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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 13 Documents
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Search results for , issue "Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi" : 13 Documents clear
KOKRISTALISASI KETOPROFEN-ASAM TARTRAT-NaCl UNTUK PENINGKATAN SIFAT KELARUTAN Muhammad Taqiyyuddin Fahmi; Eka Deddy Irawan; Budipratiwi Wisudyaningsih; Kuni Zu’aimah Barikah; Yudi Wicaksono
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1021

Abstract

Ketoprofen is a drug compound with analgesic, anti-inflammatory, and antipyretic effects with very low solubility. The research aims to increase the solubility of ketoprofen using the cocrystallization method. Cocrystallization was carried out using a solvent evaporation method using a tartaric acid coformer and adding the inorganic salt NaCl. Cocrystal solids were characterized using PXRD, DSC, FTIR, and SEM. The cocrystals were evaluated for their solubility and dissolution in distilled water. The characterization results show that the ketoprofen-tartaric acid-NaCl cocrystal solid is a crystalline solid with different solid properties than the solid starting materials of ketoprofen and tartaric acid. Ketoprofen-tartaric acid-NaCl cocrystals showed significantly higher ketoprofen solubility and dissolution (p<0.05) than initial ketoprofen solubility and dissolution
PENILAIAN RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN USIA 1-5 TAHUN DENGAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) DI PUSKESMAS CIMAHI TENGAH Sri Wahyuningsih; Faizal Hermanto; Andreanus A Soemardji; Riza Amelia; Yuliana Agustin
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1022

Abstract

Acute Respiratory Infection (ARI) is a disease that commonly occurs in children aged 1–5 years. Irrational use of antibiotics can cause bacterial resistance and unwanted side effects. This study aims to assess the rationality of antibiotic use in ISPA patients aged 1–5 years at the Central Cimahi Health Center in January–December 2022. The Central Cimahi Health Center conducted this descriptive study. This involves collecting retrospective prescription data from individuals aged 1–5 years throughout the period from January 2022 to December 2022. Data collection uses a saturated sampling method, where the total population is 526 prescriptions and prescriptions that do not meet the inclusion criteria and duplicates are 469 prescriptions, resulting in a total sample size of This research analyzed 56 recipes, both quantitatively and qualitatively. The evaluation of rationality includes the criteria for the right indication, the right drug, the right patient, and the right dose. The results show that the highest ARI characteristics are at the age of one year, namely 27% and the highest gender occurs in boys at 55%. The rationality of antibiotic use based on the criteria of right indication, right drug, right patient, and right dose shows a percentage of 100%. The Central Cimahi Community Health Center evaluates the rationality of antibiotic use in ISPA patients aged 1-5 years as rational
UJI STABILITAS FISIK SEDIAAN TEH SIRIH CINA (Peperomia pellucida) SECARA ORGANOLEPTIS BERDASARKAN METODE PENGERINGAN OVEN Susi Andriani; Fadhilah Buamona
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1023

Abstract

Tea bags are favored by people, they are easy to make and practical. There are not many teas on the market that have the properties of lowering cholesterol and uric acid. The community has made a simple preparation of Chinese betel tea for generations. The content of Chinese betel leaves are flavonoid, alkaloids, tannins, and saponins. This study aims to determine the stability of tea with accelerated testing frequency, namely organoleptic test, pH test for 3 months and hedonistic test to 24 respondents with corn sugar and without corn sugar. Making tea using oven drying. The method with an observation instrument is to make simplisia. Drying shrinkage was 7.6%. Storage of tea is carried out at room temperature 30C and gives an overview for 12 weeks the condition of the tea is still stable, this is evidenced by organoleptic tests on color, smell, and taste as well as hedonistic tests by concluding respondents. Organoleptic test results show that tea with oven drying is relatively stable at 12 weeks without any changes in color, taste and smell where the distinctive smell of Chinese betel leaves is strong, the green color is slightly brownish and the taste is typical of Chinese betel leaves. The pH test on day 21 was 4.2, day 42 was 4.5, day 63 was 4.7 and day 84 was 4.8, The pH results below 5 indicate that the tea is still suitable for consumption. Hedonistic test on 24 people obtained 100% liked tea with corn sugar.
ANALISA FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPERTENSI DI PUSKESMAS X KABUPATEN MALANG Neni Probosiwi; Lintang Bismantara; Elly Megasari; Nur Fahma Laili; Tsamrotul Ilmi; Arifani Siswidiasari
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1026

Abstract

Abstract Arterial blood pressure higher than 140/90 mmHg when measured in a calm state is known as hypertension. This study aims to evaluate the factors associated with the incidence of hypertension in Health Center X Malang Regency. This study used an experimental observational design with a cross-sectional approach. The number of respondents included in this study was 74 respondents. The number of samples taken was 74 respondents. Male respondents were 20 respondents (27.02%), female respondents were 54 respondents (72.98%). Respondents who experienced prehypertension were 13 respondents (17.56%), Stage I hypertension was 30 respondents (40.54%), Stage II hypertension was 31 respondents (41.90%). Independent variables include: gender, family history, physical activity, smoking habits, diet, rest needs. The dependent variable is: Hypertension. Analysis results using the square test with α = 0.05 (p < α) obtained results: gender (p = 0.009), family history (p = 0.021), physical activity (p = 0.047), smoking habits (p = 0.002), diet (p = 0.032), rest needs (p = 0.002) have a relationship with the incidence of hypertension in the elderly at Health Center X Malang Regency.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KRATOM (Mitragyna speciosa Korth.) TERHADAP BEBERAPA BAKTERI PENYEBAB JERAWAT Maria Ulfah; Irma Erika Herawati; Endah Kartikawati
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1027

Abstract

Acne is a common disease on the surface of the skin of the face. It will appear when the oil glands are too active and is generally followed by a bacterial infection that will cause inflammation. Bacteria that can cause acne include Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The plant that has antibacterial activity is kratom (Mitragyna speciosa Korth). Kratom leaves have secondary metabolites that can act as antibacteria, such as alkaloids, flavonoids, and saponins. The study aims to determine the antibacterial activity of ethanol extract against some bacteria causing acne using disc diffusion methods. The concentrations of the test sample ethanol extract of kratom leaves used were 60%, 30%, 15%, and 12.5%, with the positive controls used being chloramphenicol. The results of the study showed that ethanol extract at all concentrations had a barrier zone against the growth of the bacteria P. acnes, S. aureus, and S. epidermidis with a moderate barrier response category. Where best activity is shown at a concentration of 60% kratom leaf ethanol extract against P.acnes and S.aureus
EVALUASI PERESEPAN OBAT MASA PANDEMI DAN PASCA PANDEMI COVID-19 DI PUSKESMAS LOSARANG Anis Febri Nilansari; Puja Alfin Fadillah
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1029

Abstract

Pharmaceutical services play a crucial role in patient therapy success, with prescribing errors being a common issue leading to treatment failure. The COVID-19 pandemic, caused by the coronavirus, has underscored the need for evaluating drug prescriptions during and after the crisis. This study, conducted at the Losarang Community Health Center, Indramayu Regency, aims to assess prescription patterns and drug suitability based on WHO indicators. Using a retrospective approach, patient prescriptions from July to December 2020 (pandemic) and July to December 2023 (post-pandemic) were analyzed. Results indicate notable differences in prescribing trends. During the pandemic, antivirals, antibiotics, analgesics, and vitamins were commonly prescribed, whereas post-pandemic, analgesics, antibiotics, antihypertensives, antihyperglycemics, and antacids saw increased prescription rates. However, the average number of drugs per prescription sheet exceeded WHO standards during both periods, indicating potential inefficiencies. While the percentage of generic drug prescriptions met standards (100%), antibiotic prescriptions did not comply during both phases (pandemic: 100%, post-pandemic: 44.03%). Injection preparations met WHO standards (<20%) for both periods. Notably, adherence to the health center formulary was consistent with standards (100%) during both phases. In conclusion, this research underscores the need for optimizing prescribing practices to enhance patient outcomes. Strategies to reduce the number of drugs per prescription and ensure appropriate antibiotic use are imperative, emphasizing adherence to WHO guidelines and formulary recommendations.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN TEH CELUP BUNGA TELANG (Clitoria ternatea. L) DAN TEH PUTIH (Camellia sinensis) Eko Sri Wahyuningsih; Farida Nur Aeni; Farhamzah Farhamzah; Neni Sri Gunarti
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1030

Abstract

if there is an increase in free radicals in an uncontrolled amount, more antioxidants are needed to minimize and neutralize the effects of free radicals. These antioxidants can come from consumed food ingredients such as tea bags with a combination of butterfly pea flowers (Clitoria ternatea. L) and white tea (Camellia sinensis) because they have the potential to provide protection from free radicals that can damage body cells. The aim of the study was to determine the levels of antioxidants that would be obtained from combining plants that have high antioxidant activity into a preparation in the form of tea bags. The method used is in vitro using UV-Vis spectrophotometry. Testing of antioxidant activity using the DPPH (1,1-Diphenyl- 2-Picrilhydrazyl) method and data analysis using the Kruskal Walls non-parametric test. In this study the results showed that butterfly pea flowers contain alkaloid compounds, flavonoids, saponins, quinones, and tannins, as well as white tea which contains alkaloids, flavonoids, saponins, quinones, and tannins. The antioxidant activity of butterfly pea flower produced an IC50 value of 262.778 ppm, white tea produced an IC50 value of 14.091 ppm, and formulations of butterfly pea flower and white tea bags that had potential as antioxidants were F1 with an IC50 value of 16.510 ppm. Preparations of teabags of butterfly pea and white tea with a concentration ratio of 50% : 50% are effective as antioxidants and are the preferred formula based on hedonic tests which include color, smell and aroma of teabag preparations.
HUBUNGAN SELFCARE DENGAN KUALITAS HIDUP PADA PASIEN DIABETES MELLITUS DI RAWAT JALAN PUSKESMAS SUKORAME KOTA KEDIRI Nur Fahma Laili; Neni Probosiwi; Tsamrotul Ilmi; Arifani Siswidiasari; Mujtahid Bin Abd Kadir
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1034

Abstract

Diabetes mellitus is a disease that is currently an important concern. Because it is a type of disease whose number of sufferers is increasing every year. Diabetes mellitus is characterized by an increase in blood glucose levels above normal fasting > 126 mg/dl. The majority of diabetes mellitus sufferers are Type 2 where insulin sensitivity occurs so that insulin cannot be produced in sufficient quantities. The factors causing type 2 DM are a bad lifestyle. Self-care is a management action carried out by diabetes mellitus patients to maintain insulin levels and plasma sugar levels within the normal range. That so minimizing the occurrence of complications and death if the quality of life is poor. The aim of this study was to determine the relationship between self-care and quality of life in outpatients with diabetes mellitus at the Sukorame Community Health Center, Kediri City. This research uses a cross sectional design. The number of samples used a purposive sampling technique with a total sample of 93 respondents. Data collection was carried out using the Summary of Diabetes Self Care Activity (SDSCA) questionnaire and WHOQOL Questionnaire- Bref. The results of data analysis were carried out using the SPSS Chi Square Test.
SKRINING FITOKIMIA DARI EKSTRAK DAUN KANGKUNG PAGAR (Ipomoea carnea Jacq) DAN UJI ANTIBAKTERI TERHADAP Bacillus subtilis Ermi Abriyani; Lia Fikayuniar; Iin Lidia Putama Mursal; Dedeh Komalasari
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1047

Abstract

Kangkung Pagar (Ipomoea carnea Jacq) leaves is one of the plants that is used as a treatment. This study aims to determine the content of secondary metabolites and antibacterial activity of kangkong pagar leaves against Bacillus subtilis. Extraction using maceration method with n-hexane, ethyl acetat and methanol. Antibacterial assay using well diffusion method. The extract concentrations used were 40%, 60%, 80% and 100%. The positive control used was Ciprofloxacin and the negative control used was DMSO 5%. Data were analyzed by one way ANOVA test followed by Post Hoc Tukey test. The results showed that the extracts of ethyl acetate, methanol and n-hexane had a minimum inhibitory concentration of 40% with inhibition zones formed of 8.23 ​​mm, 9.4 mm and 4.2 mm. Meanwhile, at the highest concentration of 100%, an inhibition zone of 12.6 mm was formed in the ethyl acetate extract, 15.23 mm in the methanol extract and 11.4 mm in the n-hexane extract. The results showed that extract of Kangkung Pagar (Ipomoea carnea Jacq)leaves was able to inhibit the growth of Bacillus subtilis bacteria.
GAMBARAN EFEK SAMPING OBAT ANTIHIPERTENSI DI INSTALASI RAWAT INAP RUMAH SAKIT UNS Dhea Asyifa Nurmalika; Risma Sakti Pambudi; Reni Ariastuti
Jurnal Buana Farma Vol. 4 No. 2 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i2.1050

Abstract

Drugs provide beneficial effects, but can also cause detrimental effects. Drug side effects (ESO) are conditions that arise outside of the desired effects of treatment and are different for each person. The aim of this study was to determine the side effects of using antihypertensive drugs in hypertensive patients at the UNS Hospital inpatient unit. The research is descriptive in nature with primary data from medical records and MESO sheets of hypertensive patients. The research subjects were inpatient hypertension patients at UNS Hospital who met the inclusion and exclusion criteria. The data is then analyzed using the percentage of the results for each parameter. The research results showed that out of a total of 81 patients who used antihypertensive drugs, there were 32 patients (32%) who experienced ESO. Where 7 patients used single drugs and 25 patients used combination drugs. The most common ESO from single drug use was ramipril with dry cough (25%), shortness of breath (8%), dizziness (17%) and nausea and vomiting (8%). Meanwhile, ESO in combination drugs is amlodipine and ramipril with dry cough (15%), dizziness (20%) and shortness of breath (2%).

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