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Sasambo Journal of Pharmacy

sjp
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Published by Universitas Mataram

ISSN : 27232824 EISSN : 27232832 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 94 Documents

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Aktivitas antioksidan ekstrak etanol daun pecut kuda (Stachytarpheta jamaicensis (L.) Vahl) menggunakan metode ekstraksi berbasis gelombang ultrasonic Rian Jumawardi; Agus Dwi Ananto; Rizqa Fersiyana Deccati
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Free radical is an atom or molecule that has unpaired electrons, is reactive and unstable which can cause damage to cells and tissues. Secondary metabolite compounds in plants such as phenolics, flavonoids, tannins, and saponins can inhibit free radicals. One of the plants that has the potential as an antioxidant is a Stachytarpheta jamaicensis (L.) Vahl. The part of the plant that is often used as a medicinal ingredient by Indonesian people is the leaf part. The leaves of snakeweed are natural ingredients that are rich in phenolic compounds, flavonoids, tannins, and saponins. This study aims to determine the activity of free radical inhibition in the snakeweed leaf extract with Ultrasound Assisted Extraction method. Determination of free radical inhibition activity was examined using DPPH method at the concentration series of snakeweed leaf extracts of 60, 65, 70, 75, 80, and 85 ppm. The comparison solution used was vitamin C made with a concentration series of 4, 5, 6, 7, 9, and 11 ppm. The results showed that vitamin C had a free radical inhibitory activity with an IC50 value of 9.40 ± 0.07 ppm, while the extract of snakeweed leaf had free radical inhibition activity with an IC50 value of 74.32 ± 0.71 ppm. Based on the IC50 value, the intensity of free radical inhibition activity in vitamin C is classified as very strong and the extract of snakeweed leaf is strong

In silico analysis of Trisindoline 1 compound against Mpro SARS-CoV-2 as novel potential drugs candidate Fitri Lianingsih
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

The novel coronavirus 2019 (SARS-CoV-2) is one of the viruses that can infect humans and cause high mortality worldwide. The protease (Mpro) is key SARS-CoV-2 an enzyme mediates the viral replication and the transcription. Mpro is currently used as the candidate for the SARS-CoV-2 vaccine because Mpro is one of the key enzymes in the viral life cycle that essential for interactions between the virus and host cell receptor during viral entry. The Mpro can be a target protein to design the novel drug of SARS-CoV-2. The drug design from natural products that are considered to have low toxicity is needed against the virus. The study aims to determines the potential pharmacology of Trisindoline 1 compound from the sponge Hyrtios altum against SARS-CoV-2 and to find the amino acid residues between interaction ligand-protein receptors. The methods of this study use the virtual screening of Auto Dock Vina and visualization the amino acid residue using Bio via Discovery Studio. The result of this study was the selected marine compound from Trisindoline 1 may have potential to developed as inhibitor of SARS-CoV-2.Keywords: In Silico, Mpro, Sars Cov 2, Trisindoline 1, Sponges

Correlation of low body mass index and albumin level with the presence of liver dysfunction in newly diagnosed tuberculosis patients Sriyanty Sadsyam; Yulia Yusrini Djabir; Arif Santoso
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Tuberculosis (TB) patients often experience reduced appetite or nutritional malabsorption leading to malnutrition, which manifests in excessive loss of muscle mass and low body mass index (BMI). Patients with protein malnutrition is associated with increased risk of drug-induced liver injury and may require a close monitoring during the course of antituberculosis (AT) treatment. The purpose of this study was to determine the correlation of low body mass index and albumin level with liver dysfunction in patients newly diagnosed with TB prior to receiving AT drugs. This study is a nonexperimental observational study with consecutive sampling technique by following a descriptive analytic design (cohort study). The subjects were patients in the National Lung Health Center Makassar who are newly diagnosed with TB and have not received any AT drug. The BMI data and blood samples were collected and analyzed to obtain Alanine aminotransferase (ALT), Aspartat aminotransferase (AST), and Albumin levels. It was found that out of 22 total patients, 3 (14%) of the TB patients experienced liver dysfunction characterized by high level of ALT and AST levels. Both patients had normal levels of albumin despite one of them had a low BMI. The statistical showed no correlation between the low BMI or albumin level with the presence of liver dysfunction. It is concluded that the presence of liver dysfunction is not correlated with low BMI or albumin level in newly diagnosed TB patients, and hence, are not considered as independent risk factors of liver dysfunction in this population.

Formulasi sabun mandi cair dari daging putih buah semangka (Citrullus lanatus) Nurul Arfiyanti Yusuf; Nurul Sari Pandewa; Vilia Payangan; Diaz Permata
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

White flesh watermelon (Citrullus lanatus) is known to contain alkaloids, flavonoids, tannins and polyphenols. Research conducted by Rimando proves that watermelon rind contains the amino acid citrulline reaching 60% which is important in increasing levels of nitric oxide which is a regulator of blood flow, muscle energy metabolism, and mitochondrial respiration during exercise. This study aims to formulate bath soap from watermelon waste that meets the requirements with variations in the concentration of watermelon flesh extract (3%; 6%; 9%). Watermelon flesh extract was extracted by maceration process using 70% ethanol. Evaluations were carried out in the form of organoleptic, pH, free of alkali, high foam and density. The results showed that the three formulas were formulas that met the requirements according to SNI standards based on pH test, free alkali, foam height, and density.

Profil fitokimia dan aktivitas antibakteri fraksi etil asetat akar jarak pagar (Jatropha curcas Linn.) Sudarman Rahman; Stevin Carolius Angga; Erwin Prasetya Toepak; Muhammad Takdir Bachtiar
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Bacterial infections are a major cause of chronic infections and mortality that continues to threaten public health worldwide. Various medicinal plants used in folk medicine have demonstrated wound healing and antibacterial properties. The aims of the study are investigation phytochemical and antibacterial activity of ethyl acetate fraction from jarak pagar roots (Jatropha curcas Linn.). The roots were treated with maceration method using ethanol 70% and subsequently fractioned to ethyl acetate fraction. The fractions were used for phytochemical screening and antibacterial assay using Kirby and Bauer agar difussion method. The results showed that ethyl acetate fraction jarak pagar roots contained alkaloid, flavonoids, saponins, steroids, poliphenol dan tannins. The antibacterial activity of jarak pagar roots againts Staphylococcus aureus and Escherichia coli shows that the activity of this fraction with concentration 8 mg/mL has strong inhibitory potency against the growth S. aureus with inhibitory zone is 14,3 mm and has moderate inhibitory potency against E. coli with inhibitory zone is 9 mm. The increase concentrations of ethyl asetate fraction jarak pagar roots shows high inhibition diameter of bacterial growth.

Evaluasi ketersediaan obat di beberapa puskesmas wilayah kabupaten X tahun 2019 Andini Rezeki; Bella Na Fhory; Muhamad Saif Roies Yasa; Syahriah Syahriah; Nashrul Wathan
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Drug management in public health centers (Puskesmas) needs to be solve properly to ensure continuing availability and affordability medical services that efficient, effective and rational. The aims of this study are to describe and evaluate drug management in four Puskesmas on Kabupaten X, especially in planning, demanding, receiving, distribution, and storage. This study is a descriptive-evaluative study, with quantitative and qualitative methods, using retrospective data in 2019. The results show that suitability of the types of drugs available with the district drug formulary : 93.46-98.57%; accuracy of drug demand 114-416%; receiving accuracy 76-128%; dead stock 1.3-31.57%; prescriptioning generic drugs 94.72-100%; and the value of damaged drugs 0-17,37%. Results of this study can be concluded that the drug management in four Puskesmas still not optimal because not in accordance with the standard.

Incidence of Klebsiella pneumoniae producing Metallo Beta-Lactamase (MBL) at RSUP Dr. Wahidin Sudirohusodo Makassar Muhammad Jen Hamdani; Natsir Djide; Mansyur Arif
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.111

Bacterial resistance to antibiotic is one of the factors triggering infection therapy failure. This study was conducted to determine the prevalence of carbapenem-resistance Klebsiella pneumoniae infection and the phenotype of carbapenem-resistant Metallo-Beta-Lactamase (MBL)-producing Klebsiella pneumoniae isolates at RSUP Dr. Wahidin Sudirohusodo Makassar. This study included Klebsiella pneumoniae identification on each infectious patient’s isolates. The sensitivity test of antibiotics, phenotype confirmatory test, and MBL phenotypic test were conducted using agar diffusion Kirby-Bauer, Vitek-2-Compact, and Double Disc Synergy Test (DDST) method, respectively. As the result, the antibiotic sensitivity test using the Vitek-2-Compact method on 50 clinical samples (pus, sputum, blood. tissue, urine, brain fluid, and feces) found that 10 isolates (20%) were resistant to carbapenem. The phenotypic test using the Double Disc Synergy Test (DDST) method found that carbapenem-resistant isolates caused by the production of Metallo Beta Lactamase (MBL) enzymes were 2 isolates or 20% of the total carbapenem-resistant isolates.

The influence concentration gel agent propolis combination of mulberry leaf on the growth of the bacteria Propionibacterium acnes Prayitno Setiawan; Nurfitria Junita
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.126

This research was carried out with the aim of determining the inhibitory power of the combination gel of propolis extract and mulberry leaf extract against Propionibacterium acnes bacteria and determining the concentration of propolis extract that provided the greatest inhibitory power against the test bacteria. The research method includes the extraction of mulberry leaves by maceration using 70% ethanol as a solvent and the propolis extract used is a ready-to-use extract. The formulations were designed with various concentrations of propolis (0.5%, 1%, 1.5%) and 0.5% mulberry leaf concentration. Testing the antimicrobial activity of propolis extract in combination with mulberry extract in gel preparations against the growth of Propionibacterium acnes bacteria was carried out using the agar diffusion method. The results showed that the average diameter of the inhibition area at 0.5% concentration was 36.87 mm, at 1% concentration was 44.557 mm and at 1.5% concentration was 45.97 mm, positive control was 49.21 mm. Based on the data obtained, it is concluded that the gel formula with a propolis concentration of 1.5% is the preparation with the largest zone of inhibition.

Evaluasi penerapan standar pelayanan kefarmasian di Puskesmas Baiq Endang Suprihartini; Nur Radiah; Muhammad Wahyu Hidayat
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.128

Pharmacy services is a direct service and obligation to the patients regarding the pharmacy substances with the aim to increase the public health services in the field of pharmacy. The purpose of this study is to evaluate the implementation of pharmaceutical standard at the primary health services Puskesmas. This study is conducted in descriptive research, data collection using a cross sectional survey approach. The instruments in this study was a questionnaire sourced from the Regulation of the Minister of Health No. 74 of 2016 concerning pharmaceutical service standards in Puskesmas. Respondents in this study were pharmacists at the Pagesangan Puskesmas. The management activities reach 100% of drug and medical consumables, 93.75% of equipment and supporting facilities, 100% of human resources. These results indicate that the evaluation of the implementation of pharmaceutical service standards at the Puskesmas based on pharmaceutical service indicators has been carried out well at the Pagesangan Puskesmas with an average value of 96.77%. The implementation of pharmaceutical service standards at the Pagesangan Puskesmas has met all the indicators of pharmaceutical service standards at the Puskesmas.

Evaluasi pola penggunaan obat dispepsia berdasarkan indikator WHO (World Health Organization) pada pasien rawat jalan Puskesmas Karang Taliwang tahun 2019 Helen Nabila; Ni Made Amelia Ratnata Dewi; Ima Arum Lestarini
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.139

Dyspepsia is a collection of several clinical symptoms consisting of pain in the pit of the stomach, flatulence, early satiety, nausea, and vomiting. The incidence of dyspepsia at the Karang Taliwang Public Health Center until 2019 was quite high. Evaluation of drug use at the Puskesmas has never been carried out, so it is necessary to know the pattern of use of dyspepsia drugs at the Karang Taliwang Public Health Center. This review aimed to determine the pattern of dyspepsia drug use in outpatient dyspepsia at Karang Taliwang Public Health Center using prescribing indicators developed by the World Health Organization. This study is a descriptive study of retrospective drug use. Sampling using a consecutive sampling method. Prescription data and medical records were collected through observation sheets. The results of the study on drug use patterns were the average number of drug items per sheet of 2.55 prescription; the percentage of drugs prescribed with generic names was 99,37%; the percentage of prescription drugs with antibiotics was 1.61%; the percentage of prescription drugs with injection preparations was 0%; and the percentage of drugs prescribed according to the Formularium was 96.84%.

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Yayuk Andayani

Contact Email
sjp@unram.ac.id

Phone
+6281936732708

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sjp@unram.ac.id

Editorial Address
Jl. Majapahit No. 62 Mataram

Location
Kota mataram,

Nusa tenggara barat

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Yayuk Andayani

Contact Email sjp@unram.ac.id

Phone +6281936732708

Journal Mail Official sjp@unram.ac.id

Editorial Address Jl. Majapahit No. 62 Mataram

Location Kota mataram, Nusa tenggara barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Yayuk Andayani

Contact Email
sjp@unram.ac.id

Phone
+6281936732708

Journal Mail Official
sjp@unram.ac.id

Editorial Address
Jl. Majapahit No. 62 Mataram

Location
Kota mataram,

Nusa tenggara barat

INDONESIA