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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
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Search results for , issue "Vol 5 No 1 (2022)" : 12 Documents clear
Profil Pengelolaan dan Biaya Obat Tidak Digunakan pada Mahasiswa Farmasi Universitas Sari Mulia Banjarmasin Juliana Safitri Kamah; Melviani Melviani; Eirene E.M Gaghauna
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p1-7

Abstract

Introduction: Health care as a whole is based on spending on drugs. Use of drugs that are not optimal also arise which will cause losses or cost losses due to drugs that are unusedObjective: Find the management of drugs and cost of unused drugs for Pharmacy students at Sari Mulia University, Banjarmasin. Methods: Research method used a survey type. Sampling technique used purposive sampling method with a total sample of 81 respondents. Data were analyzed using Microsoft Excel program. Results: Drug management for pharmacy students, most students get drugs at pharmacies, have paid attention to drug labels or brochures when using drugs, store drugs in place protected from sunlight, and dispose of drugs when drugs have expired. Drug costs based on the highest therapeutic class, namely analgesic, antipyretic, and anti-inflammatory therapy classes, namely Rp. 182,501. Reason the drug was unused was because it was cured at a cost of Rp. 289,038,-. The method or plan managing unused drugs is plan dispose of them in the trash a cost of Rp. 302,843 of the total cost obtained is Rp. 646,695,-. Conclusion: Conclusion of study is most of the students get their drugs at pharmacies, have paid attention to drug labels or brochures when using drugs, store drugs in a place protected from sunlight, and dispose of drugs when the drug has expired. Cost of drugs that are unused in this study is Rp. 646,695,- . Keywords: Drug Management, Cost, and Drug Unused
OPTIMASI FORMULASI FAST DISINTEGRATING TABLET (FDT) DIFENHIDRAMIN HCL DENGAN AC-DI-SOL SEBAGAI SUPERDISINTEGRANT DAN MANITOL SEBAGAI BAHAN PENGISI Raihanah Raihanah; Noval Noval; Agustina Hotma Uli Tumanggor
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p8-19

Abstract

Diphenhydramine HCl is a drug that is used to reduce and block the effects of histamine in the body, to speed up the action of the drug and increase its effect, especially for pediatric and elderly patients. FDT is made with the active ingredient Diphenhydramine HCl combined with superdisintegrant Ac-Di-Sol and Mannitol as filler. To determine the effect of the optimal combination of Ac-Di-Sol and Mannitol in the FDT Diphenhydramine HCl formulation. This study uses a Quasi Experiment Design method with a Non Equivalent Control Group design. FDT was made with 5 different Ac-Di-sol and Mannitol formulations by direct compression method and then evaluated for moisture content, flow rate, angle of repose, compressibility, uniformity of size, uniformity of weight, friability, hardness, disintegration time, disintegration time and wetting time. The results of the research are descriptive analysis and Simplex Lattice Design using Software Design Expert Version 10.0. Evaluation of the physical properties of the powders showed that all formulations met the requirements of moisture content, angle of repose and compressibility, while the flow properties of all formulations did not meet the requirements. The results of the evaluation of the physical properties of FDT produced a clean white color, odorless, with a slightly bitter taste. All FDT formulations met the requirements for uniformity of weight, friability, hardness, disintegration time, and disintegration time, while the results of the uniformity of size and wetting time of all formulations did not meet the requirements. The combination of the concentration ratio of Ac-Di-Sol and Mannitol affects the aspects of brittleness, hardness, disintegration time and wetting time. Formulation 4 is the optimal formulation with the composition of Ac-Di-Sol 12.5 mg and Mannitol 7.5 mg with a desirability value of 0.953.
Floating System Tablet Ekstrak Daun Pepaya (Carica papaya L.) Kombinasi Matriks HPMC K4M dan Na CMC Martinah Martinah; Noval Noval
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p20-29

Abstract

Floating system tablets combination of HPMC K4M and Na matrix. CMC and the active substance of papaya leaf extract (Carica papaya L.), by floating in the stomach for a long time and can release the active substance from papaya leaf extract to treat ulcers in the stomach for a certain time to improve its working mechanism. This study used an experimental method with bivariate analysis. Tablet Floating system was made by direct compression method and evaluation includes evaluation of powder, evaluation of physical properties of tablets and evaluation of floating system made in five formulations with different concentrations of HPMC K4M and Na matrix. CMC. The evaluation results of powder, LOD, flow properties, and quiet angle in all formulations met the requirements, while the compressibility test at F4 did not meet the requirements. The resulting tablet has a brown color, is bitter, has a characteristic smell of extract, and is elongated in shape. Tablets in all formulations have uniformity of weight according to the requirements. The results of the hardness test showed that none of the formulations met the requirements, while the friability test of all formulations met the requirements. In the lag time test, all formulations meet the requirements of 1 second, while the floating time results show that all formulations do not meet the requirements. The evaluation results show that the optimal formulation is F5. Combination of HPMC K4M and Na matrix. CMC affects the evaluation of LOD, quiet angle, compressibility, friability, hardness, and floating time. Keywords : Papaya leaf extract (Carica papaya L.), floating system tablets, HPMC K4M and Na.CMC
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PENGELOLAAN OBAT MANDIRI DI MASYARAKAT KELURAHAN BELIMBING RT.12 KABUPATEN TABALONG Fatimatuzahra Fatimatuzahra; Melviani Melviani
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p30-36

Abstract

Introduction: Efficient drug management greatly determines the success of the overall management, to avoid inaccurate and irrational calculation of drug requirements so that appropriate drug management is necessary. Drug management aims to ensure the availability of good quality drugs, Purpose : The general purpose of this study was to determine the factors associated with self-administration of drugs in the community in Belimbing Village, rt 12, Murung Pudak District, Tabalong Regency.Method : The method used in this research is using the Cross Sectional method. The sampling technique used in this research is purposive sampling. Data analysis using Spearman Rho test..Results : The results obtained from 70 respondents to self-administration of drugs have a sufficient value (91.4%). There is no relationship between drug management and 3 factors, namely education, income, and information that have a value (p-value > 0.05)Conclusion :Based on the research that has been done, the results show that there is no significant relationship between factors and self-medication management
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Apotek Kimia Farma X Kecamatan Banjarmasin Timur Nor Ellisa; Mustaqimah Mustaqimah
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p37-40

Abstract

Background : The quality of service in the health sector is health service that lead to patient satisfaction. Satisfaction is very important in healt service because it can measure the quality of health services. Objective : The purpose of this study was to observe and identify the level of patient satisfaction with pharmaceutical service at Kimia Farma X Pharmacy, East Banjarmasin District. Methods : This type of research is observational research with descriptive research methods. Descriptive research is research carried out with the aim of making a description or description of a situation objectively with a cross sectional study with a total of 32 respondents. Result : Based on the results of the study, it was found that 11 of the 20 statements submitted to respondents were at the level of satisfaction "Quite Satisfied" with a percentage of 55%. Conclusion : Based on the results of the research that has been done, it can be concluded that the level of patient satisfaction with the quality of pharmaceutical service at Kimia Farma Pharmacy, East Banjarmasin District is Quite Satisfied.
Pengembangan Formula Spray Gel Ekstrak Etanol Daun Komba- Komba (Eupatorim Odoratum) Sebagai Kandidat Repellent Michrun Nisa; Irmayani Irmayani; Sweety Dwy Sarty
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p41-45

Abstract

Repellent is an insecticide that is used to protect the skin from mosquito bites. Spray gel is a form of developing gel preparations applied through a pump spray. Ethanol extract of komba – komba (Eupatorium odoratum) leaves with a concentration of 7% has mosquito repellent activity because it contains compounds that are toxic to mosquitoes. 100% protection at the 1st hour followed by 73% at the 6th hour. This study aims to formulate the ethanolic extract of komba-komba leaves in the form of a spray gel with a variation of the gelling agent carbopol 940: HPMC, namely, 0.5%: 0.25%; 1% : 0.5% ; and 1.5% : 0.75%. Physical evaluation of the preparation includes organoleptic test, pH test, viscosity test, spray pattern test and dry time. The evaluation results show that formula 2 meets the param eters of the physical properties of the spray gel preparation
Evaluasi Sifat Fisik Dan Uji Iritasi Sediaan Sabun Wajah Ekstrak Etanol Biji Salak Pondoh (Salacca zalacca (Gaert.) Voss) Rafi Firman Khaqiqi; Desy Nawangsari; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p46-52

Abstract

One of the beneficial parts in salak pondoh is the seeds. Salak pondoh seeds have antioxidant activity that can counteract free radicals. This potential can be utilized in the formulation of facial cleansing cosmetics. The purpose of this study was to formulate the ethanolic extract of salak pondoh seeds into a facial soap, then tested the physical properties and tested for acute irritation. The ethanol extract of salak pondoh seeds was formulated in several concentrations, namely 1%, 3% and 5%. Evaluation of the physical properties includes organoleptic tests, pH tests, foaming tests, viscosity tests and spreadability tests. The acute dermal irritation test used a rabbit. The data obtained were statistically tested using the one-way ANOVA method to determine the difference between each formula. The results is a brown liquid facial soap (with extract) and white (without extract). Evaluation of the physical properties resulted pH and foaming tests according to standards but viscosity and spreadability did not match. The non-fulfillment of the viscosity standards and the spreadability caused by the Viscosity Modifier (NaCl) in the formula needs to be adjusted further. This facial soap is moderately irritant to animal skin. The irritation is thought to occur because Sodium Lauryl Sulfate (SLS) in the formula can affect erythema and edema in the test animals. Keywords: salak pondoh seeds, facial soap, physical properties, irritation test
Formulasi dan Uji Sifat Fisik Sediaan Masker Wajah Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.)) Yeni Pratiwi; Desy Nawangsari; Dina Febrina
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p53-59

Abstract

Mangga merupakan tanaman yang memiliki banyak manfaat. Daun mangga arumanis memiliki aktivitas antibakteri yang mampu menghambat pertumbuhan sel bakteri. Mangiverin yang terkandung dalam daun mangga arumanis (Mangivera indica L.) mempunyai efek sebagai antimikroba. Ekstrak daun mangga arumanis diformulasikan dalam bentuk masker bubuk dengan kombinasi tepung beras untuk menghasilkan efek yang sinergis. Penelitian ini bertujuan untuk mengetahui pengaruh sifat fisik dan stabilitas sediaan setelah dan sebelum dilakukan uji cycling test. Masker bubuk dibuat dalam tiga formula dengan memvariasikan konsentrasi tepung beras dan ekstrak daun mangga arumanis yaitu dengan perbandingan F(1) 2:8, F(2) 4:6 dan F(3) 6:4. Secara organoleptic masker yang dihasilkan pada F(1) berwarna putih kecoklatan, bau khas, tekstur setengah padat, untuk F(2) dan F(3) berwarna kuning kecoklatan, bau khas dan tekstur setengah padat. Hasil uji homogenitas semua formula homogen,uji pH F(1) 6,3, F(2) 6,0 F(3) 5,8, uji daya lekat F(1) 33,90 detik, F(2) 33,56 detik, F(3) 30,37 detik, waktu mengering F(1) 33,90, F(2) 33,56, F(3) 30,37 menit dan uji daya sebar baik. Dapat disimpulkan bahwa masker yang dihasilkan memiliki karakteristik yang baik.
UJI AKTIVITAS ANTI INFLAMASI EKSTRAK ETANOL BAWANG MERAH (Allium Cepa L.) VARIETAS BIMA BREBES PADA TIKUS PUTIH JANTAN GALUR WISTAR Abidia Kamil; Adita Silvia; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p60-64

Abstract

Shallots are one of the leading vegetable commodities in Indonesia. The center for shallot production is Central Java Province, especially in the Brebes Regency area. Shallots (Allium cepa L) can be used as medicine, one of which is as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity and to determine the best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain. The method used is the experimental method. Shallot extract (Allium cepa L.) was extracted using 70% ethanol by maceration method. The test animals used were white male rats wistar strain as many as 25 rats weighing 200-250 grams. The test animals were divided into 5 groups, namely the negative control group (Na CMC 0.5%), the positive group (Na Diclofenac), the onion extract dose variation group (25 mg/KgBW, 50 mg/KgBW, and 100 mg/KgBW). . Treatment 1 hour afterthe hind legs of rats was induced by subplantar carrageenin. The measurement of the volume of edema on the soles of the rats' feet was observed once every 1 hour for 6 hours. The results of the study showed that there was antiinflammatory activity at the three doses (25 mg/KgBW, 50 mg/KgBW and 100 mg/KgBW) ethanol extract of shallot (Allium cepa L) Bima Brebes in male white rats of the Wistar strain. The best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain is 50 mg/KgBW.
Analisis Proteksi Radiasi Ruang Terkontrol Cath-Lab Selama Tindakan Pemeriksaan Di RSUD Murjani Sampit Manik, Jhon Wesly; Hakim, Luqman
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p65-69

Abstract

Continuous exposure to radiation on Cah Lab equipment during procedures can produce significant environmental radiation. Therefore, the safety of medical worked and the public is very important and must comply with PERKA BAPETEN No. 4 of 2020 which sets a radiation exposure limit of 20 mSv/year for radiation workers and 1 mSv/year for the environment or community. This research focused on measuring radiation exposure at three different points in the Cath Lab control room, namely point 1 on the operator's glass, point 2 on the top door, and point 3 on the bottom door. The measurement method uses a Gamma Surveymeter which is placed at a distance of 30 cm from each measurement point, then the radiation background value is recorded and each measurement point is carried out 30 times during exposure during the inspection, with variations in kV and mA. The measurement results show that the radiation exposure value at point 1 (glass) is 0.183 mSv/year, point 2 (the upper door which is parallel to the organ area) is 0.045 mSv/year, and point 3 (the bottom door which is parallel to the organ area reproduction) is 0.102 mSv/yr. All these measurement results are still within the safe limits set in accordance with PERKA BAPETEN No.4 of 2020.

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