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Muhamad Thohar Arifin
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Muhamad Thohar Arifin MD. PhD. Faculty of Medicine, Diponegoro University Jl. Prof. Soedarto, Tembalang, Kec. Tembalang, Kota Semarang, Jawa Tengah 50275 Email: dimjoffice@gmail.com
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Diponegoro International Medical Journal (DIMJ)
Published by Universitas Diponegoro
ISSN : Without     EISSN : 27455815     DOI : https://doi.org/10.14710/dimj
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 4, No 2 (2023): December 2023" : 8 Documents clear
Intraoperative Endoscopy as Guidance for Adequate Myotomy in Laparoscopic Heller Procedure: A Rare Case Report Fuadi, Ahmad Fathi; Mahfuddin, Ahmad Za'im Muhtar
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17840

Abstract

Background: Esophageal achalasia is a rare disorder characterized by the absence of lower esophageal sphincter (LES) relaxation. The cardinal symptom is progressive dysphagia. Laparoscopic Heller myotomy (LHM) for achalasia offers long-term symptom improvement. However, there is no precise length or landmark for adequate myotomy. The intraoperative endoscopy has been proposed as a tool to measure the adequacy of the myotomy. To the best of our knowledge, there is no previous report of intraoperative endoscopy during LHM in Indonesia.Case Presentation: A 30-year-old female patient complained of progressive dysphagia and major weight loss due to esophageal achalasia for the last two months. She underwent LHM after a week of preoperative nutritional support. The endoscopic was conducted after the myotomy to ensure the adequacy of the myotomy and prevent excessive myotomy.Conclusion: The use of intraoperative endoscopy offers many advantages for LHM. It ensures adequate myotomy, thereby minimizing the risk of repeat or additional procedures. Moreover, endoscopy can help identify mucosal perforation. We propose using an intraoperative endoscopy as a routine procedure for LHM.
THE EFFECT OF CALISTHENIC EXERCISE ON LEG EXPLOSIVE POWER Ricardo, William; Kumaidah, Endang; Adji, Raden Mas Soerjo; Adyaksa, Gana
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.20956

Abstract

Background: Physical fitness is a condition where the human body is able to perform daily activities without experiencing excessive fatigue. Physical exercise is one way to achieve physical fitness. Calisthenics is one of the strength exercises that utilize body weight as resistance to increase muscle strength. Previous research has shown that strength training can increase the explosive power of leg muscles measured through vertical jumps.Objective: Knowing the effect of calisthenic exercises on the explosive power of the leg muscles.Methods: Experimental research with quasi experimental design and methods of pre-test and post-test nonequivalent control group. The subjects were 37 active students of Diponegoro University, Semarang who were selected by purposive sampling and grouped into two groups. The control group without treatment (n=19), and the treatment group (n=18) were given calisthenic exercises for 6 weeks. The explosive power of the limb muscles was measured before and after the intervention with the vertical jump instrument and expressed as the vertical jump score (VJ score).Results: The results showed a significant increase in VJ score (p=0.030) in the treatment group compared to the control group. There was also a significant increase in VJ score (p<0.001) before and after the intervention in the treatment group.Conclusion: Calisthenic exercises for 6 weeks can increase muscle explosive power in the young adult age group.
Effect of DLBS3233, Metformin, and Their Combination on the Expressions of VEGF and Endometriosis Implants in Endometriosis Mice (A Mouse Model in Endometriosis Study) Wardana, Setya Girindra; Trisetiyono, Yuli; Hadijono, Raden Soerjo; Mulyantoro, Inu; Cahyanti, Ratnasari Dwi; Dewantiningrum, Julian
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.18393

Abstract

Abstract Background: Endometriosis is a gynaecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The process of angiogenesis is regulated by VEGF which plays an important role in the development of endometriosis implants. Metformin is an insulin sensitizer that is known to have a beneficial effect in the treatment of endometriosis and DLBS3233 is a PPARγ agonist, it is hoped that it can reduce VEGF and reduce endometrial implants..Objective: To explore the effect of DLBS3233, metformin, and combination on VEGF expression and endometrial implant area of endometriosis-induced mice.Methods: This experimental study used 3-months old 28 BALB/c mice of endometriosis that were randomly and equally divided into four groups (K, P1, P2, and P3). On the 15th day, the K group was given a placebo, the P1 group was given DLBS3233 0.25 mg/day for 14 days, the P2 group was given metformin 4 mg/day for 14 days and the P3 group was given a combination. The immunohistochemistry of VEGF expression was performed from the abdominal cavity and pelvic peritoneal tissues of the mice and measured by the Remmele Scale Index, while the extracted mice's endometrial implants were analyzed with a computer tracing method. All data normality tests were calculated with the Shapiro-Wilk test. The mean difference test of all groups was analyzed using the one-way ANOVA test and the Kruskal-Wallis test.Results: There were significant differences in the expressions of VEGF (p=0.005) and endometrial implants (p=0.001). Expression of VEGF in the P3 group was significantly lower compared to others and endometrial implant area in the P2 group was significantly lower compared to others.Conclusion: DLBS3233 and Metformin may be a potentially effective drug treatments for endometriosis by decreasing VEGF expression and endometrial implants. Keywords: DLBS3233, Endometriosis, Metformin, VEGF
Correlation Between VO2 Max, Speed, and Limb Muscle Explosive Power with Agility in Soccer Players Himmatul Aulia, annisa; Widodo, Sumardi; Indraswari, Darmawati Ayu; Adyaksa, Gana
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.21201

Abstract

Background: Agility is one of football's most critical anaerobic capacities. One component is the ability to change direction. Players change direction (Change of direction speed / CODS) every 2-4 seconds. Agility is influenced by several things, including speed and limb muscle explosive power, and is related to aerobic capacity, namely VO2 Max (maximum oxygen consumption) in the Running economy aspect. It is necessary to research the relationship between VO2 Max, speed, and explosive power of limb muscles with agility in soccer playersObjective: Knowing correlation between VO2 Max, speed, and limb muscle explosive power with agility in soccer players.Methods: Twenty-seven male players (Diponegoro Muda PS Undip) were involved in this study (mean±SD; age 13.22 ± 0.18 years, weight 46.78 ±1.67 kg, height 158± 1.88 cm). This research is a correlational study using a cross-sectional design. Each player will be measured VO2 Max with the Multistage Fitness Test, speed with the 20-meter sprint test, the explosive power of the limb muscles with the surgent jump test, and agility (CODS) using the Illinois agility test. The hypothesis test used is Spearman's hypothesis test and linear regression test.Results: Spearman correlation test found a strong relationship between VO2 Max and agility (r=-0.743; p= <0.001), there was a moderate relationship between speed and agility (r=0.556; p== 0.003), there was a strong relationship between muscle explosive power limbs with agility (r=-0.766; p= <0.001), and the results of linear regression of variables VO2 Max, speed, limb muscle explosive power on agility showed a strong relationship (r=0.806; r2= 0.650; p=<0.001).Conclusion: Conclusions: VO2 Max correlates with agility; speed correlates with agility; limb muscle explosive power correlates with agility; and the variables of VO2 Max, speed, and limb muscle explosive power have a relationship with agility.
Incident Rate of Vesicovaginal Fistula at Dr. Kariadi General Hospital Semarang in 2022 Zunaidhi Bahar, Rully; Arya Putra, Aditya; Agung Nugroho, Eriawan; Wiryawan Cahyono, Chemmy; Erwinanto, Erwinanto; Santosa, Ardy; Sindhu Wibisono, Dimas; Daniswara, Nanda; Rais Addin, Sofyan
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17873

Abstract

Background: Vesicovaginal fistula (VVF) is an abnormal connection between the vesicourinaria and the vagina which causes urine to continuously leak through the vagina. The etiology of VVF fistulas has changed from being obstetric to being more hysterectomy related. While management is as early as possible appropriately and prevents further complications that can occur. Aim: Analyzing the comparison of the characteristics of patients with VVF at Dr. Kariadi General Hospital Semarang in 2022.Methods: The study design in this study was a retrospective descriptive observational study. Results: During the period from 3 January to 30 December 2022, 20 patients were found with VVF. Based on the data obtained, the average age of the patients was 39.4 years. Parity in the study subjects consisted of 2 nulliparas (10%), 5 primiparas (25%) and 13 multiparas (65%). Types of fistulas in patients included 14 fistulas after gynecological surgery (70%), 4 fistulas after caesarean section (20%), 1 fistula after radiotherapy (5%) and 1 fistula after trauma (5%). Conclusion: VVF incident in Dr. Kariadi General Hospital Semarang in 2022 were 20 cases with the majority of fistula types after gynecological surgery as many as 14 cases.  
Can a Mood Tracker Improve Young People's Mental Health? Kaneko, Izumi
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.19735

Abstract

Background: Today, mental health is a major concern among all age groups. Japan is the only country among G7 countries where suicide is the largest cause of death among youths 10-19 years old. However, many people find it difficult to confide in others about private mental health issues. Objective: We pilot-tested a “Mood Tracker” tool intended to help users record, reflect upon, and exercise control over their own emotions, in order to assess its acceptability and to explore its impact among Japanese university students.Methods: Participants were 20 medical students recruited at Fukushima Medical University. They were given a calendar and a paper listing 16 different emotions, with instructions to designate a different color for each emotion on the list, and to color each day of a month according to that day’s overall emotion. In addition, participants filled out a questionnaire before, right after, and a month after mood tracking, for self-assessment of mental state and satisfaction with the tool. Results: All participants except for one completed the intervention and provided positive comments. Although not statistically significant, the proportion of students who were highly satisfied with their school life increased from 25% before the intervention to 42% one month after the intervention. Conclusion: This small-scale pilot test suggested that mood tracking was well accepted among Japanese medical students and worth further investigation for its potential to positively impact mental health. 
RISK FACTORS FOR SMELL AND TASTE DISORDER IN MILD AND MODERATE COVID-19 IN SEMARANG Dewi, Anna Mailasari Kusuma; Astika, Ismiar; Farokah, Farokah; yunika, kanti; Marliyawati, Dwi
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.17892

Abstract

ABSTRACK Background: COVID-19 can make smell and taste disorder due to Angitensin Converting Enzyme 2 (ACE2) binding to olfactory tractus and taste bud that affected by gender, age, comorbid and COVID-19 severerity.Aim: To analyze age, gender, comorbid and COVID-19 severity as risk factor for smell and or taste disorder in mild and moderate Covid -19 patient in SemarangMethods: Observational research used cross section design. Sample is COVID-19 patients age >10 years old with severity mild and moderate nonhospitalize that record on Health Center of Semarang City June – July 2021. Sampling metode using purposive sampling with secondary data. Association between variable analyze using Chi square or Fisher exact test, multivariate analyze with logistic regression.Results: Research on 4337 people, 2.0% smell disorder and 0.5% taste disorder. Prevalence COVID-19 mostly on women 50.5% and adult (20-60 years old) 82.5%. Risk factor gender, age and COVID-19 severity is not associated with smell and taste disorder on COVID-19 patients (p<0.05). Chronic liver disease as a risk factor only for smell disorder on COVID-19 patients (p 0.04, CI 3.029-786.993, RP 48.828). Conclusion: Chronic liver disease is a comorbid as a risk factor for smell disorder ini COVID-19 patients at Semarang. age, gender and other comorbid not as a risk factor for smell and or taste disorder. 
RECURRENCE IN NON-EPITHELIAL OVARIAN CANCER PATIENTS AT RSUP DR. KARIADI SEMARANG Badia, Gabriele Emi; Iskandar, Teuku Mirza; Suhartono, Suhartono
Diponegoro International Medical Journal Vol 4, No 2 (2023): December 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v4i2.20963

Abstract

BACKGROUND: Non-epithelial ovarian cancer is a very rare type, accounting for less than 10% of ovarian cancers. This type of cancer originates from germ cells or stromal-sex cord cells. Disease-free survival (DFS) in cancer is the length of time after primary treatment for cancer ends so that patients survive without signs or symptoms of cancer. Recurrence is the return of cancer that has been declared in remission, usually after a certain period in which cancer cannot be detected. Cancer can return to the same place (primary) or other parts of the body. Ovarian cancer is a disease with a high probability of recurrence, after achieving a complete response to chemotherapy, >70%. Assessment of the recurrence rate is one of the ways used to assess the effectiveness of therapyAIM: Knowing the incidence of recurrence in patients with non-epithelial ovarian cancer who have received operative therapy with or without adjuvant chemotherapyMETHOD: Descriptive study with a case series research design and analytical works. The research sample was 50 non-epithelial ovarian cancer patients who were treated at RSUP Dr. Karadi Semarang from 2018-2019 who met the inclusion criteria and did not have exclusion criteria, 22 patients were loss of follow up during observation. The data collection technique used is total sampling. Data analysis was performed using the Chi-Square test with a significance level of p<0.05.RESULT:  The most reported types of non-epithelial ovarian cancer were granulosa (39.3%), dysgerminoma (21.4%), yolk sac (17.9%), and mixed germ cell (17.9%). Most of the cancer cases are progressive (60.7%). There were 3 recurrence incidents happen during observation period, 2 patients with granulosa cell tumor in >50 years age group and 1 patient with Yolk Sac cell tumor in 20-50 years age group. Higher survival rates were found for tumor residues <2cm compared to >2cm at 6 months (54.5% vs 45.5%), 12 months (54.5% vs 36.4%), 18 months (45.5% vs 36.4%), and 24th month (45.5% vs 36.4%).CONCLUSION: Optimization of surgery depends on the type of non-epithelial ovarian cancer cells, age, and the stage when the diagnosis was first established to be a factor in the incidence of recurrence. 

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