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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Effect Phenytoin Therapy to Fibroblasts and Angiogenesis of Enterocutaneous Fistula in Wistar Rat Muhammad Budiman Irpan Bachtiar; Hermawan; Hardian; Ignatius Riwanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16901

Abstract

Background: Comprehensive wound care in enterocutaneous fistula (ECF) is the therapeutic of choicecurrently, which may increase of closure rate without surgery from 19 to 92%. Phenytoin has been reportedhave anticolagenase effect on wound healing is hoped to improve the ECF closure.Aim: The study was aimed to demonstrate the effect of phenytoin on closure of enterocutaneous fistula seenfrom the number of fibroblasts and angiogenesisMethods: This study was “Randomized Controlled trial with post test only group design” on 18 malewistar rats with ECF, that were divided randomly into three groups: group(K) control, P1(topical phenytoin),P2(oral phenytoin). After 7 days of treatment, they were terminated and histopathological examinations wereperformed to do fibroblast cell counting and the amount of angiogenesis by Hematoxilin Eosin staining.Results: Mean of the number of fibroblastin groups K, P1 and P2 were 69.50 ± 10.07, 155.50 ± 13.50 and182.16 ± 11.85 respectively (One way Anova P=0.001) and mean of the number of angiogenesis in groupsK, P1, and P2 were 95.66 ± 9.72, 178.66 ± 11.75, and 205,16 ± 9.74 respectively (One way Anova P=0.001).Post Hoc Test LSD showed thatthe number of fibroblast of group P1 vs K(P=0.001), P2 vs K(P=0.001),P1 vs P2(P=0.004) and the number of angiogenesis of group P1 vs K(P=0.001), P2 vs K(P=0.001), P2 vsP1(P=0.002).Conclusion: The therapy of topical and oral phenytoin increased the number of fibroblasts and angiogenesisin Wistar rat with ECF. Out come of oral phenytoin therapy better than topical.
Legal Policy in the Prevention of Narcotics in Indonesia Muhammad Yunus Idy; Marif; Handar Subhandi Bakhtiar
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16902

Abstract

The purpose of law enforcement against criminal acts of narcotics and psychotropic abuse is to improvethe health status and human resources of Indonesia. The new law concerning narcotics has two approachesto parties using narcotics illegally or in other words, abusing narcotics. The first approach is to see thedrug users as victims so that they must be rehabilitated, and the second approach is to look at drug users asperpetrators of criminal acts. Criminal acts related to narcotics crimes can generally be divided into 3 (three)types, namely supplying which is usually done by producers or importers, The act of distributing narcoticsand other illegal drugs carried out by dealers or sellers and then the users or people who abuse the narcotics.Therefore, the efforts to eradicate narcotics abuse must include all those three types of activities or actions.The efforts to eradicate it must start from the upstream part of the supplier.The policy in combating narcoticsabuse is a positive legal policy which is not only merely the implementation of normative juridical laws, butalso requires a factual juridical approach that is comprehensive and integral.
Recent Perspectives and Upcoming Directions in Molecular Diagnosis of Malaria: A Systematic Review Ola S. H. Almusaddar; Cyuzuzo Callixte
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16903

Abstract

Background: Malaria remains a global leading cause of morbidity and mortality. The absence of effectivevaccines is still the vital hindrance to the management and elimination of malaria. From that standpoint,accurate laboratory diagnosis could be the right hand for disease management. Objective: This reviewintended to assess the recent perspectives and upcoming directions in molecular diagnosis of malaria.Methods: This review was conducted by using internet searching tools where 35 published papers wereretrieved from the credible online publishers and among them, 27 papers that satisfy the inclusion criteriawere profoundly reviewed.Results: Among the 27 articles, 22(81.48 %) papers focus on contribution of PCR based-method in malariadiagnosis, 4(14.8%) report on comparison between polymerase chain reaction(PCR) and other moleculartechniques, 7(30%) emphasize on advantages and disadvantages of PCR, 4(14.8%) represent relationshipamong PCR and LAMP, 3(11%) discuss the most promising molecular diagnostic tools, 5(18%) focus oncomparative designs of different PCR methods, whereas 1(3.7%) emphasizes on parasite density and 2(7%)on pigment containing monocyte.Conclusion: This review conclude that microscopy remains the gold standard method for malaria diagnosisand speciation in limited resource settings but also molecular based-methods provide significant alternativeswith superior sensitivity and specificity.
Synthesis and Characterization of New Oxo-Aztedine ,Imidazoldine and Thiazolidine Rings on Creatinine and Evaluation of their Biological Activity RaadM.Muhiebes; Entesar O. AL-Tamimi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16904

Abstract

This work included preparation of new imine from the reaction of creatinine with aldehydes (4-nitrobenzaldehyde, 4- amino benzaldehyde, cinnamaldehyde) and ketone ( acetophenone ) in ethanol and thepresence of few drops glacial CH3COOH to obtain Schiff bases (1a,1b,1c,1d) Schiff bases were treatedwith monochloroacetyl chloride to produced (2a,2b,2c,2d), with glycine to synthesis (3a,3b,3c,3d) andwith 2-mercaptoacetic acid to prepare (4a,4b,4c,4d). The Prepared compounds had beenmeasured by (FTIR,and1HNMR ) spectroscopic techniques. Some of the derivatives were studied activity against antibacterial,antifungal and antioxidant.
Evaluation of Diagnostic Accuracy of Ultrasonography and Low Dose Computed Tomography in Acute Appendicitis Saradiq Mudhafar Jebur; MahmoodRadhi Jobayr; Haider Abdulameer Ghayad
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16906

Abstract

In acute appendicitis, abdominal Ultrasonography (USG) to reach a stable diagnosis and use of Low DoseComputed Tomography (LDCT) in the diagnosis of acute appendicitis is crucial. This study aimed atassessing of the accuracy of imaging modalities (USG and LDCT) in the diagnosis of children and adultswith acute appendicitis to minimize the rate of negative appendectomyA total of 42 patients, children andadults were examined, were included in this research (16 females and 26 males) ages was ranged from 5 to45 years. All patients were examined byUSG and LDCT to diagnosis acute appendicitis . The sensitivityof low dose a LDCT scan was used to diagnose acute appendicitis (96.0%) that means LDCT was able todiagnosed (96.0%) Correctly diagnose acute appendicitis patients. The specificity of LDCT in the diagnosisof acute appendicitis was (50.0%) that mean LDCT was able to diagnosed half of those with diagnosis otherthan acute appendicitis correctly, But the sensitivity of USG in diagnosis of acute appendicitis was (54.1%)that mean ultrasound was able to diagnosed (54.1%) of patients diagnosed by CT scan as acute appendicitiscorrectly.The use of low-dose computerized tomography (LDCT) provides significantly higher diagnosticaccuracy compared to ultrasound for the detection of acute appendicitis.
The Inhibitory Effect of local T.bovei Volatile Oil Against ESBL- E.coli and Klebsiella pneumoniae Isolated From Patients with Urinary Tract Infections Sawsan Qahtan Taha Al-Quhli; Safaa Abed Latef Al Maeni
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16907

Abstract

Evaluation of Oral Manifestations of Patients with Parkinson’s Disease–An Observational Study T. Gopalakrishnan; K.M.K. Mastan; P.E. Chandra Mouli; Naga Leela Guntuku; Priyadharshini A; G. Florence Sangeetha
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16908

Abstract

Background: Parkinson’s disease is the second most common neurodegenerative disorder which affectsaround four million people globally.Many of the signs of Parkinson’s disease are found in the head andneck. The typical “masklike” facial appearance with infrequent blinking and lack of expression is causedby bradykinesis.. Abnormalities in oral behaviour, such as purposeless chewing, grinding, and suckingmovements, are also well recognized in patients with Parkinson’s disease.Aim and Objectives: The aim of this study is to assess the overall oral health status of the patients withParkinson’s disease and to analyze the impact of Parkinson’s disease on the oral cavity of the individualssurviving with the disease.Materials and Methods: The study sample included 50 Parkinson’s disease patients. The patients of all agegroups and both genders were included.Results: Out of fifty patients. majority of the patient s were above 60 yrs. 6% of the patients reported withPositive family history of Parkinson’s diseases.14% of the patients had gross facial asymmetry, 68% of thepatients showed dryness of mouth.8% of the patients suffered loss of taste.14% of the patients showed hypersalivation. 54% of the patients showed gingivitis. And 76% of the patients were found having periodontitis.Conclusion: Treatment for oral and dental problems of Parkinson’s disease affected patients is mandatory.Treatment can be done by supplementing artificial saliva for dryness of mouth, dental fillings for dentalcaries, periodic scaling for periodontal problems, oral rehabilitation measures and regular dental check up
Correlation between Superoxide Dismutase 1 and 2 Polymorphisms in Asthma Patients Walaa Najah Majid; Layla Mohsen Mehdi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16909

Abstract

This study was designed to investigate the effectof polymorphisms of Superoxide desmutase1 and 2genesand how they contribute to the risk of developing asthma.A total 120 were involved in the present study anddivided into four groups and each group included 30 samples. First group was consisted 30 asthma malepatients with waterpipe smoking and second group was also 30 asthma male patients with no smoking,third group was control (no disease) with waterpipe smoking and the fourth group was control group(no disease and without waterpipe smoking).Blood samples were collected from Muthanna hospital andprivate laboratories from the periodmid-August to the mid-November 2020. To study the polymorphismphenomenon of SOD1 and SOD2 genes were assessed using RFLP- polymerase chain reaction (RFLPPCR)technique. This study confirmed that the phenomenon of polymorphism of the SOD1 genewas notassociated with the group of patients infected with asthma comparedto control group. This study conductedthat the phenomenon of polymorphism of the SOD2 geneis not associated with the group of patients infectedwith asthmacomparedto control group in presence and absence of waterpipe smoking.
The Biological Activity of Alcoholic Extracts of Cordia myxa Plant Against Klebsiella. Isolated from Infected Patients Bassam M. Shamkhy; Yass K. Abbas
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16910

Abstract

Plants have been used as drugs by humans since thousands of years ago . The study aimed to investigate theeffectiveness of alcoholic extracts of the fruits , leaves and seeds of Cordia myxa plant against pathogenicmicroorganisms (i.e. Klebsiella) . This was done in the laboratories of the Department of Life Sciences /College of Education in Nasiriya southern of Iraq . The results showed that the alcohol extract of the leaf wassignificantly superior to that of the fruit and seed extract. The results also showed that the growth inhibitionand the effectiveness against Klebsiella bacteria was at the average concentration of 300mg / mL 32.66 ±2.08 , representing the highest inhibitory concentration. It was concluded that leaves of the Cordia myxa isone of the best parts of the plant that have inhibitory effects on Klebsiella bacteria compared to the fruit andseed .
Clustering of Provinces in Indonesia based on Maternal Health Indicators Herti Maryani; Lusi Kristiana; Astridya Paramita; Pramita Andarwati; Nailul Izza
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16913

Abstract

Indonesian health issues that deserved top priority was maternal and child health because it determines thequality of the human resources of future generations. The objective of this research is to analyze the clusteringof provinces in Indonesia based on maternal health indicators. This cross-sectional study was conducted in34 provinces using secondary data from the Basic Health Research and Statistics Indonesia. Analysis ofprovincial clustering used FUZZY C-MEANS. Analysis produces six clusters. Cluster 2 has a high meanvalue of maternal health indicators that exceeded the Indonesian target, consisting of the provinces of DKIJakarta, DI Yogyakarta, and East Nusa Tenggara. Cluster 2 was formed by the value equation variable Age offirst mating, Ownership of maternal and child health monitoring book, Vitamin A Provision, K4, postpartumvisits, Iron supplementation tablets consumption and Childbirth delivery in health facilities. Indicators ofownership of the maternal and child health monitoring book for pregnant women had met Indonesia targetin all clusters. Meanwhile, the active participation of family planning program indicator was still below theIndonesia target in all clusters.

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