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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Gene Expression and Antioxidant Effects of Cinnamon (Cinnamomum Zeylanicum, Breyne) in Alloxan -Induced Diabetic Rats Hayder Ghazi Abdulshaheed; Haidar K.A.Alsaedi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16891

Abstract

Background and Aim: In this study rats, a systematic analysis was conducted to examine the antioxidantproperties of cinnamon (Cinnamomum Zeylanicum, Breyne) in controlling high blood sugar levels, and apharmacological comparison made to investigate whether or not it had a positive effect on the antioxidantsystem.Materials and Methods: Alloxan 60 mg injected into the marginal ear veins of eighteen diabetic rats Afterthis diabetic animal study, the rats were randomly assigned to 4 groups. There were six animals in each ofthe 4 groups: Group 1(C): Positive control, Received orally 5 ml normal saline (0.9% NaCl) daily. Group2(D): Negative control, Diabetes rats only, received single-dose alloxan 60 mg/kg body weight. Group3(K): Diabetes rats, received cinnamon orally 35 mg/kg body weight dissolved in 2 ml normal. Group 4(I):Diabetes rats, was given 2 I.U/ animal of insulin subcutaneously daily.Results: All animal groups were treated for four weeks.Blood samples were taken from these groups weeklyfor biochemical analysis to estimate: Blood glucose malondialdehyde(MDA), Glutathione (GSH). Theresults showed high glucose and MDA concentration associated with an increased oxidant stress alloxaninduces on diabetic animals. The statistical analysis showed that a cinnamon significant (P<0.05) reductionin glucose, MDA,GSH comparison with positive control. The level of MDA, GSH was also significantlyreduced (P<0.05) in all period comparison with the period before treated with Cinnamon extract .there was4.3-fold more Ins I upregulated in the Cinnamon -treated diabetic rats 35 percent of the control group wereheterozygous and three percent of the experimental group were mutant for that trait.Conclusion: Furthermore, Cinnamon-treated diabetic rats (group K) showed a significant increase inthe activities of both enzymatic and non-enzymatic antioxidants with concomitant overexpression ofinsulin I genes when compared to diabetic control rats (group D). Cinnamon contains antioxidants andantihyperglycemic effects at the end of the experiment.
The Role Sonographic Imaging Features in the Prediction of Necrotizing Enterocolitis Outcomes in Neonatal Patients Hayder Neamah Hassan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16892

Abstract

Necrotizing enterocolitis (NEC) is a devastating inflammatory disease of the intestinal tract that representsasignificant source of morbidity and mortality in preterm infants. The objective of the current study is tofind out the correlation between sonographic imaging features and the outcomes of necrotizing enterocolitisin children , and their role as a predictive tool for the consequences resulted from necrotizing enterocolitis.Thirty two children (patients) have been included in this study, patients were divided into three groupsaccording to the follow up outcomes: those that been recovered (Group I), those that needed surgery (GroupII) , and those that died (Group III). The study was achieved at Al-Zahra Teaching Hospital in Al-NajafCity, in Iraq , during the period between December 2020 to March 2021 .The results showed that there is asignificant difference (P value <0.05) among the three groups in terms of the following items : fluid-filleddilated bowel loop, decreased peristaltic movement, focal fluid collection , portal gas .The study concludedthat the presence of Fluid-filled dilated bowel loop, peristaltic movement, local fluid collection , portal gascan be considered as predictive tool for the poor outcomes of necrotizing enterocolitis .
Handwriting Change in Breast Cancer Patients Heba H Rohym; Ghada Mustafa Al-Galad; Noha Abdel Rahim Mohamad; Mohamed Ragab Teleb
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16893

Abstract

Background: Breast cancer is the most common cancer . In the course of cancer progression, there are specificneuromuscular disturbances that directly affect coordination. Handwriting is regarded as a vital constituentwhen it comes to the tracing of neuromuscular coordination. The Study aimed to study handwriting analysisin female cancer breast patients trying to find simple useful, non-invasive way help in early detection anddiagnosis and follow up of those patientsMethods: The study included 160 participants. The study participants were asked to write the same text (twoArabic sentences and her name in Arabic language) and draw lines in another paper, and then all handwritingsamples were scanned and examined.Results: Breast cancer patients age ranged from 30 – 76 years old with a mean ± SD of 50.3 ± 10.5.Patientsaccording to Educational level parameter were 5 groups; Illiteracy eradication program, primary ,middle,secondary, graduation and post gradates were 14 (8.75 %) , 10 (8.75 %) ,16(10 %),(80) 50 %,40 (25 %)respectively .By analysis of handwriting samples: Tremor, wide spaces between words, heavy writing pressure, slop orslant of writing upward slant or down slant and heaviness of Initial and terminal strokes were observed.After re-observation of pervious Handwriting changes and make a relation between these changes andcancer stages and lines of treatment which received, it was noticed that these changes were in samples ofpatient received multiple lines of treatment , in patients with metastasis or has another associated tumor asovarian, bladder cancers or lymphoma .Conclusion: There is no evidence of significant handwriting Changes in breast cancer samples unless patientreceived multiple lines of treatment , in patients with metastasis or has another associated tumor as ovarian,bladder cancers or lymphoma
Extraction and High Purification of Nicotine from Iraqi Tobacco Leaf Formanufacturing, Pharmaceutical, and Medicinal Uses Husam Alaa Hameed Al-Khinuliu; Essam Fadel Al-wan Al-Jumaili
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16894

Abstract

Bachground: Nicotine is highly addictive plant derived alkaloid and the most important species in humanuse today is Nicotianatabacum. There are direct health effects of chronic nicotine exposure. Even in lowdoses, nicotine causes vasoconstriction and other cardiovascular effects related to catecholamine release andpromote angiogenesis, neuroteratogenicity, and possibly some cancers. Methods: A preliminary investigationto analyze the nicotine contained in Iraqi tobacco leaves was carried out using gas chromatography-massspectrometry (GC-MS). Nicotine is an alkaloid, and alkali methanol and Lipophilic solventsystem methods(LSS) have been extracted and determined by GC-MS from tobacco leaves. Results: The detection limit fornicotine was for non-selective monitoring at the ppm level and for selective detection at the nanogram level.This is a simple method of thin layer chromatography (TLC) and chromatography mass spectrometry (GCMS)for the tobacco leave analysis of nicotine. The final purity of nicotine is 99%. Conclusion :the methodswhich used in this study gave very high purity of nicotineafter converting the crude nicotine to its esters.
Association of the TP53 Codon 72 Polymorphisms with PCOS Female Infertility in Karbala City Inam Joudah Radhi; Abdulmutalb Badr Manhy Alkhaleeli; Hameedah Hadi AbdulWahid
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16895

Abstract

To training the association of polycystic ovaries with p53 and 72 polymorphisms in the population offemale infertility in central Karbala and to search for possible interaction with the polymorphism. TheIraqi environment was suffered from acts of profanation by due to wars in Iraq, since 1990 and after 2003,An enormous number of damages and deaths were affected by destructive chemicals and radioactiveresources. These events resulted in either cancer or infertility. Infertility is one of the medical, social andpsychological burdens in Iraqi society. After 12 months or more of failure to a clinical pregnancy lead to aregular unprotected sexual intercourse.
Immunological and Biological Manifestation of Rheumatoid Arthritis Patient in Iraq RusulH.Ahmad; AyaidK.Zgair
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16896

Abstract

Rheumatoid arthritis is one of the highly incidence autoimmune disease. In present study the immunologicaland clinical biochemical test was checked in patients with RA in Iraq. Here 70 serum specimens wereobtained from patients suffer from RA and 30 serum specimens from healthy control cohorts. Antinuclearantibodies (ANA) level, C-reactive protein level, erythrocyte sedimentation rate (ESR), activity of alanineaminotransferase (ALT), activity of aspartate aminotransferase (AST), concentration of blood urea andserum creatininand diseases activity score (DAS)-28 were evaluated in sera of patients and healthy controlcohorts. The results showed that significant elevation in level of ANA, ESR, CRP and DAS-28 in patientsgroup as compared to healthy control group (P<0.05). No significant difference between patients group andhealthy control group in terms of activity of ALT, AST, concentration of blood urea and serum creatinine.The person test (r) was done to evaluate the correlation between ESR, ANA, CRP, ALT, AST, blood urea andserum creatinine. The results showed significant relation between levels of ESR, CRP and ANA and activityof disease in terms of DAS-28. The results showed no significant relation between level of CRP, ALT, AST,blood urea and serum creatinine in patient’s sera and DAS-28. It can be concluded from present study thatthe some laboratory parameters related with activity of RA such as ESR, ANA, CRP and other parametersdo not related with activity of RA such asALT, AST, blood urea and serum creatinine.
Isolation and Identification of Bacterial Burn Wound Infection in Iraqi Patient Jenan A. Ghafil; May. T. flieh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16897

Abstract

Burns are one of the most common and devastating forms of trauma. Patients with serious thermal injuryrequire immediate specialized care in order to minimize morbidity and mortality.In current study, 120samples were collected from 120 patients suffering from contaminated burns. The study was conducted afterobtaining ethical approvals from the ethics committee in the Department of Biology, College of Science,University of Baghdad as well after obtaining the patients ’consent. Samples are collected from patientsafter they have stopped using antibiotics for 48 hours.After the swabs had been cultured on different media,conventional biochemical tests to identify bacterial isolates and antimicrobial sensitivity to the most commonantibiotics were performed by vitek 2 compact .The results showed that the highest percentage of bacterialspecies was Proteus mirabilis (31.1 %). The percentage of isolation of P. aeruginosa was 17.78%. The lowestpercentage of bacterial isolates that isolated from infected wound was found in case of Staphylococcusaureus, Pseudomonas fluorescens, Acinetobacterhaemolyticus, Burkholderiacepacia, Salmonella ser.gallinarum, Sphingomonaspaucimobilis, Comamonas testosterone with 2.2 % for each isolate.
Evaluation the Genotoxicity of PHB Nanoparticle by Micronucleus Assay Jenan A.Ghafil; May. T. Flieh
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16898

Abstract

Determining the toxicity of substances in vivo is one of the most important tests that judge whether ornot they are used in the pharmaceutical field. In the present study, the genetic toxicity of treatment dosesof Polyhydroxybutyrate (PHB), PHB nanoparticles, Cefotaxime and complex of PHB nanoparticlesandcefotaxime was evaluated. The effect of these substances on the number and percentage of white bloodcells (WBCs) in mice was also tested (in vivo). Micronucleus assay was used to assess genotoxicity ofabove materials in vivo, as well as the technique of WBCs chamber was used to estimate the total numberof WBCs in mice administrated with above substances. The differential count of WBCs was measuredby staining the smears with leishman stain. The present study demonstrated that there were no significantdifferences (P>0.05) in the number of micronucleus cells in the mice injected with treatment doses of PHBnanoparticles, Cefotaxime and complex of PHB nanoparticlesand cefotaximewhen compared with miceinjected with normal saline. Similar finding was obtained in terms of counting of total WBCs and differentialcount in mice injected with treatment doses of PHB, PHB nanoparticles, Cefotaxime and complex of PHBnanoparticlesand cefotaxime when compared with WBCs total count and differential count in mice injectedwith normal saline (P>0.05). It can be concluded that there is no toxic effect of treatment doses of PHB, PHBnanoparticles, Cefotaxime and complex of PHB nanoparticlesand cefotaxime on mice.
Molecular Screening of KI and WU Polyomaviruses among Patients with Chronic Kidney Disease and Urinary Tract Infections Manar Hussein AL-Aboudy; Musa Nima AL- Jiafry; Mahdi Hussein Al-Ammar
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16899

Abstract

KIPyV and WUPyV were recognized based on commercial standard and PCR techniques. To occurrenceof KIPyV and WUPyV DNA among chronic kidney disease (CKD) and UTI patients using VP2 gene fordetection of KIPyV and VP1 gene for WUPyV. Molecular assay results of this study revealed the presenceof KIPyV in 6 (5.3%) of CKD patients and 3 (2.7%) of UTI patients while the presence of WUPyV was1 (0.88%) in CKD patients and negative result in UTI patients. WUPyV DNA and KIPyV DNA was notdetected in plasma of healthy persons. The distribution of KIPyV and WUPyV according to gender amongCKD showed a no significance difference among both sexes in which (P value = 0.27) and (P value =0.36) respectively while the distribution of KIPyV and WUPyV among urinary tract infections showed a nosignificance difference among both sexes in which (P value = 0.13) and (P value = 0.79) respectively .Thecurrent study survey about both viruses show that female was higher than male in KIPyV in which 2 (3.22%)of KIPyV DNA were detected in male and 4 (7.84%) in female out of 113 (100%) among chronic kidneydisease patients while in urinary tract infection, patients revealed a higher percentage rate of KIPyV infemale than male in which 0 (0%) of KIPyV DNA were in male and 3 (4.54%) in female out of 111 (100%)while doesn’t detect any isolate of WUPyV in both sexes.
Effect of Noise on General Health Status of Electrical Generator Workers in Iraq Mohammed Fakhri Azeez; Fatima Wanas Khudair2; Ali A. Al-Fahham
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16900

Abstract

Electrical generators in Iraq have been a series problem regarding occupational and environmental pollution.The current study aimed to determine the level of general health status among generator workers in AlDiwaniyah City Iraq, and its correlation with noise and demographic data . A descriptive cross-sectionaldesign was conducted in the current study . It was carried out at the private electrical generators inA-Diwaniyah City from the period between the 15th of October 2020 until the 15th of March 2021 . Apurposive study of 150 generator workers has been selected .General health was determined by GeneralHealth questionnaire (GHQ-28) which is comprised of 28 items, and include four aspects : somatic, social, depression and anxiety . Noise intensity level was measured by sound level meter (SLM) . The results ofthe present study revealed that average level of noise intensity inside the workers’ room was (78.12 db) ;while it was (104.14 db) near the generator . The results also showed that the assessment of most domain(social, depression, and anxiety) was moderate, except for somatic domain which it was good . There was asignificant negative correlation between noise and depression and anxiety . It has been concluded that : Mostof the generator workers showed a moderate level of general health status ; Most of the generators workershad moderate level for anxiety, depression and social aspects ; Noise intensities inside the generator roomsexceeds the upper limits accepted for human health .

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