cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Yayuk Andayani
Contact Email
sjp@unram.ac.id
Phone
+6281936732708
Journal Mail Official
sjp@unram.ac.id
Editorial Address
Jl. Majapahit No. 62 Mataram
Location
Kota mataram,
Nusa tenggara barat
INDONESIA
Sasambo Journal of Pharmacy
Published by Universitas Mataram
ISSN : 27232824     EISSN : 27232832     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 94 Documents
 2   3   4   5   6 
Potensi anti-kanker payudara tanaman songga (Strychnos lucida R.Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico Muhammad Andre Reynaldi; Arif Setiawansyah
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.149

Abstract

Songga (Styrchnos lucida R.Br) is a plant that has potential to be developed as an anti-breast cancer against. This study was conducted to predict the secondary metabolite derived from songga, which potential as anti-breast cancer through inhibition of estrogen receptor-α. A molecular docking study was carried out using Autodock Vina assisted by AutodockTool and Biovia Discovery Studio. The study used estrogen receptor-α as a protein and ten compounds from songga as ligands. The 3D structure of estrogen receptor-α and ten ligands were obtained from Protein Data Bank and the PubChem database. The result revealed that strychnine N-oxide is the compound that has the lowest free binding energy and inhibition constant with the value 9.6 kcal/mol and 0.09 µM, respectively. This indicated that strychnine N-oxide has an excellent affinity for estrogen receptor-α. Thus, this compound is predicted to inhibit the estrogen receptor-α and can be developed as anti-breast cancer. However, further investigations such as molecular dynamics simulation, in vitro and in vivo assays should be undertaken.
Potensi interaksi obat pada pasien skizofrenia di Rumah Sakit Jiwa Mutiara Sukma tahun 2020 Virnia Wanda Utami; Mudrikah Darajati; Candra Eka Puspitasari
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.151

Abstract

Schizophrenia is a chronic mental disorder characterized by distortions in thinking and behavior. Schizophrenic patients receive antipsychotic therapy (main) and non-antipsychotic (supportive) for a long time. Prescription drugs are given either single or in combination, that can possible for drug interactions. This study objective to determine the potential drug-drug interactions in schizophrenic patients. The design of this study was cross-sectional with purposive sampling technique. The data used is secondary data from the medical records of inpatient schizophrenia patients at the Mutiara Sukma Mental Hospital NTB in 2020 with a retrospective method. The sample data obtained were 109 medical records. The results showed that there were 82,2% of drug interaction cases, namely the combination of risperodone and lorazepam. The number of major interaction cases is 24,2%, moderate is 72,1% and minor is 3,6%. The high incidence of drug interactions in schizophrenic patients requires closely monitored.
Uji validitas dan reliabilitas instrumen kuesioner gambaran penggunaan obat nyeri haid secara mandiri pada mahasiswi Fakultas Kedokteran Universitas Mataram Rosa Ninty Oktamadila; Iman Surya Pratama; Ni Made Amelia Ratnata Dewi
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.154

Abstract

Self-medication often becomes a choice for various complaints, one of which is menstrual pain. Regarding the description of the use of menstrual pain medication independently, it is still limited. The use of a questionnaire as a research instrument that has been tested for validity and reliability is very necessary. Therefore, this study aims to develop and test the validity and reliability of the description of the independent use of menstrual pain medication in female students. This research is a descriptive survey type with a cross-sectional design. The validity test was carried out using a qualitative and quantitative professional assessment method, namely by using the Content Validity Ratio (CVR). An advance validity test was conducted by 5 experts and 40 respondents. The reliability test was carried out with 40 respondents and used the Chronbach Alpha value. The results of the validity test obtained 28 questions with a CVR value of 1. Facial validity was declared valid after one repair. The reliability of the test obtained Cronbach's Alpha coefficient value of 0.934. Based on the validity and reliability test of the questionnaire, it was declared valid and reliable so that all questions could be used as an instrument to find out the description of the use of menstrual pain medication independently.
Molecular docking of the bioactive compound Ocimum sanctum as an inhibitor of Sap 1 Candida albicans Gusnia Meilin Gholam
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.157

Abstract

Candida albicans (C. albicans) is the norm microbiota that lives in humans' oral cavity, digestive tract, and urinary tract. However, C. albicans, under certain circumstances can cause superficial infections of the mucosa such as oropharyngeal candidiasis (OPC) or vulvovaginal candidiasis (VVC) and even systemic infections. Secreted aspartic proteinase (Sap) 1 plays a role in the phenotype change of C. albicans. The study aimed to perform molecular docking using the bioactive compound Ocimum sanctum to inhibit Sap 1 C. albicans. Methods used include preparation of protein structures, ligands preparation, simulation of docking, and analysis and visualization. The results showed Apigenin had the highest binding energy of 7,792 kcal/mol and was followed by methyl eugenol ligand 5,361 kcal/mol, Citral 5,307 kcal/mol, Ursolic acid 4,967 kcal/mol, and Taxol 2,118 kcal/mol. Known interactions from the docking results showed that the four ligands hit the catalytic residue Asp32/Asp218, but only ursolic acid did not hit the catalytic residue. This study concludes that all ligands have binding energies that inhibit Sap 1, resulting in various interactions, amino acid residue contacts, and dissociation constants.
Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr) Qurratul Aeni; Siti Rahmatul Aini; Iman Surya Pratama
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.164

Abstract

Pineapple plants are used ethnomedicinally in various countries, especially in Indonesia. Several studies have shown that pineapple plants have pharmacological effects both in vitro and in vivo on various diseases. Ananas Plant has the potential to be cultivated as medicine products. The toxicity of Ananas comosus (L) Merr important to acknowledge. This literature review aims to provide comprehensive information through a literature review regarding the toxicity of pineapple (Ananas comosus [L.] Merr). The literature review was collected in the period 2010 to 2021 which was obtained from the Google Scholar and Pubmed databases with a total of 9544 and a study was carried out on 10 works of literature. Based on the results of 10 literatures that have met the inclusion criteria, it shows that the in vitro toxicity test on pineapple (Ananas comosus [L.] Merr) has an LC50 of 403.83 to 9000 ppm which belongs to the category of practically non-toxic to moderately toxic. In vivo toxicity test showed that LD50 > 5000 mg/kgBW showed no deaths which were classified as practically non-toxic. From the results of literature research, it can be said that toxic plants (Ananas comosus [L.] Merr) have a toxicity category of practically non-toxic to moderately toxic in vitro studies. The results of the in vivo test showed that there were no deaths in the test animals which were in the category of practically non-toxic to mildly toxic.
Molecular docking study of natural compounds from red betel (Piper crocatum Ruiz & Pav) as inhibitor of secreted aspartic proteinase 5 (Sap 5) in Candida albicans Gusnia Meilin Gholam; Iman Akhyar Firdausy
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.145

Abstract

Candida albicans can cause adverse infections in humans. The targeting of Sap 5 is due to its virulence factor in C. albicans. The method used is molecular docking using YASARA structure and BIOVIA Discovery Studio. The purpose of this study was to investigate the molecular interaction between red betel and Sap 5 as a potential inhibitor of C. albicans in infecting humans. The results showed that CHEMBL216163 (9,644 kcal/mol) and MLS000557666 (9,525 kcal/mol) have Binding energy above Pepstatin (9,484 kcal/mol) and affect the active site of Sap 5 so that the two test ligands could be further analyzed.
Perspektif mahasiswa farmasi universitas mataram terhadap vaksinasi COVID-19 Nur Amalina Sabdarrifa; Baiq Bismiranti Haris; Zulfiana Fitrianingrum Annas; Candra Eka Puspitasari
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.167

Abstract

COVID-19 is an infectious disease caused by SARS-CoV-2 with a high transmission rate. The Indonesian Ministry of Health made efforts to contain the spread of the virus by conducting a vaccination program. This study’s objective to examine the extent to which UNRAM Pharmacy students provide the opportunity to vaccinate, the known types of COVID-19 vaccines, and student responses to the outbreak of the emergence of a new variant, namely the COVID-19 Delta variant. The method used in this study was cross-sectional, with a sample of 163 active students of Pharmacy UNRAM. Sampling was done boldly by using google forms. The results of the study were 98% of respondents started to vaccinating against COVID-19. There are three types of vaccines known to students, namely Sinovac, Astra Zeneca, and Moderna.
Kecambah: Agen penghidrolisis pati yang potensial Lina Permatasari
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.174

Abstract

Starch is a group of complex carbohydrates containing amylose and amylopectin. Starch can be broken down into simpler molecules such as maltose, isomaltose, and glucose which is called the hydrolysis process. Starch hydrolysis is very useful in several food industries. Enzymatic hydrolysis of starch usually uses the amylase enzyme derived from saliva. However, if you are going to carry out the hydrolysis process on a large scale, it requires large amounts of enzymes. Therefore, this study aimed to examine the ability of enzymes in sprouts to hydrolyze starch and compare it with the ability of starch hydrolysis by saliva and HCl. The isolated sprout samples were added to the starch solution and then incubated at 37oC. Every 5 minutes the mixture was tested qualitatively with Benedict's test and iodine. The same treatment for saliva and HCL. However, HCl was incubated at 100oC. The results of the qualitative test using Benedict's test and the iodine test showed enzymatic process had a higher ability to hydrolyze starch than chemically with HCl. The α-amylase enzyme produced from sprouts showed a higher starch hydrolysis ability than saliva. Sprouts are a natural source that can be developed as a starch hydrolyzing agent.
Penetapan rendemen dan kandungan kimia ekstrak daun katuk (Sauropus androgynus (L.) Merr.) berdasarkan perbedaan metode pengeringan Fara Azzahra
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.177

Abstract

Katuk leaves contain chemicals in the form of alkaloids, triterpenoids, saponins, tannins, polyphenols, glycosides and flavonoids, so they are widely used as antioxidants. One factor can affect in chemical content and yield extract is the drying method. The purpose of this study was to determine the effect of different drying methods on yield and chemical content of katuk leaf extract. This research method was experimental Posttest Only Design. Katuk leaves were dried using wind, oven, sun and continued by maceration with ethanol 96% as solvent. The macerate was filtered and air-dried to thick extract which was calculated yield and tested chemical content form of polyphenols, alkaloids, flavonoids, saponins, tannins and terpenoids. Yield data analysis was carried out using One Way ANOVA test. The average yield value of katuk leaf extract in the wind-dry drying method was 11.86±0.23%, the sun was 12.26±0.70%, the oven was 13.64±0.74%. One Way ANOVA test showed significant differences in wind and oven drying, sun and oven drying. Phytochemical screening of each drying showed the presence of polyphenols, alkaloids, flavonoids, saponins, tannins and triterpenoids. The conclusion of this study was that the drying method affects the yield of katuk leaf extract but has no effect on chemical content.
Cyclea barbata L. Miers.: Penggunaan tradisional, fitokimia, dan aktivitas farmakologi Surya Febrianto; Fradnya Vrianka Praharsini; Zulfiana Fitrianingrum Annas; Nisa Isneni Hanifa
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.178

Abstract

Indonesian people still favor the use of traditional medicine because they believe its side effects are lower than synthetic drugs. One of the plants that can be used in traditional medicine is Cyclea barbata L. Miers, or green grass jelly. This study aimed to explain and summarize the traditional use, phytochemical content, and pharmacological activity of C. barbata. All information on C. barbata was collected from various electronic databases (Google Scholar, Science Direct, and PubMed) using important and related keywords. Secondary metabolites found in stems, roots, and leaves are alkaloids and flavonoids. The pharmacological activities of C. barbata include antibacterial, antioxidant, anti-plasmodial, immunomodulator, Alzheimer, anti-inflammatory, anti-cholesterol, and antiulcer. Although C. barbata has been used empirically, further research is still needed to ensure the effectiveness and safety of this plant.

Page 4 of 10 | Total Record : 94

 2   3   4   5   6 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol. 6 No. 2 (2025): September Vol. 6 No. 1 (2025): April Vol. 5 No. 2 (2024): September Vol. 5 No. 1 (2024): April Vol. 4 No. 2 (2023): September Vol. 4 No. 1 (2023): April Vol. 3 No. 2 (2022): September Vol. 3 No. 1 (2022): April Vol. 2 No. 2 (2021): September Vol. 2 No. 1 (2021): April Vol. 1 No. 2 (2020): September Vol. 1 No. 1 (2020): April More Issue