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Berkala Ilmiah Mahasiswa Farmasi
Published by Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia
ISSN : 23027851     EISSN : 27741710     DOI : 10.48177
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
BIMFI is a peer-reviewed and open access journal that prioritize the publication manuscript of pharmaceutical and health cluster students. This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. BIMFI receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 54 Documents
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NARRATIVE REVIEW: MONSTERA DELICIOSA SEBAGAI ANTIBAKTERI DALAM SEDIAAN SPRAY HYDROGEL 3 IN 1 Regina Desyca Sarmitha Dewi; Miftahul Janna; La Ode Muh Alfiqra; Selpirahmawati Saranani
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.79

Abstract

Introduction: Monstera deliciosa have the potential to be developed as anti-bacterial drugs due to secondary metabolite compounds such as tannins, steroids, saponins, flavonoids and alkaloids. The purpose of this review is to demonstrate potential of Monstera deliciosa as an antibacterial in spray hydrogel 3 in 1 spray dosage form. Methods: This narrative review conducted the method of literature review or the secondary data compilation from several scientific journal such as wiley, sciencedirect, portal garuda, and google scholar. Result: Monstera deliciosa have several volatile components that have been shown antibacterial activity included 1,6-Cyclodecadiene, 6,10,14-trimethyl-2-Pentadecanone, naphthalene, limonene, 1–methyl–5–methylene–8-(1-methylethyl), and 2-Furanmethanol so it can be used as an antibacterial agent in spray hydrogel 3 in 1 spray dosage form. Conclusion: Monstera deliciosa have the potential to be developed as anti-bacterial in hydrogel 3 in 1 preparation.
REVIEW ARTIKEL : TANAMAN YANG MEMILIKI AKTIVITAS ANTI-ULSER DI ASIA Nabila Putri Azzahra; Kirka Dwi Apriali1; Lika Ginanti Febriana
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.80

Abstract

Introduction : Herbal medicines have high potential in treating various diseases including gastric ulcers because they are considered safer and more comfortable. Ulcers or gastric ulcers are disorders of the stomach due to an imbalance of aggressive factors (gastric acid secretion, pepsin, and Helicobacter pylori infection) with defensive factors (prostaglandins, mucus, bicarbonate, mucosal blood flow, and intrinsic epithelial cells). Methods : The method used is a literature review study conducted by searching for keywords such as peptic ulcer disease, herbal plants, anti-stomach ulcers, and others in databases such as PubMed and Google Scholar. Results : From the literature review, 29 medicinal plants in Asia have a potential anti-ulcer activity that can prevent and help treat gastric ulcers. The table of medicinal plants is arranged based on the phytochemical analysis, the part used, and the country where the plant originates. Conclusion : Plants that have the potential to prevent and help heal gastric ulcers that are spread in Asia include phytochemicals containing flavonoids, tannins, polyphenols, alkaloids, glycosides, terpenoids, saponins with various mechanisms, namely gastroprotective, antioxidant, anti-inflammatory, anti-secretory, anti-Helicobacter. pylori, and astringents.
ANALISIS IN SILICO PENCEGAHAN PENUAAN KULIT MELALUI PENGHAMBATAN CELLULAR SENESCENCE TERTARGET INHIBISI CD36 OLEH SENYAWA AKTIF CINNAMOMUM ZEYLANICUM Putri Anggraini Budianto; Novia Permata Hapsari; Dhiya Ulhaq Salsabila
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.85

Abstract

Introduction: Increased ROS (reactive oxygen species) and SASP (senescence-associated secretory phenotype) lead to skin aging via cellular senescence. CD36 (Cluster Difference 36) is found overexpressed in senescent cells and accepts various activators that generate ROS and SASP. Cinnamon (Cinnamomum zeylanicum) has been known to exert several pharmacological effects like antioxidant and anti-senescence. However, its anti-senescence effect on CD36 has not been reported yet. This study aims to prove that cinnamon’s compounds are effective to inhibit CD36 in order to stop skin aging caused by senescence. Methods: Literature studies and in silico approaches such as database searching, molecular docking, and KNIME open analytic platform were used in this study. Result: Cinnamaldehyde is proven as a better competitive CD36 inhibitor (DICE Score: 0,886; Tanimoto Score: 0,939) with better affinity than native ligand and previously studied inhibitors (RMSD: 0,74 Å; S: -7,43 kcal/mol). Bioinformatics investigations also showed that major compounds of cinnamon target CD36 regulator, oxidoreductases, and SASP-producing receptors that co-expressed with CD36. Conclusion: Active components of cinnamon are potential to be an anti skin aging by inhibiting CD36, regulating CD36, and eradicating senescent factors.
A SKRINING VIRTUAL BERBASIS LIGAN SENYAWA PRODUK NATURAL TERHADAP SARS-COV-2 MAIN PROTEASE (Mpro) MENGGUNAKAN PENDEKATAN SIMILARITAS SUBSTRUKTUR DAN PEMBELAJARAN MESIN GP. Wahyunanda Crista Yuda
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.86

Abstract

Introduction: Increased ROS (reactive oxygen species) and SASP (senescence-associated secretory phenotype) lead to skin aging via cellular senescence. CD36 (Cluster Difference 36) is found overexpressed in senescent cells and accepts various activators that generate ROS and SASP. Cinnamon (Cinnamomum zeylanicum) has been known to exert several pharmacological effects like antioxidant and anti-senescence. However, its anti-senescence effect on CD36 has not been reported yet. This study aims to prove that cinnamon’s compounds are effective to inhibit CD36 in order to stop skin aging caused by senescence. Methods: Literature studies and in silico approaches such as database searching, molecular docking, and KNIME open analytic platform were used in this study. Result: Cinnamaldehyde is proven as a better competitive CD36 inhibitor (DICE Score: 0,886; Tanimoto Score: 0,939) with better affinity than native ligand and previously studied inhibitors (RMSD: 0,74 Å; S: -7,43 kcal/mol). Bioinformatics investigations also showed that major compounds of cinnamon target CD36 regulator, oxidoreductases, and SASP-producing receptors that co-expressed with CD36. Conclusion: Active components of cinnamon are potential to be an anti skin aging by inhibiting CD36, regulating CD36, and eradicating senescent factors.
INHIBISI DNMT3B UNTUK MENGHAMBAT PERKEMBANGAN SEL KANKER KULIT DENGAN SENYAWA MINYAK ATSIRI KAYU MANIS MELALUI STUDI IN SILICO DAN PROTEOMIK Khusnul Agustina; Putri Anggraini Budianto; Christopher Filando Santoso; Rumiyati Rumiyati
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.92

Abstract

Introduction: Cinnamon (Cinnamomum cassia) is often used as a medicinal plant because of its antioxidant properties. UV overexposure leads to many harmful impacts, one of them being the increasement rate of skin cancer risk. UV rays increase DNMT3B expression and ROS level. However, anti-skin cancer drugs that target DNMT3B have not been explored yet, and this study aims to explore cinnamon essential oil's potency in targeting DNMT3B to stop UV-induced skin cancer development. Methods: The research was carried out through an in silico and proteomic approach. Research materials were obtained from various databases including CMAUP, ChEMBL, PubChem, Google Scholar, PubMed, and RCSB. The materials that have been obtained are processed using KNIME and MOE V.2010 software Result: As a result, KNIME analysis showed many similarities between four of cinnamon's active compounds and DNMT3B inhibitors (azacytidine and decitabine). Three of the essential oil compounds; Cinnamaldehyde, cis-2-methoxy cinnamic acid, and coumarin are predicted to inhibit DNMT3B. Moreover, using the molecular docking approach, cis-2-methoxy cinnamic acid has more stable bonds compared to its native ligand (glycerol). Conclusion: In conclusion, the active compounds in cinnamon essential oil were potential to inhibit DNMT3B and prevent skin cancer development with cis-2-methoxy cinnamic acid as the most potent inhibitory compound. Keywords: Cinnamon, skin cancer, DNMT3B, cis-2-methoxycinnamic acid.
STUDI IN SILICO SENYAWA BIOAKTIF KUERSETIN KULIT JERUK NIPIS (Citrus aurantifolia) SEBAGAI AGEN ANTIKANKER PAYUDARA Ivana Kinanti Kenyori; Cut Intan Ayu Nurjanah; Maura Shavira Alamsyah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.95

Abstract

Introduction : MCF-7 cells are one of the human breast adenocarcinoma cells that are often used for research related to human breast cancer, because these cells are considered as characteristics of differentiated breast gland epithelium. Lime (Citrus aurantifolia) is a plant that contains quercetin, especially in the peel. This study aims to explore the potential of compounds contained in lime peel, namely quercetin as a treatment for breast cancer with MCF-7 cell targets. Methods : This research was conducted in slilico with molecular docking method using AutoDockTools and visualization of docking results using PyMol and LigPlot+ software. Results: The results of this study indicate that the compound quercetin contained in lime peel can be potential as an anticancer of the breast with an energy affinity value of -8.2 kcal/mol. Conclusion: This study proves that the compound quercetin in lime peel is a candidate for a new breast cancer drug. It is known that research results show that quercetin has a stronger binding to the receptor than the original ligand. In addition, quercetin compounds also have interactions with several amino acid residues so that they can provide scientific evidence that quercetin compounds have potential as anticancer breasts.
TINGKAT PENGETAHUAN PENGGUNAAN OBAT ANTIBIOTIK DI TELUKJAMBE TIMUR KARAWANG Tegar Wiguna; Desi Sintia; Listia Nurkholifah; Naufal Rizal; Silky Maulina; Theshinta Berliana; Warsono Warsono
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 1 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i1.100

Abstract

Introduction : Antibiotics are the most frequently prescribed drugs for patients but there are still many people who do not know about the use of antibiotics, causing inaccuracy in the use of antibiotics and resulting in drug resistance to germs. Methods: The research method used is descriptive method with cross sectional design. The study was carried out in East Jambe Bay in December 2021. The sampling technique in this study was accidental sampling with inclusion criteria of 20-50 years old, people in the East Jambe Bay area. Data retrieval conducted direct interviews with the number of respondents 30 to obtain primary data. Respondents who took part in this study found 30 people who were members of the East Telukjambe community and met the research inclusion factors. Results: The results of the accidental sampling test showed a significant relationship between gender and knowledge of the use of antibiotics. The level of health awareness is not only influenced by attitude factors, but also by several other individuals, from the results of this study it can be seen that respondents have a higher level of knowledge about antibiotics in answering how to use good and sufficient antibiotics. Conclusion: Based on the research results obtained from 30 respondents, the level of knowledge of the people in Telukjambe Timur towards the use of antibiotics is in the less category as many as 10 people (10%), while in the good category as many as 20 people (20%). So it can be said that the category of public knowledge about antibiotics is in sufficient.
TINJAUAN PUSTAKA : SEJARAH HIV (HUMAN IMMUNODEFICIENCY VIRUS) HINGGA PERKEMBANGAN VAKSINASI GLOBAL wil hel minah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.96

Abstract

ABSTRACT HIV (Human Immunodeficiency Virus) is a virus that damages the immune system by infecting CD4 cells (cluster of differentiation 4) which is an important part of the immune system. Damage to the immune system causes humans to lose their immune system so they are easily infected and die [1] . In March 2021, HIV cases were still increasing, as many as 427,201 people with HIV cases, and as many as 131,417 people with AIDS cases. The number of patients taking antiretroviral treatment was 269,289 people, 219,898 people were still alive and 49,391 people had died [2]. Until now there is no vaccine that can be used for HIV treatment, this trial has not succeeded in developing a working vaccine [3] . The purpose of this review is to explain the history of the development of HIV to the development of vaccines as technological updates for HIV treatment. The main challenges faced by this trial were the high antigenic variation of HIV, the presence of a latent HIV reservoir, and the difficulty of eliciting a broad neutralizing antibody response [4]. Currently, the strategy of making vaccines using traditional methods, namely Live attenuated virus, inactivated virus is not recommended for HIV treatment. Researchers have explored a new approach, namely mRNA vaccines. With this vaccine strategy it has been proven safe and effective to elicit CTLs (Cytotoxic T Lymphocytes) responses. Currently the HIV mRNA vaccine candidate from the company Moderna on August 18, 2021 has entered a phase 1 clinical trial in humans finding that 97% of people who received the vaccination had an appropriate immunological response. Keywords : Human Immunodeficiency Virus, Acquired immunodeficiency syndrome, Antiretroviral, HIV Vaccine, Self-amplifying.
UJI BIOINFORMATIC MODELING SENYAWA AKTIF BIJI MELINJO (Gnetum gnemon L.) PADA PROTEIN KANKER SERVIKS DAN SARS COV-2 Dhecella Winy Cintya Ningrum; Devi Rahmawati; Rifki Febriansah; Melany Ayu Octavia
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.98

Abstract

Introduction: Cervical cancer cases in Indonesia are ranked second with the results ofdata in 2020 of 36,633 cases. During the COVID-19 pandemic, cancer patients aresusceptible to being infected by COVID-19. Study data from China, February 2020, therewere 107 cancer patients infected with COVID-19. It should get more attention becauseweakened immune form cancer patients. The purpose of this study was to determine thepotential of active compounds from melinjo seeds in inhibiting cervical cancer proteins andSARS CoV-2. Methods: The method used is bioinformatics test (STITCH -STRING) and moleculardocking test using Autodock Vina. The results will be seen from the lowest docking score.Result: The results of the bioinformatics test were obtained in the form of target proteinsfor cervical cancer regulators, namely MYC and TP53 (Resveratrol), FN1 and MAPK1(Gnetin C), SERPINE1 and VEGFA (Oleic Acid). The results from the analysis of thebinding affinity a target protein obtained the best binding affinity for cancer proteins, namelyGnetin C with FN1 with a docking score of -10.8 kcal/mol. The best affinity for SARS CoV2 protein after Remdesivir was for Resveratrol and Nsp3 with a docking score of -7.4kcal/mol. Conclusion: The results showed that the active compounds Resveratrol and Gnetin C hadgood potential in inhibiting cervical cancer protein and SARS CoV-2 with a lower dockingscore compared to the comparison drug Keywords: Gnetum gnemon L, bioinformatic modeling, cervical cancer, SARS CoV-2
Tinjauan Pustaka: Karakteristik Dan Respon Antibodi Vanksin Dengan Sediaan Microneedle Patch Lika Ginanti Febriana
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 9 No 2 (2022): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v9i2.99

Abstract

Introduction: Vaccination is one of the greatest medical advances of modern preventive medicine. Vaccination is the most effective way to control the incidence of infectious diseases. However, the current vaccination approach faces a number of challenges that impact vaccination compliance. Most vaccines given by intramuscular (IM) or subcutaneous (SC) injection cause pain and discomfort, in most cases, leading to poor adherence due to needle phobia. The development of microneedle patch technology has been applied to various types of vaccines. Methods: The research method used is literature review. The literature sources used in this study were searched through the PubMed® and Google Scholar databases with the keywords microneedle vaccine, vaccine patch, and microneedle patch vaccine. Found 20 articles that can be used in the literature review Result: The results of research on the microneedle patch from various types of vaccines need to be studied to determine the effectiveness of the vaccine in the form of a microneedle patch. Various aspects such as the type of microneedle patch, needle height, and antibody response to vaccine preparations in the form of a microneedle patch can be indicators to assess the potential of a microneedle patch. Conclusion: Various aspects such as the type of microneedle patch, needle height, and antibody response to vaccine preparations in the form of a microneedle patch can be used as indicators to assess the potential of a microneedle patch. There are four types of microneedle, namely Solid Microneedle, Coated Microneedle, Dissolving Microneedle, and Hollow Microneedle. To penetrate the skin, the microneedle has a pointed tip with a length of 150-1500 m, a width of 50–250 m, and a tip thickness of 1–25 m. Microneedle patch can induce antibody formation to be faster.. Keywords: Microneedle Patch, Vaccine, Vaccination

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