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Rachmat Hidayat
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Bioscientia Medicina : Journal of Biomedicine and Translational Research
Published by HM Publisher
ISSN : -     EISSN : 25980580     DOI : https://doi.org/10.37275/bsm
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience
This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,165 Documents
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Differences in Cerebrospinal Fluid Glucose Levels in Meningitis Patients Based on Examination Time: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Haryando, Herpika Septi; Elfira Yusri; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1063

Abstract

Background: Cerebrospinal fluid (CSF) is a vital fluid in the central nervous system that can provide important diagnostic information, especially in cases of meningitis. CSF glucose is one of the key parameters that can help in the diagnosis and monitoring of the patient's condition. However, the stability of glucose in the CSF after sampling is of concern due to the potential for levels to decrease over time. Methods: This cross-sectional analytical observational study was conducted at Dr. M. Djamil General Hospital Padang between May and August 2023. CSF samples from patients with suspected meningitis were checked for glucose levels at three time points: the first 1 hour, 2 hours, and 4 hours after sample collection. Patients with puncture trauma and late delivery of samples (more than 30 minutes) were excluded. Results: This study involved [number of patients] CSF samples that met the inclusion criteria. The mean decrease in CSF glucose levels between the 1-hour and 2-hour examination was 5.667 mg/dL (±0.75 mg/dL), while between 1 hour and 4 hours, it was 12.183 mg/dL (±1.549 mg/dL). Statistical analysis showed significant differences (p < 0.001) between the three examination time points. Conclusion: Glucose levels in the CSF of meningitis patients decreased significantly over time after sampling. This emphasizes the importance of checking CSF glucose as soon as possible to obtain accurate results and avoid misinterpretation in the diagnosis and treatment of meningitis.
Accidental Finding of Suspected Cysticercosis Without Symptoms in Balinese Male: A Case Report Satya Pranata, Anak Agung Ngurah; I Made Suma Wirawan; Anak Agung Istri Sri Kumala Dewi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1064

Abstract

Background: Cysticercosis is one of the illnesses that the WHO considers to be neglected tropical diseases (NTD). Prevalence of cysticercosis in Asia ranged from 0.8% to 41.8%. Mostly, the central nervous system is affected. Case presentation: A 56-year-old Balinese male came to emergency department with main complaint weakness on right-side of his body since 12 hours before being admitted to the hospital. He has history of eating lawar (Balinese traditional food) mixed with fresh pig blood; the last time he ate it was 6 months. Chest examination no nodule/swelling, abscess, or hypertrophy of muscle was found. On laboratory examination WBC 7.47x103/ul, Hb 16.0 g/dL, percentage of eosinophil 5.4%, and eosinophil count 0.40x103/ul. Head CT without contrast suggesting sub-acute cerebral infarction in the left capsule internal. The patient then performed chest radiograph and accidentally multiple rice grain calcification was found. The patient treated with albendazole 15mg/kg/bb/day for 14 days. Clinical presentations of cysticercosis can vary from those with no symptoms to those symptomatic, Patients with muscular involvement are mostly asymptomatic. Increasing eosinophil in complete blood count may indicate helminth infection, to clinch the early diagnosis radiological modalities can be used. However histological findings will give a definitive diagnosis. The use of praziquantel and albendazole is the suggested antihelminth in cysticercosis. Conclusion: Pulmonary muscle involvement of cysticercosis is a rare finding. Increasing awareness of such lesions may lead to early diagnosis and prevent irreversible damage.
Virological and Clinical Studies of Viral Hemorrhagic Fever (VHF): A Systematic Literature Review Fadrian; Armen Ahmad; Zaki Mahmudi Dasril
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1065

Abstract

Background: Viral hemorrhagic fever (VHF) is a group of zoonotic diseases caused by various RNA viruses, such as Ebola, Marburg, Lassa, Crimean-Congo hemorrhagic fever (CCHF), and Dengue. VHF poses a serious threat to global public health due to high morbidity and mortality rates. This study aims to conduct a systematic literature review of virological and clinical studies of VHF to understand the characteristics of the virus, pathogenesis, clinical manifestations, risk factors, diagnosis, and current therapeutic options. Methods: A comprehensive literature search was conducted on PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2018 and 2024. Studies that met the inclusion criteria were evaluated for quality and narratively synthesized. Results: This review included 20 studies involving 2,350 VHF patients. Results demonstrated significant diversity in virologic characteristics, pathogenesis, and clinical manifestations among different types of VHF. These studies also highlight advances in molecular and serological diagnosis, as well as the development of antiviral and immunomodulatory therapies. Conclusion: This systematic literature review provides a comprehensive summary of current knowledge regarding the virology and clinical practice of VHF. These findings may guide the development of more effective prevention, diagnosis, and treatment strategies for this life-threatening disease.
Analysis of the Role of Vitamin C Hypovitaminosis in Scurvy on Bone Health: A Single Center Observational Study at Dr. Moewardi General Hospital, Surakarta, Indonesia Nefihancoro, Udi Heru; Rachmad Faisal
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1066

Abstract

Background: Scurvy, vitamin C deficiency, is a rare condition but remains relevant in Indonesia. This study aims to analyze the role of vitamin C hypovitaminosis in the development of scurvy and its impact on bone health through an observational study at Dr. Moewardi General Hospital. Surakarta. Methods: A cross-sectional observational study was conducted on 30 patients diagnosed with scurvy at Dr. Moewardi General Hospital Surakarta during the 2020-2023 period. Demographic data, medical history, nutritional status, and severity of scurvy were collected. A radiological examination of the bone is performed to assess scurvy-related changes. Descriptive, comparative, and Spearman correlation statistical analyzes were used. Results: The majority of patients were men (66.7%) with a mean age of 45 years. A history of an unbalanced diet with low fruit and vegetable intake was found in the majority of patients (86.7%). Common symptoms include fatigue (86.7%), joint pain (73.3%), bleeding gums (60%), and skin bleeding (53.3%). The severity of scurvy varied, with 10 patients (33.3%) experiencing severe scurvy. Radiological examination shows significant changes in long bones, especially osteoporosis and thinning of the cortex, which is more obvious in patients with severe scurvy. Spearman correlation analysis showed a positive correlation between the severity of scurvy and the incidence of osteoporosis (rho = 0.495, p = 0.005) and cortical thinning (rho = 0.394, p = 0.031). Conclusion: Vitamin C hypovitaminosis plays a significant role in the development of scurvy and has a negative impact on bone health. Early screening and diagnosis of scurvy are important to prevent musculoskeletal complications. Nutritional education and dietary interventions to increase vitamin C intake need to be intensified, especially in high-risk groups.
Dengue Haemorrhagic Fever with Unusual Presentations and Complications in Sanjiwani General Hospital: A Case Series Dwi Putri Anjani, I Gusti Agung; I Wayan Eka Saputra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1068

Abstract

Background: Dengue hemorrhagic fever (DHF) is a viral infection transmitted by Aedes mosquito with a wide clinical spectrum, ranging from mild fever to life-threatening complications. Atypical clinical manifestations of DHF can cause delays in diagnosis and treatment, so it is important to increase clinician awareness of these unusual manifestations. Case presentation: We report four cases of DHF with atypical manifestations: (1) A 50-year-old woman with spontaneous psoas hematoma, (2) An elderly man with pulmonary edema, (3) A young man with acute myocarditis, and (4) A middle-aged man. middle-aged with encephalopathy. Conclusion: Atypical manifestations of DHF can occur at various ages and can involve various organs. It is important for clinicians to consider dengue fever as a differential diagnosis in patients with fever and unusual clinical manifestations, especially in dengue-endemic areas. Early diagnosis and appropriate treatment can improve patient clinical outcomes.
The Role of Ferritin Levels on Vitamin D Status in Pregnant Women: An Observational Single Center Study at Hermina Hospital, Padang, Indonesia Hidayat, Hedo; Efrida; Elfira Yusri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1070

Abstract

Background: Vitamin D deficiency during pregnancy is associated with poor pregnancy outcomes. Research shows a complex interaction between iron and vitamin D. Pregnant women are susceptible to iron deficiency due to increased iron requirements during pregnancy. Ferritin reflects body iron stores and may decrease before serum iron. This study aims to analyze the relationship between ferritin levels and vitamin D status in pregnant women. Methods: This retrospective comparative cross-sectional analytical observational study involved pregnant women in the 1st, 2nd, and 3rd trimesters who underwent antenatal care at Hermina Hospital Padang from February to August 2023. Vitamin D (25(OH)D3) and ferritin were measured using enzyme-linked fluorescence assay (ELFA). Univariate and bivariate analysis used the Chi-square and odds ratio (OR) tests, with a significance of p<0.05. Results: Of 163 pregnant women (mean age 30.4 years), median ferritin levels were 25.85 ng/mL and 25(OH)D3 15.5 ng/mL. Low ferritin was found in 63.80% of subjects and sufficient vitamin D in 31.90%, insufficiency in 33.74%, and deficiency in 34.36%. There was no correlation between low ferritin and vitamin D insufficiency (OR=2.04; 95% CI 0.94-4.42; p=0.700). However, there was a significant correlation between low ferritin and vitamin D deficiency (OR=6.59; 95% CI 2.68-16.18; p=0.000). Conclusion: Pregnant women with low ferritin have a 6.59 times higher risk of experiencing vitamin D deficiency.
Effectiveness of Mechanical Treatments (Periosteal Stripping VS Non-Periosteal Stripping) on Fracture Healing: In Vivo Study Nefihancoro, Udi Heru; Septriarta Parlindungan; Ida Bagus Budhi Surya Adnyana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1071

Abstract

Background: Periosteal stripping (PS) is a controversial technique in fracture management, with studies reporting both positive and negative effects on bone healing. This study aims to evaluate the effectiveness of PS and non-periosteal stripping (NPS) on fracture healing in the Sprague Dawley rat model. Methods: This study is an in vivo experimental research. Male Sprague Dawley rats (8-10 weeks old) were divided into four groups (n=10 per group): Group I: NPS, evaluation day 14; Group II: PS, evaluation day 14; Group III: NPS, evaluation day 28 and Group IV: PS, evaluation day 28. A standard fracture was created in the tibia, and PS or NPS was performed. Radiographic evaluation was performed on days 14 and 28, with the RUST score (Radiographic Union Score for Tibia) used to assess fracture healing. Statistical analysis was performed using the Kruskal-Wallis test. Results: The RUST score showed better fracture healing in the NPS group compared to PS on day 28 (p<0.05). There was no significant difference on day 14 (p>0.05). Conclusion: NPS was more effective in accelerating fracture healing in Sprague Dawley rats than PS, especially in the later stages of healing. These findings provide further evidence of the potential adverse effects of PS and highlight the importance of considering time in assessing its efficacy.
Characteristics, Clinical, and Trichoscopic Features in Pediatric Patients with Alopecia Areata: A Single-Center Observational Study at the Dermatology Clinic of Dr. M. Djamil General Hospital Padang Yenny, Satya Wydya; Yola Fadilla; Raja Eka Citra Kalisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1072

Abstract

Background: Alopecia areata (AA) is an autoimmune disease that causes patchy hair loss. In children, AA can have a significant psychological impact. This study aims to identify the characteristics, clinical and trichoscopic features of AA pediatric patients at the dermatology clinic of Dr. M. Djamil General Hospital Padang. Methods: This cross-sectional analytical observational study involved pediatric patients (<18 years) with a diagnosis of AA who came to the dermatology clinic of Dr. M. Djamil General Hospital Padang between January 2020 to December 2023. Demographic data, disease history, clinical features, and trichoscopy examination results were collected and analyzed descriptively. Results: A total of 125 pediatric AA patients met the inclusion criteria. The majority of patients were female (62.4%) with a mean age of 10.5 years. The most common form of AA is patchy (80%), followed by alopecia totalis/universalis (12%) and ophiasis (8%). A history of atopy was found in 35.2% of patients. The most frequently found trichoscopic features were yellow dots (78.4%), black dots (64%), and broken hairs (56%). Conclusion: This study provides a comprehensive description of the characteristics, clinical and trichoscopic characteristics of AA pediatric patients at Dr. M. Djamil General Hospital Padang. These findings may provide a basis for the development of better management strategies for AA in children.
Invasive Mammary Paget’s Disease Without Underlying Malignancy: A Case Report Citra Kalisa, Raja Eka; Ennesta Asri; Indah Indria Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1073

Abstract

Background: Mammary Paget's disease (MPD) with skin invasion is a rare condition that is often associated with an underlying malignancy. However, invasive MPD without malignancy is even rarer and often misdiagnosed. Case presentation: This report presents the case of a 56-year-old woman who presented with a progressively enlarging scaly erythematous plaque on her left nipple for 6 months. Dermoscopy and histopathological examination confirmed the diagnosis of invasive MPD, but radiological examination did not reveal any malignancy. Conclusion: Invasive MPD without malignancy is a rare but important entity to recognize. Awareness of this condition can help prevent overdiagnosis and unnecessary treatment.
The Relationship between Albumin Levels with SGOT, SGPT, and de Ritis Ratio in Chronic Hepatitis B Patients: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Nursasmi, Ami Tri; Zelly Dia Rofinda; Desywar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1074

Abstract

Background: Chronic hepatitis B (CHB) is a persistent hepatitis B virus (HBV) infection and can cause progressive liver damage. This damage can be measured through a decrease in albumin levels and an increase in liver enzymes such as aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), and de Ritis ratio (AST/ALT). This study aims to analyze the relationship between albumin levels and SGOT, SGPT, and de Ritis ratio in CHB patients. Methods: This cross-sectional retrospective analytical study involved 50 CHB patients diagnosed at Dr. M. Djamil General Hospital Padang between June 2022 to June 2023. Data on albumin levels, SGOT, SGPT, and de Ritis ratio were obtained from medical records. The de Ritis ratio, SGOT, and SGPT were grouped into normal and increased. Statistical analysis used an independent t-test with a significance of p < 0.05. Results: The research subjects consisted of 26 men (52%) and 24 women (48%) with an average age of 42.46 ± 13.39 years. The mean albumin level in the increased SGOT group (3.69 ± 0.78 g/dL) was significantly lower than the normal SGOT group (4.39 ± 0.61 g/dL) (p = 0.003). The mean albumin level in the increased de Ritis ratio group (3.90 ± 0.80 g/dL) was also significantly lower than the normal de Ritis ratio group (4.46 ± 0.70 g/dL) (p = 0.006). There was no significant difference between albumin levels in the normal and increased SGPT groups (p = 0.548). Conclusion: There is a significant negative relationship between albumin levels and SGOT and de Ritis ratio in CHB patients. Decreased albumin levels may be an indicator of more severe liver damage in these patients.

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