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Rachmat Hidayat
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Bioscientia Medicina : Journal of Biomedicine and Translational Research
Published by HM Publisher
ISSN : -     EISSN : 25980580     DOI : https://doi.org/10.37275/bsm
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience
This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,258 Documents
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Botanical and Chemical Overview, Traditional Uses and Potential of Anticancer Activity from Several Costus Plants: A Narrative Review Lina Nafisah; Eli Halimah; Yoppi Iskandar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.561

Abstract

Plants in the Costus genus are known to have various activities, starting from an antibacterial agent, anti-inflammatory, antioxidant, anticancer, antidiabetic, and so on. From some previous studies that have been conducted, it is stated that some Costus plants have a high potential to be a prospective anticancer candidate in the future. This review will discuss botanical and chemical overview, traditional uses, and potential anticancer activity of several Costus plants, namely C.speciosus, C.igneus, C.spiralis, and C.pictus. In conclusion, anticancer activity assay was carried out by several methods using various cell cultures resulting in an IC50 value ranging from strong and very strong, with the strongest potency belonging to C.speciosus with an IC50 value of 13.87 µg/ml. In addition, the active phytoconstituent, mainly diosgenin, contributes to the anticancer activity, which also strengthens the potential of Costus plants.
The Relationship between Germ Patterns and Severity of Diabetic Ulcers Based on Wagner's Score at Dr. M. Djamil General Hospital Padang Gilang Dwipa Decroli; Raflis Rustam; Vendry Rivaldy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.562

Abstract

Background: Diabetes Mellitus (DM) is a condition of increasing blood sugar levels which increases the risk of macrovascular and microvascular damage, thereby reducing the quality of life of the sufferer. One of the common complications in people with diabetes mellitus is diabetic ulcers. The classification system commonly used to determine the degree of diabetic ulcers is Wagner's criteria, which consists of 5 degrees of severity. Diabetic wounds become a place for bacterial growth and the production of exudate, which results in a longer healing process and causes tissue damage. Methods: This study is a cross-sectional analytic observational study in diabetic ulcer patients treated at Dr. M. Djamil General Hospital Padang. The sampling technique in this study was consecutive sampling. The subjects of this study amounted to 36 people, with the majority aged >50 years and the female sex being found more than the male. Data analysis was performed using SPSS version 25 through univariate and bivariate analysis. Results: The grades of diabetic ulcers in the treated patients ranged from mild to severe. All subjects in this study had monomicrobial results. Gram-negative bacteria were the most commonly found, namely, 77.8%. In this study, there was no significant relationship between bacterial patterns and the severity of diabetic ulcers based on Wagner in patients treated at Dr. M Djamil General Hospital Padang (p-value > 0.05). Conclusion: Klebsiella sp is the most common type of bacteria that causes diabetic ulcers. No polymicrobial bacteria were found in this study. No correlation was found between the pattern of germs and the severity of diabetic ulcers in patients treated at Dr. M Djamil General Hospital, Padang.
Comparison of Breast Massage (Oxytocin Massage, Oketani Massage, and Marmet Massage) Against the Smoothness of Breast Milk from the Aspect of Baby's Sleep Frequency Kasad; Meliani Sukmadewi Harahap; Nurdahliana; Noviyanti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 8 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i8.564

Abstract

Background: The inability to meet breast milk production can be prevented in various ways, one of which is breast massage. The breast massage technique, at a certain point, is able to remove the blockage of blood vessels and energy blockages so that it will facilitate milk production. This study aims to determine the potential of breast massage (oxytocin massage, oketani massage, and marmet massage) to smooth breast milk from the aspect of the baby's sleep frequency. Methods: Study design method experimental with the control group. Samples were Primiparous postpartum mothers who gave birth normally and were divided into three groups, namely oxytocin massage intervention group, marmet massage, oketani massage, and control group. Data were analyzed in univariate, bivariate, and multivariate. Results: Breast massage (oxytocin, marmet and oketani) in primiparous postpartum mothers was effective in increasing the frequency of baby’s sleep. The frequency of the baby’s sleep before Marmet massage was 3.29 hours, and after Marmet massage was 5.29 hours. In the oxytocin massage intervention group, it was known that the average sleep frequency of babies before breast massage was 2.00 hours, and after breast, massage was 3.00 hours. Furthermore, in the Oketani massage intervention group, it was found that the average frequency of the baby’s sleep before breast massage was 2.00 hours, and after breast, massage was 3.00 hours. In the control group, it is known that the average sleep frequency of babies before breast massage is 0.57 hours and after breast massage is 0.71 hours. Conclusion: Oxytocin massage, marmet massage, and oketani massage have been shown to be effective in improving the smoothness of breast milk from the aspect of the baby's sleep frequency.
Orbital Lymphoma: Clinical Features and Management at Dr. M. Djamil General Hospital in 2018 Messia Refri Rahmi; Ardizal Rahman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.565

Abstract

Background: Orbital lymphoma is found in 50-60% of ocular adnexal lymphomas, with approximately 90% of orbital lymphomas being Non-Hodgkin's lymphomas. Clinical features may include proptosis, ptosis, limitation of eye movement, and salmon patch lesions on the conjunctiva. If an orbital tumor is present, an accurate histopathological examination is important in the management of orbital lymphoma. Because of nonspecific clinical signs and symptoms, some diagnostic delays may occur. The purpose of the study was to evaluate the clinical features, diagnostic approach, and treatment choice in orbital lymphomas. Methods: We identified patients diagnosed with orbital lymphoma in an outpatient clinic in Dr. M. Djamil General Hospital from January to December 2018. Patients’ medical records were reviewed retrospectively. Results: The patient group consisted of 6 patients (five males and one female) with a median age of 58 years. Proptosis and orbital swelling were the leading clinical symptoms, mainly found unilateral (five cases). The diagnosis was confirmed by a surgical biopsy. One histology result showed lymph node hyperplasia, which didn't suit the clinical manifestation and got re-reviewed. All histology results then showed non-Hodgkin’s lymphoma with the small lymphocytic type (100%). Five patients received systemic chemotherapy with the CHOP regimen protocol, and one patient refused to get further chemotherapy treatment. Conclusion: When unmatched orbital symptoms with histology results are present, re-reviewing the histology result is essential. Once the diagnosis is established, systemic chemotherapy is indicated and can proceed so there will be no delay in treatment
Correlation of Malignancy in the Hepato-Pancreato-Biliary System with Serum Bilirubin Levels in Extrahepatic Cholestasis Patients Rizqy Tansa; M. Iqbal Rivai; Avit Suchitra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.566

Abstract

Background: The incidence of hepato-pancreato-biliary system cancer is increasing worldwide, which has been recognized as a disease that is difficult to diagnose early and has a poor prognosis. No research has yet been conducted in areas with limited resources and health facilities. There is an urgent need for diagnostic methods to recommend further diagnostic modalities in the selection of curative or palliative management. Methods: Retrospective data from all cholestatic patients at Dr. M. Djamil General Hospital were collected during the period July 2020-May 2022. The data included demographic characteristics such as age, gender, preoperative, results of bilirubin fraction, and final diagnosis. Data analysis was done by bivariate and multivariate. Results: A total of 132 patients were included in this study. 35.6% of them are HPB system malignancies, with Pancreatic Adenocarcinoma being the most common diagnosis (34.4%), more in males (51.06%), and in the age group, 50 years (61.71%) is the most. Only 52.27% of patients underwent preoperative radiological imaging. Bivariate analysis showed a significant relationship between HPB system malignancies with age >50 years (p=0.024) and all bilirubin fractions (p<0.001). Multivariate analysis showed that only the bilirubin fraction was significant for the diagnosis of malignant HPB (p<0.001). Conclusion: The bilirubin fraction is a good initial indicator for predicting malignancy in the HPB system in order to increase the effectiveness of the diagnostic modality and reduce the referral duration.
Diagnosis and Management of Refeeding Syndrome Auliangi Tamayo; Roza Mulyana; Rose Dinda Martini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.567

Abstract

Refeeding syndrome (RFS) is described as a syndrome of electrolyte abnormalities and changes in body fluids with metabolic abnormalities in malnourished patients who receive refeeding either orally, enteral, or parenterally. Patients at risk for RFS are patients who have lost 10% of their previous body weight in the last 3-6 months, cancer patients who are on chemotherapy, geriatric patients with malnutrition, and patients with anorexia. Clinical manifestations are caused by electrolyte changes that affect neurons, heart and muscle disorders with various symptoms, and even death. The specific characteristics of RFS are the presence of hypophosphatemia and accompanied by other symptoms of electrolyte imbalance such as changes in sodium levels, changes in glucose, protein, fat metabolism, vitamin B1 deficiency, hypokalemia, and hypomagnesemia. The principle of management of RFS is to correct biochemical abnormalities and electrolyte and fluid imbalances. Preventive steps that can be taken are identifying individuals at risk for RFS, monitoring refeeding and administering an appropriate diet regimen.
The Role of Nutritional Status on SARS-CoV-2 IgG Levels After COVID-19 Vaccination in Palembang Ditta Puspa Anggraini; Eddy Mart Salim; Nur Riviati; Erial Bahar; Syamsu Indra; Nova Kurniati; Ahmad Rasyid; Yuniza
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.569

Abstract

Background: The elderly and geriatric population is the population most at risk for complications of COVID-19. Preliminary data show that individuals aged >59 years are estimated to experience five times more severe COVID-19 symptom onset than those aged 30 to 59 years. Nutritional status is believed to play a role in the body's ability to produce antibodies after COVID-19 vaccination. Methods: A cross-sectional analytic observational study to determine the role of nutritional status on levels of IgG SARS-CoV-2 after COVID-19 Vaccination in Palembang. IgG levels were assessed by the ECLIA method. Data analysis was carried out univariate and bivariate. Results: The mean quantitative IgG of SARS-CoV-2 in underweight nutritional status was higher with a value of 5757.42±2594.08 U/mL and with the lowest mean quantitative IgG SARS-CoV-2 in overweight nutritional status with a value of 2998.13±4386.95 U/mL. Conclusion: Nutritional status did not play a role in SARS-CoV-2 IgG levels after the COVID-19 vaccination in Palembang.
Effect of Combination of Tamsulosin and Tadalafil in Benign Prostate Hyperplasia Patients on International Prostate Symptom Score Aldeno Wahyu Anandi; Etriyel MYH; Yevri Zulfiqar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.570

Abstract

Background: Benign prostate hyperplasia (BPH) is the most common pathological condition that contributes to lower urinary tract symptoms (LUTS) in men. Alpha1-blockers are recommended as first-line therapy for LUTS due to BPH (LUTS-BPH). Phosphodiesterase 5 (PDE5-I) inhibitors, which have been used as first-line therapy for erectile dysfunction, have also been found to be effective in treating LUTS-BPH. However, the appropriate combination therapy strategy is still unclear until now. Methods: This study used an experimental design on 17 BPH patients on medical therapy. The patient was given Tamsulosin 0.4 mg monotherapy for 7 days and then continued combination therapy with Tamsulosin 0.4 mg and Tadalafil 5 mg for the next 7 days. Total IPSS score, obstruction, irritation, and quality of life (QoL) were assessed before treatment, after monotherapy, and after combination therapy. Results: The mean age of the research subjects was 62.12 years. Improvements in the total IPSS value, obstruction, irritation, and QoL showed significant changes in both types of therapy compared to the initial value. Combination therapy gave better results than monotherapy, with a mean difference in the decrease in the total IPSS value of 4.41 (p<0.001), obstruction of 3.18 (p<0.001), irritation of 1.41 (p<0.001), and QoL 0.6 (p<0.001). Conclusion: The combination therapy of Tamsulosin 0.4 mg with Tadalafil 5 mg once a day showed clinically and significantly better results than monotherapy in total IPSS, obstruction, irritation, and QoL values in LUTS-BPH patients.
Sodium Levels as a Predicting Factor for the Occurrence of Perforated Appendicitis in Children at Dr. M. Djamil General Hospital Padang Syukri Alhamda; Jon Efendi; Budi Pratama Arnofyan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.571

Abstract

Background: Perforation of the appendix can lead to life-threatening complications. Early identification of a perforation before surgery has important clinical implications. Hyponatremia was previously proposed as a marker to differentiate between perforated and non-perforated acute appendicitis. This study aims to determine the role of sodium levels as a predictive factor in the incidence of perforated appendicitis in children at Dr. M. Djamil General Hospital Padang. Methods: This research is an analytic observational study with a cross-sectional design. The research took place from March to May 2022 at Dr. M. Djamil General Hospital Padang. Samples were taken by consecutive sampling with criteria aged 0-18 years and diagnosed with acute appendicitis at Dr. M. Djamil General Hospital Padang. Results: A total of 112 samples with most of the patients (52.7%) aged 6-11 years and found a greater proportion of men (57.1%). Most of the patients underwent laparotomy procedures (57.2%). Hyponatremia was found in 58% of patients. Perforation occurred in most (59.8%) patients. SPSS results showed a significant difference between the incidence of hyponatremia in perforated and non-perforated appendicitis with a p-value <0.001. Conclusion: There is a significant relationship between sodium levels and the incidence of perforation, where the lower the sodium level, the higher the incidence of perforation.
SARS-CoV-2 Serology Antibody in Children with MIS-C (Multiple Inflammatory Syndrome in Children) Suspected Finny Fitry Yani; Indra Ihsan; Efrida
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.572

Abstract

Background: Multiple inflammatory syndromes in children (MIS-C) relate to COVID-19 severity in children. SARS-CoV-2 serology antibody is one of the diagnostic tools of MIS-C. The study aimed to describe the yield of serology antibodies of MIS-C and some characteristics found in hospitalized children with MIS-C suspects. Methods: This research was an analytic observational study. The data were collected retrospectively from some children who were hospitalized in Dr. M. Djamil General Hospital, Padang, West Sumatra, Indonesia, from April - June 2021. The inclusion criteria were children aged 1 month to 18 years, with or without contact history with the person who probable or confirmed COVID-19 and have signs and symptoms as MIS-C base on WHO criteria. Results: About eight out of 44 children showed positive serology antibodies and were diagnosed as MISC (18,2%). Based on demographic characteristics, children aged 11-15 years (27.3%) and boys were more affected (52.3%) as MIS-C suspected. Most of them were referred from a 2nd-level hospital outside Padang City (70.4%), but only 13.6% had a history of contact with COVID-19 confirmation patients. There was a significant difference in cardiovascular signs and symptoms between positive and negative serology antibody SARS-CoV-2 among children with MIS-C suspected (p<0.05), but not in fever, respiratory distress, gastrointestinal, neurology symptoms, either in laboratory results such as leukocytes, CRP and D-dimmer. Intravenous immunoglobulin, steroid, and PICU admitted showed no significant differences between the 2 groups, but more death prevalence in positive than negative. However, no significant differences (12.5% vs. 11.1%, p>0.05). Conclusion: Cardiovascular signs and symptoms could be proposed to be one of the significant differences in clinical conditions to differentiated children with MIS-C suspected and MIS-C due to serology antibody results.

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