cover
Contact Name
Masriadi
Contact Email
arimasriadi@gmail.com
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Unknown,
Unknown
INDONESIA
Indian Journal of Forensic Medicine & Toxicology
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Articles 5,497 Documents
Hepato-nephroprotective Role of Lepidium sativum against Oxidative Stress Induced by Dexamethasone in Rats Sawsan Agbashee Abraheem Alsadee
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13797

Abstract

The current research was prepared to explore the hepato-nephroprotective effect of Lepidium sativum seedaquatic extract against oxidative stress stimulated by dexamethasone in rats. Animals were classified asfollows; group one was used as control while groups 2, 3 and 4 were treated orally with Lepidium sativumseed extract (LSSE; 20 mg/kg, daily), interperitoneally with dexamethasone (DEX; 1 mg/kg BW) andLSSE plus DEX for 14 days, respectively. Administration of DEX elevated thiobarbituric acid reactivesubstances (TBARS), hydrogen peroxide (H2O2), and kidney and liver function biomarkers level, andlactate dehydrogenase activity. While enzymatic (SOD, CAT, GPx, GR, GST) and non-enzymatic (GSH)antioxidants, protein content, and alkaline phosphatase activity were significantly decreased. Otherwise, ratssupplemented with LSSE singly declined lipid peroxidation and improved most of the studied parameters.Moreover, rats pretreated with LSSE then received DEX showed significant alleviation in lipid peroxidation,antioxidant status and biochemical indices with respect to DEX treated group. Conclusively, LSSE hasbeneficial protective effects and has the capability to counteract the harmful influence of DEX. So, Lepidiumsativum might represent a novel approach in the therapy of dexamethasone because of its antioxidantproperties.
An Updated Review on Some Neurotoxic Pharmacological Agents Along with their Neurotoxic Mechanisms Muhammad Irfan Bashir1 , Nur Hidayah Kaz Abdul Aziz2 , Dzul Azri Mohamed Noor3
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13799

Abstract

This review will provide the vital information about some pharmacological agents which are Neurotoxic.Through this update, Anti-cancer, Anti-bacterial, Analgesic, Psychoactive drug and Anabolic steroidmedication are reported briefly regarding their neurotoxic mechanisms. In this review all informationregarding neurotoxic drugs is collected from 2020 published work by Web of science, Scopus, PubMed andGoogle Scholar. It is concluded that all these drugs which the part of our study are neurotoxic. There is needto discover some method to reduce their toxicity and to avoid the chronic use of these medications.
CT scan Findings of COVID-19 in Patients with Fatty Liver Israa Mohammed Sadiq1 , Kermanj Ismail Bakr1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13800

Abstract

Purpose: COVID 19) is a respiratory disease caused by a member of the coronaviruses family, named(SARS-CoV-2), discovered in December 2019 in China. This study aims to assess the association of thesimple fatty liver disease with the severity of the chest computed tomography (CT) scan findings in COVID19.Materials and Methods: It was a cross-sectional study that enrolled 322 patients with positive (RT-PCR)tests and chest CT scan findings. Patients with chronic lung and liver disease, alcoholics, and abnormal liverfunction tests excluded from the study. The liver CT scan density assessed, accordingly the patients dividedinto fatty-liver and non-fatty liver groups. The severity of lung CT changes compared between them, usingChi-square test.Conclusion: COVID patients with fatty liver have more progressive changes in the chest CT scan. Theyhave similar lung lesion distribution to non- fatty liver patients. Crazy paving lesions, septal thickening,Lymphadenopathy and plural effusion in fatty liver patients occurs in the same frequency as non-fatty liverpatients
tudying the Relationship between the Lund Mackay Score and Response to Medical Treatment in Patients with Chronic Sinusitis Gholam-Ali Dashti Khavidaki1 , Reza Gharibi1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13801

Abstract

The present study was conducted to investigate the relationship between the Lund Mackay score andresponse to medical treatment in patients with chronic sinusitis. The present study was performed crosssectionally on 150 patients referred to Khatam-ul-Anbia Hospital in Zahedan for whom the diagnosis ofchronic sinusitis was confirmed and met the study criteria. Demographic data and clinical signs of patientswere recorded and for based on CT scan, The Lund Mackay score was evaluated. Patients were treated for 4to 6 weeks and finally re-evaluated for symptoms and response to treatment. Data were analyzed using SPSSsoftware version 24, McNemar test, Mann-Whitney and other necessary tests for descriptive statistics. Asignificance level of 0.05 was considered. 3.55% of patients were male (83 patients) and 7.44% were female(67 patients). The mean score of the Lund Mackay in the present study was 92.11 with a standard deviationof 2.3. Symptoms of olfactory dysfunction, sinus pain, nasal obstruction and nasal discharge showedsignificant improvement after treatment (p <05.0). Based on the results obtained at the end of the study, thepresence of nasal polyps (p = 001.0) and nasal obstruction (p = 003.0), after the end of the treatment period,showed a significant relationship with the response to treatment. In general, this study suggested that themean score of The Lund Mackay had a significant positive relationship with the severity of patients’ clinicalsymptoms and the severity of sinusitis. Therefore, it can be considered as a suitable criterion in diagnosticand therapeutic evaluations of patients.
Impact of Meningitis on Cognitive Skills and Development in Children Seyedeh Mahsa Mahmoudinezhad Dezfouli1 , Shaqayeq Khosravi2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13802

Abstract

The present systematic review aims to investigate the impact of meningitis on the cognitive skills anddevelopment of children. In this systematic review, relevant studies were identified via searches throughmedical information databases of MEDLINE, PubMed, ISI, EMBASE, Cochrane with the keywords ofMeningitis, Meningitis and Complications, Meningitis and Children, Meningitis and Intelligence Quotient(IQ), Meningitis and Development, and their derivatives. In this study, amongst 198 articles reviewed,11 articles met the inclusion criteria. All studies, except one case, reported a decrease in growth and IQin children who experienced meningitis. Based on the results of the present study, children who haveexperienced meningitis at a younger age are more prone to disability, growth retardation, and lower IQ thanother children throughout the later years of their life.
The Association between Subclinical Hypothyroidism and Diabetic Retinopathy in the Patient with Type 2 Diabetic Alireza Hejrati1 , Maryam Hadad2 , Atousa Najmaldin1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13803

Abstract

The present study aimed to determine the relationship between subclinical hypothyroidism and diabeticretinopathy in patients with type 2 diabetes mellitus. In this cross-sectional analytical study, 150 patientswith type 2 diabetes mellitus were assessed. The eye fundus examination was performed using fundoscopyto confirm or rule out retinopathy. Thyroid hormones were also measured by special kits to diagnosesubclinical hypothyroidism. The criteria for diagnosis of this disorder include the high serum thyrotropinconcentration (? 4mIU/L) plus normal serum free thyroxin levels. Statistical analyses were done using IBMSPSS. In the study, 34.66% suffered retinopathy. A total of 24.0% suffered subclinical hypothyroidism withhigher prevalence rate in those with retinopathy as compared with the group without retinopathy (p = 0.001).Those with diabetic retinopathy also experienced longer duration of diabetes than those without this event.(p = 0.006). Analysis show a significant role for type 2 diabetes mellitus (OR = 1.121, P = 0.003), and highTSH level (OR = 1.342, P = 0.006) to predict diabetic retinopathy.This study showed an association betweenhypothyroidism, diabetes and increased TSH with retinopathy. Retinopathy is significantly predicable withthe presence of subclinical hypothyroidism and longer duration of diabetes.
A Survey of Knowledge Level about Pediatric oral/dental Health among Pediatricians Masoud Haghighikian1 , Mohsen Khaleghian1 , Ali Saberi1 , Mohammad Nasiri1
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13804

Abstract

Pediatricians play a central role in children’s health care and are the first line of care for oral/dentalconditions. The level of pediatrician knowledge about oral/dental health is not accurately determined.In this cross-sectional study, a previously adapted questionnaire was used to evaluate the level of oral/dental health knowledge among pediatricians affiliated with medical universities in Tehran, Iran. The datawere summarized through descriptive statistics and central index tests. In this study, 263 pediatricians(49.4% male) completed the questionnaire. The mean age was 43.9 years. Only 17 individuals (6.5%) hadcompleted a course of oral/dental health during their residency. The mean score was 5.9 ± 1.7. Questionnairescores were similar between male and female pediatricians. Time from graduation and completion of anoral/dental health course was not associated with better performance according to the questionnaire. Thelevel of knowledge about oral/dental health among pediatricians is inadequate. Most pediatricians havenot completed a training course on this matter. These findings highlight the need for integrated trainingprograms to improve pediatrician knowledge about oral/dental health.
Clinical Characteristics and Short-Term Outcomes of Patients with Severe COVID-19 Morteza Mousavi-Hasanzadeh1 , Alireza Kamali2 , Fatemeh Safi3 , Hossein Sarmadian4 , Amir Almasi-Has
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13805

Abstract

We Report the demographic characteristics, laboratory findings, vital signs and outcomes of 19 laboratoryconfirmed COVID-19 patients who admitted to ICU; from 15 Feb to 15 March 2020 in Arak, MarkaziProvince, Iran. Data showed that the most common laboratory findings on first day of ICU admission, wereleukocytosis (52.6%), neutrophilia (73.6%), lymphopenia (100%), anemia (100%), hyperglycemia (78.95),increased levels of INR (100%); AST (66.66%), ALT (50%) and LDH (100%). 36.36% and 45.45% ofpatients had elevated total and direct bilirubin, respectively but all of patients had normal range of ALK-p(Table 1). In term of vital signs (3 first days); SBP, DBP and PR did not have significant changes but O2saturation increased from 82.9 % to 93 % and the number of mechanical ventilated patients increased from36.8% to 73.3%
Deleted Iman Qasim Kteo Al-hussein1 , Zahraa Abdull Abbass Taher Al- Khafajy1 , Haider Mohammed Haloob ALAbe
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13806

Abstract

a
The Application of an Indigenous Polymer for the Plastination of Teaching Anatomical and Biological Specimens Alaa A. Sawad
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13807

Abstract

Plastination was fabricated in 1978 by Dr. Gunther Von Hagens at the University of Heidelberg,, Germany,which Kept for the good conservation of anatomical and biological material. The present goal was to utiliz acost- effective plastination polymers as compared to the standard S10 technique using silicone polymers. TheS10 is the original silicone polymer used for the preparation of plastinated specimens and whole dissectingbody.. Specimens were fixed in formalin 10%, dehydrated and decreasing in acetone, and at last,impregnated bylocal commercial unsaturated polyester resin and ultimately hardening at 50 °C temperature.The plastinated specimens were clean, durable ,odorless ,portable and non-toxic ,it can be kept for longdurations without any changes .The usage of widespread S10 silicon method is high costs so with the aidof using indigenous chemicals it is possible to produced low costs anatomical models for education and forstudying anatomy.