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INDONESIA
Indian Journal of Forensic Medicine & Toxicology
Published by Official Organ of Indian Association of Medico-Legal Expert
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Public Health
Arjuna Subject : Kedokteran - Epidemilogi
Articles 5,497 Documents
 87   88   89   90   91 
Study of Immunological Parameters, Hematologic Outcomes And Epidemiology Features of Renal Dysfunction Frequently in Karbala Province, Iraq Alyaa Aziz Gubiar Al-Nasrallah
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10499

Abstract

Renal failure or dysfunction: A disease occurs by a severe weakness in one kidney or both, they lose ability to do their functions effectively, resulting in the body’s inability to remove waste and fluids, Leading to a significant changes in chemistry of blood and body fluid. The study occurred in Karbala province where study samples were collected, which included (124). Samples divided in (64) patients and (60) control, patients had another division according to sex (44) male and (20) female. Immunologic parameters include (kidney injury molecules (KIM-1), pro-inflammatory TNF-?, IgG antibodies) Elabscience Kit, concentration in serum was massacred by (ELISA) Technique and hematologic test measured automatically by (Humlate plus-1 Device). The results showed increase in kidney injury in age groups beyond the age of 40 years. A significantly higher incidence of disease among males more than females. Results show significant statically variations in serum levels: 1- kidney injury molecules (KIM-1) levels was increased in serum in patients significantly compare with control. 2- (TNF-?) levels was increased in patients than control. 3- IgG levels decreased in patients than control. Another routine tests occurs to patients to know the effects of disease on blood variations, the test was included CBC count the results show CBC tests: (WBC, MHC, MCHC, RDWS, RDWC, PLT, PCT, PDWS, PDWC, P-LCC and P-LCR) have no significant differentials while CBC tests: (LYM., MON., GRA., RBC., HGB., HCT., MCV, MPV) which decrease in patient compare with control significantly. Increase kidney injury and inflammatory in serum patients with disease, by measured some parameters levels in sera as indicators for disease progression and decrease in some antibodies such as IgG concentration of in sera, as well as the hematologic tests referrer to disease may associated with anemia.
Study on Correlation between IL-33 serum level, IL-33 Gene Single Nucleotide Polymorphism and Rheumatoid Arthritis Susceptibility Hind Fouaad alhammami1 , Mahdi H. AL-Ammar2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10500

Abstract

Objective: To discuss the association between single nucleotide polymorphism (SNP) of rs1929992 in IL- 33gene and IL-33 serum level in rheumatoid arthritis (RA) susceptibility among Iraq population. Methods: A total of 50 samples were collected from 35 RA patients from November 2018 untill end of January 2019 together with 15 healthy physical examines in the same period were chosen as the subjects. The serum IL-33 levels measured by commercial ELISA kits . Erythrocyte sedimentation rate ,white blood cell were measured by standard laboratory techniques The RFLP-PCR reaction technique was used to detect the genotype distributions for rs1929992 in IL-33gene was carried out by using restriction enzyme. The frequency of each allele and genotypes distribution was calculated so as to evaluate the association between genotype distribution and RA susceptibility. Results: Serum IL-33concentration was significantly higher in patients with RA than in control groups. The homozygous genotype AA recorded higher frequency in RA patients (42.9%) than controls (6.7%) with a significant difference (P-value 0.001). Homozygote genotype GG frequency (45.7%) was a significant in patients compared to controls subject (33.3%) with a significant difference (P-value 0.016), and the genotype heterozygous GA frequency (11.4%) were non-significant in patients compared to controls (60.6%). The allele frequency for allele G was (51.4%)in patients compared with controls ( 63.3%) with a significant difference (P-value 0.022)while for the allele A was (48.6%) in patients compared with controls( 36.7% )with a significant difference (P- value 0.001). Conclusions: significant correlation between RA patients susceptibility and genotype AA and alleles at rs1929992in IL-33 gene is observed. From this study showed that the IL-33 levels were influenced by genetic variation at SNPs rs5743708and rs1929992, respectively.
Deleted Anwar Abed Nasser Dhabaan1 and Mayes Abdul-Hadi Mahdi2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10501

Abstract

a
Evaluation of Oxidative Stress and Antioxidants in Iraqi Patients with Hydatid Disease Ahmed A. Mohammed
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10502

Abstract

Antioxidants and oxidative stress status are clinically important in the detection of many diseases. In order to estimate the role of oxidative stress in hydatid disease pathogenesis, the antioxidant levels and oxidative stress status were examined in the patients of hydatid cysts. Thirty patients having active hydatid cyst of Echinococcus granulosus, previously diagnosed by X-ray, were adopted as patients’ group. Additionally, 25 healthy individuals who did not have hydatid infection or any other parasitic infection constituted the control group. Antioxidant status and oxidative stress levels were determined using biochemical tests including plasma Malondialdehyde (MDA) level, and erythrocyte Catalase (CAT), Glutathione Peroxidase (GSH Px), Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST) activity, in addition to erythrocyte Glutathione concentration GSH-conc. The statistical evaluation of plasma MDA levels showed significantly higher levels in hydatid patients than in healthy controls, while erythrocyte SOD, GSH-Px, CAT, GST and GSH levels were significantly declined in hydatid patients compared to the control which can be used as diagnostic markers in the laboratory diagnosis of the disease. To conclude, hydatid patients show elevated oxidative stress status, and therefore, the antioxidant therapy should be considered in addition to the routine medicines in this group of patients.
Pharmacological Effects of Dexamethasone in Rats Safa Azhar Razzaq1 , Israa Jawad Jaber2 , Shahd Abdulamer Kadhim3 , Ahmed Adnan Abbas4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10503

Abstract

Dexamethasone is one of the most widely used glucocorticoids which has a prominent glucocorticoid with slight mineralocorticoid property. This study was performed on twenty four adult Sprague Dawley rats to evaluate the proposed effects of dexamethasone offering as intraperitoneal injection. The animals were allocated randomly into three groups of eight rats to each. The protocol of experiment was: the control group; animals are injected intraperitoneally with 2ml of distilled water, the dexamethasone 1 group; animals are injected intraperitoneally with dexamethasone 2mg/kg, and the dexamethasone 2 group; animals are injected intraperitoneally with dexamethasone 4mg/kg. The injection period extended for one month. The results illustrate that dexamethasone cause significant declination in RBC, PCV, Hb, HDL, and neutrophils besides significant elevations in WBC, eosinophils, monocytes, LDL, TC, TG, VLDL, AST, ALT, and creatinine on a direct positive proportion with the increase in dexamethasone dose comparing with control group at (P?0.05).
Association of soluble HLA-G and HLA-G 14bp ins /del Polymorphism in some Iraqi patients with Breast Cancer Hanaa N. Abdullah1 , Alia Gh. Abdulwahid2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10504

Abstract

Human leukocyte antigen-G is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The main objective of the study is to evaluate the HLA-G 14-bp polymorphism in the 3?- untranslated region of the HLA-G gene in that associated with the susceptibility to breast cancer patients. This study has been done on 60 BC patients & 30 Benign tumor and30 control groups. Estimation of sHLA-G markers was assayed by using ELISA technique. Thus, polymorphism of HLAG HLA-G 14-bp were detected by PCR methods. The plasma levels of HLA-G shows a significant elevation in BC patients compared to benign breast tumour and controls (32.79±0.9vs. 13.84 ±0.30 and 12.72 ±0.45 ng/ml, P?0.05). There was a significant difference between newly diagnosed breast cancer patients and healthy control groups in homozygous genotype HLA-G 14-bp del/del genotyping (66.7% vs. 36.7%; OR=3.45; P?0.01). While, no significant differences in the homozygous genotypes Ins/ins frequency were observed between patients with breast cancer (6.6%) and the healthy control group (0.0%) (OR=3.45, P?0.001). There was a significant increase frequency of heterozygous genotype Ins/del in controls compared to patients (63.3%vs.26.7%). No significant difference was found between the patients and control groups at HLA-G 14bp insertion and deletion allelic frequency.
Detection of Acute Childhood Meningitis using PCR in a group of Children at Childs Central Teaching Hospital/Baghdad Rana Fahmi Shitran,1 Warqaa Y. Khudur 1, Mohammed E. Atallah2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10505

Abstract

Bacterial meningitis is an important cause of death in both developed and developing world. The study was done on 116 patients admitted to child central teaching hospital in Baghdad ,and diagnosed with meningitis depending on CSF findings and PCR results while determination of type of microorganism depend on PCR result . In this study we aimed to assess the patients regarding their numbers ,clinical manifestations , complications and type of bacteria causing the disease .Regarding the results of PCR, streptococcus meningitis at the top of the list for the bacterial causes while no any reported cases with Hemophillus influenza and this could be referred to the program of vaccination applied in Iraq which included the vaccines against both types of bacteria. Results :of 116 patient involved in this study, majority (44%) were below 1 year ,with male predominance (57.8 %).most of the patients symptoms between 1-3 days (56%).all patients presented with fever. The diagnosis depend on the PCR results (57.8%) were negative and (37.9%) showed streptococcal infection .All blood culture were surprisingly negative because majority of included patients received antibiotics in outpatient visits before admission and diagnosis. Patients admitted and followed up to one year for development of complications. Sixteen cases developed complications, (3.4%) of them with subdural effusion and most of complication occur in streptococcal positive PCR results .
Molecular Physical Properties of Cryogloblin in Patients with Hepatitis B Virus in Al-Najaf Province Ahmed Aleiwi Al Hassani1 , Adil Ibadi AL-Luhaiby2, Mohammed Jasim Al-Shamarti1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10506

Abstract

Cryoglobulins (CGs) are a cold precipitating abnormal immunoglobulins. The incidence of hepatitis B was discovered to be greater in age groups (46-55 years) relative to othe age groups. CGs were detected in 50 (33.3%) out of 150 patients with Hepatitis B. Three types of CGs precipitation nature were identified. Gelatinous (76%), flocculate (20%), and crystallineous (4%). No relation was found between patient’s age and CGs molecular physical properties. The cryocrit test of 50 serum samples revealed that CGs are characterized by their reversible precipitation at 4ºC between 12 hours to five days and solubility time at 37ºC ranged between half an hour and three hours.
Hospital Door Knobs as a Source of Bacterial Contamination: A Study in Iraqi Hospitals Zainab Salim Jaafar
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10507

Abstract

In this study, 20 swabs were collected from three hospitals in the holy city of Karbala (Al Hussein General Hospital, Al Abbas Private Hospital and Maternity Hospital). Nutrient agar was grown on solid feed medium and incubated at 37 ° C for 24-48 hours for isolation and diagnosis. Bacterial isolates obtained underwent biochemical and bacteriological tests for diagnosis. I prepared different doses of isolated bacteria according to the McFarland model. Then take 0.1 ml of 1/10000 IV dilution and add to Muller Hinton agar medium. The results of the preliminary diagnosis of the isolated bacteria showed that the positive bacteria of Cram stain were higher than those of Cram negative bacteria. The largest number of S.aureus bacteria was in the hospital environment from which swabs were taken and in all locations, especially bathrooms. By calculating the percentage of the total number of samples diagnosed for each hospital separately, the results showed that Hussein General Hospital had the highest contamination rate of 90%, while Al-Ahli Hospital had the lowest contamination rate of 40%. With regard to the effect of antiseptics, the concentration gave 75% Dettol the highest amount of inhibition of bacterial growth compared with other concentrations. On the other hand, the synergistic effect of both antiseptics (Dettol and chlorine) 75% -25% had an effect on inhibition of bacterial growth and its total elimination in the medium compared to other concentrations.
Estimation the Level of Metals (Lead, Cadmium, Copper and Zinc) In Multiple Sclerosis Patients in Basra\ Iraq Ali Diame Nashmi 1 , Ali Faris Hassan2 , Mazin Mohamed Hammady3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10508

Abstract

Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system white matter that displays a triad of pathogenic symptoms. The toxicity of heavy metals can disrupt or damage central nervous systems. Long-term exposure of human population to heavy metals has shown neurological impairments. The degenerative processes are similar to Alzheimer’s disease; Parkinson’s disease.This study compared the serum level of Lead, Cadmium, Copper and Zinc in MS patients with their levels in a control group. Methods: prospective study of cohort includes fifty Iraqi people selected from the Southern area of Multiple Sclerosis Clinic Center divided into two groups, in which the first group contains twenty five patients with MS and twenty five people without MS. Serum level of Lead, Cadmium, Copper and Zinc have been measured. Results:In the present study, there was a significant increase in the concentration of (cupper - lead –cadmium) in patients with multiple sclerosis as compared with normal people (p<0.05). There is a significant decrease in the concentration of zinc in patients with multiple sclerosis as compared with normal people (p<0.05).Conclusion: Lead, copper, cadmium and zinc could affect on the susceptibility of patients to induce MS attack.

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