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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 25 Documents
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Search results for , issue "Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science" : 25 Documents clear
Optimizing Solar Power: The Impact of N719 Dye Concentration on DSSC Efficiency with TiO2 Nanoparticles Hardani Hardani; Ho Soonmin; Khaerus Syahidi; Alpi Zaidah; Sulistiyana Sulistiyana; Alpiana Hidayatulloh; Ahmad Fudholi; Lily Maysari Angraini
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.245

Abstract

Dye-sensitized solar cells (DSSC) are photoelectrochemical, alternative energy source devices that convert light energy into electricity. In this study, DSSC with various concentrations (0.1, 0.5, and 1.0 mM) of N719 dye have been successfully prepared using simple steps. The X-ray diffraction results of the TiO2 film showed that it is polycrystalline with an anatase phase (tetragonal system) having a crystallite size of about 20 nm. The absorbance spectrum of the TiO2 film and N719 dye at various concentrations was recorded by ultraviolet-visible (UV-Vis) spectrophotometer. The bandgap energy of the TiO2 film calculated by Tauc’s formula was ~3.1 eV. The DSSC prepared using the N719 dye concentration of 1 mM achieved the highest conversion efficiency (η) of 0.298 %, respectively. Subsequently, the enhancement in efficiency was ~86 % compared with the conversion efficiency of DSSC prepared with an N719 dye concentration of 0.1 and 0.5 mM.
Potential of Bioactive Compounds In Coleus amboinicus, Lour., Leaves Against Breast Cancer By Assessment Using A Network Pharmacology Approach and Cytotoxic Test Winarto Haryadi; Kasta Gurning; Jajah Fachiroh; Endang Astuti
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.246

Abstract

Breast cancer is a disease that significantly contributes to global women death. The study aims to conduct in vitro activity testing and assessment with a bioinformatics approach using a pharmacological network of bioactive compounds from bangun-bangun (Coleus amboinicus) leaves extract as a breast cancer drug. The methods used are extraction of bioactive compounds by maceration and partition, identification and analysis of bioactive compounds using the Liquid Chromatography High-Resolution Mass Spectrometry (LC-HRMS) instrument, cytotoxic testing of breast cancer cells (MCF-7) and normal cells (CV-1) with the MTT method, and assessment with a bioinformatics approach through a network pharmacology. The results of the cytotoxic test of ethyl acetate extract provided better activity with IC50 value of 102.30 and 457.09 µg/mL against MCF-7 cancer cells and CV-1 normal cells. The selectivity index value of 4.23 indicates the potential for further development in the treatment of breast cancer. The results of the analysis of chemical compound content show various types of potential bioactive compounds as breast cancer anticancer; assessment of the bioinformatics approach through networks pharmacology with pathways in cancer provides predictions of signal transducer and activator of transcription 3 (STAT3) protein as the main therapeutic mechanism target in breast cancer treatment. This study provides initial information for further research on testing and utilizing bioactive compounds from C. amboinicus leaves as an alternative treatment for breast cancer.
Acute Toxicity Study of the Leaf and Fruit Extracts of Avicennia marina (Forssk.) on Wistar White Male Mice Duryat Duryat; Rodiani Rodiani; Tri Maryono
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.247

Abstract

Avicennia marina has at least 36 types of flavonoid compounds that are potential anti-fertility agents. The study's objectives were to obtain safe doses and assess the potential risks of using A. marina extract. Toxicity testing was conducted on Wistar rats with doses of 0, 250, 500, 1000, 2000, and 4000 mg/kg BW for leaf and fruit extracts. Observations were made to measure the level of mortality and damage to important organs (liver, kidneys, and testes) both macroscopically and microscopically. Macroscopic observation included identifying changes in shape, color, and size. Microscopic observation was done to observe organ damage through histopathological tests. Results of the study show that the administration of A. marina extract, both leaf and fruit, resulted in a 100 % survival rate at all doses given and the LD50 >8 g/kg BW. Both leaf and fruit extracts of A. marina also did not cause a decrease in the size of the kidneys and testes, but at high doses, they potentially reduced liver size. These findings indicate that using A. marina extract at recommended doses is safe. Both leaf and fruit extracts of A. marina, at a dose of 250 mg/kg BW, did not cause negative effects on the major organs (liver, kidneys, and testes) of mice. This finding suggests that using A. marina extract at 250 mg/kg BW is safe for long-term use. Administration of A. marina extract at doses up to 500 mg/kg BW did not cause liver damage in mice, but it potentially caused mild kidney damage. This finding indicates that leaf and fruit extracts of A. marina still have the potential to be used as drug candidates but with dosage regulation below 500 mg/kg BW. Administration of leaf and fruit extracts at doses of 500, 1000, and 2000 mg/kg BW has been shown to reduce the fertility of mouse sperm cells by up to 30%. This finding indicates that A. marina has the potential to be a promising, safe herbal anti-fertility agent.
Green Synthesis of Hierarchical H-ZSM-5 from Sugarcane Bagasse Silica and Application as Catalyst for Conversion of Cellulose into Glucose Mita Rilyanti; Azizah Dewi Wahyu Ningrum; Ilim Ilim; Suharso Suharso; Mulyono Mulyono; Muhammad Ayoub; Wasinton Simanjuntak
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.248

Abstract

In this study, a hydrothermal method was applied for the synthesis of hierarchical ZSM-5 from sugarcane bagasse ash (SCBA) as a precursor using starch as a green template. The synthesis was conducted by the hydrothermal method with the molar composition of 1.000:0.250:0.067:30.00 for SiO2:NaOH:Al(OH)3:H2O. For comparison, the synthesis without the use of a template was also conducted. The two zeolites synthesized were then tested as catalysts for glucose production by hydrolysis of cellulose derived from rice husk. The results indicate that starch served as an effective template for the formation of hierarchical ZSM-5 zeolite having mesopores with a surface area of 94.15 m2/g and pore diameter of 2.31 nm. The ZSM-5 synthesized with the use of a template was found to have a crystallinity of 76.33%, while the zeolite prepared without a template had a crystallinity of 79.25%. Hydrolysis experiments reveal that a glucose yield of 69.20% was achieved with the use of the H-ZSM-5 prepared with a template as a catalyst, while with the use of ZSM-5 prepared without a template the glucose yield of 42.42% was achieved. These different results justified the significantly higher performances of the ZSM-5 prepared with a template. Utilization of SCBA as raw material for the synthesis of hierarchical ZSM-5 zeolite is a part of the green chemistry initiative since this research converts the industrial waste into functional material. In addition, the utilization of SCBA is also ecologically beneficial because no excessive chemicals are required in the preparation process.
Uncovering The Pharmacological Mechanism of Ficus elastica as Anti-hyperlipidemia Candidate: LC-HRMS, Network Pharmacology, In vitro and In vivo Studies Gita Susanti; Yufri Aldi; Dian Handayani; Friardi Ismed; Arif Setiawansyah
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.249

Abstract

Hyperlipidemia is a major risk factor for cardiovascular diseases. While conventional treatments exist, there is a growing interest in natural remedies with fewer side effects. Ficus elastica has promising medicinal properties, yet its potential as an anti-hyperlipidemic agent remains unexplored. This study aimed to investigate the anti-hyperlipidemic effects of F. elastica using an integrated approach of LC-HRMS-based chemical bioinformatics and in vitro/in vivo experimental validation. The anti-hyperlipidemic potential of F. elastica and its mechanism of action were screened using integrative computational network pharmacology followed by in vitro HMG-CoA reductase inhibition and in vivo lipid-lowering activity in a hyperlipidemia rat model. Network pharmacology analysis identified STAT3, HSP90AA1, and TLR4 as potential core targets involved in lipid and atherosclerosis-related KEGG pathways. Molecular docking simulations revealed high-affinity interactions between F. elastica compounds and the identified targets, notably compound 41 and compound 61. In vitro assay demonstrated that ethanolic extract of F. elastica inhibited HMG-CoA reductase with an IC50 of 297.73 µg/mL. In vivo experiment using a hyperlipidemic rat model showed significant reductions in total cholesterol, triglycerides, and increased HDL levels. The reduction of triglycerides and elevation of HDL level after F. elastica ethanolic extract supplementation is similar to the effect from supplementation of simvastatin. These findings suggest that F. elastica ethanolic extract possesses notable anti-hyperlipidemic properties, likely mediated through multiple molecular targets and pathways. The study highlights the potential of F. elastica ethanolic extract as a promising candidate for anti-hyperlipidemic therapy and underscores the efficacy of integrating computational and experimental approaches in natural product research.

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