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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 1,258 Documents

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Pathogenesis Coronavirus Disease 2019 (COVID-19): Narrative Literature Review Sofía Lucila Rodríguez Rivera; José Antonio Infante Cantú; Héctor R. Martínez; Enrique Caro Osorio
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.551

The pathogenesis of COVID-19 occurs in 3 phases according to the pathophysiology and clinical degree. The three phases are grouped into the initial phase of infection, the pulmonary phase, and the hyperinflammatory phase. The initial phase of infection begins with the inoculation of the virus into host cells. This virus infects cells in the airways that line the alveoli. SARS CoV-2 will bind to receptors found on the epithelium of the respiratory tract, gastrointestinal tract, and endothelium of blood vessels and make its way into cells. The second phase is the pulmonary phase. In this phase, there is viral multiplication and inflammation in the lungs. The binding of SARS-CoV-2 to the ACE2 receptor causes ACE2 deficiency and an imbalance of the renin-angiotensin system (RAS). In the third phase, namely hyper inflammation, excessive cytokine production after SARS-CoV-2 infection will increase the permeability of the capillary wall membrane around the infected alveoli, causing edema, pulmonary dyspnea, and hypoxemia. The presence of plasma fluid in the alveoli and loss of elasticity due to decreased surfactant function due to type 2 pneumocyte infection caused by SARS-CoV-2 infection causes acute respiratory distress syndrome in COVID-19 patients.

High Altitude Pulmonary Physiology Erika Putri Rozita; Oea Khairsyaf; Afriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.552

High altitude is defined as regions above 2400 meters above sea level. Almost 2% of the world’s population dwells in high-altitude regions of the world. The respiratory system plays an important role in determining survival and undergoes a series of adaptive changes to compensate for hypobaric hypoxic states (decreased barometric pressure with increasing altitude) including increased alveolar ventilation, diffusion capacity, pulmonary vascular vasoconstriction, increased cardiac output, shifted of oxyhemoglobin dissociation curve and polycythemia. Being at a high altitude suddenly without compensation can be bad and cause medical problems that will arise when at an altitude due to a decrease in PaO2 caused by a drop in barometric pressure.

Risk Factors Related to Pneumonia in Toddlers in the Jeuram Health Center Work Area, Nagan Raya Aceh Regency Amiruddin; Irwansyah; Irmansyah; Burhanuddin Syam; Evi Dewi Yani; Ismail
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.553

Background: Pneumonia has several risk factors, including low exclusive breastfeeding for infants, immunization status, smoking parents, and mother's level of knowledge related to pneumonia. This study aims to analyze the relationship between risk factors and pneumonia in toddlers in the work area of the Jeuram Health Center, Seunagan District, Nagan Raya Regency. Methods: This research is an observational study with a cross-sectional design. The participants in this study were all mothers with toddlers in the working area of the Jeuram Health Center, with a total sample of 99 mothers. The sampling technique used was total sampling. Data analysis using SPSS. Results: Based on the results of statistical tests, it was concluded that the factors related to the incidence of pneumonia in toddlers in the working area of the Jeuram Health Center, Nagan Raya Regency, namely knowledge (p-value 0.017), immunization status (p-value 0.041), exposure to cigarette smoke (p-value 0.033). Conclusion: Knowledge, immunization status, and exposure to cigarette smoke are associated with the incidence of pneumonia in toddlers.

A Deadly Spontaneus Hemopneumothorax: A Case Report Muhammad Zulfikar Karim Chan; Kelly Christy; Herman Darmawan; Brilliant Bergant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.554

Background: Spontaneous hemopneumothorax (SHP) is a subtype of hemopneumothorax in which there is an accumulation of blood and air in the pleural space without trauma or other definitive cause. Spontaneous hemopneumothorax is a rare disease. Case presentation: A man, aged 32 years, came with a complaint of sudden shortness of breath due to a right hemopneumothorax patient who was put on a chest tube insertion. It looked like 1500 cc of blood came out accompanied by an air component. Next, the chest tube is connected to the water-sealed drainage. The patient found a decrease in Hb from 15 mg/dl to 12 mg/dl. In the next nine hours, the patient's Hb became 10 mg/dl. As a result of this condition, the patient underwent an emergency thoracotomy to evaluate the source of bleeding, where the patient's source bleeding was found to be an arterial vein malformation (AVM) at the apex of the lung attached to the chest wall. Anatomical and pathological examination showed confirmed arterial vein malformation. Conclusion: Spontaneous hemopneumothorax, in this case, is a rare case caused by arterial-vein malformation. The right decision in patient management will determine the outcome and outcome of the treatment given.

Overview of Discharge Plan Strategies in Rural and Remote Areas: A Narrative Literature Review Wahyu Wiryawan; Pratama Nurmalik Adhuri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.555

Discharge planning is a systematic process that includes assessment, preparation, and coordination and involves various disciplines to provide optimal service. In Indonesia, there are 62 underdeveloped areas that have limitations in health services. Discharge planning in remote areas requires adaptation to be accepted in the community. This review aims to find an effective patient discharge strategy to be implemented in rural areas. Telepharmaceuticals and telerobots act as discharge planning interventions in remote areas. Remote monitoring, such as a pharmacological intervention in late life (PILL) program that focuses on monitoring the treatment of patients with polypharmacy. Interprofessional education and collaborative practice (IPECP) is suitable to be carried out in remote areas where limited facilities stimulate health workers to collaborate. Patient activation measure (PAM) to assess the ability and engagement of patients in maintaining their health. In addition, interventions were found in the form of making patient-centered guidelines in the form of ROADMAP (rural options at discharge - model of active planning).

Extraintestinal Amoebiasis: Amebic Liver Abscess in a 48-Year-Old Male Patient Hans Wincen Winardi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.556

Background: The liver is the most common organ for abscesses. Liver abscesses can be solitary or multiple. Approximately 90% of right-lobe liver abscesses are solitary abscesses, while only 10% of left-lobe abscesses are solitary abscesses. This can occur from hematogenous spread or directly from the site of infection in the peritoneal cavity. Case presentation: A 48-year-old male patient had been administered into the internal medicine ward with the chief complaint of pain in the upper right quadrant of the abdominal increased 3 days before being admitted to the hospital. The patient also complains that pain increase when the patient moves forward and is influenced by activity. The patient walked like a person who carried his stomach. The patient complained of watery stools 3 months ago in ten days, which frequency two to three times a day. The stools are bloody and slimy. Swelling of an upper right quadrant of abdominal since 1 month ago. Decrease of appetite since 1 month ago. Decrease of body weight since 1 month ago, about 5 kilograms. Fever since 2 weeks ago, not high, disappearing, no chill, no sweat. Nauseous since 1 week ago. The patient was admitted to the hospital with awareness of compos mentis, cooperative, and his general condition appeared to be moderately ill, blood pressure 120/80 mmHg, pulse rate 86 times/minute, regular pulse, adequate filling, respiratory rate 24 times/minute, temperature 37ºC. On physical examination, the conjunctiva of the patient’s eyes was anemic. Entamoeba histolytica was found on a routine stool examination. Conclusion: The main clinical manifestations of amoebiasis are right abdominal pain can be features of iron deficiency anemia and reactive thrombocytosis. Diagnosis is based on the finding of characteristic Entamoeba histolytica in the stool. Metronidazole 500 mg three times daily dose resulted in 80% cure and a dose of 750 mg/three times daily for 10 days gave 100% cure. Treatment of reactive thrombocytosis is by curing the basic disease.

Resveratrol as a Chemopreventive Agent in Lung Cancer Therapy Fransisca Dela Verna
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.557

For decades, lung cancer has been the most widespread cancer in the world and the leading cause of cancer death. Lung malignancy is the superior cause of death in Indonesia, accompanying the second topmost number of new cases. The low survival rate of lung cancer patients reflects the therapy's low success rate due to side effects and cancer cells' resistance to chemotherapy and radiotherapy. Combination therapy, which includes the use of chemopreventive agents, can reduce the risk of side effects and resistance. Natural product-based chemopreventive agents used together with accompanying chemical anti-cancer drugs and/or actinotherapy can overcome cancer cell resistance, improve therapy effectiveness, and reduce side effects. Resveratrol is a compound belonging to the non-flavonoid polyphenolic group contained, particularly in vine fruits, berries, and some nuts. Resveratrol exhibits anti-cancer activity, according to considerable in vitro and in vivo studies, and hence has what it takes to be reasonably applied as a chemopreventive compound. The discovery of resveratrol's chemopreventive mechanism against lung cancer is expected to enable the development of a chemopreventive compound that can be used together with accompanying chemical anti-cancer drugs and/or actinotherapy.

Efficacy of N-Acetylcysteine (NAC) Against Malondialdehyde (MDA) Levels in Diabetic Cataracts: In vivo Study Dining Pratidina; M. Hidayat; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.558

Background: Diabetes mellitus is a systemic condition that affects various organs, including the eyes. N-acetylcysteine (NAC) functions as an antioxidant because it belongs to a thiol group synthesis glutathione. However, the availability of cysteine in the body is only 15%, so cysteine supplementation can help with oxidative stress in diabetic cataracts. That it will prevent the reaction of lipid peroxidase and the formation of PUFA in the lens membrane, which causes damage to lens cells and is characterized by an increase in malondialdehyde. This study aims to determine the comparison of malondialdehyde levels in the lenses of diabetic cataract rats given or without topical NAC. Methods: 36 rats were divided into the control group (received streptozotocin) and treatment group (received streptozotocin and topical NAC. Intraperitoneal injection of streptozotocin was given 90 mg/kg BW and performed once a week for 3 weeks. GDP examination was performed the next day after the rats fasted for 16 hours from the vein. In the tail, GDP > 110 mg/dl categorized as diabetes. Topical NAC was given 4 times per day for 3 weeks. At the end of the study, the lens was extracted for the measurement of malondialdehyde. Results: The mean MDA levels in the control group were higher (2.90±0.71nmol/ml) than in the treatment group (2.33±0.38nmol/ml), p<0.05. Conclusion: NAC was effective in reducing oxidative stress levels in diabetic cataract lenses by lowering MDA levels better than the group that did not receive MDA in vivo.

Sperm DNA Fragmentation Index: A Comparison Study of Success Rates among Natural, Intrauterine Insemination (IUI) and In Vitro Fertilization (IVF)-Intra Cytoplasmic Sperm Injection (ICSI) Pregnancy Programs Silvia Werdhy Lestari; Eva Zakiyah; Gita Pratama
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.559

Background: Some studies have reported a relationship between the sperm DNA fragmentation index (DFI) and the rate of fertilization and pregnancy. This study was designed to assess the mean sperm DNA fragmentation in pregnancies that occur in infertile couples, whether in natural pregnancy, intrauterine insemination (IUI), and in vitro fertilization (IVF) – intra cytoplasmic injection (ICSI). Methods: This research is an observational analytic study with a cross-sectional design. The sample taken in this study were infertile patients that underwent natural pregnancy or IUI or IVF-ICSI at Yasmin Infertility Clinic of Dr. Ciptomangunkusumo Hospital period 2018-2020 with a consecutive sampling technique. The research data was processed and analyzed by the Mann-Whitney test using the SPSS application. Results: The mean DFI of sperm in men with infertile couples who successfully conceived naturally was 10.7% (mild), while IUI was 20.4% (moderate), and IVF-ICSI was 30.5% (poor). The mean DFI in semen samples of men from infertile couples who underwent a natural program was significantly lower in those who successfully conceived compared to those who did not. Similar results were also shown in the IUI and IVF-ICSI programs, which showed a significantly lower DFI compared to non-pregnant women. Conclusion: DFI can be applied as a marker for selecting the type of pregnancy program in infertility management.

Lactating Adenoma in Pregnancy: A Case Report Satrio Sarwo Trengginas; Widyanti Soewoto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.560

Background: Lactating adenoma is a rare palpable breast lesion that occurs late in pregnancy or the lactation period and is commonly found in young primiparous women in the second or third decade of life. This case report aims to describe lactating adenoma and its management. Case presentation: A woman, 24 years old, 26 weeks pregnant, came to the Surgical Oncology Polyclinic of Dr. Moewardi Hospital Surakarta with a complaint of a lump in the right breast from the last 4 months. The lump was felt to be getting bigger, painful to the point that sometimes fluid came out of the nipple of her right breast. The patient had a history of previous lumps with a diagnosis of fibroadenoma that had been operated on. On palpation multiple nodules are palpable. Mammography examination showed a mass with partial calcification (BIRADS 3). The patient was diagnosed with a tumur of mammae dextra suspected of malignant cT2N1Mx with G1P0A0 26 weeks gestation. Histopathological examination results showed a lactating adenoma. Conclusion: There are several recommendations for the management of lactating adenoma during pregnancy. An antepartum biopsy is recommended for women with a breast mass in the first or second trimester, postpartum for masses that appear in the late third trimester, and fine-needle aspiration biopsy as an alternative for masses that appear in the early third trimester. Treatment with bromocriptine, a dopamine agonist, may be given to reduce the size of the lactating adenoma.

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Home Page

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Contact Name Rachmat Hidayat

Contact Email dr.rachmat.hidayat@gmail.com

Phone +6281949581088

Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

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Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA