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Nikki Aldi
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Jurnal Kedokteran Raflesia
Published by Universitas Bengkulu
ISSN : 24773778     EISSN : 26228343     DOI : 10.33369
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JKR (Jurnal Kedokteran Raflesia) is a peer-reviewed professional journal with the editorial board of scholars mainly in medicine, biomedic and health sciences. It is published by UNIB Press, Universitas Bengkulu, Indonesia with the ISSN (online): 2622-8343; and ISSN (print): 2477-3778. The journal seeks to disseminate research to educators around the world and is published twice a year in the months of June and December. The newest template has been published since Volume 6(2): December 2020.
Arjuna Subject : Kedokteran - Patologi dan Kedokteran Kesehatan
Articles 86 Documents
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PROBLEM SOLVING IN PULMONARY TUBERCULOSIS AMONG YOUNG ADULTS USING A FAMILY MEDICINE APPROACH: A CASE STUDY Dwi Rahma, Anggun
JURNAL KEDOKTERAN RAFLESIA Vol 11 No 2 (2025)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v11i2.44883

Abstract

Tuberculosis is one of the oldest infectious diseases and remains a health problem in Indonesia and globally. The Tangerang Regency Health Office in Banten has identified 5,000 residents in the area who are suffering from or have been exposed to tuberculosis. One program considered successful, particularly in empowering family health, is the Family Folder program for TB patients. This qualitative study employed a case study design. It was conducted by observing and examining in depth the family’s influence on a single TB case using the Family Folder. Based on the results, it can be concluded that family participation is crucial for supporting the recovery of TB patients. Family support affects patient adherence to OAT therapy and influences the patient’s life and environment. This study also found an improvement in the family’s coping score, from 1 to 5, before and after the intervention, which included holistic and comprehensive management of TB patients. Keywords: family approach, pulmonary tuberculosis, adult patient
Vitamin D3 sebagai Imunomodulator: Dampaknya terhadap Rasio Neutrofil dan Limfosit pada Tikus Model Diabetes Melitus Tipe 2 Frans Lianto Heruten; Wahyuni Dyah Parmasari; Heru Setiawan; Titiek Suharyati
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.47618

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan gangguan metabolisme kronis yang ditandai oleh kadar glukosa darah tinggi akibat penurunan sensitivitas insulin, kerusakan fungsi sel β pankreas, dan berkaitan dengan aktivasi inflamasi sistemik tingkat rendah yang berlangsung kronik. Parameter hematologi yang praktis dan terjangkau untuk memperkirakan derajat inflamasi sistemik adalah rasio neutrofil–limfosit (RNL). Peningkatan RNL telah dilaporkan berhubungan dengan progresivitas dan komplikasi diabetes melitus. Vitamin D3 diketahui memiliki efek imunomodulator dan antiinflamasi, namun pengaruhnya terhadap RNL pada kondisi DMT2 masih belum sepenuhnya dipahami. Penelitian bertujuan untuk menganalisis pengaruh pemberian vitamin D3 terhadap rasio neutrofil dan limfosit pada tikus model DMT2. Desain penelitian yaitu eksperimental laboratorik dengan pendekatan post-test only control group. Sebanyak 24 ekor tikus Wistar jantan dibagi ke dalam 6 kelompok: kelompok kontrol negatif (K-) berupa tikus normal dengan pemberian aquades; kelompok kontrol positif (K+) berupa tikus yang diinduksi hiperglikemia menggunakan aloksan dosis 120–150 mg/kgBB dan diberikan aquades; serta kelompok perlakuan (P1) dan (P2) yang menerima vitamin D3 dosis 1000 IU/kgBB dan 2000 IU/kgBB per hari setelah diinduksi diabetes. Setelah 4 minggu, dilakukan pemeriksaan darah untuk menilai jumlah neutrofil, limfosit, serta perhitungan rasio neutrofil–limfosit. Hasil penelitian menunjukkan bahwa kelompok tikus yang mendapatkan vitamin D3 memiliki rata-rata neutrofil (P1 = 30% dan P2 = 27%) yang lebih tinggi dibandingkan kelompok kontrol (K- = 24% dan K+ = 23%), sedangkan untuk rata-rata limfosit (P1 = 70% dan P2 = 72%) sedikit lebih rendah dibandingkan kelompok kontrol (K- = 76% dan K+ = 76%). Temuan ini menunjukkan bahwa pemberian vitamin D3 dapat memengaruhi profil leukosit, khususnya dengan meningkatkan persentase neutrofil dan menurunkan persentase limfosit pada tikus penelitian, namun hasil uji One way Anova diperoleh p-value 0,849 (p> 0,05) yang menunjukkan hasil yang tidak signifikan. Kesimpulan penelitian yaitu pemberian vitamin D3 tidak berpengaruh terhadap rasio neutrofil– limfosit pada tikus DMT2.
The Role of Cerebroplacental Ratio with Doppler Ultrasound Velocimetry in Predicting Spectrum with Hypertension: Systematic Review Aditya Prabawa Prabawa; Ketut Wahyu Megananda Kesuma Putra; Kadek Dwi Cakra Diningrat; I Daniswara
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.47912

Abstract

Hypertension disorders in pregnancy are serious complications that increase the risk of adverse perinatal outcomes. The purpose of this systematic review is to analyze scientific evidence regarding the role of Cerebroplacental Ratio (CPR) measured through Doppler ultrasound in predicting pregnancy outcomes in pregnant women with hypertension. This study was conducted as a systematic literature review based on the PRISMA guidelines, with nine relevant studies analyzed narratively from various databases. The results of the analysis showed that CPR was consistently proven to be a strong predictor of various adverse perinatal outcomes, including increased need for Neonatal Intensive Care Unit (NICU) care, low Apgar scores, and fetal growth restriction. Several studies also confirmed that CPR has superior predictive value compared to single Doppler indices, although variability in the cut-off values used in various studies was found. CPR is an excellent tool to assist in monitoring pregnancies with hypertension, but standardization of cut-off values is needed to maximize its universal clinical utility.
Analysis of Risk Factors Influencing the Incidence of Breast Cancer at Muhammadiyah Palembang Hospital Lulu Salsabila; Fadillah Sayuti; Siti Rohani
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.47984

Abstract

Breast cancer is a malignant disease that originates in the glandular ducts and supporting tissues of the breast and spreads to other regions of the body through a process known as metastasis. Age, hereditary factors, and dietary patterns contribute to an increased risk of developing breast cancer. This study aimed to evaluate the relationship between age, genetic variables, dietary patterns, and the incidence of breast cancer at the surgical outpatient clinic of Muhammadiyah Palembang Hospital. This study employed an observational analytic approach with a cross-sectional design. The population consisted of patients presenting with breast lumps, with a total of 45 respondents selected through purposive sampling. The findings indicated that 68.9% of the respondents were diagnosed with breast cancer, whereas 31.1% were not. Regarding age, 62.2% of the respondents were aged >40 years and had breast cancer, while 37.8% were aged ≤40 years and did not. Furthermore, 51.1% of the respondents had a family history of breast cancer and were affected by the disease, whereas 48.9% were not. In terms of dietary patterns, 37.8% of the respondents were categorized as having a high-risk diet, and 62.2% were classified as non-high risk. Statistical analysis demonstrated a significant association between age and breast cancer incidence (p < 0.001), as well as between hereditary factors and breast cancer incidence (p = 0.019). Conversely, dietary patterns were not significantly associated with the incidence of breast cancer (p = 0.235). In conclusion, age and hereditary factors are significantly associated with the occurrence of breast cancer, whereas dietary patterns show no significant association.
Polycystic Ovary Syndrome: Pathophysiology, Risk Factors, and Clinical Management – A Literature Review Luluk Hermawati; I Made Arya Subadiyasa; Nur Bebi Ulfah Irawati; Hilizza Awalina Zulfa; Nur Ayu Virginia Irawati; Rossa Amelia
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.48386

Abstract

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder commonly observed in women of reproductive age and is associated with reproductive, metabolic, and psychological disturbances. This article aims to comprehensively review the pathophysiology, risk factors, and clinical management of PCOS based on current scientific evidence. The method employed was a narrative literature review, conducted through a systematic search of scientific articles in PubMed, Scopus, Google Scholar, and ScienceDirect databases. The keywords used included polycystic ovary syndrome, PCOS pathophysiology, insulin resistance, anti-Müllerian hormone, and clinical management. Publications in English and Indonesian from 2015 to 2025 were included. The selected articles comprised original research studies, systematic reviews, and relevant literature reviews. The findings indicate that the pathophysiology of PCOS is multifactorial, involving hormonal alterations, insulin resistance, hyperandrogenism, and dysfunction of the hypothalamic–pituitary–ovarian axis, which leads to chronic anovulation. The main risk factors for PCOS include obesity, insulin resistance, sedentary lifestyle, unbalanced nutritional status, as well as metabolic and genetic predispositions, all of which contribute to the heterogeneous clinical manifestations of the syndrome. The management of PCOS is individualized and multidisciplinary, with lifestyle modification as the first-line therapy, supported by dietary interventions, physical activity, and pharmacological treatment according to clinical indications. This review highlights the importance of an integrated approach in the management of PCOS to improve clinical outcomes and prevent long-term complications.
Association of Overweight with Pain Severity in Patients with Low Back Pain (LBP) at RSUD Banten Yana Aurora Prathita; Nur Aida Hidayati; Ahmad Irwan Rusmana
JURNAL KEDOKTERAN RAFLESIA Vol 12 No 1 (2026): Juni
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v12i1.48667

Abstract

The degree of pain in Low Back Pain (LBP) can be measured using a measuring tool, namely the Visual Analogue Scale (VAS). VAS is a tool to measure the degree of pain using a horizontal line that describes the scale of pain felt by the patient. Several studies have stated that excess body weight can be a factor that aggravates the severity of pain in LBP patients. This study was carried out to investigate the relationship between excess body weight and the degree of pain in low back pain patients. This is an observational analytical study with a cross-sectional study design in LBP patients at the Neurology Clinic of RSUD Banten. Measurements were made on Body Mass Index (BMI) and pain levels using a Visual Analogue Scale (VAS). Data analysis used a chi-square statistical test. Among the 126 respondents, 66.3% were overweight and 78% experienced moderate-to-severe LBP. There was no statistically significant association between body weight status and the severity of low back pain (p= 0.129). The odds ratio (OR) obtained was 1.968 with a 95% confidence interval of 0.815 to 4.753. There was no significant association between excess body weight and pain severity in LBP patients. Analysis of other factors such as history of pain medication use, chronic disease, onset, and physical activity is needed.

Page 9 of 9 | Total Record : 86

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