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Aji Winanta
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K.H. Sudja Building G3, 2nd Floor, Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Jalan Brawijaya (Lingkar Selatan), Tamantirto, Kasihan, Bantul, Daerah Istimewa Yogyakarta
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Journal of Fundamental and Applied Pharmaceutical Science
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 27237648     EISSN : 2723763X     DOI : 10.18196
Core Subject : Health,
Medicine & Pharmacology
JFAPS focuses on various aspects of pharmaceutical sciences such as: Pharmaceutical Technology Pharmacology & Toxicology Pharmaceutical Chemistry Drug Discovery Traditional Medicine and Medicinal Herb Pharmaceutical Microbiology and Biotechnology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 4, No 2 (2024): February" : 6 Documents clear
Formulation of Shampoo from Rice Bran Extract (Oryza sativa) and Essential Oil Pomelo Peel (Citrus maxima) Hadi, Ismanurrahman; Silviyani, Amerta; Ulfah, Mariam
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19328

Abstract

Rice bran (Oryza sativa) is a by-product of rice processing that contains bioactive terpenoid compounds such as oryzanol. This compound has many pharmacological effects such as antioxidant, anti-fungal, anti-bacterial, etc. On the other hand, the essential oil of pomelo peel (Citrus maxima) has a refreshing aroma and also contains a variety of phytochemicals that are efficacious as antioxidants. This study aims to identify optimal formulations of shampoo with a combination of acetone extract from rice bran and essential oil of pomelo peel. Rice bran was extracted using acetone solvent, while essential oil from pomelo peel was obtained by distillation. Phytochemical screening of acetone extract showed the presence of terpenoids, flavonoids, alkaloids, tannins, and saponins. The extracts and essential oil were formulated into shampoo into 4 groups (FI, FII, FIII, FIV), which respectively contained 0%, 10%, 15%, and 20% extract. The results showed the evaluation of the best physical shampoo in Formula III because volunteers preferred Formula III and its better foam stability. Based on these results, it can be concluded that the acetone extract of rice bran and the essential oil of pomelo  peel could be formulated into good shampoo.
Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream Kholifah, Eva; Fitriani, Via; Shobah, Afifah Nur
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19341

Abstract

Pollution in the environment can increase the production of reactive oxygen species (ROS), which can reduce the amount of antioxidants in the skin. Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and reactive molecules. Herbaceous plant jotang (Acmella paniculata) has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which can protect the internal and external organs of the body's cells from damage caused by free radicals on the skin. One of the treatment preparations used for the skin is a cream mask, as the use or application at the final level of skin care can improve cleanliness and health and stimulate and repair skin cells. This study aims to determine a formula that has a good antioxidant value using the DPPH method (2,2-diphenyl-1-pikrilhidrazyl). In this study, preparations were made with 3 formulas, namely Formula I (1% w/w), Formula II (10%w/w), and Formula 0 (Control). Evaluation of physical properties included organoleptic tests, homogeneity tests, spreadability tests, pH tests, viscosity tests, cream-type tests, and antioxidant tests. The result showed that the organoleptic test had a cream mask dosage in the form of semi-solid, distinctive jotang odor, light and dark green, had a homogeneous dosage form, spreadability around 5.1-5.7 with an average pH value of 6, had a good viscosity value and had a type of cream M/A and a high antioxidant value in formula II (10% w/w ) with an IC50 value of 21.959 μg/ml. Based on statistical tests, significant results were obtained of 0.000p (0.05) so that it can be interpreted that there was a significant difference in each concentration of jotang herb extract to the resulting IC50 value.
Preparation and Evaluation of Mouth Dissolving Tablet of Albendazole Using Different Concentrations of Super-Disintegrant Bavaskar, Kedar Rupa; Pote, Supriya; Vidhate, Prasad; Patil, Vinit; Jain, Ashish
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19148

Abstract

Anthelmintic medications are anticipated to act more quickly and have greater absorption. Mouth-dissolving albendazole tablets were created using a direct compression approach and a mixture of super disintegrants to accomplish rapid disintegration of the tablets in the oral cavity. The preparation of ten batches of mouth-dissolving tablets using different grades of Kollidon, crospovidone, sodium starch glycolate, and croscarmellose sodium as super disintegrants produced the greatest results. For a compatibility investigation, FTIR was used to characterize the drug and physical mixture. An optimization technique was used to forecast the most effective formulation out of all the prepared combinations. All the physical characteristics of the tablet are within the limit. All preformulation results indicated good flow properties. Disintegration time and drug content of the F4 batch were found to be 28 seconds and 95.69%, respectively. In vitro release of the drug was performed in a phosphorus buffer pH 6.8 for 40 min, in which F4 shows maximum drug release. Based on the stability studies, it was confirmed that the optimized formulation remained at accelerated stability conditions. It was discovered that the mouth-dissolving tablet exhibits effective drug release.
Analysis of Pork Fatty Acid in Cornet in The Curug Market Using Gas Chromatography Widyatari, Ade Dwi; Rusdiana, Nita; Rasydy, Laode Akbar
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.18878

Abstract

Counterfeiting of food products with non-halal ingredients is starting to become a new problem in Indonesian society, the majority of whom are Muslim. One example of processed meat that is susceptible to the addition of pork components is corned beef. This research aims to determine the content and levels of fatty acids in corned beef. The method used to analyze halal food products is the GC method. The results showed that corned beef 1, 2, and 3 had dominant fatty acids such as myristic acid (1.58), (2.08), and (1.54), palmitic acid (49.91), (48.19) and (48.67), stearic acid (9.27), (10.20) and (7.24), oleic acid (58.89), (49.37) and  (59.64), and linoleic acid (12.78), (8.16) and (11.53).
Formulation and Evaluation of Formalin Washer Fluid Preparation from Garlic Peel Waste (Allium sativum L.) Burhan, Amelia Handayani; Irianto, Iramie Duma Kencana; Azizah, Shyella; Puji, Rian
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.20201

Abstract

Until 2022, there will still be many salted anchovies that contain formalin. This potential danger can be reduced by reducing the levels of formalin that may be contained in salted anchovies before consumption, one of which is by utilizing the saponin content in garlic peel waste. Garlic peel waste powder is proven to be able to reduce formalin levels in salted anchovies by up to 89.12%. However, the use of powder is less practical, and in a certain period, the powder can rot and emit an unpleasant odor. Therefore, an innovation is needed to transform the powder form into a formalin washer fluid. This study aims to determine the effect of garlic peel extract variation on several parameters evaluating the physical properties of formalin washing liquid. The extraction of garlic peel was done using the maceration method and a 70% ethanol solvent. Washing liquids were prepared using glycerin, PEG400, EDTA, and distilled water with varying extract concentrations. Evaluation of physical properties included organoleptic, pH value, specific gravity, viscosity, clarity, and physical stability of formalin washer fluid. The stability test of the physical properties of the sample liquid was carried out using the cycling test method. The samples were kept in storage conditions with extreme temperatures for 3 cycles. In each cycle, the test preparation was stored for 24 hours at 4±2oC and 24 hours at 40±2oC. The formalin washer fluid produced was in the form of a liquid with a weak to pungent garlic aroma, yellow to dark brown in color, homogeneous, clear, and had a pH value of 4. The more extract is used in the formalin washer fluid, the darker the color and the more pungent the garlic aroma will be. Increasing the concentration of garlic peel extract does not affect the pH and clarity of the preparation. The higher the concentration of extract is, the higher the specific gravity and viscosity will be. The selected formula is the formula with a 1% concentration of garlic peel extract.
Formulation and Evaluation of Natural Pigmented Lipstick from Roselle Flower and Secang Wood Extracts Monica, Eva; Yoedhistira, Chresiani Destianita; Wulandari, Cindy Dwi
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19631

Abstract

Lipstick is a cosmetic product for the lips consisting of pigments, oils, waxes, and moisturizers. Natural lipstick is safe to use and contains natural nutrients to maintain lip health. The use of synthetic dyes in lipstick can have adverse effects on the skin and health; hence, the use of natural dyes from various natural sources needs to be considered. Secang wood and Rosella flowers are plants with important compound contents that have antioxidant properties. Secang wood contains brazilin, alkaloids, flavonoids, saponins, tannins, phenylpropane, and terpenoids. Meanwhile, Rosella flowers that grow in tropical areas have anthocyanin pigments as part of flavonoids that function as antioxidants. This research aims to determine the formulation of lipstick containing extracts of Secang wood and Rosella flowers and to test the antioxidant activity of the preparation. Extraction was carried out by maceration using 70% ethanol solvent. Then, a phytochemical analysis was conducted to determine the extract content, and a lipstick formula was made by comparing the ratio of Rosella and Secang extracts. The optimal formula selection was performed using the Simplex Lattice Design method with quality testing parameters, including pH, melting point, hardness, and antioxidant activity of the preparation. The data analysis showed that the optimal ratio of the two extracts was 2.5% and 7.5% for Rosella and Secang extracts, respectively. At this composition, the optimum pH value was 5, the melting point was 57˚C, the hardness was 1.87 seconds, and the antioxidant activity was classified as strong.

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