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INDONESIA
Berkala Ilmiah Mahasiswa Farmasi
Published by Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia
ISSN : 23027851     EISSN : 27741710     DOI : 10.48177
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
BIMFI is a peer-reviewed and open access journal that prioritize the publication manuscript of pharmaceutical and health cluster students. This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. BIMFI receives manuscripts in Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutics, Pharmaceutical Microbiology and Biotechnology, Community and Clinical Pharmacy, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 54 Documents
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Optimasi Formula Patch Transdermal Ekstrak Etanol Daun Seledri untuk Pengobatan Hipertensi Ni Kadek Ayu Pramesti; I Putu Mas Arie Pradina Putri; Ni Putu Mas Arya Shinta; I Gusti Ngurah Jemmy Anton Prasetia
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.37

Abstract

Introduction: Hypertension is one of the biggest health problems for Indonesian people. Celery leaves are a plant that can be used to treat hypertension. Research shows that the ethanol extract of celery leaves at a dose of 150 mg / day can reduce blood pressure. Antihypertensive drugs have low oral bioavailability due to first pass metabolism in the liver. The use of transdermal patches can improve patient comfort and may improve low oral bioavailability. One of the important components in the patch preparation is a polymer matrix consisting of hydrophilic (PVP K-30) and hydrophobic (EC N-20) polymers. Methods: this review article using literature review and evaluation results from research journals. Results: Optimization of the formula for transdermal patch preparations was carried out using three variations of the ratio of PVP K-30 and EC N-20 for the transdermal patch polymer matrix, namely 1: 2, 2: 3, and 1: 3. The best transdermal patch formula of celery leaf ethanol extract in terms of physical characteristics parameters and has the potential to provide optimal release of active ingredients to reduce blood pressure, namely the formula with a combination of polymer matrix PVP K-30 and EC N-20 2: 3. Conclusion: The writing of this review article is to obtain the best comparison of hydrophilic polymer (PVP K-30) and hydrophobic polymer (EC N-20) in celery leaf extract patch preparations (Apium graveolens) which have the potential to provide optimal release of active ingredients to lower blood pressure.
Studi Penambatan Molekuler Senyawa Bioaktif Biji Habbatussauda (Nigella sativa) terhadap ERα sebagai Alternatif Pengobatan Kanker Payudara dalam Upaya Pemberian Data Ilmiah Thibbun Nabawi Vega Mylanda; Norman Emil Ramadhan; Rafiqah Nur Viviani
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.44

Abstract

Introduction: Estrogen receptor (ERα) is one of the main receptor targets of breast cancer treatment, so ERα inhibitors are one of the most potential drugs in the treatment of breast cancer. Searches for ERα inhibitory molecules can be found in compounds from traditional plants, such as Black Seed (Nigella sativa). Black Seed has been described by Thibbun Nabawi as a plant that can treat all diseases, but there is still no research that explains the compounds in Black Seed as an ERα inhibitor. Black Seed is known to contain several compounds that have pharmacological activities, such as antioxidants and anticancer. This study aims to determine the potential and interactions of natural compounds in Black Seed as a new treatment for breast cancer with ERα targets. Methods: This research uses molecular docking method with AutoDock 4.2 software with Lamarckian Genetic Algorithm (LGA) search method. Molecular docking is known as a fast and cost-effective research method. Results: The results of this study shows that the stigmasterol compound in Black Seed has the potential as an ERα inhibitor with an ΔG value of -10.14 kcal/mol and Ki 36.99 nM. Conclusions: This study shows that stigmasterol is a potential candidate as a new ERα inhibitor. In addition, this study obtained several amino acid residues that were thought to be important in ERα inhibitory activity, Leu346, Glu353, Leu387, and Arg394, as well as providing scientific evidence that the chemical compounds in Nigella sativa have potential as breast cancer drugs.
Narrative Review: Edible Film Strip Antioksidan dari Ekstrak Herba Kelingkit (Malpighia coccigera L.) Nur Hidayah Saputri; Febby Oliviary Derajathun; Yuni Fadilah Husain; Selpirahmawati Saranani
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.58

Abstract

Introduction: Edible Film Strip (EFS) is one of pharmaceutical preparations that could be formulated with active antioxidant ingredient from dwarf holly/kelingkit (Malphigia coccigera L). The aim of this narrative review is to narrate the article summary of the exploration outcome regarding the potential antioxidant from the extraction of dwarf holly/kelingkit in the form of EFS. Methods: This narrative review conducted the method of literature review or the secondary data compilation from several scientific journals and antioxidant activity testing from DPPH and ABTS methods as well as the EFS formulation. Result: Malpighia contains phenolic compounds in having antioxidant activity with its ability to capture an neutralize free radicals. Conclusion: The extraction of antioxidant in the EFS dosage form has the potential for the immune system and prevent degenerative diseases.
Reaksi Obat yang Tidak Dikehendaki (Rotd) pada Pasien Rawat Jalan Penyakit Ginjal Kronis Tahap Akhir di Komunitas Pasien Cuci Darah Indonesia Cabang Jawa Timur : Metode Cross Feliadewi Ruth; Martanty Aditya; Muhammad Hilmi Aftoni
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.60

Abstract

Introduction: Adverse Drug Reaction (ADR) is a side effect arising from the use of drugs with normal doses. ADR might decrease quality of life, increase frequency to doctor, and death. ADR in patients with End-Stage Renal Disease (ESRD) has not been much studied. ESRD have a greater risk of experiencing ADR because the kidneys have decreased and the drugs can accumulate in the body. Study was conducted to determine the incidence of ADR in outpatients in the final stage of ESRD. Methods: This study use cross sectional method. Demographic data and ADR status were collected from members of the Indonesian Dialysis Patient Community in East Java. Drug data had grouped into drugs that potential and no potential for ADR, then an analysis with a Chi-square test to find correlation of potential ROTD drugs and the incidence of ADR in outpatients in ESRD. Result: There are 62 respondents in this study who fulfilled the inclusion. From the test between the characteristic and ADR is a correlation between allergies and ADR (p = 0.018). Based on the results of the Chi-square test between the use of potential ADR drugs with the incidence of ADR in outpatients in the final stage of the patient did not have a correlation (p value = 0.812). Conclusion: From this study it can be concluded that there is no correlation between potential ROTD drugs with the incidence of ROTD in end-stage CKD outpatients (p = 0.812).
Review: Interaksi Antara Obat Konvensional dan Herbal untuk Diabetes Mellitus Izzah Al Mukminah; Raden Bayu Indradi
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.62

Abstract

Introduction: The prevalence of Diabetes Mellitus (DM) in Indonesia is high and has even fluctuated from 422 million to 463 million in 5 years. In the management of DM, one of which is pharmacological therapy using antihyperglycemic drugs (AHD). Currently, besides AHD, people also use herbs to treat DM. While active herbal compounds that have been shown to contribute to DM treatment are diverse and multicomponent, not all of these components are known to have therapeutic effects. Thus, the aim of this literature review is to determine the interactions that might occur between conventional and herbal drugs for DM. Method: A literature search was conducted in May 2020. The sites used were Google Scholar, Elsevier and NCBI. The keywords used to find the journal sources were "drug interactions with diabetes and herbs", "interaction of diabetic drugs and herbs", "herbs for diabetes", and "herbs for diabetes". The journals used as sources totaled 15 journals with a focus on in vivo and clinical research. Results : Multi components in these herbs, when used together with AHD, have the potential to cause interactions. Several studies reported that AHD and herbs for antidiabetic have synergistic or antagonistic interactions. Based on the literature, some drug and herbal interactions can occur, such as Metformin, Glibenclamide and Pioglitazone with Aloe vera interact synergistically. Conclusion: The potential for antagonistic and synergistic interactions emerged in several studies on herbal interactions with OAH.
Potensi Alga Coklat (Sargassum polycystum c. agardh) sebagai Produk Teh untuk Meningkatkan Imunitas Tubuh Agisna Abdul Jabar; Natasia Natasia
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.70

Abstract

Introduction: Phlorotannin, a secondary metabolite compound found in Sargassum polycystum Agardh, has been implicated as a source of immunostimultants, which plays an important role in boosting the immune system. Here, we investigated the potency of Sargassum polycystum Agardh obtained from a phlorotanin tea bag. Methods: This research was a literature study using Google Scholar and PubMed, in which we searched and compiled relevant literature sources with results that had been tested well enough. Results: The phlorotannin tea bag – which contained the dried and cut Sargassum polycystum Agardh – had the potential to boost the immune system using an immunooxidative mechanism. The antioxidant value in the tea could be influenced by the immersion process of the sample in hot water. The longer the sample was soaked, the higher its antioxidant activity became. Conclusion: A brown algae (Sargassum polycystum Agardh) tea bag as a source of phlorotannin has the potential to boost the immune system.
Potensi Penggunaan Essential Oil dari Tumbuhan di Indonesia dalam Menurunkan Berat Badan Prilly Mutiara Sandy
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.71

Abstract

Introduction: overweight and obesity are health problems that arise in developing countries. Although classified as a non-communicable disease (NCD), being overweight can cause death due to its comorbidity. Conventional obesity therapy is generally in the form of medications and surgical procedures. If consumed long-term, it will have dangerous side effects and it is invasive, and there is a possibility to relapse. Therefore, this review was aimed to collect all available data on non-invasive therapies in the form of aromatherapy inhalation containing active phytochemical constituents derived from Indonesian plants that will be possible as a natural anti-obesity agent. Methods: The data review during 2007-2021 with electronic searches through Scopus, ScienceDirect, PubMed, and Google Scholar. Articles are sorted by the keywords "obesity", "essential oils" and "mechanism" and abstract screening. Twenty-six relevant reports were obtained, which were later discussed in this review article. For the development of concepts and ideas, other literature such as books and scientific literature are used. Result: Twelve types of essential oil plants in Indonesia that can have anti-obesity activities were successfully obtained by various four mechanisms of action, ,i.e., appetite regulation, thermogenesis and stimulation of lipid metabolism, inhibition of adipogenesis, and inhibition of pancreatic lipase activity. Conclusion: Phytochemical constituents summarized in this review show that every plant's compounds play a role in anti-obesity activity. In addition to potential anti-obesity mechanisms, several effective doses can be further reviewed.
STUDI LITERATUR PEMANFAATAN SINTESIS SENYAWA PIPERIDINIL-P-KUMARAMIDA DARI ASAM-P-KUMARAT YANG DIPEROLEH DARI LIMBAH SEKAM PADI (ORYZAE SATIVA) SEBAGAI OBAT ANTI KANKER LEUKEMIA Athalia Theda Tanujaya; Steven Steven; Norman Emil Ramadhan
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.43

Abstract

Introduction: In 2018, the incidence of cancer in Indonesia reached 136.2 per 100,000 population and leukemia cancer was in the fifth position as the deadliest cancer and has killed 11,314 lives. The high cost of treating leukemia has costed the funding budget in the JKN-KIS program up to Rp3.4 trillion. Researchers have tried to use natural ingredients to develop new anti-leukemia agents. Content: One of the compounds that can inhibit leukemia cancer is piperidinyl-p-coumaramide, a derivative of p-coumaric acid which can be found and isolated from rice plant waste or Oryzae sativa. Each year, 79.2 million tons of rice are produced and generate 19.8 million tons of husk. The aim of this article is to utilize rice husk as a piperidinyl-p-coumaramide precursor for leukemia drug. Method: The method used was stratified extraction of the husk waste using a water-methanol and ethyl acetate solution. The extract was then isolated and purified by TLC. After that, the assay was analyzed using HPLC. P-coumaric acid is modified into piperidinyl-p-coumaramide by reacting it with piperidine. Conclusion: The activity of piperidinyl-p-coumaramide as an anti-leukemic cancer on p388 cells can be tested in vitro and in vivo. According to the literature study, 100 grams rice husk may generate 265.4 ± 2.4 milligrams p-coumaric acid that can be synthesized into piperidinyl-p-coumaramide which has IC50 around 5,34 µg/mL thus can be utilized as an anti-leukemia cancer.
SITRUS: INOVASI SABUN KERTAS BERBASIS LIMBAH KULIT JERUK DI TENGAH PANDEMI COVID-19 Darren Lie; Fairuz Aisya Alzura
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.57

Abstract

Introduction: Since there is no effective curative or vaccine for COVID-19 yet, preventive action will be prioritized to reduce the spread of the SAR-CoV-2 virus. One of the preventive actions is the development of cosmeceutical dosage form, which is soap, that acts as a surfactant to remove dirt and microorganism so it can destroy virus viability. On the other hand, the increasing amount of citrus peel waste in Indonesia and the importance of soap for preventive action is the motivation and reason to develop Sitrus (Citrus soap), a soap that is made from limonene (essential oil) from citrus peel waste and packed in form of paper soap (solid soap that is printed in thin and small size like a sheet of paper and will dissolve and produce foam when mixed with water). Content: Component from peel waste has antimicrobial activity through the mechanism of limonene accumulation at the plasma membrane of cell membrane, which causes integrity instability and disrupts electrochemical gradient at the cell membrane. The essential oil from citrus peel waste can be obtained by steam distillation and will be used with the total amount of 3% in Sitrus formulation. Other components in the formulation are NaOH 30% solution with the total amount of 25% as a base component in soap, stearic acid with the total amount of 11% as neutralizer, ethanol 96% solution with the total amount of 18% as solvent, glycerine with the total amount of 15% as plasticizer, and water for solvent. Sitrus is a personalized paper soap that is more economical, easy to bring everywhere and to use, not dissolved with skin components such as lipids, and has double-action (cleaning and antimicrobial activity). Conclusion: Combination of both antimicrobial activity and paper soap support Sitrus for increasing the preventive action in society in the midst of COVID-19 pandemic. Sitrus in not only remove the microbe and virus in skin surface, but also reduce the negative impact of citrus waste peel accumulation Keywords: COVID-19, preventive, paper soap, citrus peel waste
STUDI LITERATUR RASIONALITAS, DAN POLA SENSITIVITAS TERHADAP ANTIBIOTIK PADA BAKTERI STAPHYLOCOCCUS AUREUS PENYEBAB INFEKSI GANGREN DIABETES MELITUS Aprilia rina wati; ismi rahmawati; Inaratul Rizkhy Hanifah
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 2 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i2.78

Abstract

Introduction: Diabetic gangrene can be treated with antibiotics. The use of antibiotics must be done rationally. Antibiotic sensitivity patterns know which antibiotics have become resistant. The purpose of this literature study is to determine the relationship between rationality and patterns of antibiotic sensitivity in bacteria that cause gangrene infection. Methods: The research was conducted using a literature study method using journals obtained through journal sites such as search engines Scopus, Google Scholar, ScienceDirect, NCBI, PubMed, Oxford Academics, Cambridge, and Sprinkle link published between 2009-2021, obtained journals as many as 13 journals extracted from 99 existing journals. This literature study was carried out in several stages, namely, formulating problems, collecting data, extracting data, synthesizing data, and compiling a thesis. Result: The results of the literature study rationality of antibiotic use is precise indication, appropriate drug and appropriate patient. Antibiotics that are resistant in several hospitals in Indonesia are ceftriaxone, cotrimoxazole, benzylpenicillin erythromycin, ampicillin, cloramfenicol, cefoperazone, meropenem, cefixime, gentamicin, ceftazidime, ciprofloxacin, streptomycin, lincomycin, and cefotaxime. The mechanism that bacteria have in developing resistance is by enzymatic modification, changes in PBP structure, pump protein production, and changes in antibiotic targets

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