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Sasambo Journal of Pharmacy
Published by Universitas Mataram
ISSN : 27232824     EISSN : 27232832     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 94 Documents
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Analisis fitokimia dan kromatografi lapis tipis ekstrak etanol daun rosella (Hibiscus sabdariffa L.) Tira Risa Oktapiya; Nofran Putra Pratama; Nur'aini Purnamaningsih
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.181

Abstract

Rosella (Hibiscus sabdariffa L) is a plant belonging to the Malvaceae family. This plant is widely used as herbal medicine. Rosella leaves have many compounds that can function as antioxidants and antibacterials. As a crude material for traditional medicine, it is necessary to know the content of secondary metabolites contained in rosella leaves both quantitatively and qualitatively as one of the standardization parameters. The objective of this study was to determine the content of secondary metabolites contained in the ethanolic extract of rosella leaves through phytochemical analysis and Thin Layer Chromatography. Rosella leaf extraction was carried out by maceration method using 70% ethanol as solvent. Testing the content of secondary metabolites in the ethanolic extract of rosella leaves was carried out by phytochemical screening. Furthermore, the TLC test was carried out to confirm the presence of a positive group of compounds on phytochemical screening. Phytochemical screening from rosella leaves extract revealed the presence of alkaloids, flavonoids, saponins and tannins. The TLC system used in this study was able to separate the phytochemical content and gave positive results confirming the phytochemical screening results. The eluent used was chloroform:methanol:acetic acid with a ratio of 14:2:1 obtained spots with an Rf of 0.737 which is similar to the Rf standard of quercetin which is 0.762.
Aktivitas antioksidan ekstrak air daun kelor (Moringa oleifera) dengan metode DPPH serta analisis kualitatif kandungan metabolit sekunder Laili Muna
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.182

Abstract

Sunlight contains UV radiation which will have an impact on the skin if exposed continuously and cause premature aging of the skin. The use of cosmetic products that contain antioxidant compounds is needed to avoid premature aging due to exposure to UV rays. Antioxidants used in cosmetics generally come from synthetic compounds, namely BHT (Butyl hydroxytoluene) whose use will have a negative impact on the skin if used in the long term, so in this study, Moringa oleifera leaf was used as a natural antioxidant. The purpose of this study is to determine the antioxidant activity of Moringa leaf water extract by calculating IC50 and using a comparison standard of vitamin C. The method used in this study is the stratified maceration method with measurement of antioxidant activity using the DPPH method. The results showed that the aqueous extract of Moringa leaves contains secondary metabolites of flavonoids, tannins, saponins, and alkaloids that play a role in antioxidant activity. The test results of Moringa leaf water extract showed moderate antioxidant activity with an IC50 value of 87.54 ppm, while the comparison control vitamin C obtained an IC50 of 483.53 ppm. This is because vitamin C has been oxidized so that the ability to donate protons to DPPH free radicals is also reduced.
Gambaran tingkat pengetahuan swamedikasi obat diare pada warga Desa Hidirasa Kecamatan Wera Kabupaten Bima Hesti Wulandari; Ni Made Amelia Ratnata Dewi; Raisya Hasina
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.187

Abstract

Diarrhea is a health problem with high morbidity and mortality rates. Mild diarrhea is a disease that can be treated with self-medication out by the people of Hidirasa Village because of the limitations of health service centers and places to buy medicines which are still lacking and quite far away. The limited knowledge of the community is one of the sources of errors in treatment. This research was conducted with the aim of knowing the level of knowledge of self-medication of diarrhea medicine in the residents of Hidirasa Village, Wera District, Bima Regency. This research is a descriptive observational study using a cross sectional research design with a cluster sampling technique of 100 respondents. Data was obtained by distributing questionnaires to respondents. The instrument used was tested for validity and reliability. From the 25 statement items, it was declared valid because the r-count value was >0.3 and the reliability test results obtained the Cronbach's Alpha value of 0.888. In the analysis of the level of knowledge of the community is done using Microsoft Excel and categorized into good, sufficient, and less. Based on the results of the study, it can be concluded that the level of knowledge of self-medication of diarrhea drugs in the Hidirasa village community is in the good category of 36%, 62% have sufficient knowledge, and 2% have less knowledge.
Penetapan kadar vitamin C pada daun kelor (Moringa oleifera L.) dan bayam hijau (Amaranthus gangeticus L.) dengan metode spektrofotometri UV-Vis Siti Maryam Indriyati; Yayuk Andayani; Anggit Listyacahyani Sunarwidhi
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.190

Abstract

Vitamin C is a compound that cannot be formed by the body itself. Vitamin C is needed to regulate metabolic processes and normal body functions. Lack of vitamin C can cause a decrease in the immune system. During a pandemic, vitamin C is needed to improve the immune system to prevent and fight disease infections. The pandemic has caused an increase in the need and price of vitamin C supplements in the market. Fulfilling the body’s vitamin C needs can use alternatives such as Moringa leaves and green spinach. This study aims to determine the levels of vitamin C in Moringa leaves and green spinach with variations in temperature and concentration. Analysis of vitamin C was carried out using UV-Vis spectrophotometry at a wavelength of 516 nm. The results of the determination of vitamin C levels in Moringa leaves and green spinach obtained the highest levels of 24,9948% and 19,0205%, and the lowest levels of 2,2456% and 1,8710%. The results of the ANOVA test showed that there was a significant difference in the levels of vitamin C obtained at the given temperature and concentration variations.
Teh herbal terstandar simplisia bunga gemitir (Tagetes erecta Linn.) sebagai kandidat antioksidan baru Kadar Riansyah; Aliefman Hakim; Agriana Rosmalina Hidayati
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.194

Abstract

Empirically, gemitir flower (Tagetes erecta Linn.) has been used for generations as an alternative to treat whooping cough and eye pain medication. Gemitir flower is potential as an antioxidant because it contains secondary metabolites of phenolic groups, flavonoids, and alkaloids that have been shown to have antioxidant activity. As a pharmaceutical products, medicinal plants must be guaranteed quality and safety. This study aims to determine the suitability of the simplicia quality of gemitir flowers by standardization based on Indonesian Herbal Pharmacopoeia and Indonesian Materia Medica, and also to determine the antioxidant potential of standardized herbal teas of gemitir flowers. This first step of this research were standardization of gemitir flower simplicia based on specific and non-specific parameters, followed by making standardized herbal tea of gemitir flower. Antioxidant activity test was carried out on tea preparations using the DPPH method. The results showed that the simplicia of gemitir flower met all the standard parameters of specific and non-specific standardization with an ash content value of 3,47%, acid insoluble ash content of 0,11%, water soluble extract content of 24,86%, ethanol soluble extract content of 21,67%, drying shrinkage content of 9,33%, moisture content of 9,23% and foreign organic matter of 0,3%. Standardized herbal tea simplicia gemitir flower was able to inhibit 50% of DPPH free radicals at a volume of 33,87 µL. Based on the results, it can be concluded that the empirical use of gemitir flower tea potential as a natural antioxidant.
Evaluasi kesesuaian peresepan obat terhadap formularium nasional di Rumah Sakit Umum Daerah Sumbawa tahun 2021 Titania Nabilah; Ni Made Amelia Ratnata Dewi; Siti Rahmatul Aini
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.204

Abstract

Hospitals should follow the National Formulary when prescribing medications. In accordance with the National Formulary, the percentage of drug prescriptions in a hospital must be at least 80%, according to the health service quality indicator standard number 30 of 2022 about hospital prescriptions. One of West Nusa Tenggara Province's class C hospitals, the Sumbawa Regional General Hospital treats patients with National Health Insurance (NHI), whose population is steadily growing. The purpose of this study is to assess the Sumbawa Regional General Hospital's suitability to prescribe medications in 2021 in accordance with the National Formulary. Retrospective data gathering is used in the observational research design. Based on inclusion and exclusion criteria, the research sample consisted of all prescription sheets for both inpatients and outpatients at the Sumbawa Hospital from January to December 2021. Prescription forms, drug content, dosage strengths, and dosing forms are all indicators of eligibility for prescribing. By comparing the number of prescriptions for drugs written according to the National Formulary with the total number of prescriptions, the suitability percentage was computed. The National Formulary states that 87.65% of medication items are suitable for prescription. According to the National Formulary, 87.65% of medicine items were suitable, and 66.2% of prescription sheets were as well. The Sumbawa Hospital's prescriptions are not 100% in accordance with the National Formulary, yet based on drug items have exceeded the standard indicators of drug prescriptions on hospital (more than 80%).
Artikel review: Perawatan tradisional Indonesia bagi ibu pada masa nifas Lola Aprilia; Neneng Rachmalia Izzatul Mukhlishah
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.206

Abstract

Indonesia is a country that has a variety of cultures. The ethnic groups that are widespread in Indonesia have diverse cultures with their own characteristics. Culture is believed to be useful in aspects of life, one of which is related to medicine. Traditional medicine in Indonesia is a unique culture passed down from time to time, from one generation to another. This treatment is more sought after by the community because it is easy to obtain and affordable. This article purpose is to provide an overview of traditional treatments in Indonesia from several regions in Indonesia from Sabang to Merauke. This review contains care for mothers in the postpartum period from the characteristics of each region by utilizing typical Indonesian plants that grow in the surrounding environment. The cultural heritage related to this treatment is still maintained and is carried out by some people.
Comparison of the total phenolic and flavonoid contents of Amomum compactum Sol. Ex Maton from districts Linggo Asri and Paninggaran, Pekalongan Regency Mahfur Mahfur; Kharismatul Khasanah; Metha Anung Anindhita; Safira Galuh Chandra; Alfiana Nur Hidayah
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.212

Abstract

Cardamom (Amomum compactum Sol. Ex Maton) is one of the largest contribution in biopharmaceutical production plants in Indonesia that is equal to 12.22% and yield reaching 105.735 kg/year in Pekalongan Regency. The largest cardamom production in Pekalongan Regency is in 2 districts, namely Linggo Asri and Paninggaran. Cardamom is used in traditional medicines, because it has chemical compounds such as flavonoids and phenolics. The aim of this study was to compare total flavonoids and total phenolics content in Amomum compactum Sol. Ex Maton extract originates from Linggo Asri and Paninggaran district, Pekalongan Regency. The samples were extracted by water extraction, and then phytochemical contents were identified with HCl and FeCl3 reagent. The samples were calculated of total flavonoids and total phenolics content by spectrometric using aluminum chloride colorimetric assay and Folin–Ciocalteu method. The result showed a significant difference in the levels of total phenolic content between Amomum compactum Sol. Ex Maton extract origin from Linggo Asri district 41.43±0.54 µg/mg and Paninggaran district 120.55±1.89 µg/mg, but it was not found in total flavonoid content where from Linggo Asri district 289.06±4.1 µg/mg and Paninggaran district 303.81±0.5 µg/mg. The conclusion is Amomum compactum Sol. Ex Maton extract originates from Linggo Asri and Paninggaran district of Pekalongan city showed a significant difference in the levels of total phenolic content, but it was not found in total flavonoid content.
Formulasi tablet hisap ekstrak etanol daun kemangi (Ocimum sanctum L.) dengan variasi konsentrasi bahan pengikat gelatin Putri Nuryana; Windah Anugrah Subaidah; Agriana Rosmalina Hidayati
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.213

Abstract

Basil leaves (Ocimum sanctum L.) contain secondary metabolites as inhibitors of the growth of pathogenic microbes in the mouth, so they can be used as lozenges. The choice of binder in the formulation is very important, because it can affect the physical properties of the tablet. The purpose of this study was to determine the content of secondary metabolites in basil leaf extract and determine the best formula for lozenges of ethanol extract of basil leaves based on variations in gelatin binding agents. Basil leaves were extracted using the sonication method with 96% ethanol solvent and subjected to phytochemical screening (test tube and TLC). Tablets were formulated using the wet granulation method with variations of gelatin in formula 1 (5%), formula 2 (7.5%), and formula 3 (10%). The physical properties of the granules are evaluated and compressed. The resulting tablets were evaluated for physical properties. The results showed that basil leaves contained compounds belonging to the class of flavonoids, saponins and tannins. The results of the granule flow time test for formula 1 and 2 did not meet the requirements, formula 3 met the requirements for the Indonesian Pharmacopoeia Edition III. The angle of repose, settling, and granule water content tests (formula 1, 2, and 3) met the requirements of the Indonesian Pharmacopoeia Edition III. The results of tablet evaluation in the weight uniformity test for formulas 1, 2, and 3 were 257 mg ± 0.226; 248 mg ± 0.068 and 253 mg ± 0.157. Tablet hardness test of 3.721 kg ± 0.268; 4.221 kg ± 0.929 and 6.636 kg ± 1.035. Tablet friability test of 3.4% ± 0.152; 1.1% ± 0.264 and 0.9% ± 0.1. The disintegration time test was 7.6 minutes ± 2.452; 11 minutes ± 2.154 and 18.6 minutes ± 4.016. From this study it can be concluded that the ethanol extract of basil leaves has secondary metabolites of flavonoids, saponins and tannins. Variations in gelatin binder affect the physical properties of the tablet, where the concentration of gelatin binder is best in formula 3 (10%).
Uji aktivitas antimikroba ekstrak etanol buah renggak (Amomum dealbatum Roxb.) terhadap Staphylococcus aureus dan Candida albicans Muhammad Robby Rizky; Agriana Rosmalina Hidayati; Anggit Listyacahyani Sunarwidhi
Sasambo Journal of Pharmacy Vol. 4 No. 1 (2023): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i1.215

Abstract

Staphylococcus aureus and Candida albicans are microorganisms that cause infection in humans and have developed resistance to several classes of antibiotics and antifungals. Plants in the genus Amomum have been used in traditional medicine and have scientific potential as alternatives to natural antibacterial and antifungal agents. Renggak (Amomum dealbatum Roxb.) is a species of the genus Amomum that is commonly found in Lombok. Scientific research related to the antibacterial and antifungal activity of the fruit is still limited. The aim of this study was to determine the antibacterial and antifungal activity of ethanol extract of renggak fruit against Staphylococcus aureus and Candida albicans. The extraction method used sonication with 96% ethanol. Testing of antibacterial and antifungal activity by disc diffusion method. The positive control used chloramphenicol for antibacterial testing and ketoconazole for antifungal testing, while the negative control used 10% DMSO solution. The antibacterial and antifungal activity of the extract was measured based on the diameter of the inhibition zone formed around the disc. Data analysis used the Kruskall-Wallis statistical test with a 95% confidence level. The results showed that the ethanol extract had moderate activity against S. aureus at concentrations of 20% w/v & 30%w/v with inhibitory diameters ranging from 5-7 mm, while at concentrations of 40% w/v & 50% w/v. has strong activity with inhibitory diameters ranging from 10-15 mm. The ethanol extract showed no activity at concentrations of 50%, 75%, and 100% in inhibiting the growth of the fungus C. albicans. Statistical test of each extract concentration had a significant effect on the inhibition of growth of S. aureus compared to the negative control. Based on the description above, it can be concluded that the extract of renggak fruit has the potential to inhibit the growth of S. aureus.

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