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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 1,165 Documents

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Study Analysis of Total Bilirubin Levels on Mortality in COVID-19 Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Suhardi, Suryo Nugroho; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1053

Background: Coronavirus Disease 2019 (COVID-19) is caused by a positive single-stranded RNA virus. The clinical manifestations of COVID-19 are not only dominated by respiratory tract symptoms but can also show symptoms of liver damage in severe COVID-19 patients. Liver damage that occurs can cause acute liver failure and result in death. Examination of liver damage marker parameters such as total bilirubin needs to be carried out as mortality increases in COVID-19 patients. This study aims to determine the relationship between total bilirubin levels and mortality in COVID-19 patients. Methods: Cross-sectional analytical research was conducted on 40 COVID-19 patients treated at Dr. M. Djamil General Hospital Padang from July to December 2021. Examination of total bilirubin levels using the colorimetric diazo method. Bivariate analysis used the Mann-Whitney test to see the relationship between total bilirubin levels and mortality. Results: The average age of the research subjects was 61.85 (1.40) years, with 65% men and 35% women. The mortality percentage in COVID-19 patients is 65%. The median total bilirubin level was 1.95 (0.5-2.8) mg/dL. The relationship between total bilirubin levels and mortality in COVID-19 patients was found to have a p-value of <0.001. The study results showed that the median total bilirubin level in COVID-19 patients who died was relatively higher, namely 2.20 (1.4-2.8) mg/dL, compared to those who did not die, namely 0.70 (0.5-1. 6) mg/dL. Conclusion: The results of this study show that there is a relationship between total bilirubin levels and mortality in COVID-19 patients.

Differences in Carcinoembryonic Antigen (CEA) Levels Based on the Degree of Histopathological Differentiation of Colorectal Cancer: Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Reni Asprilia; Efrida; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1054

Background: Colorectal cancer is the third malignancy and second leading cause of death in the world. CEA levels before surgery can be used as a cancer marker to help staging, planning, monitoring therapy and disease recurrence. One factor that influences CEA levels is the degree of differentiation of cancer cells. This study aims to determine differences in CEA levels based on the degree of histopathological differentiation in colorectal cancer patients at Dr. M. Djamil General Hospital Padang. Methods: This study was a cross-sectional analytical observational study using medical record data from colorectal cancer patients from January 2021 – August 2023. The sample was 65 patients who met the inclusion and exclusion criteria. CEA examination uses the ELFA method. The Mann Whitney test was used to see differences in CEA levels based on the degree of differentiation, statistically significant if p < 0.05. Results: A total of 65 patients with an average age of 56.89 years, 58.5% men, 41.5% women. A total of 10 patients were stage I, 29 stage II, and 26 stage III. Based on histopathology, 50 patients were classified as low grade and 15 as high grade. Low-grade CEA levels were 67.72 (3.14-200) ng/mL, while high grade were 3.2 (0.57-11.42) ng/mL. There was a significant difference in CEA levels based on histopathological differentiation (p < 0.001). Conclusion: CEA levels are higher in low-grade than high-grade colorectal cancer.

Overview of Bacterial Profile of Bloodstream Infections in the Intensive Care Unit (ICU): Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Rara Puspita Impelleren; Yulia, Dwi; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1055

Background: Bloodstream infection (BSI) is a condition characterized by positive blood cultures in patients who have systemic infections. Bloodstream infections have developed into a threat to public health worldwide with high mortality rates in intensive care settings. This study aims to determine the bacterial profile of BSI in the intensive care unit (ICU) of Dr. M. Djamil General Hospital Padang. Methods: This study is a retrospective descriptive study with a cross-sectional design from secondary data at the Microbiology and Medical Records Installation Laboratory of Dr. M. Djamil General Hospital Padang. All blood samples from patients aged ≥18 years in the ICU who are suspected of being infected will be cultured and identified with VITEK 2 in 2022. Results: A total of 243 blood samples consisted of 126 men (52%) and 117 women (48%) with the largest age range being 41-60 years (48%). The diagnosis of BSI was found in 94% with the most common comorbidities being malignancy (42%) and stroke (15%). The most common bacterial bloodstream infections were found in the ICU of Dr. M. Djamil General Hospital Padang., namely Gram-positive bacteria (66%) and coccus (66%). The most common type of bacteria identified with the VITEK 2 automatic tool is Staphylococcus hominis. Multidrug-resistant organisms (MDRO) found in this study were 8% with the most common causes, namely extended spectrum B-lactamase (ESBL). Blood samples in this study found bacteria due to contamination by 38%. Conclusion: The BSI bacterial profile found was mostly in the ICU of Dr. M. Djamil General Hospital Padang is a Gram-positive bacterium, coccus-shaped, Staphylococcus hominis and ESBL. Blood cultures found bacteria contaminated by 38%.

Differences in D-Dimer Levels in Acute Ischemic and Hemorrhagic Stroke: Observational Study in the Emergency Department of Dr. M. Djamil General Hospital, Padang, Indonesia Yunus, Dyniyah; Elfira Yusri; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1056

Background: Stroke is the second largest cause of death worldwide with a high morbidity rate of up to 50% of survivors get chronic disability. Rapid diagnosis in patients with suspected acute ischemic or hemorrhagic stroke is very important to determine management and prognosis. D-dimer is an indirect marker of fibrinolysis which functions as a significant marker of activation of coagulation and fibrinolysis. This study aims to determine the differences in D-dimer levels in ischemic and acute hemorrhagic stroke patients in the emergency room (ER) of Dr. M. Djamil General Hospital Padang. Methods: Analytical observational research by cross-sectional design was carried out on 56 samples consisting of 28 acute ischemic and 28 acute hemorrhagic stroke samples for the period December 2022-June 2023. D-dimer levels and CTscan checked on each group and analysis is carried out. Results: The most common characteristics of research subjects were men, namely 35 patients (62.5%) and aged 51-60 years (32.1%). The mean D-dimer levels for ischemic and hemorrhagic strokes were 794.33 ng/mL (±2.63) and 1288.25 ng/mL (±2.51) with a p-value = 0.055. Conclusion: The mean D-dimer in acute hemorrhagic stroke was higher than in acute ischemic stroke but there was no statistically significant difference. The D-dimer examination cannot differentiate the type of stroke that occurred.

Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Vania Ilmi Basri; Husni; Desiekawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1057

Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major. Methods: This research is a descriptive research. Data was taken from pediatric patients with β-thalassemia major who received routine transfusions at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from January 1st – July 31st 2023. Patients underwent hematology examination, serum ferritin, serum creatinine, and estimated glomerular filtration rate calculations using the Schwartz formula. Results: A total of 55 children met the research criteria, consisting of 27 boys (49%) and 28 girls (51%). The median serum creatinine level was 0.5 (0.3-0.8) mg/dL with a range with a mean estimated glomerular filtration rate of 167 mL/minute/1.73m2. Conclusion: Glomerular hyperfiltration occurs in the majority of β-thalassemia major patients, but a decrease in

Overview Profile of High Sensitive Troponin I (hsTnI) Levels Based on Infarction Location in Acute Myocardial Infarction Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Hafni, Noer; Rismawati Yaswir; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1058

Background: Acute myocardial infarction (AMI) remains an important health problem globally. A diagnosis of AMI can be made by finding at least two of the three criteria, namely typical angina pain, electrocardiography (ECG) abnormalities, and increased cardiac biomarkers. Variations in troponin levels based on examination time and infarct location were obtained from previous studies. High-sensitive troponin I (hsTnI) is a very specific biomarker in detecting myocardial damage. This study aims to determine the description of hsTnI levels based on the location of the infarction in AMI patients of Dr. M. Djamil General Hospital Padang. The location of the infarction in AMI determines the management and prognosis for the clinician. Methods: This research is a retrospective study with a cross-sectional design at the Laboratory Installation of Dr. M. Djamil General Hospital Padang. The sample was adult patients diagnosed with AMI with complete data that met the inclusion and exclusion criteria, taken from medical records. Results: This study showed that from a total of 140 AMI patients, 67 samples met the inclusion criteria. A total of 67 AMI patients consisted of 59 men (88.06%) and 8 women (11.94%) with an average age of 60.1 + 10.5 years. The highest hsTnI levels were found at the posterior infarction location, 40,000 ng/L (16,639-48,997). The location of the infarction was dominated by the inferior infarction location in 20 people (29.9%). Conclusion: The highest hsTnI levels were found at the posterior infarction location. The location of the infarction is dominated by the inferior infarction location in AMI patients with ST elevation at Dr. M. Djamil General Hospital Padang.

Study of Analysis of Beta Human Chorionic Gonadotropin (hCG) Levels Before and After Hysterectomy in Gestational Trophoblastic Neoplasia (GTN) Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Wella Novile Izora; Rikarni; Dwi Yulia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1059

Background: Gestational trophoblastic neoplasia (GTN) is a malignant tumor originating from placental trophoblast which causes mortality due to bleeding. Trophoblast produces beta hormone human chorionic gonadotropin (hCG). Quantitative examination of serum beta hCG is used to support the diagnosis and management of GTN. Hysterectomy is performed in bleeding conditions as the main therapy besides chemotherapy. This study aims to analyze differences in beta hCG levels before and after hysterectomy in GTN patients at Dr. M. Djamil General Hospital Padang. Methods: Retrospective observational analytical research design cross-sectional from 21 samples of GTN patients for the period July 2021 to June 2023 at Dr. M. Djamil General Hospital Padang. Quantitative beta hCG level examination is carried out before and after the hysterectomy. The Shapiro-Wilk test was carried out for data normality and continued with the Wilcoxon nonparametric tests to find out significant differences in beta hCG levels. Results: The most common characteristics of GTN patients were age ≥35 years, namely 15 (71.4%) patients, multiparity in 14 (66.7%) patients, and indication for hysterectomy due to bleeding in 14 (66.7%) patients. The median beta hCG level before hysterectomy was 46,000 (117.10-653,874) mIU/mL and the median after hysterectomy was 113.3 (0.12-3,693) mIU/mL. Beta hCG levels after hysterectomy were found to be normal (<5 mIU/mL) in five patients (23.8%). There was a significant difference in beta hCG levels before and after hysterectomy (p <0.001). Conclusion: Beta hCG levels after hysterectomy decreased compared to before hysterectomy. Hysterectomy therapy is useful for reducing beta hCG levels in GTN patients.

Study Analysis of Serum Phosphorylated Tau (P-Tau) Levels with Severity and Outcome in Traumatic Brain Injury Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Istiqomah; Syafrita, Yuliarni; Fanny Adhy Putri; Syarif Indra; Restu Susanti; Reno Bestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1060

Background: Traumatic brain injury (TBI) is a global health problem that can cause death and disability in people of productive age. The diagnosis and assessment of TBI severity currently still rely on clinical examination and neuroimaging. However, limited access and cost of neuroimaging are obstacles in many health facilities. Therefore, blood-based biomarkers are needed that can help the diagnosis and prognosis of TBI. Phosphorylated Tau (p-tau) is a potential biomarker that can be measured in serum. This study aims to assess the relationship between serum p-tau levels and severity and outcome in TBI patients. Methods: This research is a comparative study with a cross-sectional design involving 70 TBI patients who came to the emergency room (ER) of Dr. M. Djamil General Hospital Padang. TBI severity was assessed using the Glasgow coma scale (GCS) and grouped into mild (GCS 13-15) and moderate to severe (GCS 3-12). Outcomes were assessed using the Glasgow outcome scale (GOS) and grouped into good (GOS 4-5) and poor (GOS 1-3). Serum p-tau levels were measured using the ELISA method. Data analysis was carried out using SPSS. Results: The median serum p-tau level in the mild TBI group was 165.84 ng/L (IQR 126.18-463.85), while in the moderate to severe TBI group, it was 177.68 ng/L (IQR 87.62-591 .93). There was a significant difference between serum p-tau levels in the mild and moderate to severe TBI groups (p=0.029). The median serum p-tau level in the good outcome group was 167.21 ng/L (IQR 87.62-463.85), while in the poor outcome group it was 187.04 ng/L (IQR 137.75-591.93). There was a significant difference between serum p-tau levels in the good and bad outcome groups (p=0.014). Conclusion: Serum p-tau levels have a significant relationship with severity and outcome in TBI patients. Elevated serum p-tau levels are associated with increased severity of TBI and poor outcomes. Further research is needed to confirm these findings and explore the potential of p-tau as a biomarker in TBI management.

Overview of Central Corneal Thickness in Patients with Glaucoma: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Prabowo, Harliady Dany; Andrini Ariesti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1061

Background: Central corneal thickness (CCT) is an important risk factor in the diagnosis and management of glaucoma. This study aims to determine the CCT picture of various types of glaucoma at Dr. M. Djamil General Hospital Padang. Methods: This descriptive retrospective study involved data from glaucoma patients at Dr. M. Djamil General Hospital Padang for the period January 2019 - December 2020. CCT data was obtained from medical records and OCT computer data. Descriptive analysis was carried out to see the distribution of CCT in ocular hypertension (OHT), glaucoma suspect (GS), normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), and juvenile open-angle glaucoma (JOAG) groups. Results: A total of 123 glaucoma patients were analyzed. The overall mean CCT was 535.50 ± 43.82 µm. The highest mean CCT was in the OHT group (566.30 ± 32.07 µm) and the lowest in POAG (523.39 ± 39.43 µm). The mean age of patients was 35.19 ± 16.20 years. The POAG group had the highest mean age (52.52 ± 9.54 years), while the JOAG group had the lowest (22.00 ± 5.84 years). Conclusion: There are variations in CCT in various types of glaucoma, with OHT having the highest CCT and POAG the lowest. This data can be a basis for consideration in the diagnosis and management of glaucoma in Indonesia.

Differences in Average Albumin Levels in Coronavirus Disease 2019 (COVID-19) Survivor and Non-Survivor Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Atrya, Doan; Rikarni; Elvira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1062

Background: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection triggers a systemic inflammatory response that can lead to a decrease in serum albumin levels. A more severe inflammatory response in non-survivor COVID-19 patients may correlate with a more significant decrease in albumin levels. This study aims to analyze differences in mean albumin levels in COVID-19 survivors and non-survivors. Methods: This cross-sectional analytical study involved 40 COVID-19 survivors and non-survivors treated at Dr. M. Djamil General Hospital Padang from July 2021 to September 2021. Serum albumin levels were checked using an automated clinical chemistry tool. Data analysis was carried out using the Mann-Whitney non-parametric test, with a significance level of p < 0.05. Results: The mean age of the study subjects was 49.4 (16.3) years, with the majority of cases occurring in men (67.5%). The median albumin levels in all COVID-19 patients, COVID-19 survivors, and COVID-19 non-survivors were 3.2 (2.20–5.00) g/dL, respectively; 4.1 (3.0–5.0) g/dL; and 2.9 (2.20–3.70) g/dL (p = 0.001). Conclusion: There is a significant difference in mean albumin levels between COVID-19 survivors and non-survivors. Lower albumin levels were found in non-survivor patients. Albumin can be a potential biomarker for predicting clinical outcomes of COVID-19 patients.

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Contact Name Rachmat Hidayat

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Phone +6281949581088

Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

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Abstract

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA