation Coefficient value of 0.616 which indicates a significant relationship with a strongdegree of relationship strength. There is a relationship between family support and medication adherencein patients with diabetes mellitus at the Ciptmulyo Health Center. The better the family support, the moreobedient the patient is undergoing treatment.
Influence of Exercise Classics on the Development the Volume of Attention of Schoolchildren Aged 8-9 Polevoy G. G
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13611

Abstract

The aim of the study: To determine the influence of exercise Classics on the development of the volume ofattention of children 9-10 years old in physical education lessons.Methods and Material: The study was conducted over a period of 9 months, in which 40 9-10-year-oldstook part. Physical education classes were held 2 times a week for 40 minutes each lesson. The level ofdevelopment of coordination abilities was assessed on the «Shuttle run» test, and the indicators of attentionvolume on the «Schulte Table» test. The programs bio-stat 2009, Microsoft excel 2016 and t-student wereused for mathematical and statistical processing of results.Results: Before the beginning of the pedagogical experiment, the indicators of school children between thegroups did not have significant differences (P>0.05). After the end of the study, the indicators in both groupsimproved. In CG, in the «Shuttle run» test, the indicators improved from 10.2±0.6 to 9.9±0.5 (P>0.05), andin the volume of attention test, the indicators improved by 6.1% (P>0.05). In EG, in the «Shuttle run 3x10m» test, the indicators improved from 9.9±0.5 to 8.5±0.4 (P<0.05), and in the «Schulte Table» test, theindicators improved by 32.1%. These results indicate the effectiveness of using exercise Classics in physicaleducation lessons in working with younger schoolchildren.Conclusion: if schoolchildren will perform exercise Classics in physical education classes at school, theywill improve not only coordination abilities, but also the volume of attention.
The Possibility of Healing Deep Wounds in Rats Using Helium Neon Laser Rabab Hajwal Al-Zamily
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13612

Abstract

Laser treatment is generally used for tissue restoration. Restorative soft tissues include objective, practicaland difficult responses.The goal of the research have being to estimate the irradiation capabilities the helium neon laser irradiationon three different types of wounds depth.Sixty young male rats were used in this study, divided into three groups. (20 per group) Wounds were createdwith different depth for the first, second and third group have been irradiated by the laser using He-Neenergies flowing 4 minutes, five out of twenty animals left without radiation is considered to control.Biopsy was taken from all rats for histological examination at 1, 3 and 7 days after surgery. The resultsshowed a clear enhancement of treatment wounds from control, Helium neon laser failure in the treatmentof very deep wounds.

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