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Current Research on Biosciences and Biotechnology
Published by Institut Teknologi Bandung
ISSN : -     EISSN : 26861623     DOI : https://doi.org/10.5614/crbb
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Materials Science & Nanotechnology Medicine & Pharmacology
The Current Research on Biosciences and Biotechnology (CRBB) encourages researchers to publish works related to the use of the biosciences and biotechnology in understanding the world around us. From Health and Medicine to Advanced Materials, these state-of-the-art research offer novel insights in a multidisciplinary environment. We encourage scientists to submit papers focusing on the following broad topics: Health and Medicine Pharmaceutical Sciences Pharmacology and Toxicology Food Microbiology and Biotechnology Biotechnology Agriculture Bio-Energy Marine Sciences Advanced Materials Environmental Sciences
Arjuna Subject : Umum - Umum
Articles 6 Documents
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Search results for , issue "Vol. 2 No. 1 (2020)" : 6 Documents clear
The effect of ascorbic acid and soybean protein hydrolysate to iron binding capacity Sri Peni Wijayanti; Erma Maryana; Ida Susanti; Noer Laily
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/QSEB7056

Abstract

The study aimed to investigate the effect of ascorbic acid and soybean protein hydrolysate to iron-binding capacity. BPPT (Agency for the Assessment and Application of Technology) developed soybean hydrolysate, which was obtained by thermal and enzymatic hydrolysis. Ascorbic acid was added in sample preparation with composition 0, 50, 75 and 100%. Soybean protein hydrolysate (SPH) was prepared by gel filtration chromatography using Sephadex G-25 to separate peptide based on molecular weight. Characterization of SPH and SPH fractions was also conducted, such as protein concentration, molecular weight, iron-binding capacity, and amino acid concentration. Iron binding capacity was determined by the colorimetric method using an ortho-phenanthroline reagent. The result showed that soybean protein hydrolysate increases iron-binding capacity 25-37 times than ascorbic acid. Arginine, aspartic acid, glutamic acid, threonine, lysine, and serine were found as amino acids responsible for iron-binding capacity in the SPH.
Phenazine-1-carboxylic acid (PCA) from cold-adapted yeast Glaciozyma antarctica PI12 Andi Rifki Rosandy; Rozida Mohd. Khalid
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/TLCY1641

Abstract

A phenazine alkaloid, phenazine-1-carboxylic acid (PCA) was isolated from the ethyl acetate extract of cold-adapted yeast Glaciozyma antarctica PI12 (Kriegeriales). The compounds were isolated by several chromatography techniques i.e. radial chromatography (RC) and thin-layer chromatography (TLC). The chemical structure was elucidated by ultraviolet (UV), infrared (IR), nuclear magnetic resonance (1D and 2D NMR) spectroscopy and mass spectrometry.
Increasing the capacity of natural killer (NK) cells in fighting advance stage ovarian cancer: A cellular immunotherapy minireview Radiana Dhewayani Antarianto; Fransisca Dela Verna; Lady Feren Pangjaya; Sanya Khaerunnisa; Dinda Shezaria; Tricia Dewi Anggraeni
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/SPNZ3413

Abstract

Global Cancer Statistics in 2018 estimated 300,000 new cases of ovarian cancer with 152,000 mortality rate each year. The Indonesian Society of Gynecologic Oncology reported 30% of gynecologic cancer is ovarian cancer, which has a 125, 000 mortality rate each year. Ovarian cancer data in Indonesia showed that 70% of patients were diagnosed with ascites or metastasis beyond the ovaries (stage III or IV). Ovarian cancer is an immunogenic disease with an immunotherapy intervention on the horizon. To assess the potency of stimulated NK cells as ovarian cancer cellular immunotherapy, literature search was collected from NCBI, ScienceDirect and Pubchem database. A total of 19 articles relevant to our search terms were included in this review. NK cells from ovarian cancer ascites exhibit low cytotoxic efficacy but can be restimulated using IL-2 or IL-15. An in vitro study that incubated NK cells with an IL-15 fusion protein enhanced the function of the ovarian cancer ascites’ NK cells or the healthy NK cells against the ovarian cancer ascites cells. Human IL-12-, IL-15- and IL-18-induced memory like (CIML) NK cells, has been proven to increase the elimination of xenograft human ovarian cancer cells over a long period of time in a mouse model. CIML NK cells also showed higher NK cell expansion and an enhanced function in the ovarian cancer ascites’ microenvironment, which was immunosuppressive. Phase I-II clinical trials on NK cell-based adoptive cellular therapies demonstrated limited clinical benefit. The major challenges are obtaining persistent NK cells with anticancer activity.
Phytochemistry and pharmacological activities of Annona genus: A review Siti Kusmardiyani; Yohanes Andika Suharli; Muhamad Insanu; Irda Fidrianny
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/KNIA7708

Abstract

Plants have been significantly used in traditional medicine by a variety of societies since antiquity, and knowledge of their safety, efficacy, and quality value can be developed through further research. The Genus Annona consisting of 119 species has been extensively researched and proven to have a diverse range of pharmacological activities such as antioxidant, antiulcer, antidiarrheal, and antiparasitic. This is because the Annona plants possess a great number of phytochemicals found in almost every part of the plant, which can be isolated to be developed into herbal medicine. Phytochemicals are classified into several classes, such as Annonaceous acetogenin, alkaloids, flavonoids, and essential oils. This article was created by collecting 137 research articles which discuss phytochemical compounds from 38 species and the pharmacological activity from 13 species.
The effect of temperature, incubation and storage time on lactic acid content, pH and viscosity of goat milk kefir Yola Desnera Putri; Nur Asni Setiani; Sohadi Warya
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/HPMQ5042

Abstract

Kefir is a fermented beverage that has probiotic properties and often used as a cosmetic or ointment raw material. Its lactic acid content is classified as AHA (alpha hydroxy acid) which is known good for skin health. The objectives were to study the influence of temperature, fermentation and storage time on the amount of lactic acid, pH and viscosity of kefir. Fermentation of kefir was performed at two different temperatures (room temperature and 37oC) for 24 and 48 h. Storage condition of kefir products was performed at cold and room temperature for 4 to 28 d. The content of lactic acid was based on the total organic acid determined using acid-base titration. The results showed that the average content of lactic acid in 48 h-fermented kefir at room temperature and 37oC were 0.9 to 2.2% with pH and viscosity characteristics were 4.1 to 4.3 and 1400 to1600 cPs, respectively. Meanwhile, during 24 d of storage, the average content of lactic acid was 1.97 to 3.54%, where pH and viscosity characteristics were 3.5 to 4.5 and 3400 to 6400 cPs, respectively. The optimum storage time of goat milk kefir is obtained on days 4 to 12 and they can be stored for up to 24 days without deterioration of kefir products.
Isolation of citronellal from Cymbopogon nardus (L) Rendle and its activity test as a burn healing in mice Yelfi Anwar; Novia Aditia Ningtiyas; Partomuan Simanjuntak
Current Research on Bioscences and Biotechnology Vol. 2 No. 1 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2020.2.1/NODZ4501

Abstract

Citronellal is one of the main compounds of essential oils of Cymbopogon nardus (L) Rendle, which is the most important chemical compound in the cosmetics and pharmacy industry. This study aimed to isolate the citronellal from the essential oil of Cymbopogon nardus (L) Rendle and activity on burns in male white mice (Mus musculus (L). The isolation method used column chromatography and n-hexane-ethyl acetate as eluent (20 : 1). The isolate obtained was used to burn activity on the back of male white mice (Mus musculus (L)). The ointment formula 0.25%, 0.5% and 1% were prepared using vaseline flavum. Based on the test using thin layer chromatography with the addition of cerium sulphate as a spotting appearance, was given one spot in the 4th isolate. Based on characterization data by UV-Vis spectrum, FTIR spectrum and GC-MS chromatogram showed that F4 isolate was citronellal. Based on the results of the burn activity on all concentrations, formula 1% showed the best burn healing activity. Citronellal can be isolated from the essential oil of Cymbopogon nardus (L) Rendle and has healing activities for burns in male white mice.

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