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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
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Association between Genetic Polymorphism of 5-HTTLPR, and SGOT, SGPT and Catalase with Alcoholism of Iraqi People Anwar A. Abdulla
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3334

Abstract

A case- control study on the relationship of 5-HTTLPR gene polymorphism with alcohol abuse among Iraqi individuals was conducted during period from December 2018 to June 2019. DNA was extracted from the blood samples of the study subjects. The genetic polymorphism analysis was conducted by Restriction Fragment Length Polymorphism (RFLP-PCR) for SLC6A4 gene. The results raveled that the odd ratio for the LL genotype was 1.697 indicating that homo mutant genotype were at higher risk for alcoholism than the wild type SS. This result showed that L allele frequency was (0.78) in alcoholism group and (0.53) in control group whereas S allele frequency was (0.22) in the alcoholism group and (0.47) in the control group. So, the results showed there was a significant difference in allele frequencies of SLC6A4gene between case and control (P<0.01; OR=1.697; 95% CI=0.86-1.64). There was a significant positive correlation between the SGOT activity and the genotype of 5-HTTLPR (SS, SL, LL).Additionally, there was a significantly increased level of liver enzymes (GOT and GPT) and catalase in serum samples of alcoholic males compared with non-alcoholic males.
Sensitive Simultaneous Estimation of Atorvastatin. Ca in Pure and Dosage Forms Via Developed CFIA Using 1,2 Naphthoquinone-4-Sulfonate as a Suitable Organic Agent
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3335

Abstract

Objectives: A sensitive visible spectrophotometric method and FIA/merging zones technique was developed for the determination of atorvastatin calcium in pure material and tablet dosage form. Method: Atorvastatin calcium has a free carboxylic moiety in its structure, which when being deprotonated in basic medium facilitates associated the reagent with the drug. This method was based on the formation of red colored chromogen of drug with 1,2-Naphthaquinone-4-sulfonate(NQS) in basic medium (NaOH). The absorbance of the chromogens was measured at their respective wavelengths of maximum absorbance against the corresponding reagent blank Results: The red colored product is directly completed in basic medium and exhibits maximum absorption at 525 nm. Different factors affecting the formation of the product and optimized in order to obtain the best conditions for the experiment and its stability were studied. Method validation was done over a concentration range of 2-10 and 1-20 ?g/mL for batch and FIA method respectively.
Gall Bladder Wall Thickness: Sonographic Accuracy and Laparoscopic Cholecystectomy Conversion Rate, Evaluated by Histopathology Mohammad Faraj Dawod Al. Jafary 1 , Ammar Fouad Abdulrazaq1 , Ayman Nadeem Kadum3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3336

Abstract

Background: Preoperative prediction of a difficult laparoscopic cholecystectomy can help the patient as well as the surgeon to prepare better for intraoperative risk and the risk of conversion to open Cholecystectomy. Aim of study: Evaluation the impact of gall bladder wall thickness, on the outcome of laparoscopic cholecystectomy and conversion rate to open cholecystectomy assessed by sonography preoperative and postoperative measurement of gall bladder wall thickness by histopathology. Patients and Methods: A prospective study conducted in the surgical unit, Department of surgery, Baghdad Teaching Hospital between November 2010 and November 2011. Abdominal Sonography performed in 110 consecutive patients before laparoscopic cholecystectomy. The surgeon re-verified sonographic finding in operative room, and postoperatively, the gall bladder specimens were sent for histopathological measurement of wall thickness. Results: Out of 110 patients with cholecystolithiasis on sonography, we encountered easy laparoscopic cholecystectomy in 80 patients (72.7%), difficult laparoscopic cholecystectomy in 24 (21.8%) and the procedure was converted to open cholecystectomy in six patients (5.5%). The difference between Sonographic and histological measurement was within 1 mm in 102 patients (92.7%), and the other 8 patients was with 1.5 mm (7.3%) with sensitivity of (100%), specificity of (83.3%) and accuracy of (97%). Conclusion: An accurate preoperative diagnostic sonography is mandatory for planned laparoscopic gall bladder surgery to provide information for the selection of the most appropriate approach and avoid intraoperative difficulties and surprises. On sonography gall bladder wall thickening is the most sensitive indicator of technical difficulties during laparoscopic cholecystectomy. Such difficulties may require conversion to laparotomy.
Evaluating the Effect of Addition of Titanium Dioxide Nanoparticle on Some Physical Properties of Flowable Composite Resin Sazgar Srbast Qasim 1, Diyar Khalid Bakr1, Dara H. Rasheed
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3337

Abstract

Objective: The flowable dental composite resins were introduced to the dental specialty because of the advantages they possess over the conventional composite resins. The use of nanotechnology in the dentistry field is one of the growing innovations in recent years. The aim of the present study was to evaluate certain physical properties of flowable dental composite after incorporation of titanium dioxide nanoparticles (TiO2NPs). Materials and Method: In the present study, TiO2NPs at 1.25 % and 2.5% concentrations were added to flowable composite, while the unmodified composite was used as control. Then the physical properties of the control and modified composite resins, including flowablity, radiopacity and water sorption and solubility were tested. Data were analyzed with One way ANOVA, using SPSS 20. Results: The results showed that there was statistically significant difference among the tested groups regarding flowability and radiopacity (P<0.05). In addition, there was no significant difference among control group and TiO2 modified groups regarding water sorption and solubility. Conclusion: Based on the results of the present study, a flowable dental composite was successfully reinforced with TiO2. Incorporation of small weight percentages of this nanofiller exhibited properties similar to the control material regarding water sorption and solubility. The flowability was slightly reduced and radiopacity of the reinforced composites was increased, these changes were acceptable for clinical applications and below ISO standards limits.
Antimicrobial Activities of Green Biosynthesized Iron Oxide Nanoparticles Using F. Carica Fruit Extract Nada Khudair Abbas1, Azhar A. F. Al- Attraqchi2, tutor Jenan Hussien Taha3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3338

Abstract

In the current study, iron oxide nanoparticles (IO NPs) were synthesized via modified green synthesis technique using F. carica fig extract as reducing agent. Furthermore, the microstructural properties of the synthesized IO NPs have been thoroughly elucidated. In details, the acquired NPs diameter was found to be in the range of 11-29 nm and of root mean square (RMS) of 0.64 nm using TEM and AFM techniques, respectively. Consequently, the antifungal and antibacterial activities of the synthesized IO NPs were screened against Candida and Aspergillus species as well as Gram-positive Staphylococcus aureus and Gram-negative Acinetobacter species, respectively. The presented IO NPs play an active role in the antimicrobial activities evidencing the well-organized materials system for biomedical applications.
Molecular Detection of Antibiotics Resistance Genes in Burkholderia Cepecia Isolated From Diabetic Foot Infection Maryam Riyadh Al-Muhanna1, Mahdi Al-Ammar1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3339

Abstract

This study aimed to isolate and diagnose Burkholderia cepetia from clinical specimens of diabetic foot and study the resistance of bacteria to antimicrobial agent in Najaf governorate from Augest 2019 to November 2019, which includes 120 clinical specimens for both sexes with an age ranged between )35-70) years old. The diagnosis of bacteria isolates was based on microscopy, as well as the culture and biochemical characteristics as an initial diagnosis. The final diagnosis by the Vitek-2 compact system . Burkholderia cepacia 8(6.6%). Antibiotic sensitivity test was examined by dick diffution method, Burkholderia cepacia isolates showed high level of resistance almost for all ?-lactam antibiotic classes under study which included;, ceftriaxone, cefoxitin and Cefepime, with percentage of (100%); ticarcllin with clavulalnic acide ,piperacllin , ceftazidime, tobramycine, ciproflaxcin and levofloxacin with percentage of (87.5%); aztreonam and amikacine with percentage(62.5); meropenem , imipenem and gentiamycin with percentage of (37.5%). At molecular study, the investigated the presence of antibiotic-resistant genes (blaImp, blaOxa, blaKpc,blaCTX-M) using PCR technique and electrophoresis systems. 6/8 Burkholderia cepacia isolates were with blaOXA and (6/8) of isolates carry blaCTX-M gene, all isolates of Burkholderia cepacia gave negative result of blaIMP and blaKPC gene. Finally PCR analysis showed that the integron gene was (3/8 %).
Evaluation the Antimicrobial Effect of Glycerin Magnesia on Some Bacteria, in-Vitro Study Maher Saber Owain1, Khalid Ismael Oleiwi2, Ali Ghazi Atiyah1, Mustafa Salah Hasan1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3340

Abstract

This study was aimed to assess the efficacy of glycerin magnesia on some bacteria. A thirty percent of glycerin magnesia were prepared as explained below. Many types of bacteria including Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, Acinetobacter, E. coli, Pseudomonas aeruginosa, Salmonella spp. were selected for this study and obtained from university of Tikrit, college of veterinary medicine. A bacterial broth were prepared, a then a sterile swab were emulsify in these broth and streaked on muller hinton agar plate and allowed till dry, then a holes were filled with a given glycerin magnesia and incubated for 24hrs. at 37?C . The results showed that a higher antibacterial effects of glycerin magnesia against Staphylococcus aureus followed by Proteus spp., Pseudomonas aeruginosa, Salmonella spp., Acinitobacter, E. coli, Staphylococcus epidermidis respectively. In conclusion, the glycerin magnesia have a wide range antibacterial effect and can be used in future in wound healing.
The Role of CTX-II , Dyslipidemia ,Vitamin D in Polycystic Ovary Syndrome Samah Amer Hammood1 Alaauldeen S. M. AL-Sallami2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3341

Abstract

This study aimed to study the serum measurement of clinical value of type II collagen (CTX-II) in syndrome of polycystic ovary in women and indicter as osteoarthritis disease marker analyzed in future levels with a recent available immune enzyme-linked sorbent assay (ELISA) kit. For increasing sensitivity test, the protocol was modified. Levels of CTX-II increased significantly as well total protein, while decrease vitamin D and difference in lipid profile were practical between the patients compared with healthy women’s. The obtained results suggested the monitoring interest of the serum CTX-II for the OA development in patients of polycystic ovary syndrome in women and the relevance of the analysis of multiple time point for this biomarker.
Prevalence of Histopathological Diagnosis of Benign and Malignant Breast Lesions in Al-Muthanna Province for Two Years Duration Sarah Ali Abed1; Ali Adnan Jabbar2; Roaa Salih Mahdi3; Ali Mohammed Khaleel4; Suha Suhiel Hussein5;
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3342

Abstract

Introduction: Breast cancer (BC) is a common form of cancer among women globally. It is considered 5th cause of death in females with equally to 522,000 patients / year. Nowadays it is considered 15.4% of death in developed countries after lung cancer. In developing nations, breast cancer considered the 1st cause of death for females 324,000 cases of deaths (14.3%) for total deaths. Method: One hundred and six female patients with breast lesion were collected from the Al-Hussein Teaching Hospital Laboratory/Histopathology department –Al-Muthanna province, during the period from January 2018 to January 2020. The data for cases were collected to study the age, type of breast lesion whether benign or malignant. Haematoxylin/ Eosin staining done in Al-Hussein Teaching Hospital Laboratory / Histopathology department. Results: Cross sectional study for 106 patients done in Al- Muthanna proven for assessment breast mass and identify malignant and benign lesion, mean age of patients was (39.4 ± 15.8) years old, with min age 13 years and max age was 81 years old. Types of biopsy taken from surgeon were 71% excisional biopsy, 21% mastectomy and 8% true cut biopsy. After pathological assessment of biopsies showed 51% malignant and 49% benign. In addition, this assessment distributed as following: fibroadenoma 31.1%, IDC/ grade II 29.2%, IDC/ grade III 9.4%, ILC and fibrocystic changes 5.7% and IDC grade I 3.8% and other types of malignant and benign after pathological assessment. Significant association between age groups and cancer of breast. Conclusion: After pathological assessment of biopsies, malignant breast cancer (IDC/ grade II, IDC/ grade III, ILC and fibrocystic changes) most common changes, significant association between age group and breast cancer development more age group 41- 50 years old and then (31- 40), (51– 60) years old respectively.
A Histological and Histochemical Study on Olfactory Bulbs to Detection Amyloid Protein Depositions by Congo-Red and Routine Staining Techniques Rajaa Ali Moheiseen Al- Taee1, Muna Hussain Al-Aameli2, Yarub Modhar Al-Qazwini3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3346

Abstract

In this study, histological and histochemical techniques were used to examine olfactory bulbs in the albino rat male. Thirty male albino rats were split into three age groups (10 animals each) in the current research: Group I: consider as a control group, including adult animals aged 3 months .Group II: include animals aged 6 months. Group III: include animals aged 12 months. The histological architecture of the layers of olfactory bulbs and their main cells was identified by using H & E staining techniques, meanwhile the composition of each layer in albino rat was evident. In the glomerular and mitral cell layer of group III, olfactory bulbs showed reduced neural density. Modified staining with Congo - red was conducted for histochemical studies. Compacted amyloid cores were found in group III animals’ olfactory bulbs, while dispersed amyloid cores were found in group II&III olfactory bulbs’ cortex. The present study adds to our knowledge of the impact of amyloid protein on olfactory bulbs and their prospective neurodegeneration involvement.

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